未登录 Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling (May, 10.1038/s43018-024-00768-3, 2024) Rezvan, Ali; Romain, Gabrielle; Fathi, Mohsen; Heeke, Darren; Martinez-Paniagua, Melisa; An, Xingyue; Bandey, Irfan N.; Montalvo, Melisa J.; Adolacion, Jay R. T.; Saeedi, Arash; Sadeghi, Fatemeh; Fousek, Kristen; Puebla-Osorio, Nahum; Cooper, Laurence J. N.; Bernatchez, Chantale; Singh, Harjeet; Ahmed, Nabil; Mattie, Mike; Bot, Adrian; Neelapu, Sattva; Varadarajan, Navin 分享 收藏
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling 通过动态多维单细胞分析鉴定弥漫性大b细胞淋巴瘤中临床有效的CAR T细胞亚群 Rezvan, Ali; Romain, Gabrielle; Fathi, Mohsen; Heeke, Darren; Martinez-Paniagua, Melisa; An, Xingyue; Bandey, Irfan N.; Montalvo, Melisa J.; Adolacion, Jay R. T.; Saeedi, Arash; Sadeghi, Fatemeh; Fousek, Kristen; Puebla-Osorio, Nahum; Cooper, Laurence J. N.; Bernatchez, Chantale; Singh, Harjeet; Ahmed, Nabil; Mattie, Mike; Bot, Adrian; Neelapu, Sattva; Varadarajan, Navin 分享 收藏
IL7 increases targeted lipid nanoparticle-mediated mRNA expression in T cells in vitro and in vivo by enhancing T cell protein translation IL7通过增强T细胞蛋白翻译增加体外和体内T细胞中靶向脂质纳米颗粒介导的mRNA表达 Tilsed, Caitlin M.; Sadiq, Barzan A.; Papp, Tyler E.; Areesawangkit, Phurin; Kimura, Kenji; Noguera-Ortega, Estela; Scholler, John; Cerda, Nicholas; Aghajanian, Haig; Bot, Adrian; Mui, Barbara; Tam, Ying; Weissman, Drew; June, Carl H.; Albelda, Steven M.; Parhiz, Hamideh 分享 收藏
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma Locke, Frederick L.; Filosto, Simone; Chou, Justin; Vardhanabhuti, Saran; Perbost, Regis; Dreger, Peter; Hill, Brian T.; Lee, Catherine; Zinzani, Pier L.; Kroeger, Nicolaus; Lopez-Guillermo, Armando; Greinix, Hildegard; Zhang, Wangshu; Tiwari, Gayatri; Budka, Justin; Marincola, Francesco M.; To, Christina; Mattie, Mike; Schupp, Marco; Cheng, Paul; Bot, Adrian; Shen, Rhine; Bedognetti, Davide; Miao, Harry; Galon, Jerome 分享 收藏
Product Attributes of CAR T-cell Therapy Differentially Associate with Efficacy and Toxicity in Second-line Large B-cell Lymphoma (ZUMA-7) Filosto, Simone; Vardhanabhuti, Saran; Canales, Miguel A.; Poire, Xavier; Lekakis, Lazaros J.; de Vos, Sven; Portell, Craig A.; Wang, Zixing; To, Christina; Schupp, Marco; Poddar, Soumya; Trinh, Tan; Warren, Carmen M.; Aguilar, Ethan G.; Budka, Justin; Cheng, Paul; Chou, Justin; Bot, Adrian; Shen, Rhine R.; Westin, Jason R. 分享 收藏
Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies Ghobadi, Armin; Landmann, Jack H.; Carter, Alun; Cooper, Matthew L.; Selli, Mehmet Emrah; Chang, Jufang; Baker, Matthew; Miller, Christopher A.; Ferraro, Francesca; Chen, David Y.; Smith, Amanda M.; LaValle, Taylor A.; Duncavage, Eric J.; Chou, Justin; Tam, Victor; Benoun, Joseph M.; Nater, Jenny; Scholler, Nathalie; Milletti, Francesca; Vezan, Remus; Bot, Adrian; Rossi, John M.; Singh, Nathan 分享 收藏
