未登录 BRD4-mediated repression of p53 is a target for combination therapy in AML Latif, Anne-Louise; Newcombe, Ashley; Li, Sha; Gilroy, Kathryn; Robertson, Neil A.; Lei, Xue; Stewart, Helen J. S.; Cole, John; Terradas, Maria Terradas; Rishi, Loveena; McGarry, Lynn; McKeeve, Claire; Reid, Claire; Clark, William; Campos, Joana; Kirschner, Kristina; Davis, Andrew; Lopez, Jonathan; Sakamaki, Jun-ichi; Morton, Jennifer P.; Ryan, Kevin M.; Tait, Stephen W. G.; Abraham, Sheela A.; Holyoake, Tessa; Higgins, Brian; Huang, Xu; Blyth, Karen; Copland, Mhairi; Chevassut, Timothy J. T.; Keeshan, Karen; Adams, Peter D. 分享 收藏
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy (vol 17, pg 487, 2019) Kinstrie, Ross; Horne, Gillian A.; Morrison, Heather; Irvine, David; Munje, Chinmay; Castaneda, Eduardo Gomez; Moka, Hothri A.; Dunn, Karen; Cassels, Jennifer E.; Parry, Narissa; Clarke, Cassie J.; Scott, Mary T.; Clark, Richard E.; Holyoake, Tessa L.; Wheadon, Helen; Copland, Mhairi 分享 收藏
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease Horne, G. A.; Stobo, J.; Kelly, C.; Mukhopadhyay, A.; Latif, A. L.; Dixon-Hughes, J.; McMahon, L.; Cony-Makhoul, P.; Byrne, J.; Smith, G.; Koschmieder, S.; BrUemmendorf, T. H.; Schafhausen, P.; Gallipoli, P.; Thomson, F.; Cong, W.; Clark, R. E.; Milojkovic, D.; Helgason, G. V.; Foroni, L.; Nicolini, F. E.; Holyoake, T. L.; Copland, M. 分享 收藏
CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy Kinstrie, Ross; Horne, Gillian A.; Morrison, Heather; Irvine, David; Munje, Chinmay; Castaneda, Eduardo Gomez; Moka, Hothri A.; Dunn, Karen; Cassels, Jennifer E.; Parry, Narissa; Clarke, Cassie J.; Scott, Mary T.; Clark, Richard E.; Holyoake, Tessa L.; Wheadon, Helen; Copland, Mhairi 分享 收藏
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors Baquero, Pablo; Dawson, Amy; Mukhopadhyay, Arunima; Kuntz, Elodie M.; Mitchell, Rebecca; Olivares, Orianne; Lanniciello, Angela; Scott, Mary T.; Dunn, Karen; Nicastri, Michael C.; Winkler, Jeffrey D.; Michie, Alison M.; Ryan, Kevin M.; Halsey, Christina; Gottlieb, Eyal; Keaney, Erin P.; Murphy, Leon O.; Amaravadi, Ravi K.; Holyoake, Tessa L.; Helgason, G. Vignir 分享 收藏
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia Zhang, Bin; Le Xuan Truong Nguyen; Li, Ling; Zhao, Dandan; Kumar, Bijender; Wu, Herman; Lin, Allen; Pellicano, Francesca; Hopcroft, Lisa; Su, Yu-Lin; Copland, Mhairi; Holyoake, Tessa L.; Kuo, Calvin J.; Bhatia, Ravi; Snyder, David S.; Ali, Haris; Stein, Anthony S.; Brewer, Casey; Wang, Huafeng; McDonald, Tinisha; Swiderski, Piotr; Troadec, Estelle; Chen, Ching-Cheng; Dorrance, Adrienne; Pullarkat, Vinod; Yuan, Yate-Ching; Perrotti, Danilo; Carlesso, Nadia; Forman, Stephen J.; Kortylewski, Marcin; Kuo, Ya-Huei; Marcucci, Guido 分享 收藏
Targeting BCR-ABL-Independent TKI Resistance in Chronic Myeloid Leukemia by mTOR and Autophagy Inhibition Mitchell, Rebecca; Hopcroft, Lisa E. M.; Baquero, Pablo; Allan, Elaine K.; Hewit, Kay; James, Daniel; Hamilton, Graham; Mukhopadhyay, Arunima; O'Prey, Jim; Hair, Alan; Melo, Junia V.; Chan, Edmond; Ryan, Kevin M.; Maguer-Satta, Veronique; Druker, Brian J.; Clark, Richard E.; Mitra, Subir; Herzyk, Pawel; Nicolini, Franck E.; Salomoni, Paolo; Shanks, Emma; Calabretta, Bruno; Holyoake, Tessa L.; Helgason, G. Vignir 分享 收藏
