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RTx-303, an Orally Bioavailable Polθ Polymerase Inhibitor That Potentiates PARP Inhibitors in BRCA Mutant Tumors Chandramouly, Gurushankar; Fried, William; Gordon, John; Ralph, Douglas; Keuk, Channita; Kumari, Sangeeta; Ramanjulu, Mercy; Auerbacher, William; Minakhin, Leonid; Tredinnick, Taylor; Tiberi, Bernadette; Morton, George; Betsch, Robert; Cai, Kathy Q.; Vekariya, Umeshkumar M.; Tyagi, Mrityunjay; Skorski, Tomasz; Karakashev, Sergey; Johnson, Neil; Childers Jr, Wayne E.; Chen, Xiaojiang S.; Pomerantz, Richard T. 分享 收藏
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Structural basis for a Polθ helicase small-molecule inhibitor revealed by cryo-EM Ito, Fumiaki; Li, Ziyuan; Minakhin, Leonid; Chandramouly, Gurushankar; Tyagi, Mrityunjay; Betsch, Robert; Krais, John J.; Taberi, Bernadette; Vekariya, Umeshkumar; Calbert, Marissa; Skorski, Tomasz; Johnson, Neil; Chen, Xiaojiang S.; Pomerantz, Richard T. 分享 收藏
BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance Nesic, Ksenija; Krais, John J.; Wang, Yifan; Vandenberg, Cassandra J.; Patel, Pooja; Cai, Kathy Q.; Kwan, Tanya; Lieschke, Elizabeth; Ho, Gwo-Yaw; Barker, Holly E.; Bedo, Justin; Casadei, Silvia; Farrell, Andrew; Radke, Marc; Shield-Artin, Kristy; Penington, Jocelyn S.; Geissler, Franziska; Kyran, Elizabeth; Betsch, Robert; Xu, Lijun; Zhang, Fan; Dobrovic, Alexander; Olesen, Inger; Kristeleit, Rebecca; Oza, Amit; McNeish, Iain; Ratnayake, Gayanie; Traficante, Nadia; DeFazio, Anna; Bowtell, David D. L.; Harding, Thomas C.; Lin, Kevin; Swisher, Elizabeth M.; Kondrashova, Olga; Scott, Clare L.; Johnson, Neil; Wakefield, Matthew J. 分享 收藏
FAM122A ensures cell cycle interphase progression and checkpoint control by inhibiting B55α/PP2A through helical motifs Wasserman, Jason S.; Faezov, Bulat; Patel, Kishan R.; Kurimchak, Alison M.; Palacio, Seren M.; Glass, David J.; Fowle, Holly; McEwan, Brennan C.; Xu, Qifang; Zhao, Ziran; Cressey, Lauren; Johnson, Neil; Duncan, James S.; Kettenbach, Arminja N.; Dunbrack Jr, Roland L.; Grana, Xavier 分享 收藏
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors Fried, William; Tyagi, Mrityunjay; Minakhin, Leonid; Chandramouly, Gurushankar; Tredinnick, Taylor; Ramanjulu, Mercy; Auerbacher, William; Calbert, Marissa; Rusanov, Timur; Hoang, Trung; Borisonnik, Nikita; Betsch, Robert; Krais, John J.; Wang, Yifan; Vekariya, Umeshkumar M.; Gordon, John; Morton, George; Kent, Tatiana; Skorski, Tomasz; Johnson, Neil; Childers, Wayne; Chen, Xiaojiang S.; Pomerantz, Richard T. 分享 收藏
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4′-Ethynyl-2′-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress Calbert, Marissa L.; Chandramouly, Gurushankar; Adams, Clare M.; Saez-Ayala, Magali; Kent, Tatiana; Tyagi, Mrityunjay; Ayyadevara, V. S. S. Abhinav; Wang, Yifan; Krais, John J.; Gordon, John; Atkins, Jessica; Toma, Monika M.; Betzi, Stephane; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Goldman, Aaron R.; Gorman, Nicole; Mitra, Ramkrishna; Childers, Wayne E.; Grana, Xavier; Skorski, Tomasz; Johnson, Neil; Hurtz, Christian; Morelli, Xavier; Eischen, Christine M.; Pomerantz, Richard T. 分享 收藏
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Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities Brca1功能的遗传分离揭示了依赖于突变的pol θ 漏洞 Krais, John J.; Glass, David J.; Chudoba, Ilse; Wang, Yifan; Feng, Wanjuan; Simpson, Dennis; Patel, Pooja; Liu, Zemin; Neumann-Domer, Ryan; Betsch, Robert G.; Bernhardy, Andrea J.; Bradbury, Alice M.; Conger, Jason; Yueh, Wei-Ting; Nacson, Joseph; Pomerantz, Richard T.; Gupta, Gaorav P.; Testa, Joseph R.; Johnson, Neil 分享 收藏
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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency 复制缺口是PARP抑制剂合成致死率与BRCA缺乏症的关键决定因素 Cong, Ke; Peng, Min; Kousholt, Arne Nedergaard; Lee, Wei Ting C.; Lee, Silviana; Nayak, Sumeet; Krais, John; VanderVere-Carozza, Pamela S.; Pawelczak, Katherine S.; Calvo, Jennifer; Panzarino, Nicholas J.; Turchi, John J.; Johnson, Neil; Jonkers, Jos; Rothenberg, Eli; Cantor, Sharon B. 分享 收藏
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors TET2和DNMT3A突变对DNA修复和白血病细胞对PARP抑制剂的敏感性产生不同的影响 Maifrede, Silvia; Le, Bac Viet; Nieborowska-Skorska, Margaret; Golovine, Konstantin; Sullivan-Reed, Katherine; Dunuwille, Wangisa M. B.; Nacson, Joseph; Hulse, Michael; Keith, Kelsey; Madzo, Jozef; Caruso, Lisa Beatrice; Gazze, Zachary; Lian, Zhaorui; Padella, Antonella; Chitrala, Kumaraswamy N.; Bartholdy, Boris A.; Matlawska-Wasowska, Ksenia; Di Marcantonio, Daniela; Simonetti, Giorgia; Greiner, Georg; Sykes, Stephen M.; Valent, Peter; Paietta, Elisabeth M.; Tallman, Martin S.; Fernandez, Hugo F.; Litzow, Mark R.; Minden, Mark D.; Huang, Jian; Martinelli, Giovanni; Vassiliou, George S.; Tempera, Italo; Piwocka, Katarzyna; Johnson, Neil; Challen, Grant A.; Skorski, Tomasz 分享 收藏
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia Di Marcantonio, Daniela; Martinez, Esteban; Kanefsky, Joice S.; Huhn, Jacklyn M.; Gabbasov, Rashid; Gupta, Anushk; Krais, John J.; Peri, Suraj; Tan, YinFei; Skorski, Tomasz; Dorrance, Adrienne; Garzon, Ramiro; Goldman, Aaron R.; Tang, Hsin-Yao; Johnson, Neil; Sykes, Stephen M. 分享 收藏
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