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W. Nicholas Haining

Harvard Medical School

54H指数
193论文数
2.6W被引数
收录论文 74
发表时间
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
err2024-09-17
err0
PREAI
errWeiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.
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Innate immune activation restricts priming and protective efficacy of the radiation attenuated PfSPZ malaria vaccine-
err2024-04-30
err2
errOAAI
errSenkpeil, Leetah; Bhardwaj, Jyoti; Little, Morgan R.; Holla, Prasida; Upadhye, Aditi; Fusco, Elizabeth M.; Swanson II, Phillip A.; Wiegand, Ryan E.; Macklin, Michael D.; Bi, Kevin; Flynn, Barbara J.; Yamamoto, Ayako; Gaskin, Erik L.; Sather, D. Noah; Oblak, Adrian L.; Simpson, Edward; Gao, Hongyu; Haining, W. Nicholas; Yates, Kathleen B.; Liu, Xiaowen; Murshedkar, Tooba; Richie, Thomas L.; Sim, B. Kim Lee; Otieno, Kephas; Kariuki, Simon; Xuei, Xiaoling; Liu, Yunlong; Polidoro, Rafael B.; Hoffman, Stephen L.; Oneko, Martina; Steinhardt, Laura C.; Schmidt, Nathan W.; Seder, Robert A.; Tran, Tuan M.
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Enhancing TCR T cell function in solid tumors through in vivo combinatorial screens and single-cell analysis
err2024-03-22
err0
PREAI
errPolyak, Dina; Fuhriman, Jessica; Susanto, Josephine; Merrell, Allyson; Simon, Mandi; Oh, Catherine; Cordazo, Andrew; DeTomasso, David; Tocchini, Carla; Sail, Vibhavari; Cui, Eric; Milush, Jeff; Gray-Rupp, Levi; Galvin, Brendan; Murriel, Christopher; Zheng, Grace; Boroughs, Angela C.; Thakore, Pratiksha; Oh, Soyoung; Freimer, Jake; Chen, Bob; Eidenschenk, Celine; Wheeler, Emily; Levine, Jacob; Huetter, Jan-Christian; Schartner, Jill; Geiger-Schuller, Katie; Rozenblatt-Rosen, Orit; Rutz, Sascha; Mellman, Ira; Haining, W. Nicholas
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AB-2100, a PSMA-inducible CA9-specific CAR T cell product for the treatment of ccRCC provides long-term tumor responses in preclinical mouse model
err2024-03-22
err0
PREAI
errMohanty, Suchismita; Chen, Jeremy; Gomez, Alma; Boroughs, Angela; Scarfo, Irene; Lim, Laura; Dang, Kevin; Chew, Marvin; Sudhakah, Rakesh; Nguyen, Michelle; Gardner, Thomas J.; Millare, Beatriz; Zhang, James; Moskowitz, Darrian; Zhou, Stanley; Xie, Neroli H.; Attanasio, Nickolas; Fearon, Amanda; Chan, Ivan; Sail, Vibhavari; Thomas, Vince; Smith, Jennesa; McDevitt, Jennifer; Gray-Rupp, Levi; Gonzalez, Alba; Murriel, Christopher; Haining, W. Nicholas
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Pooled CRISPR screening coupled with single-cell sequencing identifies modifiers of CAR T cell state in the context of chronic antigen stimulation
err2024-03-22
err0
PREAI
errJoshi, Sahil; Wozniak, Glenn; Gagnon, John; Vucci, Kristina; Merrell, Allyson; Simon, Mandi; Oh, Catherine; Cardozo, Andrew; DeTomaso, David; Chow, Julie; Zheng, Grace; Boroughs, Angela; Joho, Keith; Thakore, Pratiksha; Oh, Soyoung; Freimer, Jake; Cass, Ashley; Sail, Vibhavari; Tocchini, Carla; Sandoval, Marian; Liu, Andrea; Cui, Eric; Drever, Matt; Galvin, Brendan; Milush, Jeff; Gray-Rupp, Levi; Wheeler, Emily; Chen, Bob; Levine, Jacob; Eidenschenk, Celine; Schartner, Jill; Geiger-Schuller, Katie; Huetter, Jan-Christian; Rutz, Sascha; Rozenblatt-Rosen, Orit; Mellman, Ira; Haining, W. Nicholas
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Logic-gated CAR T cell product AB-1015 response to ovarian cancer models with heterogeneous levels of ALPG/P antigen
err2024-03-04
err0
PREAI
errPolyak, Dina; Beckman, Erik; Balakrishnan, Preethi Bala; Yun, Hongruo; Tang, Xinyan; Feng, Jun; Attansio, Nickolas; Cass, Ashley; Santoro, Stephen; Gonzalez-Junca, Alba; Haining, W. Nicholas; Murriel, Christopher L.