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A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients Vezzalini, Marzia; Mafficini, Andrea; Tomasello, Luisa; Lorenzetto, Erika; Moratti, Elisabetta; Fiorini, Zeno; Holyoake, Tessa L.; Pellicano, Francesca; Krampera, Mauro; Tecchio, Cristina; Yassin, Mohamed; Al-Dewik, Nader; Ismail, Mohamed A.; Al Sayab, Ali; Monne, Maria; Sorio, Claudio 分享 收藏
Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition Scott, Mary T.; Korfi, Koorosh; Saffrey, Peter; Hopcroft, Lisa E. M.; Kinstrie, Ross; Pellicano, Francesca; Guenther, Carla; Gallipoli, Paolo; Cruz, Michelle; Dunn, Karen; Jorgensen, Heather G.; Cassels, Jennifer E.; Hamilton, Ashley; Crossan, Andrew; Sinclair, Amy; Holyoake, Tessa L.; Vetrie, David 分享 收藏
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ATG7 regulates energy metabolism, differentiation and survival of Philadelphia-chromosome-positive cells Karvela, Maria; Baquero, Pablo; Kuntz, Elodie M.; Mukhopadhyay, Arunima; Mitchell, Rebecca; Allan, Elaine K.; Chan, Edmond; Kranc, Kamil R.; Calabretta, Bruno; Salomoni, Paolo; Gottlieb, Eyal; Holyoake, Tessa L.; Helgason, G. Vignir 分享 收藏
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia Irvine, David A.; Zhang, Bin; Kinstrie, Ross; Tarafdar, Anuradha; Morrison, Heather; Campbell, Victoria L.; Moka, Hothri A.; Ho, Yinwei; Nixon, Colin; Manley, Paul W.; Wheadon, Helen; Goodlad, John R.; Holyoake, Tessa L.; Bhatia, Ravi; Copland, Mhairi 分享 收藏
Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenance Vukovic, Milica; Guitart, Amelie V.; Sepulveda, Catarina; Villacreces, Arnaud; O'Duibhir, Eoghan; Panagopoulou, Theano I.; Ivens, Alasdair; Menendez-Gonzalez, Juan; Iglesias, Juan Manuel; Allen, Lewis; Glykofrydis, Fokion; Subramani, Chithra; Armesilla-Diaz, Alejandro; Post, Annemarie E. M.; Schaak, Katrin; Gezer, Deniz; So, Chi Wai Eric; Holyoake, Tessa L.; Wood, Andrew; O'Carroll, Donal; Ratcliffe, Peter J.; Kranc, Kamil R. 分享 收藏
Mtss1 is a critical epigenetically regulated tumor suppressor in CML Schemionek, M.; Herrmann, O.; Reher, M. M.; Chatain, N.; Schubert, C.; Costa, I. G.; Haenzelmann, S.; Gusmao, E. G.; Kintsler, S.; Braunschweig, T.; Hamilton, A.; Helgason, G. V.; Copland, M.; Schwab, A.; Mueller-Tidow, C.; Li, S.; Holyoake, T. L.; Bruemmendorf, T. H.; Koschmieder, S. 分享 收藏
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DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia Valent, Peter; Sadovnik, Irina; Racil, Zdenek; Herrmann, Harald; Blatt, Katharina; Cerny-Reiterer, Sabine; Eisenwort, Gregor; Lion, Thomas; Holyoake, Tessa; Mayer, Jiri 分享 收藏
Dual Glutathione-S-Transferase-θ1 and -μ1 Gene Deletions Determine Imatinib Failure in Chronic Myeloid Leukemia Davies, A.; Giannoudis, A.; Zhang, J. E.; Austin, G.; Wang, L.; Holyoake, T. L.; Mueller, M. C.; Foroni, L.; Kottaridis, P. D.; Pirmohamed, M.; Clark, R. E. 分享 收藏
The Antiproliferative Activity of Kinase Inhibitors in Chronic Myeloid Leukemia Cells Is Mediated by FOXO Transcription Factors Pellicano, Francesca; Scott, Mary T.; Helgason, G. Vignir; Hopcroft, Lisa E. M.; Allan, Elaine K.; Aspinall-O'Dea, Mark; Copland, Mhairi; Pierce, Andrew; Huntly, Brian J. P.; Whetton, Anthony D.; Holyoake, Tessa L. 分享 收藏
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