John E. Janik - Publications, H-index & Citations

John E. Janik

incyte

50H指数

211论文数

1.1W被引数

收录论文 29

发表时间

First-in-human phase I open-label study of the anti-TIM-3 monoclonal antibody INCAGN02390 in patients with select advanced or metastatic solid tumors INCAGN02390抗-TIM-3单克隆抗体在选择性晚期或转移性实体瘤患者中的首次人体I期开放标签研究

ONCOLOGIST

IF4.2

2025-07-01

PREAI

Gutierrez, Martin E.; Tang, Shou-Ching; Powderly, John D.; Balmanoukian, Ani S.; Hoyle, Paul E.; Dong, Zhiwan; Cheng, Lulu; Gong, Xiaohua; Janik, John E.; Bourayou, Nawel; Hamid, Omid

First-in-human phase I open-label study of the LAG-3 antagonist antibody INCAGN02385 in patients with select advanced or metastatic solid tumors 首次人体I期开放标签研究：LAG-3拮抗剂抗体INCAGN02385在特定晚期或转移性实体瘤患者中的应用

ONCOLOGIST

IF4.2

2025-07-01

PREAI

Powderly II, John D.; Gutierrez, Martin E.; Balmanoukian, Ani S.; Hoyle, Paul E.; Dong, Zhiwan; Cheng, Lulu; Chen, Xuejun; Janik, John E.; Bourayou, Nawel; Hamid, Omid

First-in-human phase I study of INCAGN02390, a TIM-3 monoclonal antibody antagonist in patients with advanced malignancies

ANNALS OF ONCOLOGY

IF65.4

2022-09-01

OAAI

Gutierrez, M. E.; Tang, S-C.; Powderly, J. D.; Balmanoukian, A. S.; Janik, J.; Hoyle, P.; Wei, W.; Gong, X.; Hamid, O.

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance (vol 20, pg 1231, 2019)

NATURE IMMUNOLOGY

IF27.6

2019-09-24

OAAI

Verma, Vivek; Shrimali, Rajeev K.; Ahmad, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandre, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L.; Flaherty, Keith T.; Wargo, Jennifer A.; Boland, Genevieve M.; Sullivan, Ryan J.; Getz, Gad; Hammond, Scott A.; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E.; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N.

PD-1 blockade in subprimed CD8 cells induces dysfunctional PD-1+CD38hi cells and anti-PD-1 resistance

NATURE IMMUNOLOGY

IF27.6

2019-07-29

239

OAAI

Verma, Vivek; Shrimalim, Rajeev K.; Ahmadm, Shamim; Dai, Winjie; Wang, Hua; Lu, Sumin; Nandrelm, Rahul; Gaur, Pankaj; Lopez, Jose; Sade-Feldman, Moshe; Yizhak, Keren; Bjorgaard, Stacey L.; Flaherty, Keith T.; Wargo, Jennifer A.; Boland, Genevieve M.; Sullivan, Ryan J.; Getz, Gad; Hammond, Scott A.; Tan, Ming; Qi, Jingjing; Wong, Phillip; Merghoub, Taha; Wolchok, Jedd; Hacohen, Nir; Janik, John E.; Mkrtichyan, Mikayel; Gupta, Seema; Khleif, Samir N.

MAP kinase inhibition induces metabolic reprogramming in T-cells leading to induction of stem cell memory CD8 cells that enhance potency of adoptive cell therapy and anti-OX40 antibody

CANCER RESEARCH

IF16.6

2018-07-01

PREAI

Verma, Vivek; Ahmad, Shamim; Zeng, Peng; Mkrtichyan, Mikayel; Barry, Simon T.; Smith, Paul D.; Rodriguez, Paulo C.; Janik, John E.; Gupta, Seema; Khleif, Samir N.

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

JOURNAL FOR IMMUNOTHERAPY OF CANCER

IF10.6

2018-06-20

118

OAAI

Nayak-Kapoor, Asha; Hao, Zhonglin; Sadek, Ramses; Dobbins, Robin; Marshall, Lisa; Vahanian, Nicholas N.; Ramsey, W. Jay; Kennedy, Eugene; Mautino, Mario R.; Link, Charles J.; Lin, Ray S.; Royer-Joo, Stephanie; Liang, Xiaorong; Salphati, Laurent; Morrissey, Kari M.; Mahrus, Sami; McCall, Bruce; Pirzkall, Andrea; Munn, David H.; Janik, John E.; Khleif, Samir N.

Enhanced Therapeutic Efficacy and Memory of Tumor-Specific CD8 T Cells by Ex Vivo PI3K-δ Inhibition

CANCER RESEARCH

IF16.6

2017-08-01

OAAI

Abu Eid, Rasha; Ahmad, Shamim; Lin, Yuan; Webb, Mason; Berrong, Zuzana; Shrimali, Rajeev; Kumai, Takumi; Ananth, Sudha; Rodriguez, Paulo C.; Celis, Esteban; Janik, John; Mkrtichyan, Mikayel; Khleif, Samir N.

