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Human Proteoglycan Linkage Region Glycosyltransferases are Dimeric and Show Unexpected Specificities 人蛋白聚糖连接区糖基转移酶是二聚体并表现出意外的特异性 Weidler, Sascha; Bundgaard, Ole; Hessefort, Markus; Raedisch, Marisa; Graf, Christopher Gunther Franz; Lam, Kevin; Neubauer, Vanessa J.; Eisenreich, Johanna; Koehler, Leonhard; Moremen, Kelley W.; Steentoft, Catharina; Clausen, Henrik; Huang, Teng-yi; Hung, Shang-cheng; Steegborn, Clemens; Weyand, Michael; Unverzagt, Carlo 分享 收藏
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Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J. 分享 收藏
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity 具有细胞活性的线粒体脱酰基酶Sirtuin 4的特异性抑制剂 Pannek, Martin; Alhalabi, Zayan; Tomaselli, Daniela; Menna, Martina; Fiorentino, Francesco; Robaa, Dina; Weyand, Michael; Puhlmann, Maximilian; Tomassi, Stefano; Barreca, Federica; Tafani, Marco; Zaganjor, Elma; Haigis, Marcia C.; Sippl, Wolfgang; Rotili, Dante; Mai, Antonello; Steegborn, Clemens 分享 收藏
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells Zwergel, Clemens; Aventaggiato, Michele; Garbo, Sabrina; Di Bello, Elisabetta; Fassari, Bruno; Noce, Beatrice; Castiello, Carola; Lambona, Chiara; Barreca, Federica; Rotili, Dante; Fioravanti, Rossella; Schmalz, Thomas; Weyand, Michael; Niedermeier, Amelie; Tripodi, Marco; Colotti, Gianni; Steegborn, Clemens; Battistelli, Cecilia; Tafani, Marco; Valente, Sergio; Mai, Antonello 分享 收藏
Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation Sun, Shan; Fushimi, Makoto; Rossetti, Thomas; Kaur, Navpreet; Ferreira, Jacob; Miller, Michael; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Levin, Lonny R.; Buck, Jochen; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel; Meinke, Peter T.; Huggins, David J. 分享 收藏
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Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential (vol 13, 1013845, 2022) Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Buck, Hannes; Steegborn, Clemens; Myers, Robert W.; Meinke, Peter T.; Levin, Lonny R.; Buck, Jochen 分享 收藏
On-demand male contraception via acute inhibition of soluble adenylyl cyclase Balbach, Melanie; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Ritagliati, Carla; Myers, Robert W. W.; Huggins, David J. J.; Steegborn, Clemens; Miranda, Ileana C. C.; Meinke, Peter T. T.; Buck, Jochen; Levin, Lonny R. R. 分享 收藏
Design, Synthesis, and Pharmacological Evaluation of Second- Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates Miller, Michael; Rossetti, Thomas; Ferreira, Jacob; Ghanem, Lubna; Balbach, Melanie; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Kehr, Maria; Coquille, Sandrine; Heuvel, Joop van den; Steegborn, Clemens; Fushimi, Makoto; Finkin-Groner, Efrat; Myers, Robert W.; Kargman, Stacia; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T. 分享 收藏
Potent and Specific Activators for Mitochondrial Sirtuins Sirt3 and Sirt5 Suenkel, Benjamin; Valente, Sergio; Zwergel, Clemens; Weiss, Sandra; Di Bello, Elisabetta; Fioravanti, Rossella; Aventaggiato, Michele; Amorim, Joao A.; Garg, Neha; Kumar, Surinder; Lombard, David B.; Hu, Tuo; Singh, Pankaj K.; Tafani, Marco; Palmeira, Carlos M.; Sinclair, David; Mai, Antonello; Steegborn, Clemens 分享 收藏
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Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression Hu, Tuo; Shukla, Surendra K.; Vernucci, Enza; He, Chunbo; Wang, Dezhen; King, Ryan J.; Jha, Kanupriya; Siddhanta, Kasturi; Mullen, Nicholas J.; Attri, Kuldeep S.; Murthy, Divya; Chaika, Nina, V; Thakur, Ravi; Mulder, Scott E.; Pacheco, Camila G.; Fu, Xiao; High, Robin R.; Yu, Fang; Lazenby, Audrey; Steegborn, Clemens; Lan, Ping; Mehla, Kamiya; Rotili, Dante; Chaudhary, Sarika; Valente, Sergio; Tafani, Marco; Mai, Antonello; Auwerx, Johan; Verdin, Eric; Tuveson, David; Singh, Pankaj K. 分享 收藏
Constitutively Activating GNAS Somatic Mutation in Right Ventricular Outflow Tract Tachycardia Ip, James E.; Xu, Linna; Dai, Jie; Steegborn, Clemens; Jaffre, Fabrice; Evans, Todd; Cheung, Jim W.; Basson, Craig T.; Panaghie, Gianina; Krogh-Madsen, Trine; Abbott, Geoffrey W.; Lerman, Bruce B. 分享 收藏
Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10) Fushimi, Makoto; Buck, Hannes; Balbach, Melanie; Gorovyy, Anna; Ferreira, Jacob; Rossetti, Thomas; Kaur, Navpreet; Levin, Lonny R.; Buck, Jochen; Quast, Jonathan; van den Heuvel, Joop; Steegborn, Clemens; Finkin-Groner, Efrat; Kargman, Stacia; Michino, Mayako; Foley, Michael A.; Miller, Michael; Liverton, Nigel J.; Huggins, David J.; Meinke, Peter T. 分享 收藏
Natural Glycoforms of Human Interleukin 6 Show Atypical Plasma Clearance Reif, Andreas; Lam, Kevin; Weidler, Sascha; Lott, Marie; Boos, Irene; Lokau, Juliane; Bretscher, Christian; Moennich, Manuel; Perkams, Lukas; Schmaelzlein, Marina; Graf, Christopher; Fischer, Jan-Patrick; Lechner, Carolin; Hallstein, Kerstin; Becker, Stefan; Weyand, Michael; Steegborn, Clemens; Schultheiss, Gerhard; Rose-John, Stefan; Garbers, Christoph; Unverzagt, Carlo 分享 收藏
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