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K

Kiyoshi Yoshimura

clinical research institute of clinical pharmacology and therapeutics

34H指数
220论文数
3.5K被引数
收录论文 69
发表时间
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Association of Prior Local Therapy with Outcomes Within Systemic Therapy Regimen Cohorts in Advanced Soft Tissue Sarcoma: A Retrospective Cohort Study先前局部治疗与系统性治疗方案队列中高级别软组织肉瘤预后的相关性：一项回顾性队列研究
errCancers
IF4.4
err2026-08-29
err0
errOAAI
errRyotaro Ohkuma; Tomoyuki Ishiguro; Hirotsugu Ariizumi; Masahiro Shimokawa; Go Ikeda; Takahiro Yoshizawa; Yuya Hirasawa; Risako Suzuki; Toshiaki Tsurui; Emiko Mura; Rika Sasaki; Shuichi Komori; Kosuke Toyofuku; Masako Kato; Kanae Shimada; Shingo Miyamoto; Kouzou Murakami; Yoshihiro Nakagami; Kazuhiko Oshinomi; Yutaro Kubota; Hiroo Ishida; Takeshi Aoki; Masahiko Murakami; Kiyoshi Yoshimura; Satoshi Wada; Katsuhito Takahashi; Takuya Tsunoda; Atsushi Horiike
err分享
err收藏
Association of Intratumoral Macrophage Subsets with Treatment Outcomes in Patients with Stage IV Solid Tumors肿瘤内巨噬细胞亚群与IV期实体瘤患者治疗结局的关联
errLaboratory Investigation
IF4.2
err2026-08-12
err0
errOAAI
errRyotaro Ohkuma; Nobuyuki Onishi; Aya Misawa; Makoto Watanabe; Jian Jin; Hirotsugu Ariizumi; Masahiro Shimokawa; Go Ikeda; Risako Suzuki; Toshiaki Tsurui; Yutaro Kubota; Yosuke Sasaki; Mayumi Homma; Kiyoshi Yoshimura; Toshiko Yamochi; Shinichi Kobayashi; Takuya Tsunoda; Atsushi Horiike; Satoshi Wada
err分享
err收藏
Efficacy of anti-GD2 antibody immunotherapy with filgrastim and teceleukin versus standard treatment with sargramostim, aldesleukin and isotretinoin in children with high-risk neuroblastoma在儿童高危神经母细胞瘤中，抗-GD2抗体免疫疗法联合非格司亭和泰西罗金与标准治疗（联合沙格司亭、阿地白介素和他扎罗汀）的疗效比较
errInternational Journal of Clinical Oncology
IF2.8
err2026-07-23
err0
PREAI
errChika Nitani; Junichi Hara; Hiroshi Kawamoto; Tomoaki Taguchi; Yuki Yuza; Shuhei Karakawa; Kimikazu Matsumoto; Toshimi Kimura; Kenichi Yoshimura; Kiyoshi Yoshimura; Akinobu Hamada
err分享
err收藏
Gut microbiome functional pathways outperform taxonomic profiles in predicting immune checkpoint inhibitor response in non-small cell lung cancer: an interpretable machine learning approach with SHAP肠道微生物组功能通路在预测非小细胞肺癌免疫检查点抑制剂应答方面优于分类谱：一种可解释的机器学习方法与SHAP
errFrontiers in Immunology
IF5.9
err2026-05-15
err0
errOAAI
errFW Feifei Wei; YN Yoshiro Nakahara; JI Junya Isobe; YI Yuka Igarashi; HS Haruhiro Saito; SM Shuji Murakami; TK Tetsuro Kondo; HH Hidetomo Himuro; TK Taku Kouro; TM Tomoya Matsui; SW Satoshi Wada; TT Takuya Tsunoda; KY Kiyoshi Yoshimura †; TS Tetsuro Sasada †
err分享
err收藏
Cetirizine suppresses cancer-associated fibroblast-mediated fibrotic remodeling and epithelial–mesenchymal transition via histamine H1 receptor inverse agonism西替利嗪通过组胺H1受体反向激动作用抑制癌相关成纤维细胞介导的纤维化重塑和上皮-间质转化
errBreast Cancer Research
IF5.6
err2026-04-26
err0
errOAAI
errAya Sasaki; Masahiro Hosonuma; Yuki Maruyama; Eiji Funayama; Hitoshi Toyoda; Toshiaki Tsurui; Kohei Tajima; Rie Nakashima; Yoshitaka Yamazaki; Akira Orimo; Tatsunori Oguchi; Kiyoshi Yoshimura; Atsuo Kuramasu
err分享
