未登录 Discovery of ORIC-533, an Orally Bioavailable CD73 Inhibitor That Maintains Activity in High AMP Environments to Reverse Tumor Immunosuppression Moore, Jared T.; Kawai, Hiroyuki; Blank, Brian R.; Wu, Kejia; Yeh, Chien-Hung; Zhu, Liusheng; Pham, Johnny D.; Rew, Yosup; Eksterowicz, John; Salaniwal, Sumeet; Sutimantanapi, Dena; Warne, Robert; Yuen, Natalie; Metzger, Todd C.; Chan, Brenda; Huang, Tom; Chen, Xi; Chen, Yuping; Duong, Frank; Kong, Wayne; Chang, Jae H.; Sun, Jessica D.; Zavorotinskaya, Tatiana; Ye, Quiping; Al-Sayah, Mohammad A.; Jackson, Erica; Junttila, Melissa R.; Fantin, Valeria R.; Ndubaku, Chudi O.; Sun, Daqing; Du, Xiaohui; Friedman, Lori S. 分享 收藏
ORIC-114, a highly selective, brain penetrant EGFR and HER2 inhibitor, demonstrates best-in-class properties against Exon 20 insertions and other atypical EGFR mutations Junttila, M.; Repellin, C. E.; Warne, R.; Long, J. E.; Sambucetti, L.; Ashley, P.; Andreatta, G.; Baik, J.; Salaniwal, S.; Colas, C.; Romero, A.; Soroceanu, L.; Patel, R.; Maneval, E. Chow; Multani, P. S.; Daemen, A.; Friedman, L. 分享 收藏
A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death 新型小分子CD73抑制剂引发免疫介导的多发性骨髓瘤细胞死亡 Ray, Arghya; Du, Ting; Wan, Xueping; Song, Yan; Pillai, Sindhu C.; Musa, Md. Abu; Fang, Teng; Moore, Jared; Blank, Brian; Du, Xiaohui; Chen, Xi; Warne, Robert; Sutimantanapi, Dena; Lui, Fang; Zavorotinskaya, Tatiana; Colas, Christophe; Friedman, Lori; Junttila, Melissa R.; Chauhan, Dharminder; Anderson, Kenneth C. 分享 收藏
Discovery of ORIC-944, a novel inhibitor of PRC2 with best-in-class properties for the treatment of prostate cancer Marx, Matthew A.; Burns, Aaron C.; Arora, Nidhi; Bobinski, Thomas P.; Briere, David M.; Calinisan, Andrew; Gunn, Robin J.; Ketcham, John M.; Lawson, David; Lee, Matthew; Olson, Peter; Smith, Christopher R.; Sudhakar, Niranjan; Christensen, James G.; Chen, Chelsea X.; Yuen, Natalie; Ulicna, Livia; Duong, Frank; Colas, Christophe; Ramnath, Anjana; Xu, Ron; Maneval, Edna Chow; Multani, Pratik S.; Patel, Rupal; Kumar, Archana; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S. 分享 收藏
ORIC-944, a potent and selective allosteric PRC2 inhibitor with best-in-class properties, demonstrates combination synergy with AR pathway inhibitors in prostate cancer models Daemen, Anneleen; Yuen, Natalie; Wang, Amber; Pankov, Aleksandr; Ulicna, Livia; Chen, Chelsea; Duong, Frank L.; Long, Jason; Marx, Matthew A.; Christensen, James G.; Friedman, Lori S.; Junttila, Melissa R. 分享 收藏
ORIC-613, a potential first- and best-in-class, orally bioavailable, potent and selective PLK4 inhibitor with synthetic lethality in TRIM37 high cancer models Edgar, Kyle A.; McRee, Siobhan; Andretta, Gina; Chen, Chelsea; Colas, Christophe; Fang, Wei; Kong, Wayne; Long, Jason; Liu, Fang; Moore, Jared; Pankov, Aleskandr; Shore, Dan; Tan, Joanne; Warne, Robert; Ulicna, Livia; Vekariya, Rakesh; Daemen, Anneleen; Romero, F.; Junttila, Melissa R.; Friedman, Lori S. 分享 收藏
