Samuel R. Denmeade - Publications, H-index & Citations

Samuel R. Denmeade

Johns Hopkins School of Medicine

64H指数

560论文数

1.7W被引数

收录论文 100

发表时间

Long-term outcomes and treatment cessation in patients with long term response to first line treatment of metastatic prostate cancer 长期反应对转移性前列腺癌一线治疗患者的长期结局及治疗中止情况

Oncologist

IF4.2

2026-09-23

OAAI

Monica Meeks; Yasaman Iranmanesh; Hyunsoo Song; Amanda L Blackford; Arya Rasouli; Alex Baras; Samuel R Denmeade; Mark C Markowski; Channing J Paller; Michael A Carducci; Emmanuel S Antonarakis; Mario A Eisenberger; Catherine H Marshall

Castration Resistance Accelerates Prostate Cancer Kinetics 去势抵抗加速前列腺癌动力学

The Prostate

IF0

2026-04-08

OAAI

Sheila Jonnatan; Luka Cavka; Angelo M. De Marzo; Samuel R. Denmeade; Mark C. Markowski; Emmanuel S. Antonarakis; Bruce J. Trock; Catherine H. Marshall; Ravi A. Madan; David J. Einstein; Laura A. Sena

WOMBAT (ANZUP 2201): A Phase 2, Single-arm Study of Bipolar Androgen Therapy in Patients with Nonmetastatic Castration-resistant Prostate Cancer with Prostate-specific Antigen Progression on Darolutamide WOMBAT (ANZUP 2201)：一项关于双极雄激素疗法在达罗他胺治疗期间前列腺特异性抗原进展的非转移性去势抵抗性前列腺癌患者中的单臂Ⅱ期研究

European Urology Oncology

IF9.3

2026-02-21

PREAI

Barak Talmor; Carole A. Harris; Christopher Gianacas; David Pook; Thean Hsiang Tan; Ian D. Davis; Laurence Krieger; Gavin Marx; Arsha Anton; Sharad Sharma; Jeffrey C. Goh; Kay Xu; Ganes Pranavan; Haryani M. Dhillon; Emmanuel S. Antonarakis; Samuel R. Denmeade; Lisa Horvath; Samantha R. Oakes; Ray Allen; Antoinette Fontela

Bipolar androgen therapy as platform for personalized medicine in castration-resistant prostate cancer

Discover Oncology

IF2.9

2026-01-17

OAAI

Wolfgang Lilleby; Hans Geinitz; Samuel Denmeade

Muscadine Grape Skin Extract in Biochemically Recurrent Prostate Cancer: A Randomized, Placebo-Controlled, Biomarker-Enriched Trial in Patients With the SOD2 Ala/Ala Variant 蛇皮葡萄提取物在生物化学复发性前列腺癌中的应用：一项针对携带SOD2 Ala/Ala变异患者的随机、安慰剂对照、生物标志物富集试验

PROSTATE

IF2.5

2025-05-05

PREAI

Mandl, A.; Zahurak, M. L.; Metri, N. A.; Shore, N. D.; Mao, S.; McKay, R. R.; Taplin, M. E.; Szmulewitz, R. Z.; Maughan, B. L.; Reichert, Z. R.; Kessler, E. R.; Heath, E. I.; Dreicer, R.; Stein, C. A.; Milne, G. L.; Sfanos, K. S.; Ernst, S. E.; Mummert, L. A.; Cruz-Lebron, A.; Michel, S. L. J.; Kane, M. A.; Hursey, M.; Worth, M. A.; Wagner, W. D.; Eshleman, J. R.; Debeljak, M.; Xu, L.; Cao, H.; Dowling, D.; Marshall, C. H.; Markowski, M. C.; Denmeade, S. R.; Eisenberger, M. A.; Antonarakis, E. S.; Carducci, M. A.; Paller, C. J.

Inferred clonal hematopoiesis from tumor DNA sequencing among men with prostate cancer: correlation with somatic tumor alterations and outcomes 从前列腺癌患者肿瘤DNA测序中推断出的克隆性造血：与肿瘤体细胞改变及预后的相关性

ONCOLOGIST

IF4.2

2025-04-22

OAAI

Iranmanesh, Yasaman; Omar, Noha; Rasouli, Arya; Baras, Alex; Pasca, Sergiu; Gondek, Lukasz P.; Tsai, Hua-Ling; Denmeade, Samuel R.; Carducci, Michael A.; Paller, Channing J.; Markowski, Mark C.; Luo, Jun; Eisenberger, Mario A.; Antonarakis, Emmanuel S.