err收藏
Elevated plasma IgG is associated with improved treatment response and survival in advanced non‑small cell lung cancer patients treated with anti‑PD‑1 therapy血浆IgG升高与接受抗PD-1治疗晚期非小细胞肺癌患者的治疗反应改善及生存率提高相关
errScientific Reports
IF3.9
err2026-04-20
err0
errOAAI
errRyotaro Ohkuma; Nobuyuki Onishi; Makoto Watanabe; Jian Jin; Hirotsugu Ariizumi; Masahiro Shimokawa; Go Ikeda; Tomoyuki Ishiguro; Risako Suzuki; Toshiaki Tsurui; Yutaro Kubota; Kiyoshi Yoshimura; Shinichi Kobayashi; Takuya Tsunoda; Atsushi Horiike; Satoshi Wada
err分享
err收藏
Correction: Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expression更正：Akkermansia muciniphila在PD-L1低表达的非小细胞肺癌患者中预测对免疫检查点抑制剂的临床反应
errFrontiers in Immunology
IF5.9
err2026-03-27
err0
errOAAI
errTS Takashi Shimizu; RO Ryotaro Ohkuma; MH Mayumi Homma; SN Shingo Nakayama; YS Yosuke Sasaki; SM Satoshi Muto; KI Katsuaki Ieguchi; MW Makoto Watanabe; AT Akashi Taguchi; DT Daisuke Takayanagi; YW Youichiro Wada; AH Atsushi Horiike; YK Yutaro Kubota; HA Hirotsugu Ariizumi; MS Masahiro Shimokawa; YH Yuya Hirasawa; TI Tomoyuki Ishiguro; RS Risako Suzuki; NI Nana Iriguchi; EM Emiko Mura; KY Kiyoshi Yoshimura; MT Mayumi Tsuji; YK Yuji Kiuchi; HS Hiroyuki Suzuki; TY Toshiko Yamochi
err分享
err收藏
Vinegar intake in patients undergoing immune checkpoint inhibitor therapy: food frequency questionnaire study接受免疫检查点抑制剂治疗的患者醋摄入情况：食物频率问卷调查研究
errFrontiers in Immunology
IF5.9
err2025-12-11
err0
errOAAI
errHirotsugu Ariizumi; Miyuki Shimazui; Chisato Ogawa; Mika Kaneki; Nanaho Saito; Emiko Mura; Risako Suzuki; Toshiaki Tsurui; Nana Iriguchi; Tomoyuki Ishiguro; Yuya Hirasawa; Masahiro Shimokawa; Ryotaro Ohkuma; Yutaro Kubota; Atsushi Horiike; Satoshi Wada; Kiyoshi Yoshimura; Kouzou Murakami; Takuya Tsunoda
err分享
err收藏
Tumor Akkermansia muciniphila predicts clinical response to immune checkpoint inhibitors in non-small-cell lung cancer patients with low PD-L1 expressionAkkermansia muciniphila在PD-L1低表达的非小细胞肺癌患者中预测对免疫检查点抑制剂的临床反应
errFrontiers in Immunology
IF5.9
err2025-09-08
err0
errOAAI
errTakashi Shimizu; Ryotaro Ohkuma; Mayumi Homma; Shingo Nakayama; Yosuke Sasaki; Satoshi Muto; Katsuaki Ieguchi; Makoto Watanabe; Akashi Taguchi; Daisuke Takayanagi; Youichiro Wada; Atsushi Horiike; Yutaro Kubota; Hirotsugu Ariizumi; Masahiro Shimokawa; Yuya Hirasawa; Tomoyuki Ishiguro; Risako Suzuki; Nana Iriguchi; Emiko Mura; Kiyoshi Yoshimura; Mayumi Tsuji; Yuji Kiuchi; Hiroyuki Suzuki; Toshiko Yamochi
err分享
err收藏
Inosine shapes PD-1 blockade responses and synergizes with dual PD-1/CTLA-4 immunotherapy to enhance antitumor immunity次黄苷塑造PD-1阻断反应，并与双重PD-1/CTLA-4免疫疗法协同作用以增强抗肿瘤免疫。
errcancer immunology immunotherapy
IF0
err2025-08-19
err0
errOAAI
errYoichiro Narikawa; Atsuo Kuramasu; Masahiro Hosonuma; Masakazu Murayama; Eiji Funayama; Akiko Sasaki; Yuta Baba; Hitoshi Toyoda; Junya Isobe; Kohei Tajima; Rie Nakashima; Aya Sasaki; Yuki Maruyama; Yoshitaka Yamazaki; Midori Shida; Toshiaki Tsurui; Yuya Hirasawa; Hirotsugu Ariizumi; Tomoyuki Ishiguro; Risako Suzuki; Ryotaro Ohkuma; Yutaro Kubota; Takehiko Sambe; Mayumi Tsuji; Satoshi Wada; Atsushi Horiike; Shinichi Kobayashi; Takuya Tsunoda; Sei Kobayashi; Hitome Kobayashi; Tatsunori Oguchi; Toshikazu Shimane; Yuji Kiuchi; Kiyoshi Yoshimura