Preclinical activity of ORIC-114, a highly selective, brain penetrant, irreversible kinase inhibitor, against atypical mutations in EGFR Junttila, M. R.; Warne, R.; Repellin, C.; Sambucetti, L.; Chang, J.; Kim, S.; Kim, H. Y.; Shin, D. G.; Park, D. H.; Patel, R.; Maneval, E. Chow; Multani, P. S.; Daemen, A.; Friedman, L. 分享 收藏
Selective PLK4 inhibition demonstrates synthetic lethality in TRIM37 amplified neuroblastoma and breast cancer models while less selective inhibitors do not Mcree, Siobhan K.; Chen, Chelsea; Colas, Christophe; Fang, Wie; Kong, Wayne; Liu, Fang; Long, Jason; Moore, Jared; Pankov, Alex; Shore, Dan; Tan, Joanne; Warne, Robert; Vekariya, Rakesh; Young, Amy; Daemen, Anneleen; Romero, Anthony; Junttila, Melissa R.; Friedman, Lori S.; Edgar, Kyle A. 分享 收藏
Biomarker strategy for a phase 1 study of ORIC-944, a potent and selective allosteric PRC2 inhibitor, in patients with metastatic prostate cancer Daemen, Anneleen; Yuen, Natalie; Pankov, Aleksandr; Ariazi, Eric A.; Katewa, Subhash D.; Duong, Frank L.; Wang, Amber; Barkund, Shravani; Kaushik, Shelly; Sun, Jessica D.; Friedman, Lori S.; Junttila, Melissa R. 分享 收藏
Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα Hanan, Emily J.; Braun, Marie-Gabrielle; Heald, Robert A.; MacLeod, Calum; Chan, Connie; Clausen, Saundra; Edgar, Kyle A.; Eigenbrot, Charles; Elliott, Richard; Endres, Nicholas; Friedman, Lori S.; Gogol, Emily; Gu, Xiao-Hui; Thibodeau, Rebecca Hong; Jackson, Philip S.; Kiefer, James R.; Knight, Jamie D.; Nannini, Michelle; Narukulla, Raman; Pace, Amanda; Pang, Jodie; Purkey, Hans E.; Salphati, Laurent; Sampath, Deepak; Schmidt, Stephen; Sideris, Steve; Song, Kyung; Sujatha-Bhaskar, Swathi; Ultsch, Mark; Wallweber, Heidi; Xin, Jianfeng; Yeap, SiewKuen; Young, Amy; Zhong, Yu; Staben, Steven T. 分享 收藏
The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2-) advanced/metastatic breast cancer Bardia, Aditya; Mayer, Ingrid; Winer, Eric; Linden, Hannah M.; Ma, Cynthia X.; Parker, Barbara A.; Bellet, Meritxell; Arteaga, Carlos L.; Cheeti, Sravanthi; Gates, Mary; Chang, Ching-Wei; Fredrickson, Jill; Spoerke, Jill M.; Moore, Heather M.; Giltnane, Jennifer; Friedman, Lori S.; Maneval, Edna Chow; Chan, Iris; Jhaveri, Komal 分享 收藏
ORIC-114, an orally bioavailable, irreversible kinase inhibitor, has superior brain penetrant properties and enhanced potency in preclinical studies of HER2-positive breast cancer Junttila, Melissa R.; Long, Jason E.; Warne, Robert; Kim, Sunghwan; Lee, Younho; Kim, Hwan; Kang, Juhee; Seok, Jiyoon; Yoo, Jihye; Lee, Youngyi; Seo, Dong-Hyuk Seo; Son, Jung Beom; Kim, Daekwon; Choi, Hwan Geun; Kim, Nam Doo; Zavorotinskaya, Tatiana; Chan, Chelsea; Panuwat, Matthew; Sun, Jessica; Chang, Jae H.; Friedman, Lori S. 分享 收藏
Biomarker results supporting selection of RP2D from a phase 1b study of ORIC-101, a glucocorticoid receptor antagonist, in combination with enzalutamide in patients with metastatic prostate cancer progressing on enzalutamide Daemen, Anneleen; Barkund, Shravani; Johnson, Ann; Pankov, Aleksandr; Wang, Amber W.; Zhou, Haiying; Multani, Pratik S.; Maneval, Edna Chow; Friedman, Lori S.; Patel, Rupal 分享 收藏
