Roger M. Howard - Publications, H-index & Citations

Roger M. Howard

Pfizer

19H指数

40论文数

1.7K被引数

收录论文 22

发表时间

Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2025-03-01

OAAI

Allais, Christophe; Bernier, Louise; Blakemore, David C.; Casavant, Jeffrey; Cheng, Xiayun; Choi, Chulho; Chuba, Matthew; Corbett, Matthew S.; Dirico, Kenneth J.; Farrell, William; France, Scott P.; Godin, Francois; Howard, Roger M.; Ingle, Gajendra; Kung, Daniel W.; Limburg, David C.; Loach, Richard P.; Lombardo, Vincent M.; Rezaei, Hadi; Sach, Neal W.; Taylor, Alexandria P.; Thakellapalli, Haresh

Photoenzymatically-induced asymmetric hydroarylation of alkenes with (hetero)aryl halides 光酶催化的卤代(杂)芳烃与烯烃的不对称芳基加成反应

CHEMICAL COMMUNICATIONS

IF4.2

2025-01-01

PREAI

Jones, Corey L.; Quinn, Alandra; Wang, Xiaochun (Alex); Smith, Jason K.; Casavant, Jeffrey M.; Berritt, Simon; Knauber, Thomas; Martinez, Carlos A.; Livada, Jovan; France, Scott P.; Richardson, Paul; Howard, Roger M.; Yayla, Hatice G.

Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-09-30

PREAI

Blakemore, Caroline A.; Humphrey, John M.; Yang, Eddie; Kohrt, Jeffrey T.; Morse, Peter Daniel; Howard, Roger M.; Yayla, Hatice G.; Knauber, Thomas; Xie, Longfei; Makowski, Teresa; Raggon, Jeffrey W.; Watson, Rebecca B.; Ende, Christopher W. Am; Ryder, Tim; White, Ormacinda; Koos, Martin R. M.; Kumar, Rajesh; Shi, Feng; Li, Jie; Wang, Huan; Chen, Like; Wang, Julai

Probing the chemical 'reactome' with high-throughput experimentation data

NATURE CHEMISTRY

IF20.2

2024-01-02

OAAI

King-Smith, Emma; Berritt, Simon; Bernier, Louise; Hou, Xinjun; Klug-McLeod, Jacquelyn L.; Mustakis, Jason; Sach, Neal W.; Tucker, Joseph W.; Yang, Qingyi; Howard, Roger M.; Lee, Alpha A.

Operator-free HPLC automated method development guided by Bayesian optimization 由贝叶斯优化指导的无操作员HPLC自动化方法开发

DIGITAL DISCOVERY

IF5.6

2024-01-01

OAAI

Dixon, Thomas M.; Williams, Jeanine; Besenhard, Maximilian; Howard, Roger M.; MacGregor, James; Peach, Philip; Clayton, Adam D.; Warren, Nicholas J.; Bourne, Richard A.

A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate 对于庞大的胺底物，还原性转氨酶转换为亚胺还原酶模式

ACS CATALYSIS

IF13.1

2023-01-12

OAAI

Gilio, Amelia K.; Thorpe, Thomas W.; Heyam, Alex; Petchey, Mark R.; Pogranyi, Balazs; France, Scott P.; Howard, Roger M.; Karmilowicz, Michael J.; Lewis, Russell; Turner, Nicholas; Grogan, Gideon

Machine learning directed multi-objective optimization of mixed variable chemical systems 面向机器学习的混合变量化工系统多目标优化

CHEMICAL ENGINEERING JOURNAL

IF13.2

2023-01-01

OAAI

Kershaw, Oliver J.; Clayton, Adam D.; Manson, Jamie A.; Barthelme, Alexandre; Pavey, John; Peach, Philip; Mustakis, Jason; Howard, Roger M.; Chamberlain, Thomas W.; Warren, Nicholas J.; Bourne, Richard A.

Parallel multi-droplet platform for reaction kinetics and optimization

CHEMICAL SCIENCE

IF7.4

2023-01-01

OAAI

Eyke, Natalie S.; Schneider, Timo N.; Jin, Brooke; Hart, Travis; Monfette, Sebastien; Hawkins, Joel M.; Morse, Peter D.; Howard, Roger M.; Pfisterer, David M.; Nandiwale, Kakasaheb Y.; Jensen, Klavs F.

Cell-free in vitro reduction of carboxylates to aldehydes: With crude enzyme preparations to a key pharmaceutical building block

BIOTECHNOLOGY JOURNAL

IF3.1

2021-01-25

OAAI

Schwarz, Anna; Hecko, Sebastian; Rudroff, Florian; Kohrt, Jeffrey T.; Howard, Roger M.; Winkler, Margit

