未登录 Multi-tissue transcriptome-wide association study identifies novel candidate genes and pleiotropy effects across four abdominal hernia subtypes 多组织转录组-wide关联研究识别了四种腹疝亚型的候选基因和新陈代谢效应 Chaar, Dima L.; Jiang, Chen; Cowan, Brandon; Patel, Sahil; Kvale, Mark; Yin, Jie; Mostaedi, Rouzbeh; Ahituv, Nadav; Jorgenson, Eric; Hoffmann, Thomas J.; Choquet, Helene 分享 收藏
Genomic and phenotypic correlates of mosaic loss of chromosome Y in blood 血液中嵌合体Y染色体缺失的基因组与表型相关性 Jakubek, YA; Ma, XL; Stilp, AM; Yu, FL; Bacon, J; Wong, JW; Aguet, F; Ardlie, K; Arnett, DK; Barnes, K; Bis, JC; Blackwell, T; Becker, LC; Boerwinkle, E; Bowler, RP; Budoff, MJ; Carson, AP; Chen, JW; Cho, MH; Coresh, J; Cox, NJ; Vries, PSD; Demeo, DL; Fardo, DW; Fornage, M; Guo, XQ; Hall, ME; Heard-Costa, N; Hidalgo, B; Irvin, MR; Johnson, AD; Jorgenson, E; Kenny, EE; Kessler, MD; Levy, D; Li, Y; Lima, JAC; Liu, YM; Locke, AE; Loos, RJF; Machiela, MJ; Mathias, RA; Mitchell, BD; Murabito, JM; Mychaleckyj, JC; North, KE; Orchard, P; Parker, SCJ; Pershad, Y; Peyser, PA; Pratte, KA; Psaty, BM; Raffield, LM; Redline, S; Rich, SS; Rotter, JI; Shah, SJ; Smith, JA; Smith, AP; Smith, A; Taub, MA; Tiwari, HK; Tracy, R; Tuftin, B; Bick, AG; Sankaran, VG; Reiner, AP; Scheet, P; Auer, PL 分享 收藏
Genome-wide association analyses identify distinct genetic architectures for age-related macular degeneration across ancestries 全基因组关联分析确定不同祖先年龄相关性黄斑变性的不同遗传结构 Gorman, Bryan R.; Voloudakis, Georgios; Igo, Robert P., Jr.; Kinzy, Tyler; Halladay, Christopher W.; Bigdeli, Tim B.; Zeng, Biao; Venkatesh, Sanan; Bailey, Jessica N. Cooke; Crawford, Dana C.; Markianos, Kyriacos; Dong, Frederick; Schreiner, Patrick A.; Zhang, Wen; Hadi, Tamer; Anger, Matthew D.; Stockwell, Amy; Melles, Ronald B.; Yin, Jie; Choquet, Helene; Kaye, Rebecca; Patasova, Karina; Patel, Praveen J.; Yaspan, Brian L.; Jorgenson, Eric; Hysi, Pirro G.; Lotery, Andrew J.; Gaziano, J. Michael; Tsao, Philip S.; Fliesler, Steven J.; Sullivan, Jack M.; Greenberg, Paul B.; Wu, Wen-Chih; Assimes, Themistocles L.; Pyarajan, Saiju; Roussos, Panos; Peachey, Neal S.; Iyengar, Sudha K. 分享 收藏
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation 特应性皮炎的欧洲和多血统全基因组关联荟萃分析突出了全身免疫调节的重要性 Budu-Aggrey, Ashley; Kilanowski, Anna; Sobczyk, Maria K.; Shringarpure, Suyash S.; Mitchell, Ruth; Reis, Kadri; Reigo, Anu; Maegi, Reedik; Nelis, Mari; Tanaka, Nao; Brumpton, Ben M.; Thomas, Laurent F.; Sole-Navais, Pol; Flatley, Christopher; Espuela-Ortiz, Antonio; Herrera-Luis, Esther; Lominchar, Jesus V. T.; Bork-Jensen, Jette; Marenholz, Ingo; Arnau-Soler, Aleix; Jeong, Ayoung; Fawcett, Katherine A.; Baurecht, Hansjorg; Rodriguez, Elke; Alves, Alexessander Couto; Kumar, Ashish; Sleiman, Patrick M.; Chang, Xiao; Medina-Gomez, Carolina; Hu, Chen; Xu, Cheng-jian; Qi, Cancan; El-Heis, Sarah; Titcombe, Philip; Antoun, Elie; Fadista, Joao; Wang, Carol A.; Thiering, Elisabeth; Wu, Baojun; Kress, Sara; Kothalawala, Dilini M.; Kadalayil, Latha; Duan, Jiasong; Zhang, Hongmei; Hadebe, Sabelo; Hoffmann, Thomas; Jorgenson, Eric; Choquet, Helene; Risch, Neil; Njolstad, Pal; Andreassen, Ole A.; Johansson, Stefan; Almqvist, Catarina; Gong, Tong; Ullemar, Vilhelmina; Karlsson, Robert; Magnusson, Patrik