Izhak Kehat - Publications, H-index & Citations

Izhak Kehat

pennsylvania medicine

33H指数

77论文数

9.4K被引数

收录论文 34

发表时间

mTORC1 and nuclear ERK spatially control translation in cardiomyocytes through 4EBP1 phosphorylation mTORC1和核内ERK通过4EBP1磷酸化空间调控心肌细胞翻译

Science Signaling

IF6.6

2026-04-01

PREAI

Uchida, Keita; Scarborough, Emily A.; Pruzinsky, Elizabeth; Stone, Kathlyene R.; Hartman, Hali; Kelly, Daniel P.; Edwards, Jonathan J.; Kehat, Izhak; Prosser, Benjamin L.

Recruitment of transcriptional effectors by Cas9 creates cis-regulatory elements and demonstrates distance-dependent transcriptional regulation Cas9招募转录效应因子形成顺式调控元件，并证明了距离依赖性的转录调控。

iScience

IF4.1

2025-11-12

OAAI

Jubran Boulos; Arkadiy K. Golov; Nadav Keren; Itai Erlich; Nardeen Shehadeh; Nili Avidan; Hagai Kariti; Omer Sadeh; Lilac Haimovich-Caspi; Adam Helms; Noam Kaplan; Izhak Kehat

Imaging of Existing and Newly Translated Proteins Elucidates Mechanisms of Sarcomere Turnover

CIRCULATION RESEARCH

IF16.2

2024-08-02

OAAI

Douvdevany, Guy; Erlich, Itai; Haimovich-Caspi, Lilac; Mashiah, Tomer; Prondzynski, Maksymilian; Pricolo, Maria Rosaria; Alegre-Cebollada, Jorge; Linke, Wolfgang A.; Carrier, Lucie; Kehat, Izhak

Localized translation and sarcomere maintenance requires ribosomal protein SA in mice

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2024-05-14

OAAI

Haddad, Rami; Sadeh, Omer; Ziv, Tamar; Erlich, Itai; Haimovich-Caspi, Lilac; Shemesh, Ariel; van der Velden, Jolanda; Kehat, Izhak

RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy

COMMUNICATIONS BIOLOGY

IF5.1

2023-12-05

OAAI

Krumbein, Miriam; Oberman, Froma; Cinnamon, Yuval; Golomb, Mordechai; May, Dalit; Vainer, Gilad; Belzer, Vitali; Meir, Karen; Fridman, Irina; Haybaeck, Johannes; Poelzl, Gerhard; Kehat, Izhak; Beeri, Ronen; Kessler, Sonja M.; Yisraeli, Joel K.

RNAs are localized and translated at discrete cardiomyocyte microdomains

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2022-12-01

PREAI

Scarborough, Emily; Uchida, Keita; Kehat, Izhak; Prosser, Benjamin

Live imaging of translation in living cardiomyocytes at superresolution

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2022-12-01

PREAI

Erlich, Itai; Douvdevany, Guy; Haddad, Rami; Caspi, Lilac; Kehat, Izhak

Spatial sub-sarcomeric proteomic analysis reveals novel sarcomeric proteins

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2022-12-01

PREAI

Haddad, Rami; Shkedi, Omer; Ehrlich, Itai; Ataweh, Nardeen; Caspi, Lilac; Kehat, Izhak

SIKs (Salt-Inducible Kinases) in Arterial Restenosis

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IF7.4

2021-09-01

OAAI

Shkedi, Omer; Kehat, Izhak

Dual specific phosphatases (DUSPs) in cardiac hypertrophy and failure

CELLULAR SIGNALLING

IF3.7

2021-08-01

PREAI

Mutlak, Michael; Kehat, Izhak

Microtubules orchestrate local translation to enable cardiac growth

NATURE COMMUNICATIONS

IF15.7

2021-03-11

OAAI

Scarborough, Emily A.; Uchida, Keita; Vogel, Maria; Erlitzki, Noa; Iyer, Meghana; Phyo, Sai Aung; Bogush, Alexey; Kehat, Izhak; Prosser, Benjamin L.

