未登录 BID expression determines the apoptotic fate of cancer cells after abrogation of the spindle assembly checkpoint by AURKB or TTK inhibitors BID表达决定了AURKB或TTK抑制剂废除纺锤体组装检查点后癌细胞的凋亡命运 Bertran-Alamillo, Jordi; Gimenez-Capitan, Ana; Roman, Ruth; Talbot, Sara; Whiteley, Rebecca; Floc'h, Nicolas; Martinez-Perez, Elizabeth; Martin, Matthew J.; Smith, Paul D.; Sullivan, Ivana; Terp, Mikkel G.; Saeh, Jamal; Marino-Buslje, Cristina; Fabbri, Giulia; Guo, Grace; Xu, Man; Tornador, Cristian; Aguilar-Hernandez, Andres; Reguart, Noemi; Ditzel, Henrik J.; Martinez-Bueno, Alejandro; Nabau-Moreto, Nuria; Gasco, Amaya; Rosell, Rafael; Pease, J. Elizabeth; Polanska, Urszula M.; Travers, Jon; Urosevic, Jelena; Molina-Vila, Miguel A. 分享 收藏
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells EGFR抑制剂osimertinib药物耐受性持久细胞的治疗脆弱性 Criscione, Steven W. W.; Martin, Matthew J. J.; Oien, Derek B. B.; Gorthi, Aparna; Miragaia, Ricardo J. J.; Zhang, Jingwen; Chen, Huawei; Karl, Daniel L. L.; Mendler, Kerrin; Markovets, Aleksandra; Gagrica, Sladjana; Delpuech, Oona; Dry, Jonathan R. R.; Grondine, Michael; Hattersley, Maureen M. M.; Urosevic, Jelena; Floc'h, Nicolas; Drew, Lisa; Yao, Yi; Smith, Paul D. D. 分享 收藏
Brain metastatic outgrowth and osimertinib resistance are potentiated by RhoA in EGFR-mutant lung cancer Adua, Sally J.; Arnal-Estape, Anna; Zhao, Minghui; Qi, Bowen; Liu, Zongzhi Z.; Kravitz, Carolyn; Hulme, Heather; Strittmatter, Nicole; Lopez-Giraldez, Francesc; Chande, Sampada; Albert, Alexandra E.; Melnick, Mary-Ann; Hu, Bomiao; Politi, Katerina; Chiang, Veronica; Colclough, Nicola; Goodwin, Richard J. A.; Cross, Darren; Smith, Paul; Nguyen, Don X. 分享 收藏
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Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation 靶向DNA损伤反应成分可在ATM缺陷的癌细胞中诱导STING依赖性I型IFN反应增强，并驱动树突状细胞活化 Lopez-Pelaez, Marta; Young, Lucy; Vazquez-Chantada, Mercedes; Nelson, Nadine; Durant, Steve; Wilkinson, Robert W.; Poon, Edmund; Gaspar, Miguel; Valge-Archer, Viia; Smith, Paul; Dovedi, Simon J. 分享 收藏
Knowledge graph-based recommendation framework identifies drivers of resistance in EGFR mutant non-small cell lung cancer Gogleva, Anna; Polychronopoulos, Dimitris; Pfeifer, Matthias; Poroshin, Vladimir; Ughetto, Michael; Martin, Matthew J.; Thorpe, Hannah; Bornot, Aurelie; Smith, Paul D.; Sidders, Ben; Dry, Jonathan R.; Ahdesmaki, Miika; McDermott, Ultan; Papa, Eliseo; Bulusu, Krishna C. 分享 收藏
Anti-PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC Tu, Eric; McGlinchey, Kelly; Wang, Jixin; Martin, Philip; Ching, Steven L. K.; Floc'h, Nicolas; Kurasawa, James; Starrett, Jacqueline H.; Lazdun, Yelena; Wetzel, Leslie; Nuttall, Barrett; Ng, Felicia S. L.; Coffman, Karen T.; Smith, Paul D.; Politi, Katerina; Cooper, Zachary A.; Streicher, Katie 分享 收藏