CRM1 regulates androgen receptor stability and impacts DNA repair pathways in prostate cancer, independent of the androgen receptor CRM1调节雄激素受体稳定性并影响前列腺癌中的DNA修复途径，独立于雄激素受体

FASEB JOURNAL

IF4.2

2025-01-28

OAAI

Kumar, Rajendra; Mendonca, Janet; Shetty, Abhishek; Yang, Yuhan; Owoyemi, Olutosin; Wilson, Lillian; Boyapati, Kavya; Topiwala, Deven; Thomas, Naiju; Nguyen, Huong; Luo, Jun; Paller, Channing J.; Denmeade, Samuel R.; Carducci, Michael A.; Kachhap, Sushant K.

Baseline serum testosterone and differential efficacy of bipolar androgen therapy and enzalutamide in the randomized TRANSFORMER trial

PROSTATE CANCER AND PROSTATIC DISEASES

IF5.8

2024-05-07

PREAI

Kanayama, Mayuko; Tsai, Hua-Ling; Wang, Hao; Antonarakis, Emmanuel S.; Denmeade, Samuel R.; Luo, Jun

CTP synthase 1 is a synthetic vulnerability in prostate cancer treated with supraphysiological androgen

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Jonnatan, Sheila; Kumar, Rajendra; Vakkala, Varsha; Vasan, Karthik; Chalmers, Zachary R.; Schmidt, Daniel R.; Beer, Philip A.; Vander Heiden, Matthew G.; Denmeade, Samuel R.; Chandel, Navdeep S.; Sena, Laura A.

LSD1 inhibition transcriptionally reprograms neuroendocrine prostate cancer exposing unique therapeutic vulnerabilities

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Jasmine, Sumer M.; Mandl, Adel; Dalrymple, Susan L.; Kim, Sunghyun; Dias, Jennifer; Kleppe, Maria; Celatka, Cassandra; Tapper, Amy; Coleman, Ilsa; Nelson, Peter; Rienhoff, Hugh; Denmeade, Samuel R.; Brennen, W. Nathaniel

A Phase 1/2 multicenter trial of DKN-01 as monotherapy or in combination with docetaxel for the treatment of metastatic castration-resistant prostate cancer (mCRPC)

PROSTATE CANCER AND PROSTATIC DISEASES

IF5.8

2024-02-10

OAAI

Wise, David R.; Pachynski, Russell K.; Denmeade, Samuel R.; Aggarwal, Rahul R.; Deng, Jiehui; Febles, Victor Adorno; Balar, Arjun V.; Economides, Minas P.; Loomis, Cynthia; Selvaraj, Shanmugapriya; Haas, Michael; Kagey, Michael H.; Newman, Walter; Baum, Jason; Troxel, Andrea B.; Griglun, Sarah; Leis, Dayna; Yang, Nina; Aranchiy, Viktoriya; Machado, Sabrina; Waalkes, Erika; Gargano, Gabrielle; Soamchand, Nadia; Puranik, Amrutesh; Chattopadhyay, Pratip; Fedal, Ezeddin; Deng, Fang-Ming; Ren, Qinghu; Chiriboga, Luis; Melamed, Jonathan; Sirard, Cynthia A.; Wong, Kwok-Kin

Bipolar androgen therapy plus nivolumab for patients with metastatic castration-resistant prostate cancer: the COMBAT phase II trial

NATURE COMMUNICATIONS

IF15.7

2024-01-02

OAAI

Markowski, Mark C.; Taplin, Mary-Ellen; Aggarwal, Rahul; Sena, Laura A.; Wang, Hao; Qi, Hanfei; Lalji, Aliya; Sinibaldi, Victoria; Carducci, Michael A.; Paller, Channing J.; Marshall, Catherine H.; Eisenberger, Mario A.; Sanin, David E.; Yegnasubramanian, Srinivasan; Gomes-Alexandre, Carolina; Ozbek, Busra; Jones, Tracy; De Marzo, Angelo M.; Denmeade, Samuel R.; Antonarakis, Emmanuel S.

Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer

NATURE REVIEWS UROLOGY

IF14.6

2023-10-31

PREAI

Mori, Joakin O.; Elhussin, Isra; Brennen, W. Nathaniel; Graham, Mindy K.; Lotan, Tamara L.; Yates, Clayton C.; De Marzo, Angelo M.; Denmeade, Samuel R.; Yegnasubramanian, Srinivasan; Nelson, William G.; Denis, Gerald V.; Platz, Elizabeth A.; Meeker, Alan K.; Heaphy, Christopher M.

Concurrent high-dose IV Vitamin C (IVC) and docetaxel for metastatic castrate-resistant prostate cancer (mCRPC): A randomized, placebo-controlled, double-blind phase II trial

ANNALS OF ONCOLOGY

IF65.4

2023-10-01

OAAI

Paller, C.; Zahurek, M.; Mandl, A.; Rudek, M.; Heath, E.; Marshall, C. H.; Markowski, M. C.; Lalji, A.; Metri, N.; Hoimes, C. J.; Taksey, J.; Durham, J.; Kelly, W.; Antonarakis, E. S.; Eisenberger, M.; Carducci, M. A.; Denmeade, S.; Levine, M.

Molecular pathology studies reveal PD1+CD8 T cell density correlates with response to supraphysiological testosterone treatment in pre-treatment biopsies and MYC mRNA and protein correlate with response after treatment

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Alexandre, Carolina Gomes; Hicks, Jessica; Jones, Tracy; Isaacs, John T.; Bowers, Kiara; Skist, Alyza; Sena, Laura; Meyers, Jennifer; Antonarakis, Emmanuel; Sanin, David; Qi, Hanfei; Denmeade, Samuel; Markowski, Mark; Yegnasubramanian, Srinivasan; De Marzo, Angelo

Neoadjuvant enoblituzumab in localized prostate cancer: a single-arm, phase 2 trial

NATURE MEDICINE

IF50

2023-04-03

PREAI

Shenderov, Eugene; De Marzo, Angelo M. M.; Lotan, Tamara L. L.; Wang, Hao; Chan, Sin; Lim, Su Jin; Ji, Hongkai; Allaf, Mohamad E. E.; Chapman, Carolyn; Moore, Paul A. A.; Chen, Francine; Sorg, Kristina; White, Andrew M. M.; Church, Sarah E. E.; Hudson, Briana; Fields, Paul A. A.; Hu, Shaohui; Denmeade, Samuel R. R.; Pienta, Kenneth J. J.; Pavlovich, Christian P. P.; Ross, Ashley E. E.; Drake, Charles G. G.; Pardoll, Drew M. M.; Antonarakis, Emmanuel S. S.

Updated analyses for RESTORE cohort C: A trial of bipolar androgen therapy for patients with newly castration-resistant prostate cancer

EUROPEAN JOURNAL OF CANCER

IF7.1

2023-03-01

OAAI

Sena, Laura A.; Wang, Tingchang; Wang, Hao; Markowski, Mark C.; Antonarakis, Emmanuel S.; Denmeade, Samuel R.

The testosterone paradox of advanced prostate cancer: mechanistic insights and clinical implications

NATURE REVIEWS UROLOGY

IF14.6

2022-12-21

OAAI

Kumar, Rajendra; Sena, Laura A.; Denmeade, Samuel R.; Kachhap, Sushant

Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2022-12-01

OAAI

Sena, Laura A.; Kumar, Rajendra; Sanin, David E.; Thompson, Elizabeth A.; Rosen, D. Marc; Dalrymple, Susan L.; Antony, Lizamma; Yang, Yuhan; Gomes-Alexandre, Carolina; Hicks, Jessica L.; Jones, Tracy; Bowers, Kiara A.; Eskra, Jillian N.; Meyers, Jennifer; Gupta, Anuj; Skaist, Alyza; Yegnasubramanian, Srinivasan; Luo, Jun; Brennen, W. Nathaniel; Kachhap, Sushant K.; Antonarakis, Emmanuel S.; De Marzo, Angelo M.; Isaacs, John T.; Markowski, Mark C.; Denmeade, Samuel R.

Clinical Efficacy of Bipolar Androgen Therapy in Men with Metastatic Castration-Resistant Prostate Cancer and Combined Tumor-Suppressor Loss

EUROPEAN UROLOGY OPEN SCIENCE

IF4.5

2022-07-01

OAAI

Markowski, Mark C.; Wang, Hao; De Marzo, Angelo M.; Schweizer, Michael T.; Antonarakis, Emmanuel S.; Denmeade, Samuel R.

研究方向