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Coagulation proteases modulate nucleic acid uptake and cGAS-STING-IFN induction in the tumor microenvironment 凝血蛋白酶调控肿瘤微环境中的核酸摄取和cGAS-STING-IFN诱导 Wilgenbus, Petra; Pott, Jennifer; Pagel, Sven; Witzler, Claudius; Royce, Jennifer; Marini, Federico; Reyda, Sabine; Madhusudhan, Thati; Kindler, Thomas; Hausen, Anne; Gaida, Matthias M.; Weiler, Hartmut; Ruf, Wolfram; Graf, Claudine 分享 收藏
The Chimeric Antigen Receptor T Cell Target Claudin 6 Is a Marker for Early Organ-Specific Epithelial Progenitors and Is Expressed in Some Pediatric Solid Tumor Entities 嵌合抗原受体T细胞靶点Claudin 6是早期器官特异性上皮祖细胞的标志物，并且表达于某些儿童实体瘤实体中。 Seidmann, Larissa; Wingerter, Arthur; Metzig, Marie Oliver; Bornas, Angelina; El Malki, Khalifa; Ustjanzew, Arsenij; Ortmueller, Franziska; Kamyshanskiy, Yevgeniy; Kindler, Thomas; Laible, Mark; Mohr, Xenia; Henninger, Nicole; Russo, Alexandra; Beck, Olaf; Alt, Francesca; Wehling, Pia; Roth, Wilfried; Paret, Claudia; Faber, Joerg 分享 收藏
Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation 急性对BET抑制剂的耐药性通过p300协同激活重塑补偿性转录程序 Shah, Viral; Giotopoulos, George; Osaki, Hikari; Meyerhoefer, Markus; Meduri, Eshwar; Gallego-Crespo, Aaron; Behrendt, Malte Andreas; Saura-Panella, Maria; Schubert, Benedict; Yun, Haiyang; Horton, Sarah J.; Singh, Shuchi Agrawal; Haehnel, Patricia S.; Basheer, Faisal; Lugo, Dave; Kuehn, Michael; Guezguez, Borhane; Theobald, Matthias; Kindler, Thomas; Gallipoli, Paolo; Yeh, Paul; Dawson, Mark A.; Prinjha, Rab; Huntly, Brian J. P.; Sasca, Daniel 分享 收藏
Multi-omic profiling in cholangiocarcinoma to enable scientific advancement within the DKFZ/NCT/DKTK MASTER study 多组学分析在胆管癌中的应用，以推动DKFZ/NCT/DKTK MASTER研究中的科学进展 Nichetti, F.; Korell, F.; Schwab, M.; Hoffmeister, P. K. M.; Huellein, J.; Uhrig, S.; Teleanu, M-V; Kreutzfeldt, S.; Horak, P.; Glimm, H.; Heining, C.; Rieke, D. T.; Kindler, T.; Huebschmann, D.; Springfeld, C.; Jenzer, M.; Heilig, C. E.; Froehling, S.; Koehler, B. C. 分享 收藏
Inavolisib in cancers with activating PIK3CA mutations: Results from the CRAFT trial Inavolisib在具有激活性PIK3CA突变的癌症中的研究：CRAFT试验的结果 Heilig, C. E.; Teleanu, M-V.; Desuki, A.; Kindler, T.; Deschler, B.; Kunzmann, V.; von Bubnoff, N.; Illert, L.; Rieke, D. T.; Suesse, H.; Heiligenthal, L.; Kreutzfeldt, S.; Horak, P.; Steindorf, K.; Benner, A.; Huebschmann, D.; Schweigert, N.; Glimm, H.; Froehling, S.; Schlenk, R. F. 分享 收藏
Randomized phase II study of trabectedin/olaparib compared to physician's choice in subjects with previously treated advanced or recurrent solid tumors harboring DNA repair deficiencies 随机对照II期研究，比较曲贝替定/奥拉帕利与医生选择方案在既往接受过治疗的、存在DNA修复缺陷的晚期或复发性实体瘤患者中的疗效。 Schlenk, R. F.; Ruebsam, M.; Teleanu, M-V.; Richter, S.; Siveke, J. T.; Wagner, S.; Kopp, H-G.; Kindler, T.; Illert, L.; Golf, A. H-E.; Dorman, K.; Schreck, N.; Benner, A.; Suesse, H.; Freitag, A.; von Kalle, C.; Glimm, H.; Huebschmann, D.; Froehling, S.; Heilig, C. E. 分享 收藏
Multi-omic and functional analysis for classification and treatment of sarcomas with FUS-TFCP2 or EWSR1-TFCP2 fusions 基于FUS-TFCP2或EWSR1-TFCP2融合基因的肉瘤分类与治疗的多组学及功能分析 Schoepf, Julia; Uhrig, Sebastian; Heilig, Christoph E.; Lee, Kwang-Seok; Walther, Tatjana; Carazzato, Alexander; Dobberkau, Anna Maria; Weichenhan, Dieter; Plass, Christoph; Hartmann, Mark; Diwan, Gaurav D.; Carrero, Zunamys, I; Ball, Claudia R.; Hohl, Tobias; Kindler, Thomas; Rudolph-Haehnel, Patricia; Helm, Dominic; Schneider, Martin; Nilsson, Anna; Ora, Ingrid; Imle, Roland; Banito, Ana; Russell, Robert B.; Jones, Barbara C.; Lipka, Daniel B.; Glimm, Hanno; Huebschmann, Daniel; Hartmann, Wolfgang; Froehling, Stefan; Scholl, Claudia 分享 收藏
