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O

Owen J. Sansom

Cancer Research UK Scotland Institute
H指数:113
被引数:5.1万

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A tumour-derived organoid biobank maps cancer gene dependencies

肿瘤来源的类器官生物样本库绘制了癌症基因依赖图谱

Nature
IF48.5
2026-08-050
OA
C. Herranz-Ors; S. G. Bhosle; A. E. Beck; J. G. R. Gilbert; G. Picco; J. Espejo Valle-Inclan; F. Muyas; S. Valentini; A. E. Andres; R. Ansari; S. Barthorpe; G. Battarbee; C. M. Beaver; S. Brocklesby; J. Cantwell; C. A. Collins; J. Davis; H. G. Dimitrova; J. Doran; E. Efendi; K. Evans; M. Fekry; T. A. Fowler; M. Garcia-Casado; J. A. T. Griffiths; C. Hall; R. Hamer; C. Hardy; Z. Hewitson; E. Hitch; L. Holland; D. A. Jackson; N. Joshi; A. Kavasakali; L. Letchford; H. B. Lightfoot; H. Lingala; I. Mali; K. May; T. Mironenko; J. Morris; C. Pacini; S. Price; G. Robert-Tissot; H. A. Rogers; J. V. Smith; K. Smith; E. Souster; W. J. Spence; F. Thomas; S. F. Vieira; S. Walker; G. Alfonsin; H. Bermingham; H. Coles; D. P. Ennis; A. Freeman; G. Giannone; N. Grehan; E. A. Griffiths; J. Hall; S. L. Lee; E. Y. L. Leung; C. Loreno; C. Millington; A. Mirnezami; B. Nutzinger; K. Orzechowska; C. M. A. Pinna; A. M. Redmond; K. Roberts; S. Roy; D. A. Sanders; P. Taniere; M. Vias; K. Wanigasooriya; M. R. Stratton; L. M. Staudt; U. McDermott; J. D. Brenton; I. A. McNeish; A. Biankin; O. J. Sansom; I. Cortes-Ciriano; T. J. Underwood; R. C. Fitzgerald; A. D. Beggs; H. E. Francies; M. J. Garnett
Mitochondrial metabolism determines chemotherapy sensitivity in colorectal cancer

线粒体代谢决定结直肠癌的化疗敏感性

Nature Metabolism
IF20.8
2026-07-230
OA
Deborah Y. Moss; Connor N. Brown; Andrew M. Shaw; Christopher McCann; Nikita Lewis; Matilda Downs; Rebecca Wurelly; Ciara Cunningham; Aaron Philips; Niamh Doherty; Sarah Gallagher; William J. McDaid; Andrew Roe; Aisling Y. Coughlan; Brenton Cavanagh; Callum Ormsby; Fiammetta Falcone; Rachel McCole; Scott Monteith; Emily Rogan; Sudhir B. Malla; Alexandra J. Emerson; Letitia Mohammed-Smith; Shaun Sharkey; Aoife Leonard; Peter F. Gallagher; Arindam Banerjee; Sandra Van Schaeybroeck; Sufyan Pandor; Brian Quinn; Brett Greer; Christopher Elliott; Sarah Maguire; Aideen E. Ryan; Philip D. Dunne; Mary Mallon; Stephanie Craig; Omar Aftab; Laura C. Greaves; Bryan P. Marzullo; Daniel A. Tennant; Vicky Coyle; Ian G. Mills; Owen Sansom; Tríona Ní Chonghaile; Daniel B. Longley; Simon S. McDade; Melissa J. LaBonte; Emma M. Kerr
Viral mimicry redirects immunosuppressed colorectal tumour landscapes towards a proinflammatory and CMS1-like regenerative state

病毒模拟将免疫抑制性结直肠癌景观重定向为促炎性和CMS1样再生状态

Communications Biology
IF5.1
2026-05-260
OAAI
Shania M. Corry; Svetlana Sakhnevych; Noha Ehssan Mohamed; Sudhir B. Malla; Ryan Byrne; Andrew Young; Raheleh Amirkhah; Courtney Bull; Andrea Lees; Keara Redmond; Tamsin R. M. Lannagan; Rachel A. Ridgway; Fiona R. Taggart; Natalie C. Fisher; Tim Maughan; Mark Lawler; Andrew D. Campbell; Simon J. Leedham; Aideen E. Ryan; Daniel B. Longley; Donna M. Small; Owen J. Sansom; Philip D. Dunne
Author Correction: A complex secretory program orchestrated by the inflammasome controls paracrine senescence

