Shigeyuki Chaki - Publications, H-index & Citations

Shigeyuki Chaki

taisho pharmaceutical co., ltd.

56H指数

227论文数

9.1K被引数

收录论文 87

发表时间

Dual orexin receptor antagonists in insomnia: Toward a new therapeutic paradigm 失眠症中的双 orexin 受体拮抗剂：迈向一种新的治疗范式

Pharmacology Biochemistry and Behavior

IF2.5

2025-10-24

OAAI

Shigeyuki Chaki; Yumiko Imadera

Preclinical pharmacological profiles of vornorexant, a novel potent dual orexin receptor antagonist Vornorexant的预临床药理学特征，一种新型强效双重食欲素受体拮抗剂

pharmacology and experimental therapeutics

IF0

2025-06-06

OAAI

Hirohiko Hikichi; Yuichi Tokumaru; Atsuki Taruta; Yoshihiro Konno; Jun-ichi Karasawa; Kenichi Fukumoto; Toshiyuki Marumo; Yasuyuki Fujii; Teisuke Takahashi; Takao Yoshimizu; Shigeyuki Chaki; Noriko Hino; Naoki Kojima

Orexin receptors: possible therapeutic targets for psychiatric disorders

PSYCHOPHARMACOLOGY

IF3.3

2025-03-01

PREAI

Chaki, Shigeyuki

Melanin-concentrating hormone receptor: A therapeutic target for novel anxiolytics

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2024-09-01

PREAI

Chaki, Shigeyuki

Role of mGlu receptors in psychiatric disorders - Recent advances

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2023-11-01

OAAI

Pilc, Andrzej; Chaki, Shigeyuki

mGlu2/3 receptor antagonists for depression: overview of underlying mechanisms and clinical development

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

IF3.7

2023-01-30

PREAI

Chaki, Shigeyuki; Watanabe, Mai

A Novel Potent and Selective Histamine H3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, and Wake-Promoting and Procognitive Effects in Rodents

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2020-11-01

OAAI

Hino, Noriko; Marumo, Toshiyuki; Kotani, Makiko; Shimazaki, Toshiharu; Kaku-Fukumoto, Ayaka; Hikichi, Hirohiko; Karasawa, Jun-ichi; Tomishima, Yasumitsu; Komiyama, Hiroko; Tatsuda, Emi; Nozawa, Dai; Nakamura, Toshio; Chaki, Shigeyuki

Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability 发现MGS0274，一种代谢型谷氨酸受体2/3激动剂的酯前药，具有改善的口服生物利用度

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2020-10-01

PREAI

Urabe, Hiroki; Miyakoshi, Naoki; Ohtake, Norikazu; Nozoe, Akiko; Ochi, Motoki; Fukasawa, Misako; Kinoshita, Kohnosuke; Yamaguchi, Jun-ichi; Marumo, Toshiyuki; Hikichi, Hirohiko; Chaki, Shigeyuki; Hashihayata, Takashi

Efficacy and safety of TS-121, a novel vasopressin V1B receptor antagonist, as adjunctive treatment for patients with major depressive disorder: A randomized, double-blind, placebo-controlled study 新型血管加压素V1B受体拮抗剂TS-121作为重度抑郁症患者辅助治疗的疗效和安全性: 一项随机，双盲，安慰剂对照研究

JOURNAL OF PSYCHIATRIC RESEARCH

IF3.2

2020-09-01

OAAI

Kamiya, Makoto; Sabia, Helene D.; Marella, Julie; Fava, Maurizio; Nemeroff, Charles B.; Umeuchi, Hideo; Iijima, Michihiko; Chaki, Shigeyuki; Nishino, Izumi

Recent advances in the antidepressant actions of ketamine and agents having ketamine-like antidepressant profiles

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2020-09-01

PREAI

Chaki, Shigeyuki

Safety and pharmacokinetic profiles of MGS0274 besylate (TS-134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

IF3

2020-06-10

OAAI

Watanabe, Mai; Marcy, Brian; Kinoshita, Kohnosuke; Fukasawa, Misako; Hikichi, Hirohiko; Chaki, Shigeyuki; Okuyama, Shigeru; Gevorkyan, Hakop; Yoshida, Shigeru

Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT1A receptor stimulation

NEUROPSYCHOPHARMACOLOGY

IF7.1

2020-05-12

OAAI

Fukumoto, Kenichi; Fogaca, Manoela, V; Liu, Rong-Jian; Duman, Catharine H.; Li, Xiao-Yuan; Chaki, Shigeyuki; Duman, Ronald S.

AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine

BIOLOGICAL PSYCHIATRY

IF9

2018-10-01

PREAI

Yang, Chun; Kobayashi, Shizuka; Nakao, Kazuhito; Dong, Chao; Han, Mei; Qu, Youge; Ren, Qian; Zhang, Ji-chun; Ma, Min; Toki, Hidetoh; Yamaguchi, Jun-ichi; Chaki, Shigeyuki; Shirayama, Yukihiko; Nakazawa, Kazu; Manabe, Toshiya; Hashimoto, Kenji

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model

PSYCHOPHARMACOLOGY

IF3.3

2018-09-13

PREAI

Zhang, Kai; Toki, Hidetoh; Fujita, Yuko; Ma, Min; Chang, Lijia; Qu, Youge; Harada, Shingo; Nemoto, Tetsuhiro; Mizuno-Yasuhira, Akiko; Yamaguchi, Jun-ichi; Chaki, Shigeyuki; Hashimoto, Kenji

(2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice

NEUROPSYCHOPHARMACOLOGY

IF7.1

2018-05-03

OAAI

Yamaguchi, Jun-ichi; Toki, Hidetoh; Qu, Youge; Yang, Chun; Koike, Hiroyuki; Hashimoto, Kenji; Mizuno-Yasuhira, Akiko; Chaki, Shigeyuki

mGlu receptors as potential targets for novel antidepressants

CURRENT OPINION IN PHARMACOLOGY

IF4.2

2018-02-01

PREAI

Chaki, Shigeyuki; Fukumoto, Kenichi

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine

BIOLOGICAL PSYCHIATRY

IF9

2017-09-01

149

PREAI

Yang, Chun; Qu, Youge; Abe, Masahito; Nozawa, Dai; Chaki, Shigeyuki; Hashimoto, Kenji

mGlu2/3 Receptor Antagonists as Novel Antidepressants

TRENDS IN PHARMACOLOGICAL SCIENCES

IF19.9

2017-06-01

PREAI

Chaki, Shigeyuki

High-Contrast PET Imaging of Vasopressin V1B Receptors with a Novel Radioligand, 11C-TASP699

JOURNAL OF NUCLEAR MEDICINE

IF9.1

2017-04-27

OAAI

Koga, Kazumi; Nagai, Yuji; Hanyu, Masayuki; Yoshinaga, Mitsukane; Chaki, Shigeyuki; Ohtake, Norikazu; Ozaki, Satoshi; Zhang, Ming-Rong; Suhara, Tetsuya; Higuchi, Makoto

Antidepressant Potential of (R)-Ketamine in Rodent Models: Comparison with (S)-Ketamine

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2017-04-01

219

OAAI

Fukumoto, Kenichi; Toki, Hidetoh; Iijima, Michihiko; Hashihayata, Takashi; Yamaguchi, Jun-ichi; Hashimoto, Kenji; Chaki, Shigeyuki

研究方向