err分享
err收藏
Intestinal and esophageal microbiota in esophageal cancer development and treatment食管癌发展与治疗中的肠道和食管微生物群
errGUT MICROBES
IF11
err2025-05-16
err0
errOAAI
errYuta Baba; Kohei Tajima; Kiyoshi Yoshimura
err分享
err收藏
Ki-67 expression in anti-programmed cell death protein-1 antibody-bound CD8+ T cells as a predictor of clinical benefitKi-67表达在程序性死亡蛋白-1抗体结合的CD8+ T细胞中作为临床获益的预测指标
errDISCOVER ONCOLOGY
IF2.9
err2025-03-18
err0
errOAAI
errTsurui, Toshiaki; Hosonuma, Masahiro; Sasaki, Aya; Maruyama, Yuuki; Amari, Yasunobu; Funayama, Eiji; Tajima, Kohei; Toyoda, Hitoshi; Isobe, Junya; Yamazaki, Yoshitaka; Baba, Yuta; Shida, Midori; Udaka, Yuko; Mura, Emiko; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Hirasawa, Yuya; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Wada, Satoshi; Kuramasu, Atsuo; Tsuji, Mayumi; Kiuchi, Yuji; Tsunoda, Takuya; Yoshimura, Kiyoshi
err分享
err收藏
Evaluation of patient immunocompetence for immune checkpoint inhibitor therapy using the psoas muscle index: a retrospective cohort study
errFRONTIERS IN ONCOLOGY
IF3.3
err2025-02-06
err0
errOAAI
errTsurui, Toshiaki; Hamada, Kazuyuki; Mura, Emiko; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Hirasawa, Yuya; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Wada, Satoshi; Yoshimura, Kiyoshi; Tsuji, Mayumi; Kiuchi, Yuji; Tsunoda, Takuya
err分享
err收藏
Association between the ABCC11 gene polymorphism-determined earwax properties and external auditory canal microbiota in healthy adults
errMICROBIOLOGY SPECTRUM
IF3.8
err2025-02-04
err0
errOAAI
errAmari, Yasunobu; Hosonuma, Masahiro; Mizukami, Takuya; Isobe, Junya; Azetsu, Yuki; Funayama, Eiji; Maruyama, Yuki; Tsurui, Toshiaki; Tajima, Kohei; Sasaki, Aya; Yamazaki, Yoshitaka; Nakano, Ryota; Sano, Yutaka; Ishida, Atsushi; Nakanishi, Tatsuya; Mochizuki, Seiji; Yoshizawa, Yuri; Kumagai, Sumito; Yasuhara, Sakiko; Ryu, Kakei; Oguchi, Tatsunori; Kuramasu, Atsuo; Yoshimura, Kiyoshi; Sambe, Takehiko; Kobayashi, Sei; Uchida, Naoki
err分享
err收藏
Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors免疫应激诱导的肿瘤突变负荷及新抗原表达在4T1乳腺癌细胞中的作用：长期存活于接受免疫检查点抑制剂治疗患者的一种潜在机制
errCANCER GENOMICS & PROTEOMICS
IF2.6
err2024-12-27
err0
errOAAI
errIshiguro, Tomoyuki; Takeda, Kazuyuki; Takayanagi, Daisuke; Mura, Emiko; Suzuki, Risako; Tsurui, Toshiaki; Iriguchi, Nana; Hirasawa, Yuya; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Kubota, Yutaro; Horiike, Atsushi; Izumizaki, Masahiko; Wada, Satoshi; Yoshimura, Kiyoshi; Hoffman, Robert m.; Tsunoda, Takuya
err分享
err收藏
Chemotherapy combined with immune checkpoint inhibitors may overcome the detrimental effect of high neutrophil-to-lymphocyte ratio prior to treatment in esophageal cancer patients
errFRONTIERS IN ONCOLOGY
IF3.3
err2024-10-11
err0
errOAAI
