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Arlene H. Sharpe

broad institute
H指数:154
被引数:10.9万

个人简介

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教育背景

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工作经历

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荣誉奖项

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Stability and progressive differentiation of TFR cells are intrinsically and extrinsically controlled by TFH programs

TFR细胞的稳定性和渐进分化由TFH程序内在和外在控制。

Nature Immunology
IF27.6
2026-01-130
OAAI
Jeong-Mi Lee; Paulo Lisboa Raeder; Ridwan B. Rashid; Hengcheng Zhang; Cody S. Nelson; Sierra G. Richardson; Kelly P. Burke; Pragya Chandrakar; Manuel A. Podestà; Maya G. Gempler; Cole Batty; Dejun Kong; Samuel J. Gavzy; Marina W. Shirkey; Cyrus Yang; Jonathan S. Bromberg; Marcia C. Haigis; Wayne A. Marasco; Arlene H. Sharpe; Peter T. Sage
B-cell-specific checkpoint molecules that regulate anti-tumour immunity (vol 619, pg 348, 2023)

B细胞特异性检查点分子对肿瘤免疫的调控（vol 619, pg 348, 2023）

NATURE
IF48.5
2025-03-170
PRE
Bod, Lloyd; Kye, Yoon-Chul; Shi, Jingwen; Triglia, Elena Torlai; Schnell, Alexandra; Fessler, Johannes; Ostrowski, Stephen M.; Von-Franque, Max Y.; Kuchroo, Juhi R.; Barilla, Rocky M.; Zaghouani, Sarah; Christian, Elena; Delorey, Toni Marie; Mohib, Kanishka; Xiao, Sheng; Slingerland, Nadine; Giuliano, Christopher J.; Ashenberg, Orr; Li, Zhaorong; Rothstein, David M.; Fisher, David E.; Rozenblatt-Rosen, Orit; Sharpe, Arlene H.; Quintana, Francisco J.; Apetoh, Lionel; Regev, Aviv; Kuchroo, Vijay K.
Targeting RGMb interactions: Discovery and preclinical characterization of potent anti-RGMb antibodies blocking multiple ligand bindings

靶向RGMb相互作用: 阻断多种配体结合的有效抗RGMb抗体的发现和临床前表征

MABS
IF7.3
2024-11-260
OAAI
Meira, Maria; Frey, Aurore; Chekkat, Neila; Rybczynska, Magda; Sellam, Zaki; Park, Joon Seok; Gazzaniga, Francesca Smylie; Parmentier, Alexia; Le Gall, Marianne; Freeman, Gordon James; Kasper, Dennis Lee; Sharpe, Arlene Helen; Rambeaux, Eric; Shamshiev, Abdijapar
Neuropeptide signalling orchestrates T cell differentiation

神经肽信号调控T细胞分化

Nature
IF48.5
2024-10-160
PRE
Yu Hou; Linyu Sun; Martin W. LaFleur; Linglin Huang; Conner Lambden; Pratiksha I. Thakore; Kathryn Geiger-Schuller; Kimitoshi Kimura; Longjun Yan; Yue Zang; Ruihan Tang; Jingwen Shi; Rocky Barilla; Liwen Deng; Ayshwarya Subramanian; Antonia Wallrapp; Hee Sun Choi; Yoon-Chul Kye; Orr Ashenberg; Geoffrey Schiebinger; John G. Doench; Isaac M. Chiu; Aviv Regev; Arlene H. Sharpe; Vijay K. Kuchroo
Epigenetic tuning of PD-1 expression improves exhausted T cell function and viral control
NATURE IMMUNOLOGY
IF27.6
2024-09-170
PRE
Weiss, Sarah A.; Huang, Amy Y.; Fung, Megan E.; Martinez, Daniela; Chen, Alex C. Y.; LaSalle, Thomas J.; Miller, Brian C.; Scharer, Christopher D.; Hegde, Mudra; Nguyen, Thao H.; Rowe, Jared H.; Osborn, Jossef F.; Patterson, Dillon G.; Sifnugel, Natalia; Mei-An Nolan, C.; Davidson, Richard A.; Schwartz, Marc A.; Bally, Alexander P. R.; Neeld, Dennis K.; LaFleur, Martin W.; Boss, Jeremy M.; Doench, John G.; Haining, W. Nicholas; Sharpe, Arlene H.; Sen, Debattama R.
Deciphering the effects of age on T cell immunity and immunotherapy
CANCER RESEARCH
IF16.6
2024-03-220
PRE
Han, SeongJun; Georgiev, Peter; Schneider, Jaime; Huang, Amy; Nugmanova, Zhanel; Nguyen, Thao H.; Yao, Conghui; Johnson, Sheila; Joshi, Shakchhi; Dhiman, Ishita; Drijvers, Jefte M.; Fung, Megan; Rowe, Jared H.; Miller, Brian C.; Freeman, Gordon J.; Ringel, Alison E.; Haigis, Marcia C.; Sharpe, Arlene H.
Framework for in vivo T cell screens
JOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
2024-02-272
OAAI
Milling, Lauren E.; Markson, Samuel C.; Tjokrosurjo, Qin; Derosia, Nicole M.; Streeter, Ivy S. L.; Hickok, Grant H.; Lemmen, Ashlyn M.; Nguyen, Thao H.; Prathima, Priyamvada; Fithian, William; Schwartz, Marc A.; Hacohen, Nir; Doench, John G.; Lafleur, Martin W.; Sharpe, Arlene H.
Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model