RTK-Dependent Inducible Degradation of Mutant PI3Kα Drives GDC-0077 (Inavolisib) Efficacy 突变体PI3Kα 的RTK依赖性诱导降解驱动GDC-0077 (Inavolisib) 功效 Song, Kyung W.; Edgar, Kyle A.; Hanan, Emily J.; Hafner, Marc; Oeh, Jason; Merchant, Mark; Sampath, Deepak; Nannini, Michelle A.; Hong, Rebecca; Phu, Lilian; Forrest, William F.; Stawiski, Eric; Schmidt, Stephen; Endres, Nicholas; Guan, Jane; Wallin, Jeffrey J.; Cheong, Jonathan; Plise, Emile G.; Phillips, Gail D. Lewis; Salphati, Laurent; Heffron, Timothy P.; Olivero, Alan G.; Malek, Shiva; Staben, Steven T.; Kirkpatrick, Donald S.; Dey, Anwesha; Friedman, Lori S. 分享 收藏
GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER plus Breast Cancer Liang, Jun; Zbieg, Jason R.; Blake, Robert A.; Chang, Jae H.; Daly, Stephen; DiPasquale, Antonio G.; Friedman, Lori S.; Gelzleichter, Thomas; Gill, Matthew; Giltnane, Jennifer M.; Goodacre, Simon; Guan, Jane; Hartman, Steven J.; Ingalla, Ellen Rei; Kategaya, Lorn; Kiefer, James R.; Kleinheinz, Tracy; Labadie, Sharada S.; Lai, Tommy; Li, Jun; Liao, Jiangpeng; Liu, Zhiguo; Mody, Vidhi; McLean, Neville; Metcalfe, Ciara; Nannini, Michelle A.; Oeh, Jason; O'Rourke, Martin G.; Ortwine, Daniel F.; Ran, Yingqing; Ray, Nicholas C.; Roussel, Fabien; Sambrone, Amy; Sampath, Deepak; Schutt, Leah K.; Vinogradova, Maia; Wai, John; Wang, Tao; Wertz, Ingrid E.; White, Jonathan R.; Yeap, Siew Kuen; Young, Amy; Zhang, Birong; Zheng, Xiaoping; Zhou, Wei; Zhong, Yu; Wang, Xiaojing 分享 收藏
Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production Du, Xiaohui; Moore, Jared; Blank, Brian R.; Eksterowicz, John; Sutimantanapi, Dena; Yuen, Natalie; Metzger, Todd; Chan, Brenda; Huang, Tom; Chen, Xi; Chen, Yuping; Duong, Frank; Kong, Wayne; Chang, Jae H.; Sun, Jessica; Zavorotinskaya, Tatiana; Ye, Qiuping; Junttila, Melissa R.; Ndubaku, Chudi; Friedman, Lori S.; Fantin, Valeria R.; Sun, Daqing 分享 收藏
CD73 inhibition with a novel orally bioavailable small molecule blocks adenosine production and rescues T-cells activation Zavorotinskaya, Tatiana; Blank, Brian; Chan, Brenda; Chen, Chelsea; Chen, Yuping; Du, Xiaohui; Duong, Frank; Friedman, Lori; Huang, Tom; Junttila, Melissa R.; Kong, Wayne; Metzger, Todd C.; Moore, Jared T.; Sun, Daqing; Sun, Jessica; Sutimantanapi, Dena; Yuen, Natalie 分享 收藏
Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors Vasan, Neil; Razavi, Pedram; Johnson, Jared L.; Shao, Hong; Shah, Hardik; Antoine, Alesia; Ladewig, Erik; Gorelick, Alexander; Lin, Ting-Yu; Toska, Eneda; Xu, Guotai; Kazmi, Abiha; Chang, Matthew T.; Taylor, Barry S.; Dickler, Maura N.; Jhaveri, Komal; Chandarlapaty, Sarat; Rabadan, Raul; Reznik, Ed; Smith, Melissa L.; Sebra, Robert; Schimmoller, Frauke; Wilson, Timothy R.; Friedman, Lori S.; Cantley, Lewis C.; Scaltriti, Maurizio; Baselga, Jose 分享 收藏
ORIC-101 overcomes resistance to diverse chemotherapeutics across cancer types Zhou, Haiying; Barkund, Shravani; Pankov, Aleksandr; Hegde, Ganapati; Kong, Wayne; Narayanan, Padmini; Sun, Jessica D.; Kabbarah, Omar; Friedman, Lori S.; Daemen, Anneleen 分享 收藏
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