90Y-daclizumab, an anti-CD25 monoclonal antibody, provided responses in 50% of patients with relapsed Hodgkin's lymphoma anti-CD25单克隆抗体90Y-daclizumab在50% 例复发性霍奇金淋巴瘤患者中提供了反应

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2015-10-05

OAAI

Janik, John E.; Morris, John C.; O'Mahony, Deirdre; Pittaluga, Stefania; Jaffe, Elaine S.; Redon, Christophe E.; Bonner, William M.; Brechbiel, Martin W.; Paik, Chang H.; Whatley, Millie; Chen, Clara; Lee, Jae-Ho; Fleisher, Thomas A.; Brown, Maggie; White, Jeffrey D.; Stewart, Donn M.; Fioravanti, Suzanne; Lee, Cathryn C.; Goldman, Carolyn K.; Bryant, Bonita R.; Junghans, Richard P.; Carrasquillo, Jorge A.; Worthy, Tat'Yana; Corcoran, Erin; Conlon, Kevin C.; Waldmann, Thomas A.

Phase 1a study of the safety, pharmacokinetics, and pharmacodynamics of GDC-0919 in patients with recurrent/advanced solid tumors

EUROPEAN JOURNAL OF CANCER

IF7.1

2015-09-01

PREAI

Nayak, A.; Hao, Z.; Sadek, R.; Dobbins, R.; Marshall, L.; Vahanian, N.; Ramsey, J.; Kennedy, E.; Mautino, M.; Link, C.; Lin, R.; Royer-Joo, S.; Morrissey, K.; Mahrus, S.; McCall, B.; Pirzkall, A.; Munn, D.; Janik, J.; Khleif, S.

Akt1 and-2 inhibition diminishes terminal differentiation and enhances central memory CD8+ T-cell proliferation and survival Akt1和-2抑制减少终末分化并增强中央记忆CD8 T细胞增殖和存活

ONCOIMMUNOLOGY

IF6.3

2015-02-03

OAAI

Abu Eid, Rasha; Friedman, Kevin M.; Mkrtichyan, Mikayel; Walens, Andrea; King, William; Janik, John; Khleif, Samir N.

Radiation Therapy for Management of Patients with HTLV-1-associated Adult T-cell Leukemia/Lymphoma

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

IF6.5

2011-10-01

PREAI

Simone, C. B.; Stewart, D. M.; Lita, E.; Kreitman, R. J.; Conlon, K.; Janik, J. E.; Morris, J. C.; Kaushal, A.

Impacting tumor cell-fate by targeting the inhibitor of apoptosis protein survivin

MOLECULAR CANCER

IF33.9

2011-04-06

148

OAAI

Kelly, Ronan J.; Lopez-Chavez, Ariel; Citrin, Deborah; Janik, John E.; Morris, John C.

Mycosis fungoides and Sezary syndrome

LANCET

IF88.5

2008-03-01

215

PREAI

Hwang, Sam T.; Janik, John E.; Jaffe, Elaine S.; Wilson, Wyndham H.

Induction of the IL-9 gene by HTLV-I tax stimulates the spontaneous proliferation of primary ATL cells by a paracrine mechanism

CYTOKINE

IF3.7

2007-07-01

PREAI

Chen, Jing; Petrus, Mike; Bryant, Bonita; Nguyen, Vinh Phue; Starner, Mindy; Goldman, Carolyn; Bamford, Richard; Morris, John C.; Janik, John E.; Waldmarm, Thomas A.

Effective therapy of murine models of human leukemia and lymphoma with radiolabeled anti-CD30 antibody, HeFi-1

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2007-05-15

OAAI

Zhang, Meili; Yao, Zhengsheng; Patel, Hiral; Garmestani, Kayhan; Zhang, Zhuo; Talanov, Vladimir S.; Plascjak, Paul S.; Goldman, Carolyn K.; Janik, John E.; Brechbiel, Martin W.; Waldmann, Thomas A.

Comment on Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade

JOURNAL OF IMMUNOLOGY

IF3.4

2006-05-01

OAAI

O'Mahony, Deirdre; Janik, John E.

Preclinical and phase I clinical trial of blockade of IL-15 using Mikβ1 monoclonal antibody in T cell large granular lymphocyte leukemia Mikβ1单克隆抗体阻断T细胞大颗粒淋巴细胞白血病IL-15的临床前及 ⅰ 期临床试验

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2005-12-30

OAAI

Morris, JC; Janik, JE; White, JD; Fleisher, TA; Brown, M; Tsudo, M; Goldman, CK; Bryant, B; Petrus, M; Top, L; Lee, CC; Gao, W; Waldmann, TA