Ipatasertib and atezolizumab in cancers with increased PI3K-AKT pathway activity: First results from the CRAFT trial Heilig, C. E.; Singh, M.; Teleanu, M-V.; Desuki, A.; Kindler, T.; Bitzer, M.; Baier, B. D.; Kunzmann, V.; von Bubnoff, N.; Suesse, H.; Heiligenthal, L.; Steindorf, K.; Benner, A.; Kreutzfeldt, S.; Heining, C.; Horak, P.; Huebschmann, D.; Glimm, H.; Froehling, S.; Schlenk, R. F. 分享 收藏
Targeted therapy of desmoplastic small round cell tumor guided by multilayered molecular profiling Renner, M.; Oles, M.; Paramasivam, N.; Schneider, A.; Heilig, C. E.; Modugno, C.; Herremans, C.; Mock, A.; Lipka, D.; Bauer, S.; Kindler, T.; Brandts, C. H.; Keilholz, U.; Boerries, M.; Kuster, B.; Huebschmann, D.; Schlesner, M.; Glimm, H.; Schlenk, R. F.; Froehling, S. 分享 收藏
Deep molecular profiling of advanced synovial sarcoma as a basis for interventional clinical trials Schlenk, R. F.; Oles, M.; Bauer, S.; Kindler, T.; Klauschen, F.; Brandts, C. H.; Rieke, D. T.; Illert, L.; Boerries, M.; Heining, C.; Horak, P.; Bitzer, M.; Dirksen, U.; Sparber-Sauer, M.; Teleanu, M-V.; Kreutzfeldt, S.; Glimm, H.; Huebschmann, D.; Heilig, C. E.; Froehling, S. 分享 收藏
Value of broad molecular profiling for cancer diagnosis Werstein, L. V. A.; Heilig, C. E.; Teleanu, M-V.; Huellein, J.; Singh, M.; Bauer, S.; Kindler, T.; Klauschen, F.; Brandts, C. H.; Rieke, D. T.; Illert, L.; Boerries, M.; Kreutzfeldt, S.; Horak, P.; Huebschmann, D.; Lipka, D. B.; Glimm, H.; Hartmann, W.; Froehling, S. 分享 收藏
Randomized phase-III study of low-dose cytarabine and etoposide? plus ?/- all-trans retinoic acid in older unfit patients with NPM1-mutated acute myeloid leukemia Schlenk, R. F.; Weber, D.; Krzykalla, J.; Kindler, T.; Wulf, G.; Hertenstein, B.; Salih, H. R.; Suedhoff, T.; Krauter, J.; Martens, U.; Wessendorf, S.; Runde, V.; Tischler, H. J.; Bentz, M.; Koller, E.; Heuser, M.; Thol, F.; Benner, A.; Ganser, A.; Doehner, K.; Doehner, H. 分享 收藏
Menin inhibitor ziftomenib (KO-539) synergizes with drugs targeting chromatin regulation or apoptosis and sensitizes acute myeloid leukemia with MLL rearrangement or NPM1 mutation to venetoclax Rausch, Johanna; Dzama, Margarita M.; Dolgikh, Nadezda; Stiller, Hanna L.; Bohl, Stephan R.; Lahrmann, Catharina; Kunz, Kerstin; Kessler, Linda; Echchannaoui, Hakim; Chen, Chun-Wei; Kindler, Thomas; Doehner, Konstanze; Burrows, Francis; Theobald, Matthias; Sasca, Daniel; Kuehn, Michael W. M. 分享 收藏
Profile of the multicenter cohort of the German Cancer Consortium's Clinical Communication Platform 德国癌症联盟临床交流平台多中心队列的概况 Maier, Daniel; Vehreschild, Joerg Janne; Uhl, Barbara; Meyer, Sandra; Berger-Thuermel, Karin; Boerries, Melanie; Braren, Rickmer; Gruenwald, Viktor; Hadaschik, Boris; Palm, Stefan; Singer, Susanne; Stuschke, Martin; Juarez, David; Delpy, Pierre; Lambarki, Mohamed; Hummel, Michael; Engels, Caecilia; Andreas, Stefanie; Goekbuget, Nicola; Ihrig, Kristina; Burock, Susen; Keune, Dietmar; Eggert, Angelika; Keilholz, Ulrich; Schulz, Hagen; Buettner, Daniel; Loeck, Steffen; Krause, Mechthild; Esins, Mirko; Ressing, Frank; Schuler, Martin; Brandts, Christian; Brucker, Daniel