Risk Factors for the Development of Functional Tricuspid Regurgitation and Their Population-Attributable Fractions

JACC-CARDIOVASCULAR IMAGING

IF15.2

2020-08-01

PREAI

Mutlak, Diab; Khalil, Jawad; Lessick, Jonathan; Kehat, Izhak; Agmon, Yoram; Aronson, Doron

Lack of Increased Cardiovascular Risk due to Functional Tricuspid Regurgitation in Patients with Left-Sided Heart Disease

JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

IF6

2019-12-01

PREAI

Mutlak, Diab; Khoury, Emad; Lessick, Jonathan; Kehat, Izhak; Agmon, Yoram; Aronson, Doron

Extracellular signal-regulated kinase (ERK) activation preserves cardiac function in pressure overload induced hypertrophy 细胞外信号调节激酶 (ERK) 激活可在压力超负荷诱导的肥大中保持心脏功能

INTERNATIONAL JOURNAL OF CARDIOLOGY

IF3.2

2018-11-01

PREAI

Mutlak, Michael; Schlesinger-Laufer, Michal; Haas, Tali; Shofti, Rona; Ballan, Nimer; Lewis, Yair E.; Zuler, Mor; Zohar, Yaniv; Caspi, Lilac H.; Kehat, Izhak

Localization of transcripts, translation, and degradation for spatiotemporal sarcomere maintenance

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2018-03-01

PREAI

Lewis, Yair E.; Moskovitz, Anner; Mutlak, Michael; Heineke, Joerg; Caspi, Lilac H.; Kehat, Izhak

Analysis of rat cardiac myocytes and fibroblasts identifies combinatorial enhancer organization and transcription factor families

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

IF4.7

2018-03-01

PREAI

Golan-Lagziel, Tal; Lewis, Yair E.; Shkedi, Omer; Douvdevany, Guy; Caspi, Lilac H.; Kehat, Izhak

Salt-inducible kinase induces cytoplasmic histone deacetylase 4 to promote vascular calcification

EMBO REPORTS

IF6.2

2017-06-06

OAAI

Abend, Alon; Shkedi, Omer; Fertouk, Michal; Caspi, Lilac H.; Kehat, Izhak

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair 用于心力衰竭建模和修复的先进成熟的定义工程人类心肌

CIRCULATION

IF38.6

2017-05-09

471

OAAI

Tiburcy, Malte; Hudson, James E.; Balfanz, Paul; Schlick, Susanne; Meyer, Tim; Liao, Mei-Ling Chang; Levent, Elif; Raad, Farah; Zeidler, Sebastian; Wingender, Edgar; Riegler, Johannes; Wang, Mouer; Gold, Joseph D.; Kehat, Izhak; Wettwer, Erich; Ravens, Ursula; Dierickx, Pieterjan; van Laake, Linda W.; Goumans, Marie Jose; Khadjeh, Sara; Toischer, Karl; Hasenfuss, Gerd; Couture, Larry A.; Unger, Andreas; Linke, Wolfgang A.; Araki, Toshiyuki; Neel, Benjamin; Keller, Gordon; Gepstein, Lior; Wu, Joseph C.; Zimmermann, Wolfram-Hubertus

Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination 许多具有独特特征的蛋白质在单泛素化后被26s蛋白酶体降解

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2016-07-06

146

OAAI

Braten, Ori; Livneh, Ido; Ziv, Tamar; Admon, Arie; Kehat, Izhak; Caspi, Lilac H.; Gonen, Hedva; Bercovich, Beatrice; Godzik, Adam; Jahandideh, Samad; Jaroszewski, Lukasz; Sommer, Thomas; Kwon, Yong Tae; Guharoy, Mainak; Tompa, Peter; Ciechanover, Aaron

ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling 心肌细胞和巨噬细胞之间的ATF3-dependent串扰促进心脏适应性重构

INTERNATIONAL JOURNAL OF CARDIOLOGY

IF3.2

2015-11-01

PREAI

Koren, L.; Alishekevitz, D.; Elhanani, O.; Nevelsky, A.; Hai, T.; Kehat, I.; Shaked, Y.; Aronheim, A.

研究方向