Kristian Birchall - Publications, H-index & Citations

Kristian Birchall

lifearc, accelerator building, open innovation campus, stevenage sg1 2fx, u.k.

20H指数

44论文数

1.2K被引数

收录论文 20

发表时间

The future of machine learning for small-molecule drug discovery will be driven by data 用于小分子药物发现的机器学习的未来将由数据驱动

NATURE COMPUTATIONAL SCIENCE

IF18.3

2024-10-15

PREAI

Durant, Guy; Boyles, Fergus; Birchall, Kristian; Deane, Charlotte M.

Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?

FRONTIERS IN MOLECULAR NEUROSCIENCE

IF3.8

2024-04-15

OAAI

Kuemper, Sandra; Cairns, Andrew G.; Birchall, Kristian; Yao, Zhi; Large, Jonathan M.

Identification of novel p-cresol inhibitors that reduce Clostridioides difficile's ability to compete with species of the gut microbiome

SCIENTIFIC REPORTS

IF3.9

2023-06-11

OAAI

Harrison, Mark A.; Farthing, Rebecca J.; Allen, Nyasha; Ahern, Lucy M.; Birchall, Kristian; Bond, Michael; Kaur, Harparkash; Wren, Brendan W.; Bergeron, Julien R. C.; Dawson, Lisa F.

Incorporating Target-Specific Pharmacophoric Information into Deep Generative Models for Fragment Elaboration

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2022-05-02

OAAI

Hadfield, Thomas E.; Imrie, Fergus; Merritt, Andy; Birchall, Kristian; Deane, Charlotte M.

Fragment-based target screening as an empirical approach to prioritising targets: a case study on antibacterials

DRUG DISCOVERY TODAY

IF7.5

2020-11-01

OAAI

Canning, Peter; Birchall, Kristian; Kettleborough, Catherine A.; Merritt, Andy; Coombs, Peter J.

Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2020-10-01

OAAI

Dohrke, Jan-Niklas; Watson, Jake F.; Birchall, Kristian; Greger, Ingo H.

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-04-27

PREAI

Pant, Shishir M.; Mukonoweshuro, Amanda; Desai, Bimbisar; Ramjee, Manoj K.; Selway, Christopher N.; Tarver, Gary J.; Wright, Adrian G.; Birchall, Kristian; Chapman, Timothy M.; Tervonen, Topi A.; Klefstrom, Juha

The serine proteinase hepsin is an activator of pro-matrix metalloproteinases: molecular mechanisms and implications for extracellular matrix turnover

SCIENTIFIC REPORTS

IF3.9

2017-12-01

OAAI

Wilkinson, David J.; Desilets, Antoine; Lin, Hua; Charlton, Sarah; Arques, Maria del Carmen; Falconer, Adrian; Bullock, Craig; Hsu, Yu-Chen; Birchall, Kristian; Hawkins, Alastair; Thompson, Paul; Ferrell, William R.; Lockhart, John; Plevin, Robin; Zhang, Yadan; Blain, Emma; Lin, Shu-Wha; Leduc, Richard; Milner, Jennifer M.; Rowan, Andrew D.

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches

ACS CHEMICAL BIOLOGY

IF3.8

2017-10-30

OAAI

McIntyre, Patrick J.; Collins, Patrick M.; Vrzal, Lukas; Birchall, Kristian; Arnold, Laurence H.; Mpamhanga, Chido; Coombs, Peter J.; Burgess, Selena G.; Richards, Mark W.; Winter, Anja; Veverka, Vaclav; von Delft, Frank; Merritt, Andy; Bayliss, Richard

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

NATURE COMMUNICATIONS

IF15.7

2017-09-05

105

OAAI

Baker, David A.; Stewart, Lindsay B.; Large, Jonathan M.; Bowyer, Paul W.; Ansell, Keith H.; Jimenez-Diaz, Mar-A B.; El Bakkouri, Majida; Birchall, Kristian; Dechering, Koen J.; Bouloc, Nathalie S.; Coombs, Peter J.; Whalley, David; Harding, Denise J.; Smiljanic-Hurley, Ela; Wheldon, Mary C.; Walker, Eloise M.; Dessens, Johannes T.; Lafuente, Maria Jose; Sanz, Laura M.; Gamo, Francisco-Javier; Ferrer, Santiago B.; Hui, Raymond; Bousema, Teun; Angulo-Barturen, I. Igo; Merritt, Andy T.; Croft, Simon L.; Gutteridge, Winston E.; Kettleborough, Catherine A.; Osborne, Simon A.

Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger

ACS CHEMICAL BIOLOGY

IF3.8

2014-10-24

OAAI

Miller, Thomas C. R.; Rutherford, Trevor J.; Birchall, Kristian; Chugh, Jasveen; Fiedler, Marc; Bienz, Mariann

Biochemical and Antiparasitic Properties of Inhibitors of the Plasmodium falciparum Calcium-Dependent Protein Kinase PfCDPK1

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

IF4.5

2014-10-01

OAAI

Ansell, Keith H.; Jones, Hayley M.; Whalley, David; Hearn, Alisdair; Taylor, Debra L.; Patin, Emmanuel C.; Chapman, Timothy M.; Osborne, Simon A.; Wallace, Claire; Birchall, Kristian; Large, Jonathan; Bouloc, Nathalie; Smiljanic-Hurley, Ela; Clough, Barbara; Moon, Robert W.; Green, Judith L.; Holder, Anthony A.

Optimization of an Imidazopyridazine Series of Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 (PfCDPK1)

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2014-04-11

OAAI

Chapman, Timothy M.; Osborne, Simon A.; Wallace, Claire; Birchall, Kristian; Bouloc, Nathalie; Jones, Hayley M.; Ansell, Keith H.; Taylor, Debra L.; Clough, Barbara; Green, Judith L.; Holder, Anthony A.

Fragment-based hit identification: thinking in 3D

DRUG DISCOVERY TODAY

IF7.5

2013-12-01

139

PREAI

Morley, Andrew D.; Pugliese, Angelo; Birchall, Kristian; Bower, Justin; Brennan, Paul; Brown, Nathan; Chapman, Tim; Drysdale, Martin; Gilbert, Ian H.; Hoelder, Swen; Jordan, Allan; Ley, Steven V.; Merritt, Andy; Miller, David; Swarbrick, Martin E.; Wyatt, Paul G.

Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2010-09-01

PREAI

Sorrell, Fiona J.; Greenwood, Gemma K.; Birchall, Kristian; Chen, Beining

Use of Reduced Graphs To Encode Bioisosterism for Similarity-Based Virtual Screening

JOURNAL OF CHEMICAL INFORMATION AND MODELING

IF5.3

2009-06-01

PREAI

Birchall, Kristian; Gillet, Valerie J.; Willett, Peter; Ducrot, Pierre; Luttmann, Claude