作者更正：由炎症小体调控的复杂分泌程序控制旁分泌衰老

Nature Cell Biology
IF19.1
2026-04-280
PRE
Juan Carlos Acosta; Ana Banito; Torsten Wuestefeld; Athena Georgilis; Peggy Janich; Jennifer P. Morton; Dimitris Athineos; Tae-Won Kang; Felix Lasitschka; Mindaugas Andrulis; Gloria Pascual; Kelly J. Morris; Sadaf Khan; Hong Jin; Gopuraja Dharmalingam; Ambrosius P. Snijders; Thomas Carroll; David Capper; Catrin Pritchard; Gareth J. Inman; Thomas Longerich; Owen J. Sansom; Salvador Aznar Benitah; Lars Zender; Jesús Gil
Nucleophosmin supports WNT-driven hyperproliferation and tumor initiation

核磷蛋白支持WNT驱动的过度增殖和肿瘤启动

Nature Genetics
IF29
2025-12-180
OAAI
Georgios Kanellos; Chiara Giacomelli; Alexander Raven; Nikola Vlahov; Hu Jin; Pauline Herviou; Sudhir B. Malla; Nadia Nasreddin; Patricia P. Centeno; Constantinos Alexandrou; Kathryn Gilroy; Rachel L. Baird; Kathryn Pennel; June Munro; Joseph A. Waldron; Holly Hall; Leah Officer-Jones; Sheila Bryson; Douglas Strathdee; Sergio Lilla; Sara Zanivan; Vivienne Morrison; Colin Nixon; Rachel A. Ridgway; Crispin Miller; John R. P. Knight; Andrew D. Campbell; Philip D. Dunne; John Le Quesne; Joanne Edwards; Peter J. Park; Martin Bushell; Owen J. Sansom
Inhibiting translation elongation by reducing eIF5A activity induces feedback inhibition of initiation, limiting tumour cell proliferation

通过降低eIF5A活性抑制翻译延伸，会诱导启动的反馈抑制，从而限制肿瘤细胞增殖。

Nature Communications
IF15.7
2025-12-130
OAAI
Aristeidis P. Sfakianos; Rebecca M. Raven; Tom Smith; Xiao-Ming Sun; Thomas E. Mulroney; Mariavittoria Pizzinga; Veronica Dezi; Angela Rubio Tenor; Mark Stoneley; Cameron H. Cole; Karam Al-Doori; Hashim Ahmed Nur; Rachel L. Pennie; Ian Powley; Leah Officer-Jones; Ritwick Sawarkar; Martin Turner; Marion MacFarlane; Owen J. Sansom; Martin Bushell; John Le Quesne; Robert F. Harvey; Anne E. Willis
Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis (vol. 124, pg. 1069, 2014)

p53突变相关的肌球蛋白-X上调促进乳腺癌侵袭和转移（vol. 124, pg. 1069, 2014）

JOURNAL OF CLINICAL INVESTIGATION
IF13.6
2025-12-010
PRE
Arjonen, Antti; Kaukonen, Riina; Mattila, Elina; Rouhi, Pegah; Hognas, Gunilla; Sihto, Harri; Miller, Bryan W.; Morton, Jennifer P.; Bucher, Elmar; Taimen, Pekka; Virtakoivu, Reetta; Cao, Yihai; Sansom, Owen J.; Joensuu, Heikki; Ivaska, Johanna
MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance

MAPK驱动的上皮细胞可塑性驱动结直肠癌治疗抵抗

Nature
IF48.5
2025-11-240
PRE
Mark White; Megan L. Mills; Laura M. Millett; Kathryn Gilroy; Yourae Hong; Lucas B. Zeiger; Rosalin J. Simpson; Shania M. Corry; Amelia Ligeza; Tamsin R. M. Lannagan; Susanti Susanti; Rachel A. Ridgway; Ayse S. Yazgili; Lucile Grzesiak; Raheleh Amirkhah; Catriona A. Ford; Nikola Vlahov; Hannah Tovell; Leah Officer-Jones; Catherine Ficken; Rachel Pennie; Arafath K. Najumudeen; Alexander Raven; Nadia Nasreddin; Ekansh Chauhan; Andrew S. Papanastasiou; Colin Nixon; Vivienne Morrison; Rene Jackstadt; Janet S. Graham; Crispin J. Miller; Sarah J. Ross; Simon T. Barry; Valeria Pavet; Richard H. Wilson; John Le Quesne; Philip D. Dunne; Sabine Tejpar; Simon Leedham; Andrew D. Campbell; Owen J. Sansom
Hepatic zonation determines tumorigenic potential of mutant β-catenin