K. E.; Szwajda, Agnieszka; Burchard, Esteban G.; Thyssen, Jacob P.; Hansen, Torben; Karhus, Line L.; Dantoft, Thomas M.; Jeanrenaud, Alexander C. S. N.; Ghauri, Ahla; Arnold, Andreas; Homuth, Georg; Lau, Susanne; Noethen, Markus M.; Huebner, Norbert; Imboden, Medea; Visconti, Alessia; Falchi, Mario; Bataille, Veronique; Hysi, Pirro; Ballardini, Natalia; Boomsma, Dorret I.; Hottenga, Jouke J.; Mueller-Nurasyid, Martina; Ahluwalia, Tarunveer S.; Stokholm, Jakob; Chawes, Bo; Schoos, Ann-Marie M.; Esplugues, Ana; Bustamante, Mariona; Raby, Benjamin; Arshad, Syed; German, Chris; Esko, Tonu; Milani, Lili A.; Metspalu, Andres; Terao, Chikashi; Abuabara, Katrina; Loset, Mari; Hveem, Kristian; Jacobsson, Bo; Pino-Yanes, Maria; Strachan, David P.; Grarup, Niels; Linneberg, Allan; Lee, Young-Ae; Probst-Hensch, Nicole; Weidinger, Stephan; Jarvelin, Marjo-Riitta; Melen, Erik; Hakonarson, Hakon; Irvine, Alan D.; Jarvis, Deborah; Nijsten, Tamar; Duijts, Liesbeth; Vonk, Judith M.; Koppelmann, Gerard H.; Godfrey, Keith M.; Barton, Sheila J.; Feenstra, Bjarke; Pennell, Craig E.; Sly, Peter D.; Holt, Patrick G.; Williams, L. Keoki; Bisgaard, Hans; Bonnelykke, Klaus; Curtin, John; Simpson, Angela; Murray, Clare; Schikowski, Tamara; Bunyavanich, Supinda; Weiss, Scott T.; Holloway, John W.; Min, Josine L.; Brown, Sara J.; Standl, Marie; Paternoster, Lavinia 分享 收藏
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Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci 大规模多性状全基因组关联分析确定了数百个青光眼风险位点 Han, Xikun; Gharahkhani, Puya; Hamel, Andrew R.; Ong, Jue Sheng; Renteria, Miguel E.; Mehta, Puja; Dong, Xianjun; Pasutto, Francesca; Hammond, Christopher; Young, Terri L.; Hysi, Pirro; Lotery, Andrew J.; Jorgenson, Eric; Choquet, Helene; Hauser, Michael; Bailey, Jessica Cooke N.; Nakazawa, Toru; Akiyama, Masato; Shiga, Yukihiro; Fuller, Zachary L.; Wang, Xin; Hewitt, Alex W.; Craig, Jamie E.; Pasquale, Louis R.; Mackey, David A.; Wiggs, Janey L.; Khawaja, Anthony P.; Segre, Ayellet, V; MacGregor, Stuart 分享 收藏
Rare coding variants in CHRNB2 reduce the likelihood of smoking Rajagopal, Veera R.; Watanabe, Kyoko; Mbatchou, Joelle; Ayer, Ariane M.; Quon, Peter; Sharma, Deepika A.; Kessler, Michael; Praveen, Kavita; Gelfman, Sahar; Parikshak, Neelroop; Otto, Jacqueline; Bao, Suying; Chim, Shek Man; Pavlopoulos, Elias; Avbersek, Andreja; Kapoor, Manav; Chen, Esteban; Jones, Marcus; Leblanc, Michelle; Emberson, Jonathan; Collins, Rory; Torres, Jason; Morales, Pablo Kuri; Tapia-Conyer, Roberto; Alegre, Jesus; Berumen, Jaime; Shuldiner, Alan; GHS REGN DiscovEHR Collaboration; Regeneron Genetics Ctr; Balasubramanian, Suganthi; Abecasis, Goncalo R.; Kang, Hyun; Marchini, Jonathan; Stahl, Eli; Jorgenson, Eric; Sanchez, Robert; Liedtke, Wolfang; Anderson, Matthew; Cantor, Michael; Lederer, David; Baras, Aris; Coppola, Giovanni 分享 收藏
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MiXcan: a framework for cell-type-aware transcriptome-wide association studies with an application to breast cancer Song, Xiaoyu; Ji, Jiayi; Rothstein, Joseph H.; Alexeeff, Stacey E.; Sakoda, Lori C.; Sistig, Adriana; Achacoso, Ninah; Jorgenson, Eric; Whittemore, Alice S.; Klein, Robert J.; Habel, Laurel A.; Wang, Pei; Sieh, Weiva 分享 收藏