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-12-24

OAAI

Gopalsamy, Ariamala; Aulabaugh, Ann E.; Barakat, Amey; Beaumont, Kevin C.; Cabral, Shawn; Canterbury, Daniel P.; Casimiro-Garcia, Agustin; Chang, Jeanne S.; Chen, Ming Z.; Choi, Chulho; Dow, Robert L.; Fadeyi, Olugbeminiyi O.; Feng, Xidong; France, Scott P.; Howard, Roger M.; Janz, Jay M.; Jasti, Jayasankar; Jasuja, Reema; Jones, Lyn H.; King-Ahmad, Amanda; Knee, Kelly M.; Kohrt, Jeffrey T.; Limberakis, Chris; Liras, Spiros; Martinez, Carlos A.; McClure, Kim F.; Narayanan, Arjun; Narula, Jatin; Novak, Jonathan J.; O'Connell, Thomas N.; Parikh, Mihir D.; Piotrowski, David W.; Plotnikova, Olga; Robinson, Ralph P.; Sahasrabudhe, Parag, V; Sharma, Raman; Thuma, Benjamin A.; Vasa, Dipy; Wei, Liuqing; Wenzel, A. Zane; Withka, Jane M.; Xiao, Jun; Yayla, Hatice G.

Scalable, Telescoped Hydrogenolysis-Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-10-28

PREAI

Blakemore, Caroline A.; France, Scott P.; Samp, Lacey; Nason, Deane M.; Yang, Eddie; Howard, Roger M.; Coffman, Karen J.; Yang, Qingyi; Smith, Aaron C.; Evrard, Edelweiss; Li, Wei; Dai, Linlin; Yang, Lixia; Chen, Zhiguang; Zhang, Qingli; He, Fangyan; Zhang, Jiesen

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2019-11-19

OAAI

Thorpe, Thomas W.; France, Scott P.; Hussain, Shahed; Marshall, James R.; Zawodny, Wojciech; Mangas-Sanchez, Juan; Montgomery, Sarah L.; Howard, Roger M.; Daniels, David S. B.; Kumar, Rajesh; Parmeggiani, Fabio; Turner, Nicholas J.

Extending the application of biocatalysis to meet the challenges of drug development

NATURE REVIEWS CHEMISTRY

IF51.7

2018-11-20

307

PREAI

Devine, Paul N.; Howard, Roger M.; Kumar, Rajesh; Thompson, Matthew P.; Truppo, Matthew D.; Turner, Nicholas J.

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination 鉴定进行还原胺化的亚胺还原酶家族的新细菌成员

CHEMCATCHEM

IF3.9

2018-01-11

OAAI

France, Scott P.; Howard, Roger M.; Steflik, Jeremy; Weise, Nicholas J.; Mangas-Sanchez, Juan; Montgomery, Sarah L.; Crook, Robert; Kumar, Rajesh; Turner, Nicholas J.

Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2017-11-07

OAAI

France, Scott P.; Aleku, Godwin A.; Sharma, Mahima; Mangas-Sanchez, Juan; Howard, Roger M.; Steflik, Jeremy; Kumar, Rajesh; Adams, Ralph W.; Slabu, Iustina; Crook, Robert; Grogan, Gideon; Wallace, Timothy W.; Turner, Nicholas J.

One-Pot Cascade Synthesis of Mono- and Disubstituted Piperidines and Pyrrolidines using Carboxylic Acid Reductase (CAR), ω-Transaminase (ω-TA), and Imine Reductase (IRED) Biocatalysts 使用羧酸还原酶 (CAR)，ω-转氨酶 (ω-ta) 和亚胺还原酶 (IRED) 生物催化剂一锅级联合成单取代和双取代的哌啶和吡咯烷

ACS CATALYSIS

IF13.1

2016-05-12

159

PREAI

France, Scott P.; Hussain, Shahed; Hill, Andrew M.; Hepworth, Lorna J.; Howard, Roger M.; Mulholland, Keith R.; Flitsch, Sabine L.; Turner, Nicholas J.

The use of environmental metrics to evaluate green chemistry improvements to the synthesis of (S,S)-reboxetine succinate

GREEN CHEMISTRY

IF9.2

2012-01-01

PREAI

Assaf, Georges; Checksfield, Graham; Critcher, Doug; Dunn, Peter J.; Field, Stuart; Harris, Laurence J.; Howard, Roger M.; Scotney, Gemma; Scott, Adam; Mathew, Suju; Walker, Geoffrey M. H.; Wilder, Alexander

Commercial Synthesis of (S,S)-Reboxetine Succinate: A Journey To Find the Cheapest Commercial Chemistry for Manufacture

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2011-10-11

PREAI

Hayes, Stewart T.; Assaf, Georges; Checksfield, Graham; Cheung, Chi; Critcher, Doug; Harris, Laurence; Howard, Roger; Mathew, Suju; Regius, Christian; Scotney, Gemrna; Scott, Adam

Convergent Asymmetric Synthesis of Two Complex TRPV1 Antagonists

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2011-08-08

PREAI

Butcher, Kenneth J.; Denton, Steven M.; Field, Stuart E.; Gillmore, Adam T.; Harbottle, Gareth W.; Howard, Roger M.; Laity, Daniel A.; Ngono, Christian J.; Pibworth, Benjamin A.

Development of an Asymmetric Hydrogenation Route to (S)-N-Boc-2,6-dimethyltyrosine

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2011-06-07

PREAI

Praquin, Celine F. B.; de Koning, Pieter D.; Peach, Philip J.; Howard, Roger M.; Spencer, Sarah L.

研究方向