Jeffrey L. Brodsky - Publications, H-index & Citations

Jeffrey L. Brodsky

department of biological sciences

79H指数

394论文数

2.5W被引数

收录论文 196

发表时间

Targeting HDAC and proteostasis to eradicate quiescent cancer cells 靶向HDAC和蛋白质稳态以清除休眠癌细胞

Cancer Gene Therapy

IF5

2026-08-13

OAAI

Qi Jiang; Michelle Ertel; Austin Arrigo; Amjad Hijazzi; Sara Sannino; Jennifer L. Goeckeler-Fried; April Sagan; Ian Beddows; Betsy Ann Varghese; Daniel D. Brown; Wayne Stallaert; Adrian Lee; Amanda M. Clark; Hui Shen; Jeffrey L. Brodsky; Hatice U. Osmanbeyoglu; Ronald J. Buckanovich

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment

CHANNELS

IF3.2

2026-01-22

PREAI

Kok, Morgan; Aizenman, Elias; Guerriero, Christopher J.; Brodsky, Jeffrey L.

Reconstitution of CFTR ubiquitination identifies lysine-420 as a regulator of cell surface residence and current CFTR泛素化的重组实验确定了赖氨酸-420为细胞表面驻留时间和电流的调节因子

Biochemistry and Biophysics Reports

IF2.2

2025-12-01

OAAI

Goeckeler-Fried, Jennifer L.; Zeng, Xuemei; Hong, Jeong S.; Joshi, Disha; Yang, Zhengrong; Jiang, Fan; Kappes, John C.; Sorscher, Eric J.; Brodsky, Jeffrey L.

Thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis 甲状腺中ER分子伴侣GRP170的表达对于高效的TSH介导的甲状腺激素合成是必需的。

JCI INSIGHT

IF6.1

2025-09-09

PREAI

Zhang, Xiaohan; Young, Crystal; Liao, Xiao-Hui; Refetoff, Samuel; Mutchler, Stephanie M.; Brodsky, Jeffrey L.; Buck, Teresa M.; Arvan, Peter

Inefficient maturation of disease-linked mutant forms of the KCC2 potassium-chloride cotransporter correlates with predicted pathogenicity

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-04-01

OAAI

Kok, Morgan; Singh, Ishika; Aizenman, Elias; Brodsky, Jeffrey L.

Excess dietary sodium restores electrolyte and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron 饮食中过量的钠可恢复小鼠肾单位中内质网分子伴侣GRP170丢失引起的电解质和水稳态

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY

IF3.4

2025-02-01

PREAI

Porter, Aidan W.; Vorndran, Hannah E.; Marciszyn, Allison; Mutchler, Stephanie M.; Subramanya, Arohan R.; Kleyman, Thomas R.; Hendershot, Linda M.; Brodsky, Jeffrey L.; Buck, Teresa M.

Identification of polycystin 2 missense mutants targeted for endoplasmic reticulum-associated degradation

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IF4.7

2025-02-01

PREAI

Guerriero, Christopher J.; Carattino, Marcelo D.; Sharp, Katherine G.; Kantz, Luke J.; Gresko, Nikolay P.; Caplan, Michael J.; Brodsky, Jeffrey L.

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

MOLECULAR METABOLISM

IF6.6

2024-12-01

OAAI

Wang, Haizhen; Nikain, Cyrus; Fortounas, Konstantinos I.; Amengual, Jaume; Tufanli, Ozlem; La Forest, Maxwell; Yu, Yong; Wang, Meng C.; Watts, Russell; Lehner, Richard; Qiu, Yunping; Cai, Min; Kurland, Irwin J.; Goldberg, Ira J.; Rajan, Sujith; Hussain, M. Mahmood; Brodsky, Jeffrey L.; Fisher, Edward A.

Characterization of hyperactive mutations in the renal potassium channel ROMK uncovers unique effects on channel biogenesis and ion conductance

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2024-09-01

OAAI

Nguyen, Nga H.; Sheng, Shaohu; Banerjee, Anupam; Guerriero, Christopher J.; Chen, Jingxin; Wang, Xueqi; Mackie, Timothy D.; Welling, Paul A.; Kleyman, Thomas R.; Bahar, Ivet; Carlson, Anne E.; Brodsky, Jeffrey L.

The emerging role of fat-inducing transcript 2 in endoplasmic reticulum proteostasis and lipoprotein biogenesis

CURRENT OPINION IN LIPIDOLOGY

IF4.6

2024-08-22

PREAI

Brodsky, Jeffrey L.; Iyer, Anuradha; Fortounas, Konstantinos I.; Fisher, Edward A.

