未登录 Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras 可逆性小分子多变量Ras抑制剂对Ras的活性形式和非活性形式显示出可调节的亲和力。 Parry, Charles W.; Pellicano, Francesca; Schuttelkopf, Alexander W.; Beyer, Kim S.; Bower, Justin; Bryson, Amy; Cameron, Kenneth; Cerutti, Nichole M.; Clark, Jonathan P.; Davidson, Stuart C.; Davies, Keneth; Drysdale, Martin J.; Engelman, Jeffrey; Estevan-Barber, Anna; Gohlke, Andrea; Gray, Christopher H.; Guthy, Daniel A.; Hong, Min; Hopkins, Alana; Hutchinson, Luke D.; Konczal, Jennifer; Maira, Michel; McArthur, Duncan; Mezna, Mokdad; McKinnon, Heather; Nepravishta, Ridvan; Ostermann, Nils; Pasquali, Camila C.; Pollock, Katie; Pugliese, Angelo; Rooney, Nicholas; Schmiedeberg, Niko; Shaw, Paul; Velez-Vega, Camilo; West, Christopher; West, Ryan; Zecri, Frederic; Taylor, John B. 分享 收藏
Pharmacological inhibition of PMS2 increases tumor mutational burden, induces microsatellite instability and elicits immune mediated rejection in vivo Piumatti, Eleonora; Hervieu, Alexia; Riou, Philippe; Blagg, Julian; Peall, Adam; Weeks, Sam; Rodriguez-Plata, Maria T.; Rospo, Giuseppe; Arunachalam, Sasi; Meier, Bettina; Tongue, Paige; McLaren, Tessa; Parmar, Kalpesh; Patel, Pradip; Clark, David; Langley, Gareth; Nichols, Charles; Rousseau, Benoit; Winship, Paul; Baker, Matthew; Drysdale, Martin; Germano, Giovanni; Bardelli, Alberto 分享 收藏
NP1867, a potent, selective, covalent small molecule inhibitor of DNA Mismatch Repair (MMR) protein PMS2, functionally inhibits MMR in cells and elicits COSMIC mutational signatures consistent with MMR-deficient patient samples Blagg, Julian; Riou, Philippe; Hervieu, Alexia; Piumatti, Eleonora; Rospo, Giuseppe; Arunachalam, Sasi; Meier, Bettina; Weeks, Sam; Rodriguez, Maria; Parmar, Kalpesh; Patel, Pradip; Peall, Adam; Tongue, Paige; McLaren, Tess; Workman, Robert; Bago, Ruzica; Robjohns, Stuart; Beaumont, Rebecca; Briggs, Mike; Langley, Gareth; Nichols, Charles; Clark, David; Winship, Paul; Rousseau, Benoit; Baker, Matthew; Drysdale, Martin; Germano, Giovanni; Bardelli, Alberto 分享 收藏
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Comparative effectiveness of Sotrovimab versus no treatment in initially non-hospitalised high-risk patients with COVID-19 in North West London during omicron predominance: a retrospective cohort study using the discover dataset Drysdale, M.; Galimov, E. R.; Yarwood, M. J.; Levick, B.; Gibbons, D. C.; Watkins, J. D.; Young, S.; Pierce, B. F.; Kerr, W.; Birch, H. J.; Kamalati, T.; Brett, S. J. 分享 收藏
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Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction McKinney, David C.; McMillan, Brian J.; Ranaghan, Matthew; Moroco, Jamie A.; Brousseau, Merissa; Mullin-Bernstein, Zachary; O'Keefe, Meghan; McCarren, Patrick; Mesleh, Michael F.; Mulvaney, Kathleen M.; Robinson, Foxy; Singh, Ritu; Bajrami, Besnik; Wagner, Florence F.; Hilgraf, Robert; Drysdale, Martin J.; Campbell, Arthur J.; Skepner, Adam; Timm, David E.; Porter, Dale; Kaushik, Virendar K.; Sellers, William R.; Ianari, Alessandra 分享 收藏
A RAC-GEF network critical for early intestinal tumourigenesis Pickering, K. A.; Gilroy, K.; Cassidy, J. W.; Fey, S. K.; Najumudeen, A. K.; Zeiger, L. B.; Vincent, D. F.; Gay, D. M.; Johansson, J.; Fordham, R. P.; Miller, B.; Clark, W.; Hedley, A.; Unal, E. B.; Kiel, C.; McGhee, E.; Machesky, L. M.; Nixon, C.; Johnsson, A. E.; Bain, M.; Strathdee, D.; van Hoof, S. R.; Medema, J. P.; Anderson, K., I; Brachmann, S. M.; Stucke, V. M.; Malliri, A.; Drysdale, M.; Turner, M.; Serrano, L.; Myant, K.; Campbell, A. D.; Sansom, O. J. 分享 收藏
A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma Birch, Joanna L.; Strathdee, Karen; Gilmour, Lesley; Vallatos, Antoine; McDonald, Laura; Kouzeli, Ariadni; Vasan, Richa; Qaisi, Abdulrahman Hussain; Croft, Daniel R.; Crighton, Diane; Gill, Kathryn; Gray, Christopher H.; Konczal, Jennifer; Mezna, Mokdad; McArthur, Duncan; Schuttelkopf, Alexander W.; McConnell, Patricia; Sime, Mairi; Holmes, William M.; Bower, Justin; McKinnon, Heather J.; Drysdale, Martin; Olson, Michael F.; Chalmers, Anthony J. 分享 收藏