Multidimensional single-cell analysis identifies a role for CD2-CD58 interactions in clinical antitumor T cell responses 多维单细胞分析确定了CD2-CD58相互作用在临床抗肿瘤T细胞反应中的作用 Romain, Gabrielle; Strati, Paolo; Rezvan, Ali; Fathi, Mohsen; Bandey, Irfan N.; Adolacion, Jay R. T.; Heeke, Darren; Liadi, Ivan; Marques-Piubelli, Mario L.; Solis, Luisa M.; Mahendra, Ankit; Vega, Francisco; Cooper, Laurence J. N.; Singh, Harjeet; Mattie, Mike; Bot, Adrian; Neelapu, Sattva S.; Varadarajan, Navin 分享 收藏
Tumor immune contexture is a determinant of anti-CD19 CAR T cell efficacy in large B cell lymphoma 肿瘤免疫环境是anti-CD19 CAR T细胞在大b细胞淋巴瘤中疗效的决定因素 Scholler, Nathalie; Perbost, Regis; Locke, Frederick L.; Jain, Michael D.; Turcan, Sarah; Danan, Corinne; Chang, Edmund C.; Neelapu, Sattva S.; Miklos, David B.; Jacobson, Caron A.; Lekakis, Lazaros J.; Lin, Yi; Ghobadi, Armin; Kim, Jenny J.; Chou, Justin; Plaks, Vicki; Wang, Zixing; Xue, Allen; Mattie, Mike; Rossi, John M.; Bot, Adrian; Galon, Jerome 分享 收藏
Multiomic dynamic single-cell profiling of CAR T cell populations associated with efficacy Rezvan, Ali; Romain, Gabrielle; Fathi, Mohsen; Heeke, Darren; Martinez-Paniagua, Melisa; An, Xingyue; Bandey, Irfan N.; Liadi, Ivan; Cooper, Laurence J. N.; Singh, Harjeet; Bot, Adrian; Neelapu, Sattva; Varadarajan, Navin 分享 收藏
A Critical Role for Fas-Mediated Off-Target Tumor Killing in T-cell Immunotherapy Upadhyay, Ranjan; Boiarsky, Jonathan A.; Pantsulaia, Gvantsa; Svensson-Arvelund, Judit; Lin, Matthew J.; Wroblewska, Aleksandra; Bhalla, Sherry; Scholler, Nathalie; Bot, Adrian; Rossi, John M.; Sadek, Norah; Parekh, Samir; Lagana, Alessandro; Baccarini, Alessia; Merad, Miriam; Brown, Brian D.; Brody, Joshua D. 分享 收藏
TCR-engineered T cells targeting E7 for patients with metastatic HPV-associated epithelial cancers 针对转移性HPV相关上皮癌患者的靶向E7的TCR工程T细胞 Nagarsheth, Nisha B.; Norberg, Scott M.; Sinkoe, Andrew L.; Adhikary, Sabina; Meyer, Thomas J.; Lack, Justin B.; Warner, Andrew C.; Schweitzer, Colleen; Doran, Stacey L.; Korrapati, Soumya; Stevanovic, Sanja; Trimble, Cornelia L.; Kanakry, Jennifer A.; Bagheri, Mohammad Hadi; Ferraro, Erin; Astrow, Stephanie H.; Bot, Adrian; Faquin, William C.; Stroncek, David; Gkitsas, Nikolaos; Highfill, Steven; Hinrichs, Christian S. 分享 收藏
POTENTIATION OF T-CELL MEDIATED TUMOR KILLING VIA MODULATION OF THE FAS/FASL PATHWAY Boiarsky, Jonathan; Upadhyay, Ranjan; Svensson-Arvelund, Judit; Wroblewska, Aleksandra; Bhalla, Sherry; Scholler, Nathalie; Bot, Adrian; Rossi, John; Parekh, Samir; Sadek, Norah; Baccarini, Alessia; Merad, Miriam; Brown, Brian; Brody, Joshua 分享 收藏
Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma 肿瘤负荷，炎症和产品属性决定了axicabtagene ciloleucel在大b细胞淋巴瘤中的结局 Locke, Frederick L.; Rossi, John M.; Neelapu, Sattva S.; Jacobson, Caron A.; Miklos, David B.; Ghobadi, Armin; Oluwole, Olalekan O.; Reagan, Patrick M.; Lekakis, Lazaros J.; Lin, Yi; Sherman, Marika; Better, Marc; Go, William Y.; Wiezorek, Jeffrey S.; Xue, Allen; Bot, Adrian 分享 收藏