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X-CHIME enables combinatorial, inducible, lineage-specific and sequential knockout of genes in the immune system
err2023-11-27
err3
errOAAI
errLafleur, Martin W.; Lemmen, Ashlyn M.; Streeter, Ivy S. L.; Nguyen, Thao H.; Milling, Lauren E.; Derosia, Nicole M.; Hoffman, Zachary M.; Gillis, Jacob E.; Tjokrosurjo, Qin; Markson, Samuel C.; Huang, Amy Y.; Anekal, Praju V.; Montero Llopis, Paula; Haining, W. Nicholas; Doench, John G.; Sharpe, Arlene H.
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High-throughput arrayed screening of logic-gated CARs enables the selection of candidates for ccRCC with optimal potency and fidelity traits
err2023-04-04
err0
PREAI
errMehta, Nishant; Thomas, Jamie; Yashin, Edward; Fua, Andrea; Li, Jonathan; Chen, Jonathan; Lim, Laura; Chua, Je; Cardozo, Andrew; Sandoval, Marian; Nguyen, Duy P.; Hong, Ziyan; Wu, Jimmy; Sue, Catherine; Guzman, Gustavo; Wang, Li; Panagiotopoulou, Sofia K.; Xu, Sophie; Boroughs, Angela C.; Haining, W. Nicholas
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A neovasculature-inducible CA9 CAR resistant to FASL and TGFb mediated suppression for the treatment of ccRCC
err2023-04-04
err0
PREAI
errBoroughs, Angela C.; Scarfo, Irene; Attanasio, Nickolas; Gardner, Thomas; Smith, Jenessa B.; McDevitt, Jennifer; Lim, Laura; Mehta, Nishant; Mohanty, Suchismita; Zhang, James; Cui, Eric; Sail, Vibhavari; Fearon, Amanda; Williams, Samuel; Santoro, Stephen; Haining, W. Nicholas; Gray-Rupp, Levi
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Tunable STAT activation by synthetic pathway activators (SPAs) increases engineered T-cell potency and persistence
err2023-04-04
err0
PREAI
errGardner, Thomas J.; Millare, Beatriz; Yao, Anzhi; Cass, Ashley; Mohanty, Suchismita; Chen, Jeremy; Gomez, Alma; DeTomaso, David; Ku, Manching; Berthoin, Lionel; Lim, Meng; Ong, Azalea; Thomas, Vince; Quant, Nicholas; Hsu, Brian; Casbon, Amy-Jo; Bezman, Natalie; Cooper, Aaron; Gray-Rupp, Levi; Boroughs, Angela C.; Haining, W. Nicholas
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Targeting mammalian SWI/SNF chromatin remodeling complexes to improve T cell-based cancer immunotherapies
err2023-04-04
err0
PREAI
errBattistello, Elena; Hixon, Kimberlee; Comstock, Dawn E.; Collings, Clayton K.; Chen, Xufeng; Hernaez, Javier Rodriguez; Lee, Soobeom; Ntatsoulis, Konstantinos; Cesarano, Annamaria; Hockemeyer, Kathryn; Haining, W. Nicholas; Witkowski, Matthew T.; Qi, Jun; Tsirigos, Aristotelis; Perna, Fabiana; Aifantis, Ioannis; Kadoch, Cigall
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Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models
err2023-04-04
err0
PREAI
errGardner, Thomas J.; Litterman, Adam; Singh, Brenal K.; Silva, Luisa; Hari, Mukund; Zhou, Stanley; Tang, Colin; Joshi, Sahil; Gagnon, John; Takacsi-Nagy, Oliver; Hall, Jason; Pope, Hans; Zhang, James; Gomez, Alma; Chen, Jeremy; Mohanty, Suchismita; Thomas, Vince; Quant, Nicholas; Millare, Beatriz; Casbon, Amy-Jo; Bezman, Natalie; Gray-Rupp, Levi; Boroughs, Angela C.; Haining, W. Nicholas
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Overcoming resistance to immunotherapy due to loss of antigen presentation
err2023-04-04
err0
PREAI
errMiller, Brian C.; Choutri, Yacine; Al Abosy, Rose; Huang, Amy; Cox, Emily K.; Zimmerman, Matthew P.; Chong, Wan Lin; Vietor, Katherine J.; Collier, Jenna; Weiss, Sarah A.; Sen, Debattama; Haining, W. Nicholas; Sharpe, Arlene H.
