未登录 Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma 选择性废除S6K2将脂质稳态识别为MAPK抑制剂耐药的NRAS突变黑色素瘤的生存易损性 Lipchick, Brittany; Guterres, Adam N.; Chen, Hsin-Yi; Zundell, Delaine M.; Del Aguila, Segundo; Reyes-Uribe, Patricia I.; Tirado, Yulissa; Basu, Subhasree; Yin, Xiangfan; Kossenkov, Andrew V.; Lu, Yiling; Mills, Gordon B.; Liu, Qin; Goldman, Aaron R.; Murphy, Maureen E.; Speicher, David W.; Villanueva, Jessie 分享 收藏
Stromal changes in the aged lung induce an emergence from melanoma dormancy (vol 606, pg 396, 2022) 老年肺的间质变化诱导黑色素瘤休眠状态的终止（vol 606, pg 396, 2022） Fane, Mitchell E.; Chhabra, Yash; Alicea, Gretchen M.; Maranto, Devon A.; Douglass, Stephen M.; Webster, Marie R.; Rebecca, Vito W.; Marino, Gloria E.; Almeida, Filipe; Ecker, Brett L.; Zabransky, Daniel J.; Huser, Laura; Beer, Thomas; Tang, Hsin-Yao; Kossenkov, Andrew; Herlyn, Meenhard; Speicher, David W.; Xu, Wei; Xu, Xiaowei; Jaffee, Elizabeth M.; Aguirre-Ghiso, Julio A.; Weeraratna, Ashani T. 分享 收藏
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TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation Hao, Xue; Zhao, Bo; Towers, Martina; Liao, Liping; Monteiro, Edgar Luzete; Xu, Xin; Freeman, Christina; Peng, Hongzhuang; Tang, Hsin-Yao; Havas, Aaron; Kossenkov, Andrew V.; Berger, Shelley L.; Adams, Peter D.; Speicher, David W.; Schultz, David; Marmorstein, Ronen; Zaret, Kenneth S.; Zhang, Rugang 分享 收藏
Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity Zhang, Xue; Pant, Shishir M.; Ritch, Cecily C.; Tang, Hsin-Yao; Shao, Hongguang; Dweep, Harsh; Gong, Yao-Yu; Brooks, Rebekah; Brafford, Patricia; Wolpaw, Adam J.; Lee, Yool; Weeraratna, Ashani; Sehgal, Amita; Herlyn, Meenhard; Kossenkov, Andrew; Speicher, David; Sorger, Peter K.; Santagata, Sandro; Dang, Chi V. 分享 收藏
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Parkin ubiquitination of Kindlin-2 enables mitochondria-associated metastasis suppression Yeon, Minjeong; Bertolini, Irene; Agarwal, Ekta; Ghosh, Jagadish C.; Tang, Hsin-Yao; Speicher, David W.; Keeney, Frederick; Sossey-Alaoui, Khalid; Pluskota, Elzbieta; Bialkowska, Katarzyna; Plow, Edward F.; Languino, Lucia R.; Skordalakes, Emmanuel; Caino, M. Cecilia; Altieri, Dario C. 分享 收藏
Lysosomal lipid peroxidation regulates tumor immunity Bhardwaj, Monika; Lee, Jennifer J.; Versace, Amanda M.; Harper, Sandra L.; Goldman, Aaron R.; Crissey, Mary Ann S.; Jain, Vaibhav; Singh, Mahendra Pal; Vernon, Megane; Aplin, Andrew E.; Lee, Seokwoo; Morita, Masao; Winkler, Jeffrey D.; Liu, Qin; Speicher, David W.; Amaravadi, Ravi K. 分享 收藏
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Myc Regulation of a Mitochondrial Trafficking Network Mediates Tumor Cell Invasion and Metastasis 线粒体运输网络的Myc调控介导肿瘤细胞侵袭和转移 Agarwal, Ekta; Altman, Brian J.; Seo, Jae Ho; Bertolini, Irene; Ghosh, Jagadish C.; Kaur, Amanpreet; Kossenkov, Andrew, V; Languino, Lucia R.; Gabrilovich, Dmitry, I; Speicher, David W.; Dang, Chi, V; Altieri, Dario C. 分享 收藏
TXNRD1 drives innate immune response in senescent cells to promote tumor immune surveillance and age-associated inflammation Hao, Xue; Zhao, Bo; Towers, Martina; Liao, Liping; Tang, Hsin Yao; Havas, Aaron; Kossenkov, Andrew V.; Berger, Shelley; Adams, Peter D.; Speicher, David W.; Zhang, Rugang 分享 收藏
Targeting UGCG Overcomes Resistance to Lysosomal Autophagy Inhibition 靶向UGCG克服了对溶酶体自噬抑制的抗性 Jain, Vaibhav; Harper, Sandra L.; Versace, Amanda M.; Fingerman, Dylan; Brown, Gregory Schuyler; Bhardwaj, Monika; Crissey, Mary Ann S.; Goldman, Aaron R.; Ruthel, Gordon; Liu, Qin; Zivkovic, Aleksandra; Stark, Holgar; Herlyn, Meenhard; Gimotty, Phyllis A.; Speicher, David W.; Amaravadi, Ravi K. 分享 收藏
PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma (vol 7, e165688, 2022) Sharma, Gaurav; Ojha, Rani; Noguera-Ortega, Estela; Rebecca, Vito W.; Attanasio, John; Liu, Shujing; Piao, Shengfu; Lee, Jennifer J.; Nicastri, Michael C.; Harper, Sandra L.; Ronghe, Amruta; Jain, Vaibhav; Winkler, Jeffrey D.; Speicher, David W.; Mastio, Jerome; Gimotty, Phyllis A.; Xu, Xiaowei; Wherry, E. John; Gabrilovich, Dmitry I.; Amaravadi, Ravi K. 分享 收藏
Circadian lncRNA ADIRF-AS1 binds PBAF and regulates renal clear cell tumorigenesis Brooks, Rebekah; Monzy, Judith; Aaron, Bailey; Zhang, Xue; Kossenkov, Andrew; Hayden, James; Keeney, Frederick; Speicher, David W.; Zhang, Lin; Dang, Chi V. 分享 收藏
HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors Guan, Lei; Wu, Bin; Li, Ting; Beer, Lynn A.; Sharma, Gaurav; Li, Mingyue; Lee, Chin Nien; Liu, Shujing; Yang, Changsong; Huang, Lili; Frederick, Dennie T.; Boland, Genevieve M.; Shao, Guangcan; Svitkina, Tatyana M.; Cai, Kathy Q.; Chen, Fangping; Dong, Meng-Qiu; Mills, Gordon B.; Schuchter, Lynn M.; Karakousis, Giorgos C.; Mitchell, Tara C.; Flaherty, Keith T.; Speicher, David W.; Chen, Youhai H.; Herlyn, Meenhard; Amaravadi, Ravi K.; Xu, Xiaowei; Guo, Wei 分享 收藏
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