A Phase I, Open-label, Dose-escalation, and Cohort Expansion Study to Evaluate the Safety and Immune Response to Autologous Dendritic Cells Transduced With AdGMCA9 (DC-AdGMCAIX) in Patients With Metastatic Renal Cell Carcinoma Faiena, Izak; Comin-Anduix, Begona; Berent-Maoz, Beata; Bot, Adrian; Zomorodian, Nazy; Sachdeva, Ankush; Said, Jonathan; Cheung-Lau, Gardenia; Pang, Jia; Macabali, Mignonette; Chodon, Thinle; Wang, Xiaoyan; Cabrera, Paula; Kaplan-Lefko, Paula; Chamie, Karim; Belldegrun, Arie S.; Pantuck, Allan J.; Drakaki, Alexandra 分享 收藏
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Activation of CAR and non-CAR T cells within the tumor microenvironment following CAR T cell therapy Chen, Pei-Hsuan; Lipschitz, Mikel; Weirather, Jason L.; Jacobson, Caron; Armand, Philippe; Wright, Kyle; Hodi, F. Stephen; Roberts, Zachary J.; Sievers, Stuart A.; Rossi, John; Bot, Adrian; Go, William; Rodig, Scott J. 分享 收藏
Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma (vol 26, pg 270, 2020) Brudno, Jennifer N.; Lam, Norris; Vanasse, Danielle; Shen, Yueh-wei; Rose, Jeremy J.; Rossi, John; Xue, Allen; Bot, Adrian; Scholler, Nathalie; Mikkilineni, Lekha; Roschewski, Mark; Dean, Robert; Cachau, Raul; Youkharibache, Philippe; Patel, Rashmika; Hansen, Brenna; Stroncek, David F.; Rosenberg, Steven A.; Gress, Ronald E.; Kochenderfer, James N. 分享 收藏
Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma 在b细胞淋巴瘤患者中anti-CD19具有完全人结合结构域的CAR T细胞的安全性和可行性 Brudno, Jennifer N.; Lam, Norris; Vanasse, Danielle; Shen, Yueh-wei; Rose, Jeremy J.; Rossi, John; Xue, Allen; Bot, Adrian; Scholler, Nathalie; Mikkilineni, Lekha; Roschewski, Mark; Dean, Robert; Cachau, Raul; Youkharibache, Philippe; Patel, Rashmika; Hansen, Brenna; Stroncek, David F.; Rosenberg, Steven A.; Gress, Ronald E.; Kochenderfer, James N. 分享 收藏
Pretreatment immunoscore and an inflamed tumor microenvironment (TME) are associated with efficacy in patients (Pts) with refractory large B cell lymphoma treated with axicabtagene ciloleucel (Axi-Cel) in ZUMA-1 Rossi, John M.; Galon, Jerome; Chang, Edmund; Perbost, Regis; Scholler, Nathalie; Turcan, Sarah; Danan, Corinne; Locke, Frederick L.; Neelapu, Sattva S.; Miklos, David B.; Jacobson, Caron A.; Lekakis, Lazaros J.; Lin, Yi; Ghobadi, Armin; Milletti, Francesca; Go, William Y.; Bot, Adrian 分享 收藏
Characteristics of the pretreatment tumor microenvironment may influence clinical response in patients with refractory large B cell lymphoma treated with axicabtagene ciloleucel (axi-cel) in the pivotal ZUMA-1 Rossi, John M.; Galon, Jerome; Turcan, Sarah; Danan, Corinne; Locke, Frederick L.; Neelapu, Sattva S.; Miklos, David B.; Jacobson, Caron A.; Lekakis, Lazaros J.; Lin, Yi; Ghobadi, Armin; Go, William Y.; Bot, Adrian 分享 收藏
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