P.; Husmann, Gabriele; Oellerich, Thomas; Metzger, Patrick; Voigt, Frederik; Illert, Anna L.; Theobald, Matthias; Kindler, Thomas; Sudhof, Ursula; Reckmann, Achim; Schwinghammer, Felix; Nasseh, Daniel; Weichert, Wilko; von Bergwelt-Baildon, Michael; Bitzer, Michael; Malek, Nisar; Oener, Oeznur; Schulze-Osthoff, Klaus; Bartels, Stefan; Haier, Joerg; Ammann, Raimund; Schmidt, Anja Franziska; Guenther, Bernd; Janning, Melanie; Kasper, Bernd; Loges, Sonja; Stilgenbauer, Stephan; Kuhn, Peter; Tausch, Eugen; Runow, Silvana; Kerscher, Alexander; Neumann, Michael; Breu, Martin; Lablans, Martin; Serve, Hubert 分享 收藏
Genomics-based personalized oncology of advanced thymic epithelial tumors Mohrmann, Lino; Rostock, Lysann; Oles, Malgorzata; Jahn, Arne; Arlt, Marie; Paramasivam, Nagarajan; Johrens, Korinna; Rupp, Luise; Schmitz, Marc; Richter, Daniela; Uhrig, Sebastian; Frohlich, Martina; Hutter, Barbara; Hullein, Jennifer; Wolf, Elena E.; Hanf, Dorothea; Gieldon, Laura; Kreutzfeldt, Simon; Heilig, Christoph E.; Teleanu, Veronica; Lipka, Daniel B.; Mock, Andreas; Jelas, Ivan; Rieke, Damian T.; Wiesweg, Marcel; Boerries, Melanie; Illert, Anna L.; Desuki, Alexander; Kindler, Thomas; Krackhardt, Angela M.; Westphalen, C. Benedikt; Grosch, Heidrun; Apostolidis, Leonidas; Stenzinger, Albrecht; Kerle, Irina A.; Heining, Christoph; Hubschmann, Daniel; Schrock, Evelin; Frohling, Stefan; Glimm, Hanno 分享 收藏
Genomic, transcriptomic, functional, and mechanistic characterization of rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusions Schoepf, Julia; Uhrig, Sebastian; Heilig, Christoph E.; Lee, Kwang-Seok; Walther, Tatjana; Carazzato, Alexander; Dobberkau, Anna Maria; Weichenhan, Dieter; Plass, Christoph; Hartmann, Mark; Diwan, Gaurav; Carrero, Zunamys; Ball, Claudia R.; Hohl, Tobias; Kindler, Thomas; Rudolph-Hahnel, Patricia; Nilsson, Anna; Ora, Ingrid; Imle, Roland; Banito, Ana; Russell, Robert; Jones, Barbara C.; Lipka, Daniel B.; Glimm, Hanno; Hubschmann, Daniel; Hartmann, Wolfgang; Frohling, Stefan; Scholl, Claudia 分享 收藏
Comprehensive cancer predisposition testing within the prospective MASTER trial identifies hereditary cancer patients and supports treatment decisions for rare cancers Jahn, A.; Rump, A.; Widmann, T. J.; Heining, C.; Horak, P.; Hutter, B.; Paramasivam, N.; Uhrig, S.; Gieldon, L.; Drukewitz, S.; Kuebler, A.; Bermudez, M.; Hackmann, K.; Porrmann, J.; Wagner, J.; Arlt, M.; Franke, M.; Fischer, J.; Kowalzyk, Z.; William, D.; Weth, V.; Oster, S.; Froehlich, M.; Huellein, J.; Gonzalez, C. Valle; Kreutzfeldt, S.; Mock, A.; Heilig, C. E.; Lipka, D. B.; Moehrmann, L.; Hanf, D.; Oles, M.; Teleanu, V.; Allgaeuer, M.; Ruhnke, L.; Kutz, O.; Knurr, A.; Lassmann, A.; Endris, V.; Neumann, O.; Penzel, R.; Beck, K.; Richter, D.; Winter, U.; Wolf, S.; Pfuetze, K.; Geoerg, C.; Meissburger, B.; Buchhalter, I.; Augustin, M.; Aulitzky, W. E.; Hohenberger, P.; Kroiss, M.; Schirmacher, P.; Schlenk, R. F.; Keilholz, U.; Klauschen, F.; Folprecht, G.; Bauer, S.; Siveke, J. T.; Brandts, C. H.; Kindler, T.; Boerries, M.; Illert, A. L.; von Bubnoff, N.; Jost, P. J.; Metzeler, K. H.; Bitzer, M.; Schulze-Osthoff, K.; von Kalle, C.; Brors, B.; Stenzinger, A.; Weichert, W.; Huebschmann, D.; Froehling, S.; Glimm, H.; Schroeck, E.; Klink, B. 分享 收藏
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