errHirasawa, Yuya; Kubota, Yutaro; Mura, Emiko; Suzuki, Risako; Tsurui, Toshiaki; Iriguchi, Nana; Ishiguro, Tomoyuki; Ohkuma, Ryotaro; Shimokawa, Masahiro; Ariizumi, Hirotsugu; Horiike, Atsushi; Wada, Satoshi; Yamashita, Takeshi; Ariyoshi, Tomotake; Goto, Satoru; Otsuka, Koji; Murakami, Masahiko; Kiuchi, Yuji; Yoshimura, Kiyoshi; Tsunoda, Takuya
err分享
err收藏
MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cellsMHC I类多肽相关序列B脱落通过激活NKG2DLow T细胞调节胰腺肿瘤免疫
errSCIENTIFIC REPORTS
IF3.9
err2024-10-08
err0
errOAAI
errToyoda, Hitoshi; Kuramasu, Atsuo; Hosonuma, Masahiro; Murayama, Masakazu; Narikawa, Yoichiro; Isobe, Junya; Baba, Yuta; Tajima, Kohei; Funayama, Eiji; Shida, Midori; Maruyama, Yuki; Sasaki, Aya; Hirasawa, Yuya; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Kobayashi, Sei; Horiike, Atsushi; Hida, Noriko; Sambe, Takehiko; Nobe, Koji; Wada, Satoshi; Kobayashi, Hitome; Tsuji, Mayumi; Kobayashi, Shinichi; Tsunoda, Takuya; Kudo, Yoshifumi; Kiuchi, Yuji; Yoshimura, Kiyoshi
err分享
err收藏
Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody异丁酸增强anti-PD-1抗体的抗肿瘤作用
errSCIENTIFIC REPORTS
IF3.9
err2024-05-17
err7
errOAAI
errMurayama, Masakazu; Hosonuma, Masahiro; Kuramasu, Atsuo; Kobayashi, Sei; Sasaki, Akiko; Baba, Yuta; Narikawa, Yoichiro; Toyoda, Hitoshi; Isobe, Junya; Funayama, Eiji; Tajima, Kohei; Sasaki, Aya; Maruyama, Yuki; Yamazaki, Yoshitaka; Shida, Midori; Hamada, Kazuyuki; Hirasawa, Yuya; Tsurui, Toshiaki; Ariizumi, Hirotsugu; Ishiguro, Tomoyuki; Suzuki, Risako; Ohkuma, Ryotaro; Kubota, Yutaro; Horiike, Atsushi; Sambe, Takehiko; Tsuji, Mayumi; Wada, Satoshi; Kobayashi, Shinichi; Shimane, Toshikazu; Tsunoda, Takuya; Kobayashi, Hitome; Kiuchi, Yuji; Yoshimura, Kiyoshi
err分享
err收藏
Promotive clinical effects of pembrolizumab with necitumumab in patients having advanced non-small cell lung cancer with PD-L1 expression of 50% or higher in a phase II study (K-TAIL-202)
errCANCER RESEARCH
IF16.6
err2024-04-05
err0
PREAI
errHoriike, Atsushi; Wakui, Hiroshi; Sugawara, Shunichi; Minegishi, Yuji; Tasaka, Sadatomo; Kusumoto, Sojiro; Sakatani, Toshio; Suzuki, Hiroyuki; Hosomi, Yukio; Tambo, Yuichi; Shimokawa, Tsuneo; Ishida, Hiroo; Miyauchi, Eisaku; Naoki, Katsuhiko; Fukuhara, Tatsuro; Mura, Emiko; Tsurui, Toshiaki; Suzuki, Risako; Iriguchi, Nana; Ishiguro, Tomoyuki; Hirasawa, Yuya; Manabe, Ryo; Shimokawa, Masahiro; Ohkuma, Ryotaro; Ariizumi, Hirotsugu; Kubota, Yutaro; Hamada, Kazuyuki; Takenoshita, Sachiko; Ryu, Kakei; Sambe, Takehiko; Inoue, Eisuke; Wada, Satoshi; Yoshimura, Kiyoshi; Sagara, Hironori; Kobayashi, Shinichi; Tsunoda, Takuya
err分享
err收藏
The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers
errEXPERT REVIEW OF MOLECULAR DIAGNOSTICS
IF3.6
err2023-11-10
err8
PREAI
errTsunedomi, Ryouichi; Shindo, Yoshitaro; Nakajima, Masao; Yoshimura, Kiyoshi; Nagano, Hiroaki
err分享
err收藏

研究方向

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合作学者
合作期刊
L
Lewis L. Lanier
H 指数: 165 · 论文数: 709
D
Drew M. Pardoll
H 指数: 164 · 论文数: 892
C
Christine A. Iacobuzio–Donahue
H 指数: 135 · 论文数: 1.0K
C
Charles G. Drake
H 指数: 133 · 论文数: 1.2K
L
Lieping Chen
H 指数: 131 · 论文数: 709
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