鼠同源CT2A肿瘤模型中的抗原呈递缺陷，间充质分化和对免疫疗法的抵抗力

FRONTIERS IN IMMUNOLOGY
IF5.9
2023-12-281
OAAI
Iorgulescu, J. Bryan; Ruthen, Neil; Ahn, Ryuhjin; Panagioti, Eleni; Gokhale, Prafulla C.; Neagu, Martha; Speranza, Maria C.; Eschle, Benjamin K.; Soroko, Kara M.; Piranlioglu, Raziye; Datta, Meenal; Krishnan, Shanmugarajan; Yates, Kathleen B.; Baker, Gregory J.; Jain, Rakesh K.; Suva, Mario L.; Neuberg, Donna; White, Forest M.; Chiocca, E. Antonio; Freeman, Gordon J.; Sharpe, Arlene H.; Wu, Catherine J.; Reardon, David A.
Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade

补充甲酸盐可增强抗肿瘤CD8 T细胞的适应性和PD-1阻断的功效

CANCER DISCOVERY
IF33.3
2023-09-2014
OA
Rowe, Jared H.; Elia, Ilaria; Shahid, Osmaan; Gaudiano, Emily F.; Sifnugel, Natalia E.; Johnson, Sheila; Reynolds, Amy G.; Fung, Megan E.; Joshi, Shakchhi; LaFleur, Martin W.; Park, Joon Seok; Pauken, Kristen E.; Rabinowitz, Joshua D.; Freeman, Gordon J.; Haigis, Marcia C.; Sharpe, Arlene H.
Metabolic modulation of mitochondrial mass during CD4+T cell activation
CELL CHEMICAL BIOLOGY
IF7.2
2023-09-012
OAAI
Kurmi, Kiran; Liang, Dan; van de Ven, Robert; Georgiev, Peter; Gassaway, Brandon Mark; Han, Seongjun; Notarangelo, Giulia; Harris, Isaac S.; Yao, Cong-Hui; Park, Joon Seok; Hu, Song-Hua; Peng, Jingyu; Drijvers, Jefte M.; Boswell, Sarah; Sokolov, Artem; Dougan, Stephanie K.; Sorger, Peter K.; Gygi, Steven P.; Sharpe, Arlene H.; Haigis, Marcia C.

研究方向

暂未获取到该数据
G
Gordon J. Freeman
H 指数:174论文数:1,090被引数:13.0万
P
Peter T. Sage
H 指数:36论文数:119被引数:9,395
V
Vijay K. Kuchroo
H 指数:157论文数:686被引数:11.1万
M
Martin W. LaFleur
H 指数:22论文数:104被引数:8,510
M
Marcia C. Haigis
H 指数:75论文数:294被引数:3.4万
W
W. Nicholas Haining
H 指数:54论文数:193被引数:2.6万
K
Kristen E. Pauken
H 指数:34论文数:162被引数:1.5万
B
Bruce R. Blazar
H 指数:148论文数:1,548被引数:9.0万
R
Rafi Ahmed
H 指数:162论文数:771被引数:10.8万
M
Mohamed H. Sayegh
H 指数:103论文数:592被引数:3.8万