未登录 Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2 用酵母聚糖和MLi2处理的WT-LRRK2和G2019S-LRRK2小鼠小胶质细胞中的差异LRRK2信号传导和基因表达 Nazish, Iqra; Mamais, Adamantios; Mallach, Anna; Bettencourt, Conceicao; Kaganovich, Alice; Warner, Thomas; Hardy, John; Lewis, Patrick A.; Pocock, Jennifer; Cookson, Mark R.; Bandopadhyay, Rina 分享 收藏
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LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson's disease Kedariti, Maria; Frattini, Emanuele; Baden, Pascale; Cogo, Susanna; Civiero, Laura; Ziviani, Elena; Zilio, Gianluca; Bertoli, Federico; Aureli, Massimo; Kaganovich, Alice; Cookson, Mark R.; Stefanis, Leonidas; Surface, Matthew; Deleidi, Michela; Di Fonzo, Alessio; Alcalay, Roy N.; Rideout, Hardy; Greggio, Elisa; Plotegher, Nicoletta 分享 收藏
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LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies LAG3在人和鼠神经元中不表达，并且不调节 α-突触核蛋白病 Emmenegger, Marc; De Cecco, Elena; Hruska-Plochan, Marian; Eninger, Timo; Schneider, Matthias M.; Barth, Melanie; Tantardini, Elena; de Rossi, Pierre; Bacioglu, Mehtap; Langston, Rebekah G.; Kaganovich, Alice; Bengoa-Vergniory, Nora; Gonzalez-Guerra, Andres; Avar, Merve; Heinzer, Daniel; Reimann, Regina; Haesler, Lisa M.; Herling, Therese W.; Matharu, Naunehal S.; Landeck, Natalie; Luk, Kelvin; Melki, Ronald; Kahle, Philipp J.; Hornemann, Simone; Knowles, Tuomas P. J.; Cookson, Mark R.; Polymenidou, Magdalini; Jucker, Mathias; Aguzzi, Adriano 分享 收藏
High-frequency head impact causes chronic synaptic adaptation and long-term cognitive impairment in mice Sloley, Stephanie S.; Main, Bevan S.; Winston, Charisse N.; Harvey, Alex C.; Kaganovich, Alice; Korthas, Holly T.; Caccavano, Adam P.; Zapple, David N.; Wu, Jian-young; Partridge, John G.; Cookson, Mark R.; Vicini, Stefano; Burns, Mark P. 分享 收藏
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues G2019S和R1441C LRRK2突变对小鼠组织中LRRK2和Rab10磷酸化的不同影响 Iannotta, Lucia; Biosa, Alice; Kluss, Jillian H.; Tombesi, Giulia; Kaganovich, Alice; Cogo, Susanna; Plotegher, Nicoletta; Civiero, Laura; Lobbestael, Evy; Baekelandt, Veerle; Cookson, Mark R.; Greggio, Elisa 分享 收藏
LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies 在突触核蛋白病的啮齿动物模型中，LRRK2通过NFATc2介导小胶质细胞神经毒性 Kim, Changyoun; Beilina, Alexandria; Smith, Nathan; Li, Yan; Kim, Minhyung; Kumaran, Ravindran; Kaganovich, Alice; Mamais, Adamantios; Adame, Anthony; Iba, Michiyo; Kwon, Somin; Lee, Won-Jae; Shin, Soo-Jean; Rissman, Robert A.; You, Sungyong; Lee, Seung-Jae; Singleton, Andrew B.; Cookson, Mark R.; Masliah, Eliezer 分享 收藏
Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes Filippini, Alice; Mutti, Veronica; Faustini, Gaia; Longhena, Francesca; Ramazzina, Ileana; Rizzi, Federica; Kaganovich, Alice; Roosen, Dorien A.; Landeck, Natalie; Duffy, Megan; Tessari, Isabella; Bono, Federica; Fiorentini, Chiara; Greggio, Elisa; Bubacco, Luigi; Bellucci, Arianna; Missale, Mariacristina; Cookson, Mark R.; Gennarelli, Massimo; Russo, Isabella 分享 收藏
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network Beilina, Alexandra; Bonet-Ponce, Luis; Kumaran, Ravindran; Kordich, Jennifer J.; Ishida, Morie; Mamais, Adamantios; Kaganovich, Alice; Saez-Atienzar, Sara; Gershlick, David C.; Roosen, Dorien A.; Pellegrini, Laura; Malkov, Vlad; Fell, Matthew J.; Harvey, Kirsten; Bonifacino, Juan S.; Moore, Darren J.; Cookson, Mark R. 分享 收藏
Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils Russo, Isabella; Kaganovich, Alice; Ding, Jinhui; Landeck, Natalie; Mamais, Adamantios; Varanita, Tatiana; Biosa, Alice; Tessari, Isabella; Bubacco, Luigi; Greggio, Elisa; Cookson, Mark R. 分享 收藏
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Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2 Langston, Rebekah G.; Rudenko, Iakov N.; Kumaran, Ravindran; Hauser, David N.; Kaganovich, Alice; Ponce, Luis Bonet; Mamais, Adamantios; Ndukwe, Kelechi; Dillman, Allissa A.; Al-Saif, Amr M.; Beilina, Aleksandra; Cookson, Mark R. 分享 收藏
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Molecular Changes in the Absence of Severe Pathology in the Pulvinar in Dementia With Lewy Bodies Erskine, Daniel; Ding, Jinhui; Thomas, Alan J.; Kaganovich, Alice; Khundakar, Ahmad A.; Hanson, Peter S.; Taylor, John-Paul; McKeith, Ian G.; Attems, Johannes; Cookson, Mark R.; Morris, Christopher M. 分享 收藏
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Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7 Chia, Ruth; Haddock, Sara; Beilina, Alexandra; Rudenko, Iakov N.; Mamais, Adamantios; Kaganovich, Alice; Li, Yan; Kumaran, Ravindran; Nalls, Michael A.; Cookson, Mark R. 分享 收藏
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease Beilina, Alexandria; Rudenko, Iakov N.; Kaganovich, Alice; Civiero, Laura; Chau, Hien; Kalia, Suneil K.; Kalia, Lorraine V.; Lobbestael, Evy; Chi, Ruth; Ndukwe, Kelechi; Ding, Jinhui; Nalls, Mike A.; Olszewski, Maciej; Hauser, David N.; Kumaran, Ravindran; Lozano, Andres M.; Baekelandt, Veerle; Greene, Lois E.; Taymans, Jean-Marc; Greggio, Elisa; Cookson, Mark R. 分享 收藏
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