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma ANGPTL7，眼内压升高和青光眼的治疗靶点 Praveen, Kavita; Patel, Gaurang C.; Gurski, Lauren; Ayer, Ariane H.; Persaud, Trikaladarshi; Still, Matthew D.; Miloscio, Lawrence; Van Zyl, Tave; Di Gioia, Silvio Alessandro; Brumpton, Ben; Krebs, Kristi; Asvold, Bjorn Olav; Chen, Esteban; Chavali, Venkata R. M.; Fury, Wen; Gudiseva, Harini, V; Hyde, Sarah; Jorgenson, Eric; Lefebvre, Stephanie; Li, Dadong; Li, Alexander; Mclninch, James; Patel, Brijeshkumar; Rabinowitz, Jeremy S.; Salowe, Rebecca; Schurmann, Claudia; Seidelin, Anne-Sofie; Stahl, Eli; Sun, Dylan; Teslovich, Tanya M.; Tybjaerg-Hansen, Anne; Willer, Cristen; Waldron, Scott; Walley, Sabrina; Yang, Hua; Zaveri, Sarthak; Hu, Ying; Hveem, Kristian; Melander, Olle; Milani, Lili; Stender, Stefan; O'Brien, Joan M.; Jones, Marcus B.; Abecasis, Goncalo R.; Cantor, Michael N.; Weyne, Jonathan; Karalis, Katia; Economides, Aris; Della Gatta, Giusy; Ferreira, Manuel A.; Yancopoulos, George D.; Baras, Aris; Romano, Carmelo; Coppola, Giovanni 分享 收藏
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Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development Simcoe, Mark J.; Shah, Ameet; Fan, Baojian; Choquet, Helene; Weisschuh, Nicole; Waseem, Naushin H.; Jiang, Chen; Melles, Ronald B.; Ritch, Robert; Mahroo, Omar A.; Wissinger, Bernd; Jorgenson, Eric; Wiggs, Janey L.; Garway-Heath, David F.; Hysi, Pirro G.; Hammond, Christopher J. 分享 收藏
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Genetic variation affects morphological retinal phenotypes extracted from UK Biobank optical coherence tomography images (vol 17, e1009497, 2021) Currant, Hannah; Hysi, Pirro; Fitzgerald, Tomas W.; Gharahkhani, Puya; Bonnemaijer, Pieter W. M.; Senabouth, Anne; Hewitt, Alex W.; Atan, Denize; Aung, Tin; Charng, Jason; Choquet, Helene; Craig, Jamie; Khaw, Peng T.; Klaver, Caroline C. W.; Kubo, Michiaki; Ong, Jue-Sheng; Pasquale, Louis R.; Reisman, Charles A.; Daniszewski, Maciej; Powell, Joseph E.; Pebay, Alice; Simcoe, Mark J.; Thiadens, Alberta A. H. J.; van Duijn, Cornelia M.; Yazar, Seyhan; Jorgenson, Eric; MacGregor, Stuart; Hammond, Chris J.; Mackey, David A.; Wiggs, Janey L.; Foster, Paul J.; Patel, Praveen J.; Birney, Ewan; Khawaja, Anthony P. 分享 收藏
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Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program 不同受试者的全基因组测序确定白细胞性状的遗传相关性: NHLBI TOPMed计划 Mikhaylova, Anna, V; McHugh, Caitlin P.; Polfus, Linda M.; Raffield, Laura M.; Boorgula, Meher Preethi; Blackwell, Thomas W.; Brody, Jennifer A.; Broome, Jai; Chami, Nathalie; Chen, Ming-Huei; Conomos, Matthew P.; Cox, Corey; Curran, Joanne E.; Daya, Michelle; Ekunwe, Lynette; Glahn, David C.; Heard-Costa, Nancy; Highland, Heather M.; Hobbs, Brian D.; Ilboudo, Yann; Jain, Deepti; Lange, Leslie A.; Miller-Fleming, Tyne W.; Min, Nancy; Moon, Jee-Young; Preuss, Michael H.; Rosen, Jonathon; Ryan, Kathleen; Smith, Albert, V; Sun, Quan; Surendran, Praveen; de Vries, Paul S.; Walter, Klaudia; Wang, Zhe; Wheeler, Marsha; Yanek, Lisa R.; Zhong, Xue; Abecasis, Goncalo