肝区室分布决定了突变型β-catenin的致瘤潜能

Nature
IF48.5
2025-11-190
OA
Alexander Raven; Kathryn Gilroy; Hu Jin; Joseph A. Waldron; Holly Leslie; June Munro; Holly Hall; Rachel A. Ridgway; Catriona A. Ford; Doga C. Gulhan; Nikola Vlahov; Megan L. Mills; Andrew Hartley; Eve Anderson; Sheila Bryson; Nathalie Sphyris; Miryam Müller; Stephanie May; Barbara Cadden; Colin Nixon; Scott H. Waddell; Rachel Guest; Luke Boulter; Nick Barker; Hans Clevers; Hao Zhu; Johanna Ivaska; Douglas Strathdee; Crispin J. Miller; Nigel B. Jamieson; Martin Bushell; Peter J. Park; Thomas G. Bird; Owen J. Sansom
Loss of colonic fidelity enables multilineage plasticity and metastasis

结肠特异性的丧失促进多谱系可塑性和转移

Nature
IF48.5
2025-06-040
OAAI
Patrizia Cammareri; Michela Raponi; Yourae Hong; Caroline V. Billard; Nat Peckett; Yujia Zhu; Fausto D. Velez-Bravo; Nicholas T. Younger; Donnchadh S. Dunican; Sebastian Ö.-G. Pohl; Aslihan Bastem Akan; Nora J. Doleschall; John Falconer; Mark White; Jean Quinn; Kathryn Pennel; Roberta Garau; Sudhir B. Malla; Philip D. Dunne; Richard R. Meehan; Owen J. Sansom; Joanne Edwards; Malcolm G. Dunlop; Farhat V. N. Din; Sabine Tejpar; Colin W. Steele; Kevin B. Myant
Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling

上皮GREMLIN1通过基质重塑破坏肠上皮-间质细胞通讯，诱导Wnt依赖性的异位干细胞微环境。

Nature Communications
IF15.7
2025-06-040
OAAI
Eoghan J. Mulholland; Hayley L. Belnoue-Davis; Gabriel N. Valbuena; Nuray Gunduz; Amelia Ligeza; Muyang Lin; Sujata Biswas; Ester Gil Vasquez; Sulochana Omwenga; Nadia Nasreddin; Michael C. Hodder; Lai Mun Wang; Aik Seng Ng; Elizabeth Jennings; Kim S. Midwood; Neesha Dedi; Shazia Irshad; Rachel A. Ridgway; Toby J. Phesse; James East; Ian PM Tomlinson; Gareth CG Davies; Owen J. Sansom; Simon J. Leedham
Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition

使用代谢成像监测治疗性mTORC1/2通路抑制后肿瘤反应的异质性

DISEASE MODELS & MECHANISMS
IF3.3
2025-02-280
OAAI
Ling, Stephanie; Dexter, Alex; Race, Alan M.; Sharma, Shreya; Hamm, Gregory; Polanska, Urszula M.; Marshall, John F.; Takats, Zoltan; Brindle, Kevin; Yuneva, Mariia O.; Poulogiannis, George; Campbell, Andrew D.; Sansom, Owen J.; Goodwin, Richard J. A.; Bunch, Josephine; Barry, Simon T.

研究方向

暂未获取到该数据
J
Jennifer P. Morton
H 指数:77论文数:391被引数:2.4万
R
Rachel A. Ridgway
H 指数:47论文数:254被引数:1.1万
A
Andrew D. Campbell
H 指数:39论文数:325被引数:6,403
A
Alan R. Clarke
H 指数:69论文数:384被引数:2.3万
C
Colin Nixon
H 指数:56论文数:400被引数:1.2万
J
Joanne Edwards
H 指数:66论文数:703被引数:1.4万
P
Paul Timpson
H 指数:70论文数:510被引数:1.4万
D
Dimitris Athineos
H 指数:34论文数:107被引数:8,391
S
Simon T. Barry
H 指数:57论文数:552被引数:1.3万
T
Tamsin R.M. Lannagan
H 指数:19论文数:159被引数:1,984