Current insights and assumptions on α-synuclein in Lewy body disease 路易体病中 α-突触核蛋白的当前见解和假设

ACTA NEUROPATHOLOGICA

IF9.3

2024-08-14

OAAI

Leak, Rehana K.; Clark, Rachel N.; Abbas, Muslim; Xu, Fei; Brodsky, Jeffrey L.; Chen, Jun; Hu, Xiaoming; Luk, Kelvin C.

Optimization of the fluorogen-activating protein tag for quantitative protein trafficking and colocalization studies in S. cerevisiae

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2024-07-01

PREAI

Oppenheimer, Katherine G.; Hager, Natalie A.; McAtee, Ceara K.; Filiztekin, Elif; Shang, Chaowei; Warnick, Justina A.; Bruchez, Marcel P.; Brodsky, Jeffrey L.; Prosser, Derek C.; Kwiatkowski, Adam, V; O'Donnell, Allyson F.

The biogenesis of potassium transporters: implications of disease-associated mutations

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

IF6.4

2024-07-01

PREAI

Kok, Morgan; Brodsky, Jeffrey L.

The HERCulean task of recognizing, ubiquitinating, and shielding misfolded integral membrane proteins

JOURNAL OF CELL BIOLOGY

IF6.4

2024-06-05

OAAI

Guerriero, Christopher J.; Brodsky, Jeffrey L.

Loss of Grp170 results in catastrophic disruption of endoplasmic reticulum function

MOLECULAR BIOLOGY OF THE CELL

IF2.7

2024-04-01

OAAI

Mann, Melissa J.; Melendez-Suchi, Chris; Vorndran, Hannah E.; Sukhoplyasova, Maria; Flory, Ashley R.; Irvine, Mary Carson; Iyer, Anuradha R.; Guerriero, Christopher J.; Brodsky, Jeffrey L.; Hendershot, Linda M.; Buck, Teresa M.

A new combinatorial therapy that synergistically targets the NuRD complex and proteostasis to eradicate quiescent ovarian cancer cells

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Jiang, Qi; Ertel, Michelle; Panesso-Gomez, Santiago; Sannino, Sara; Sagan, April; Cole, Alexander J.; McGonigal, Stacy C.; Varghese, Betsy Ann; Stallaert, Wayne; Brodsky, Jeffrey L.; Osmanbeyoglu, Hatice U.; Buckanovich, Ronald J.

The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2

NEUROCHEMISTRY INTERNATIONAL

IF4

2024-03-01

PREAI

Kok, Morgan; -Scott, Karen Hartnett; Happe, Cassandra L.; Macdonald, Matthew L.; Aizenman, Elias; Brodsky, Jeffrey L.

J-domain proteins: From molecular mechanisms to diseases J结构域蛋白: 从分子机制到疾病

CELL STRESS & CHAPERONES

IF3.2

2024-02-01

OAAI

Marszalek, Jaroslaw; De Los Rios, Paolo; Cyr, Douglas; Mayer, Matthias P.; Adupa, Vasista; Andreasson, Claes; Blatch, Gregory L.; Braun, Janice E. A.; Brodsky, Jeffrey L.; Bukau, Bernd; Chapple, J. Paul; Conz, Charlotte; Dementin, Sebastien; Genevaux, Pierre; Genest, Olivier; Goloubinoff, Pierre; Gestwicki, Jason; Hammond, Colin M.; Hines, Justin K.; Ishikawa, Koji; Joachimiak, Lukasz A.; Kirstein, Janine; Liberek, Krzysztof; Mokranjac, Dejana; Nillegoda, Nadinath; Ramos, Carlos H. I.; Rebeaud, Mathieu; Ron, David; Rospert, Sabine; Sahi, Chandan; Shalgi, Reut; Tomiczek, Bartlomiej; Ushioda, Ryo; Ustyantseva, Elizaveta; Ye, Yihong; Zylicz, Maciej; Kampinga, Harm H.

The generation of detergent-insoluble clipped fragments from an ERAD substrate in mammalian cells

SCIENTIFIC REPORTS

IF3.9

2023-12-06

OAAI

Daskivich, Grant J.; Brodsky, Jeffrey L.

Genome mining yields putative disease-associated ROMK variants with distinct defects 基因组挖掘产生具有明显缺陷的推定疾病相关ROMK变体

PLOS GENETICS

IF3.7

2023-11-13

OAAI

Nguyen, Nga H.; Sarangi, Srikant; Mcchesney, Erin M.; Sheng, Shaohu; Durrant, Jacob D.; Porter, Aidan W.; Kleyman, Thomas R.; Pitluk, Zachary W.; Brodsky, Jeffrey L.

研究方向