未登录 Risk Assessment and Control of N-Nitrosamines in Antibody-Drug Conjugates: Current Industry Practices 抗体-药物结合物中N-亚硝胺的风险评估和控制: 当前行业惯例 Bulger, Paul G.; Jones, Michael T.; Ford, J. Gair; Schrier, Kate; Cole, Kevin P.; Bernardoni, Frank; Dirat, Olivier; Zhang, Qunying; Chahrour, Osama; Miller, Joy; Bonaga, Llorente; Parsons, Andrew T.; Yang, Lan 分享 收藏
Risk Evaluation of N-Nitrosamines in Drug-Linker Intermediates Used To Generate Antibody-Drug Conjugates 用于产生抗体-药物偶联物的药物-接头中间体中N-亚硝胺的风险评估 Chahrour, Osama; Bulger, Paul G.; Dirat, Olivier; Schrier, Kate; Parsons, Andrew T.; Ford, J. Gair; Bernardoni, Frank; Hetrick, Evan M.; Bonaga, Llorente R.; Cole, Kevin P.; Miller, Joy; Zhang, Qunying; Jones, Michael T. 分享 收藏
Oxetane Promise Delivered: Discovery of Long-Acting IDO1Inhibitors Suitable for Q3W Oral or Parenteral Dosing Li, Derun; Sloman, David L.; Achab, Abdelghani; Zhou, Hua; McGowan, Meredeth A.; White, Catherine; Gibeau, Craig; Zhang, Hongjun; Pu, Qinglin; Bharathan, Indu; Hopkins, Brett; Liu, Kun; Ferguson, Heidi; Fradera, Xavier; Lesburg, Charles A.; Martinot, Theodore A.; Qi, Ji; Song, Zhiguo J.; Yin, Jingjun; Zhang, Huangguang; Song, Licheng; Wan, Baoqiang; DAddio, Suzanne; Solban, Nicolas; Miller, J. Richard; Zamlynny, Beata; Bass, Alan; Freeland, Elizabeth; Ykoruk, Bridget; Hilliard, Catherine; Ferraro, Jude; Zhai, Jin; Knemeyer, Ian; Otte, Karin M.; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin 分享 收藏
Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action (vol 4, 927, 2021) Palte, Rachel L.; Juan, Veronica; Gomez-Llorente, Yacob; Bailly, Marc Andre; Chakravarthy, Kalyan; Chen, Xun; Cipriano, Daniel; Fayad, Ghassan N.; Fayadat-Dilman, Laurence; Gathiaka, Symon; Greb, Heiko; Hall, Brian; Handa, Mas; Hsieh, Mark; Kofman, Esther; Lin, Heping; Miller, J. Richard; Nguyen, Nhung; O'Neil, Jennifer; Shaheen, Hussam; Sterner, Eric; Strickland, Corey; Sun, Angie; Taremi, Shane; Scapin, Giovanna 分享 收藏
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors Li, Derun; Zhang, Hongjun; Lyons, Thomas W.; Lu, Min; Achab, Abdelghani; Pu, Qinglin; Childers, Matthew; Mitcheltree, Matthew J.; Wang, Jialiang; Martinot, Theodore A.; McMinn, Spencer E.; Sloman, David L.; Palani, Anandan; Beard, Adam; Nogle, Lisa; Gathiaka, Symon; Sauri, Josep; Kim, Hai-Young; Adpressa, Donovon; Spacciapoli, Peter; Miller, J. Richard; Palte, Rachel L.; Lesburg, Charles A.; Cumming, Jared; Fischer, Christian 分享 收藏
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors Hopkins, Brett; Zhang, Hongjun; Bharathan, Indu; Li, Derun; Pu, Qinglin; Zhou, Hua; Martinot, Theodore A.; Fradera, Xavier; Lammens, Alfred; Lesburg, Charles A.; Cohen, Ryan D.; Ballard, Jeanine; Knemeyer, Ian; Otte, Karin; Vincent, Stella; Miller, J. Richard; Solban, Nicolas; Cheng, Mangeng; Geda, Prasanthi; Smotrov, Nadya; Song, Xuelei; Bennett, David Jonathan; Han, Yongxin 分享 收藏
Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology 基于结构的脯氨酸衍生精氨酸酶抑制剂的免疫肿瘤学口服生物利用度提高的发现 Lu, Min; Zhang, Hongjun; Li, Derun; Childers, Matthew; Pu, Qinglin; Palte, Rachel L.; Gathiaka, Symon; Lyons, Thomas W.; Palani, Anandan; Fan, Peter W.; Spacciapoli, Peter; Miller, J. Richard; Cho, Hyelim; Cheng, Mangeng; Chakravarthy, Kalyan; O'Neil, Jennifer; Eangoor, Padmanabhan; Beard, Adam; Kim, Hai-Young; Sauri, Josep; Gunaydin, Hakan; Sloman, David L.; Siliphaivanh, Phieng; Cumming, Jared; Fischer, Christian 分享 收藏
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds Vara, Brandon A.; Levi, Samuel M.; Achab, Abdelghani; Candito, David A.; Fradera, Xavier; Lesburg, Charles A.; Kawamura, Shuhei; Lacey, Brian M.; Lim, Jongwon; Methot, Joey L.; Xu, Zangwei; Xu, Haiyan; Smith, Dustin M.; Piesvaux, Jennifer A.; Miller, J. Richard; Bittinger, Mark; Ranganath, Sheila H.; Bennett, David J.; DiMauro, Erin F.; Pasternak, Alexander 分享 收藏
Identification of Potent Reverse Indazole Inhibitors for HPK1 Yu, Elsie C.; Methot, Joey L.; Fradera, Xavier; Lesburg, Charles A.; Lacey, Brian M.; Siliphaivanh, Phieng; Liu, Ping; Smith, Dustin M.; Xu, Zangwei; Piesvaux, Jennifer A.; Kawamura, Shuhei; Xu, Haiyan; Miller, J. Richard; Bittinger, Mark; Pasternak, Alexander 分享 收藏
Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors Li, Derun; Deng, Yongqi; Achab, Abdelghani; Bharathan, Indu; Hopkins, Brett Andrew; Yu, Wensheng; Zhang, Hongjun; Sanyal, Sulagna; Pu, Qinglin; Zhou, Hua; Liu, Kun; Lim, Jongwon; Fradera, Xavier; Lesburg, Charles A.; Lammens, Alfred; Martinot, Theodore A.; Cohen, Ryan D.; Doty, Amy C.; Ferguson, Heidi; Nickbarg, Elliott B.; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Abeywickrema, Pravien; Andrews, Christine; Chamberlin, Chad; Mabrouk, Omar; Curran, Patrick; Richards, Matthew; Saradjian, Peter; Miller, J. Richard; Knemeyer, Ian; Otte, Karin M.; Vincent, Stella; Sciammetta, Nunzio; Pasternak, Alexander; Bennett, David Jonathan; Han, Yongxin 分享 收藏
Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice Aslamkhan, Amy G.; Xu, Qiuwei; Loughlin, Amy; Vu, Heather; Pacchione, Stephen; Bhatt, Bhavana; Garfinkel, Ivy; Styring, Tara Grady; LaFranco-Scheuch, Lisa; Pearson, Kara; Reynolds, Spencer; Li, Nianyu; Zhou, Heather; Miller, J. Richard; Solban, Nicolas; Bass, Alan; Glaab, Warren E. 分享 收藏
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors 发现有效且可口服的双环 [1.1.1] 戊烷衍生的Indoleamine-2，3-双加氧酶1 (IDO1) 抑制剂 Pu, Qinglin; Zhang, Hongjun; Guo, Liangqin; Cheng, Mangeng; Doty, Amy C.; Ferguson, Heidi; Fradera, Xavier; Lesburg, Charles A.; McGowan, Meredeth A.; Miller, J. Richard; Geda, Prasanthi; Song, Xuelei; Otte, Karin; Sciammetta, Nunzio; Solban, Nicolas; Yu, Wensheng; Sloman, David L.; Zhou, Hua; Lammens, Alfred; Neumann, Lars; Bennett, David Jonathan; Pasternak, Alexander; Han, Yongxin 分享 收藏
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy 合理设计的人精氨酸酶双环抑制剂的发现和优化，以增强癌症免疫治疗 Mitcheltree, Matthew J.; Li, Derun; Achab, Abdelghani; Beard, Adam; Chakravarthy, Kalyan; Cheng, Mangeng; Cho, Hyelim; Eangoor, Padmanabhan; Fan, Peter; Gathiaka, Symon; Kim, Hai-Young; Lesburg, Charles A.; Lyons, Thomas W.; Martinot, Theodore A.; Miller, J. Richard; McMinn, Spencer; O'Neil, Jennifer; Palani, Anandan; Palte, Rachel L.; Sauri, Josep; Sloman, David L.; Zhang, Hongjun; Cumming, Jared N.; Fischer, Christian 分享 收藏
Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1) 在Indoleamine-2，3-双加氧酶-1 (IDO1) 的血红素置换抑制剂中战略性地掺入极性 White, Catherine; McGowan, Meredeth A.; Zhou, Hua; Sciammetta, Nunzio; Fradera, Xavier; Lim, Jongwon; Joshi, Elizabeth M.; Andrews, Christine; Nickbarg, Elliott B.; Cowley, Phillip; Trewick, Sarah; Augustin, Martin; von Koeenig, Konstanze; Lesburg, Charles A.; Otte, Karin; Knemeyer, Ian; Woo, Hyun; Yu, Wensheng; Cheng, Mangeng; Spacciapoli, Peter; Geda, Prasanthi; Song, Xuelei; Smotrov, Nadya; Curran, Patrick; Heo, Mee Ra; Abeywickrema, Pravien; Miller, J. Richard; Bennett, David Jonathan; Han, Yongxin 分享 收藏
Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases Zhang, Hongjun; Lapointe, Blair T.; Anthony, Neville; Azevedo, Rita; Cals, Jos; Correll, Craig C.; Daniels, Matthew; Deshmukh, Sujal; van Eenenaam, Hans; Ferguson, Heidi; Hegde, Laxminarayan G.; Karstens, Willem Jan; Maclean, John; Miller, J. Richard; Moy, Lily Y.; Simov, Vladimir; Nagpal, Sunil; Oubrie, Arthur; Palte, Rachel L.; Parthasarathy, Gopal; Sciammetta, Nunzio; van der Stelt, Mario; Woodhouse, Janice D.; Trotter, B. Wesley; Barr, Kenneth 分享 收藏
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy 发现用于癌症免疫疗法的氨基-环丁基芳烃衍生的Indoleamine-2，3-双加氧酶1 (IDO1) 抑制剂 Zhang, Hongjun; Liu, Kun; Pu, Qinglin; Achab, Abdelghani; Ardolino, Michael J.; Cheng, Mangeng; Deng, Yongqi; Doty, Amy C.; Ferguson, Heidi; Fradera, Xavier; Knemeyer, Ian; Kurukulasuriya, Ravi; Lam, Yu-hong; Lesburg, Charles A.; Martinot, Theodore A.; McGowan, Meredeth A.; Miller, J. Richard; Otte, Karin; Biju, Purakattle J.; Sciammetta, Nunzio; Solban, Nicolas; Yu, Wensheng; Zhou, Hua; Wang, Xiao; Bennett, David Jonathan; Han, Yongxin 分享 收藏
Mg2+ regulation of kinase signaling and immune function Kanellopoulou, Chryssa; George, Alex B.; Masutani, Evan; Cannons, Jennifer L.; Ravell, Juan C.; Yamamoto, Tori N.; Smelkinson, Margery G.; Du Jiang, Ping; Matsuda-Lennikov, Mami; Reilley, Julie; Handon, Robin; Lee, Ping-Hsien; Miller, J. Richard; Restifo, Nicholas P.; Zheng, Lixin; Schwartzberg, Pamela L.; Young, Matthew; Lenardo, Michael J. 分享 收藏
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RORγt inhibitors suppress TH17 responses in inflammatory arthritis and inflammatory bowel disease de Wit, Jelle; Al-Mossawi, M. Hussein; Huehn, Michael H.; Arancibia-Carcamo, Carolina V.; Doig, Karen; Kendrick, Benjamin; Gundle, Roger; Taylor, Peter; Mcclanahan, Terri; Murphy, Erin; Zhang, Hongjun; Barr, Ken; Miller, J. Richard; Hu, Xiao; Aicher, Thomas D.; Morgan, Rodney W.; Glick, Gary D.; Zaller, Dennis; Correll, Craig; Powrie, Fiona; Bowness, Paul 分享 收藏
Identification of an allosteric binding site for RORγt inhibition 鉴定ror γ t抑制的变构结合位点 Scheepstra, Marcel; Leysen, Seppe; van Almen, Geert C.; Miller, J. Richard; Piesvaux, Jennifer; Kutilek, Victoria; van Eenennaam, Hans; Zhang, Hongjun; Barr, Kenneth; Nagpal, Sunil; Soisson, Stephen M.; Kornienko, Maria; Wiley, Kristen; Elsen, Nathaniel; Sharma, Sujata; Correll, Craig C.; Trotter, B. Wesley; van der Stelt, Mario; Oubrie, Arthur; Ottmann, Christian; Parthasarathy, Gopal; Brunsveld, Luc 分享 收藏
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