R.; Almasy, Laura; Barnes, Kathleen C.; Beaty, Terri H.; Becker, Lewis C.; Blangero, John; Boerwinkle, Eric; Butterworth, Adam S.; Chavan, Sameer; Cho, Michael H.; Choquet, Helene; Correa, Adolfo; Cox, Nancy; DeMeo, Dawn L.; Faraday, Nauder; Fornage, Myriam; Gerszten, Robert E.; Hou, Lifang; Johnson, Andrew D.; Jorgenson, Eric; Kaplan, Robert; Kooperberg, Charles; Kundu, Kousik; Laurie, Cecelia A.; Lettre, Guillaume; Lewis, Joshua P.; Li, Bingshan; Li, Yun; Lloyd-Jones, Donald M.; Loos, Ruth J. F.; Manichaikul, Ani; Meyers, Deborah A.; Mitchell, Braxton D.; Morrison, Alanna C.; Ngo, Debby; Nickerson, Deborah A.; Nongmaithem, Suraj; North, Kari E.; O'Connell, Jeffrey R.; Ortega, Victor E.; Pankratz, Nathan; Perry, James A.; Psaty, Bruce M.; Rich, Stephen S.; Soranzo, Nicole; Rotter, Jerome, I; Silverman, Edwin K.; Smith, Nicholas L.; Tang, Hua; Tracy, Russell P.; Thornton, Timothy A.; Vasan, Ramachandran S.; Zein, Joe; Mathias, Rasika A.; Reiner, Alexander P.; Auer, Paul L. 分享 收藏
Whole genome sequence analysis of platelet traits in the NHLBI Trans-Omics for Precision Medicine (TOPMed) initiative NHLBI精准医学跨组学 (TOPMed) 计划中血小板性状的全基因组序列分析 Little, Amarise; Hu, Yao; Sun, Quan; Jain, Deepti; Broome, Jai; Chen, Ming-Huei; Thibord, Florian; McHugh, Caitlin; Surendran, Praveen; Blackwell, Thomas W.; Brody, Jennifer A.; Bhan, Arunoday; Chami, Nathalie; de Vries, Paul S.; Ekunwe, Lynette; Heard-Costa, Nancy; Hobbs, Brian D.; Manichaikul, Ani; Moon, Jee-Young; Preuss, Michael H.; Ryan, Kathleen; Wang, Zhe; Wheeler, Marsha; Yanek, Lisa R.; Abecasis, Goncalo R.; Almasy, Laura; Beaty, Terri H.; Becker, Lewis C.; Blangero, John; Boerwinkle, Eric; Butterworth, Adam S.; Choquet, Helene; Correa, Adolfo; Curran, Joanne E.; Faraday, Nauder; Fornage, Myriam; Glahn, David C.; Hou, Lifang; Jorgenson, Eric; Kooperberg, Charles; Lewis, Joshua P.; Lloyd-Jones, Donald M.; Loos, Ruth J. F.; Min, Yuan-, I; Mitchell, Braxton D.; Morrison, Alanna C.; Nickerson, Deborah A.; North, Kari E.; O'Connell, Jeffrey R.; Pankratz, Nathan; Psaty, Bruce M.; Vasan, Ramachandran S.; Rich, Stephen S.; Rotter, Jerome, I; Smith, Albert, V; Smith, Nicholas L.; Tang, Hua; Tracy, Russell P.; Conomos, Matthew P.; Laurie, Cecelia A.; Mathias, Rasika A.; Li, Yun; Auer, Paul L.; Thornton, Timothy; Reiner, Alexander P.; Johnson, Andrew D.; Raffield, Laura M. 分享 收藏
A polygenic risk score for asthma in a large racially diverse population 大量种族多样化人群中哮喘的多基因风险评分 Sordillo, Joanne E.; Lutz, Sharon M.; Jorgenson, Eric; Iribarren, Carlos; McGeachie, Michael; Dahlin, Amber; Tantisira, Kelan; Kelly, Rachel; Lasky-Su, Jessica; Sakornsakoplat, Phuwanat; Moll, Matthew; Cho, Michael H.; Wu, Ann Chen 分享 收藏
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans Nair, K. Saidas; Srivastava, Chitrangda; Brown, Robert V.; Koli, Swanand; Choquet, Helene; Kang, Hong Soon; Kuo, Yien-Ming; Grimm, Sara A.; Sutherland, Caleb; Badea, Alexandra; Johnson, G. Allan; Zhao, Yin; Yin, Jie; Okamoto, Kyoko; Clark, Graham; Borras, Terete; Zode, Gulab; Kizhatil, Krishnakumar; Chakrabarti, Subhabrata; John, Simon W. M.; Jorgenson, Eric; Jetten, Anton M. 分享 收藏
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