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Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
err2023-04-01
err35
errOAAI
errBattistello, Elena; Hixton, Kimberlee A.; Comstock, Dawn E.; Collings, Clayton K.; Chen, Xufeng; Hernaez, Javier Rodriguez; Lee, Soobeom; Crvantes, Kasey S.; Hinkley, Madeline M.; Ntatsoulis, Konstantinos; Cesarano, Annamaria; Hockemeyer, Kathryn; Haining, W. Nicholas; Witkowski, Matthew T.; Qi, Jun; Tsiriges, Aristotelis; Perna, Fabiana; Aifantis, Iannis; Kadoch, Cigall
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When Cancer Cells Become the Enablers of an Antitumor Immune Response
err2022-10-05
err6
errOAAI
errRibas, Antoni; Haining, W. Nicholas; Schumacher, Ton N. M.
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In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer体内CRISPR筛选揭示了癌症免疫逃避途径的景观
err2022-09-23
err82
PREAI
errDubrot, Juan; Du, Peter P.; Lane-Reticker, Sarah Kate; Kessler, Emily A.; Muscato, Audrey J.; Mehta, Arnav; Freeman, Samuel S.; Allen, Peter M.; Olander, Kira E.; Ockerman, Kyle M.; Wolfe, Clara H.; Wiesmann, Fabius; Knudsen, Nelson H.; Tsao, Hsiao-Wei; Iracheta-Vellve, Arvin; Schneider, Emily M.; Rivera-Rosario, Andrea N.; Kohnle, Ian C.; Pope, Hans W.; Ayer, Austin; Mishra, Gargi; Zimmer, Margaret D.; Kim, Sarah Y.; Mahapatra, Animesh; Ebrahimi-Nik, Hakimeh; Frederick, Dennie T.; Boland, Genevieve M.; Haining, W. Nicholas; Root, David E.; Doench, John G.; Hacohen, Nir; Yates, Kathleen B.; Manguso, Robert T.
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Retention of epigenetic and transcriptional memory among reprogrammed T cells (T-iPSCs) imparts selective advantage for T cell re-differentiation
err2022-05-01
err0
PREAI
errWilliams, Robin L.; Morrow, Alyssa; Allred, Jeremy; Tolar, Jakub; Haining, W. Nicholas; Yosef, Nir; Blazar, Bruce R.
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PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
err2022-03-09
err28
errOAAI
errCollins, Natalie B.; Al Abosy, Rose; Miller, Brian C.; Bi, Kevin; Zhao, Qihong; Quigley, Michael; Ishizuka, Jeffrey J.; Yates, Kathleen B.; Pope, Hans W.; Manguso, Robert T.; Shrestha, Yashaswi; Wadsworth, Marc; Hughes, Travis; Shalek, Alex K.; Boehm, Jesse S.; Hahn, William C.; Doench, John G.; Haining, W. Nicholas
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Batf-mediated epigenetic control of effector CD8+ T cell differentiation
err2022-02-18
err30
errOAAI
errTsao, Hsiao-Wei; Kaminski, James; Kurachi, Makoto; Barnitz, R. Anthony; DiIorio, Michael A.; LaFleur, Martin W.; Ise, Wataru; Kurosaki, Tomohiro; Wherry, E. John; Haining, W. Nicholas; Yosef, Nir
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Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
err2021-07-26
err67
errOAAI
errTonnerre, Pierre; Wolski, David; Subudhi, Sonu; Al-Jabban, Jihad; Hoogeveen, Ruben C.; Damasio, Marcos; Drescher, Hannah K.; Bartsch, Lea M.; Tully, Damien C.; Sen, Debattama R.; Bean, David J.; Brown, Joelle; Torres-Cornejo, Almudena; Robidoux, Maxwell; Kvistad, Daniel; Alatrakchi, Nadia; Cui, Ang; Lieb, David; Cheney, James A.; Gustafson, Jenna; Lewis-Ximenez, Lia L.; Massenet-Regad, Lucile; Eisenhaure, Thomas; Aneja, Jasneet; Haining, W. Nicholas; Chung, Raymond T.; Hacohen, Nir; Allen, Todd M.; Kim, Arthur Y.; Lauer, Georg M.
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