A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo McKinnon, Heather J.; Birch, Joanna; McDonald, Laura; Sime, Mairi; Croft, Daniel; Crighton, Diane; Drysdale, Martin; Gilmore, Lesley; Gray, Christopher; Konczal, Jennifer; McArthur, Duncan; McConnell, Patricia; Mezna, Mokdad; Schuettelkopf, Alexander; Strathdee, Karen; Bower, Justin; Olson, Michael F.; Chalmers, Anthony J. 分享 收藏
Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress Port, Jennifer; Muthalagu, Nathiya; Raja, Meera; Ceteci, Fatih; Monteverde, Tiziana; Kruspig, Bjorn; Hedley, Ann; Kalna, Gabriela; Lilla, Sergio; Neilson, Lisa; Brucoli, Martina; Gyuraszova, Katarina; Tait-Mulder, Jacqueline; Mezna, Mokdad; Svambaryte, Silvija; Bryson, Amy; Sumpton, David; McVie, Allan; Nixon, Colin; Drysdale, Martin; Esumi, Hiroyasu; Murray, Graeme I.; Sansom, Owen J.; Zanivan, Sara R.; Murphy, Daniel J. 分享 收藏
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer Unbekandt, Mathieu; Belshaw, Simone; Bower, Justin; Clarke, Maeve; Cordes, Jacqueline; Crighton, Diane; Croft, Daniel R.; Drysdale, Martin J.; Garnett, Mathew J.; Gill, Kathryn; Gray, Christopher; Greenhalgh, David A.; Hall, James A. M.; Konczal, Jennifer; Lilla, Sergio; McArthur, Duncan; McConnell, Patricia; McDonald, Laura; McGarry, Lynn; McKinnon, Heather; McMenemy, Carol; Mezna, Mokdad; Morrice, Nicolas A.; Munro, June; Naylor, Gregory; Rath, Nicola; Schuttelkopf, Alexander W.; Sime, Mairi; Olson, Michael F. 分享 收藏
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A Central Role for Biophysics in Cancer Drug Discovery - Development of Candidate Small Molecule Inhibitors in Mutant KRas Gohlke, Andrea; Bower, Justin; Brown, Peter N.; Cameron, Ken S.; Drysdale, Martin; Goodwin, Gillian; Gray, Christopher; Konczal, Jen; McArthur, Duncan; McKinnon, Heather; Mezna, Mokdad; Pugliese, Angelo; Schuettelkopf, Alexander W. 分享 收藏
Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery Croft, Daniel; Francis, Stuart; Bower, Justin; Gohlke, Andrea; Goodwin, Gillian; Gray, Christopher; Konczal, Jennifer; Macconnachie, Sophie; McConnell, Patricia; McDonald, Laura; McKinnon, Heather; Mezna, Mokdad; Parry, Charles; Paul, Nikki; Pugliese, Angelo; Schuettelkopf, Alexander; Machesky, Laura; Drysdale, Martin 分享 收藏
Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks Bilsland, Alan E.; Pugliese, Angelo; Liu, Yu; Revie, John; Burns, Sharon; McCormick, Carol; Cairney, Claire J.; Bower, Justin; Drysdale, Martin; Narita, Masashi; Sadaie, Mahito; Keith, W. Nicol 分享 收藏
A novel small-molecule MRCK inhibitor blocks cancer cell invasion Unbekandt, Mathieu; Croft, Daniel R.; Crighton, Diane; Mezna, Mokdad; McArthur, Duncan; McConnell, Patricia; Schuettelkopf, Alexander W.; Belshaw, Simone; Pannifer, Andrew; Sime, Mairi; Bower, Justin; Drysdale, Martin; Olson, Michael F. 分享 收藏
Fragment-based hit identification: thinking in 3D Morley, Andrew D.; Pugliese, Angelo; Birchall, Kristian; Bower, Justin; Brennan, Paul; Brown, Nathan; Chapman, Tim; Drysdale, Martin; Gilbert, Ian H.; Hoelder, Swen; Jordan, Allan; Ley, Steven V.; Merritt, Andy; Miller, David; Swarbrick, Martin E.; Wyatt, Paul G. 分享 收藏
Targeting conserved water molecules: Design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization Davies, Nicholas G. M.; Browne, Helen; Davis, Ben; Drysdale, Martin J.; Foloppe, Nicolas; Geoffrey, Stephanie; Gibbons, Ben; Hart, Terance; Hubbard, Roderick; Jensen, Michael Rugaard; Mansell, Howard; Massey, Andrew; Matassova, Natalia; Moore, Jonathan D.; Murray, James; Pratt, Robert; Ray, Stuart; Robertson, Alan; Roughley, Stephen D.; Schoepfer, Joseph; Scriven, Kirsten; Simmonite, Heather; Stokes, Stephen; Surgenor, Allan; Webb, Paul; Wood, Mike; Wright, Lisa; Brough, Paul 分享 收藏
Adenosine-Derived Inhibitors of 78 kDa Glucose Regulated Protein (Grp78) ATPase: Insights into Isoform Selectivity Macias, Alba T.; Williamson, Douglas S.; Allen, Nicola; Borgognoni, Jenifer; Clay, Alexandra; Daniels, Zoe; Dokurno, Pawel; Drysdale, Martin J.; Francis, Geraint L.; Graham, Christopher J.; Howes, Rob; Matassova, Natalia; Murray, James B.; Parsons, Rachel; Shaw, Terry; Surgenor, Allan E.; Terry, Lindsey; Wang, Yikang; Wood, Mike; Massey, Andrew J. 分享 收藏
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