Pharmacological inhibition of MERTK induces in vivo retinal degeneration: a multimodal imaging ocular safety assessment Hamm, Gregory; Maglennon, Gareth; Williamson, Beth; Macdonald, Ruth; Doherty, Ann; Jones, Stewart; Harris, Jayne; Blades, James; Harmer, Alexander R.; Barton, Peter; Rawlins, Philip B.; Smith, Paul; Winter-Holt, Jon; McMurray, Lindsay; Johansson, Julia; Fitzpatrick, Paul; McCoull, William; Coen, Muireann 分享 收藏
Gain and loss of function genome-wide CRISPR screens identify Hippo signalling as an important driver of resistance in EGFR mutant lung cancer Pfeifer, Matthias; Brammeld, Jonathan; Price, Stacey; Martin, Matthew; Thorpe, Hannah; Bornot, Aurelie; Banks, Ercia; Guan, Nin; Dunn, Shanade; Guerriero, Maria Lisa; O'Neill, Daniel; Pilling, James; Gianni, Davide; Brownell, James; Smith, Paul; McDermott, Ultan 分享 收藏
Biomarker-Directed Phase II Platform Study in Patients With EGFR Sensitizing Mutation-Positive Advanced/Metastatic Non-Small Cell Lung Cancer Whose Disease Has Progressed on First-Line Osimertinib Therapy (ORCHARD) Yu, Helena A.; Goldberg, Sarah B.; Le, Xiuning; Piotrowska, Zofia; Goldman, Jonathan W.; De Langen, Adrianus J.; Okamoto, Isamu; Cho, Byoung Chul; Smith, Paul; Mensi, Ilhem; Ambrose, Helen; Kraljevic, Silvija; Maidment, Julie; Chmielecki, Juliann; Li-Sucholeiki, Xiaocheng; Doughton, Gail; Patel, Gargi; Jewsbury, Phil; Szekeres, Phil; Riess, Jonathan W. 分享 收藏
Potent and Selective Inhibitors of the Epidermal Growth Factor Receptor to Overcome C797S-Mediated Resistance Finlay, M. Raymond, V; Barton, Peter; Bickerton, Sue; Bista, Michal; Colclough, Nicola; Cross, Darren A. E.; Evans, Laura; Floc'h, Nicolas; Gregson, Clare; Guerot, Carine M.; Hargreaves, David; Kang, Xiaoming; Lenz, Eva M.; Li, Xu; Liu, Yi; Lorthioir, Olivier; Martin, Matthew J.; McKerrecher, Darren; McWhirter, Claire; O'Neill, Daniel; Orme, Jonathan P.; Mosallanejad, Arash; Rahi, Amar; Smith, Paul D.; Talbot, Verity; Ward, Richard A.; Wrigley, Gail; Wylot, Marta; Xue, Lin; Yao, Tieguang; Ye, Yang; Zhao, Xiliang 分享 收藏
Optimization of an Imidazo[1,2-a]pyridine Series to Afford Highly Selective Type I1/2 Dual Mer/Axl Kinase Inhibitors with In Vivo Efficacy McCoull, William; Boyd, Scott; Brown, Martin R.; Coen, Muireann; Collingwood, Olga; Davies, Nichola L.; Doherty, Ann; Fairley, Gary; Goldberg, Kristin; Hardaker, Elizabeth; He, Guang; Hennessy, Edward J.; Hopcroft, Philip; Hodgson, George; Jackson, Anne; Jiang, Xiefeng; Karmokar, Ankur; Laine, Anne-Laure; Lindsay, Nicola; Mao, Yumeng; Markandu, Roshini; McMurray, Lindsay; McLean, Neville; Mooney, Lorraine; Musgrove, Helen; Nissink, J. Willem M.; Pflug, Alexander; Reddy, Venkatesh Pilla; Rawlins, Philip B.; Rivers, Emma; Schimpl, Marianne; Smith, Graham F.; Tentarelli, Sharon; Travers, Jon; Troup, Robert, I; Walton, Josephine; Wang, Cheng; Wilkinson, Stephen; Williamson, Beth; Winter-Holt, Jon; Yang, Dejian; Zheng, Yuting; Zhu, Qianxiu; Smith, Paul D. 分享 收藏
Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of EGFR-mutant lung cancer Eser, Pinar Ozden; Paranal, Raymond M.; Son, Jieun; Ivanova, Elena; Kuang, Yanan; Haikala, Heidi M.; To, Ciric; Okoro, Jeffrey J.; Dholakia, Kshiti H.; Choi, Jihyun; Eum, Yoonji; Ogino, Atsuko; Missios, Pavlos; Ercan, Dalia; Xu, Man; Poitras, Michael J.; Wang, Stephen; Ngo, Kenneth; Dills, Michael; Yanagita, Masahiko; Lopez, Timothy; Lin, Mika; Tsai, Jeanelle; Floch, Nicolas; Chambers, Emily S.; Heng, Jennifer; Anjum, Rana; Santucci, Alison D.; Michael, Kesi; Schuller, Alwin G.; Cross, Darren; Smith, Paul D.; Oxnard, Geoffrey R.; Barbie, David A.; Sholl, Lynette M.; Bahcall, Magda; Palakurthi, Sangeetha; Gokhale, Prafulla C.; Paweletz, Cloud P.; Daley, George Q.; Janne, Pasi A. 分享 收藏
Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers 亚克隆EGFR T790M突变对晚期EGFR突变型非小细胞肺癌的临床影响 Vaclova, Tereza; Grazini, Ursula; Ward, Lewis; O'Neill, Daniel; Markovets, Aleksandra; Huang, Xiangning; Chmielecki, Juliann; Hartmaier, Ryan; Thress, Kenneth S.; Smith, Paul D.; Barrett, J. Carl; Downward, Julian; de Bruin, Elza C. 分享 收藏
Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy Nissink, J. Willem M.; Bazzaz, Sana; Blackett, Carolyn; Clark, Matthew A.; Collingwood, Olga; Disch, Jeremy S.; Gikunju, Diana; Goldberg, Kristin; Guilinger, John P.; Hardaker, Elizabeth; Hennessy, Edward J.; Jetson, Rachael; Keefe, Anthony D.; McCoull, William; McMurray, Lindsay; Olszewski, Allison; Overman, Ross; Pflug, Alexander; Preston, Marian; Rawlins, Philip B.; Rivers, Emma; Schimpl, Marianne; Smith, Paul; Truman, Caroline; Underwood, Elizabeth; Warwicker, Juli; Winter-Holt, Jon; Woodcock, Simon; Zhang, Ying 分享 收藏
Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo Osum, Sara H.; Coutts, Alexander W.; Duerre, Dylan J.; Tschida, Barbara R.; Kirstein, Mark N.; Fisher, James; Bell, W. Robert; Delpuech, Oona; Smith, Paul D.; Widemann, Brigitte C.; Moertel, Christopher L.; Largaespada, David A.; Watson, Adrienne L. 分享 收藏
AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib Flemington, Vikki; Davies, Emma J.; Robinson, David; Sandin, Linda C.; Delpuech, Oona; Zhang, Pei; Hanson, Lyndsey; Farrington, Paul; Bell, Sigourney; Falenta, Katarzyna; Gibbons, Francis D.; Lindsay, Nicola; Smith, Aaron; Wilson, Joanne; Roberts, Karen; Tonge, Michael; Hopcroft, Philip; Willis, Sophie E.; Roudier, Martine P.; Rooney, Claire; Coker, Elizabeth A.; Jaaks, Patricia; Garnett, Mathew J.; Fawell, Stephen E.; Jones, Clifford D.; Ward, Richard A.; Simpson, Iain; Cosulich, Sabina C.; Pease, J. Elizabeth; Smith, Paul D. 分享 收藏
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MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects Verma, Vivek; Jafarzadeh, Nazli; Boi, Shannon; Kundu, Subhadip; Jiang, Zhinuo; Fan, Yiping; Lopez, Jose; Nandre, Rahul; Zeng, Peng; Alolaqi, Fatmah; Ahmad, Shamim; Gaur, Pankaj; Barry, Simon T.; Valge-Archer, Viia E.; Smith, Paul D.; Banchereau, Jacques; Mkrtichyan, Mikayel; Youngblood, Benjamin; Rodriguez, Paulo C.; Gupta, Seema; Khleif, Samir N. 分享 收藏
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