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PARG inhibitor sensitivity correlates with accumulation of single- stranded DNA gaps in preclinical models of ovarian cancer PARG抑制剂敏感性与卵巢癌临床前模型中单链DNA缺口的积累相关 Ravindranathan, Ramya; Somuncu, Ozge; da Costa, Alexandre Andre B. A.; Mukkavalli, Sirisha; Lamarre, Benjamin P.; Nguyen, Huy; Grochala, Carter; Jiao, Yuqing; Liu, Joyce; Kochupurakkal, Bose; Parmar, Kalindi; Shapiro, Geoffrey I.; D'Andrea, Alan D. 分享 收藏
Ovarian Cancer/Fallopian Tube Cancer/Primary PeritonealCancer, Version 3.2024Featured Updates to the NCCN Guidelines 卵巢癌/输卵管癌/原发性腹膜癌，版本3.2024 NCCN指南重点更新 Liu, Joyce; Berchuck, Andrew; Backes, Floor J.; Cohen, Joshua; Grisham, Rachel; Leath, Charles A., III; Martin, Lainie; Matei, Daniela; Miller, David S.; Robertson, Sharon; Barroilhet, Lisa; Uppal, Shitanshu; Hendrickson, Andrea Wahner; Gershenson, David M.; Gray, Heidi J.; Hakam, Ardeshir; Jain, Angela; Konecny, Gottfried E.; Moroney, John; Ratner, Elena; Schorge, John; Thaker, Premal H.; Werner, Theresa L.; Zsiros, Emese; Behbakht, Kian; Chen, Lee-May; Derosa, Marie; Eisenhauer, Eric L.; Leiserowitz, Gary; Litkouhi, Babak; Mchale, Michael; Percac-Lima, Sanja; Rodabaugh, Kerry; Vargas, Roberto; Jones, Frankie; Kovach, Emily; Hang, Lisa; Ramakrishnan, Swathi; Alvarez, Ronald D.; Armstrong, Deborah K. 分享 收藏
The USP1 Inhibitor KSQ-4279 Overcomes PARP Inhibitor Resistance in Homologous Recombination-Deficient Tumors Cadzow, Louise; Brenneman, Jehrod; Tobin, Erica; Sullivan, Pamela; Nayak, Sumeet; Ali, Janid A.; Shenker, Sol; Griffith, Jim; McGuire, Michael; Grasberger, Paula; Mishina, Yuji; Murray, Morgan; Dodson, Anne E.; Gannon, Hugh; Krall, Elsa; Hixon, Jeff; Chipumuro, Edmond; Sinkevicius, Kerstin; Gokhale, Prafulla C.; Ganapathy, Suthakar; Matulonis, Ursula A.; Liu, Joyce F.; Olaharski, Andrew; Sangurdekar, Dipen; Liu, Hanlan; Wilt, Jeremy; Schlabach, Michael; Stegmeier, Frank; Wylie, Andrew A. 分享 收藏
Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity da Costa, Alexandre A.; Somuncu, Ozge; Ravindranathan, Ramya; Mukkavalli, Sirisha; Martignetti, David B.; Nguyen, Huy; Jiao, Yuqing; Lamarre, Benjamin P.; Sadatrezaei, Golbahar; Moreau, Lisa; Liu, Joyce; Iyer, Divya R.; Lazaro, Jean-Bernard; Shapiro, Geoffrey I.; Parmar, Kalindi; D'Andrea, Alan D. 分享 收藏
Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors Chen, Jian Jenny; Vincent, Melanie Y.; Shepard, Dale; Peereboom, David; Mahalingam, Devalingam; Battiste, James; Patel, Manish R.; Juric, Dejan; Wen, Patrick Y.; Bullock, Andrea; Selfridge, Jennifer Eva; Pant, Shubham; Liu, Joyce; Li, Wendy; Fyfe, Susanne; Wang, Suming; Zota, Victor; Mahoney, James; Watnick, Randolph S.; Cieslewicz, Michael; Watnick, Jing 分享 收藏
A phase 2, two-stage study of mirvetuximab soravtansine (IMGN853) in combination with pembrolizumab in patients with microsatellite stable (MSS) recurrent or persistent endometrial cancer Porter, Rebecca L.; Xiong, Niya; Tayob, Nabihah; Polak, Madeline; Sawyer, Hannah; Hayes, Martin; Gardner, Jeanette; Campos, Susana; Horowitz, Neil; Krasner, Carolyn; Lee, Elizabeth K.; Liu, Joyce F.; Stover, Elizabeth H.; Veneris, Jennifer; Wright, Alexi A.; Matulonis, Ursula A.; Konstantinopoulos, Panagiotis 分享 收藏
PARG inhibitor sensitivity is correlated with accumulation of single strand DNA gaps in preclinical models of ovarian cancer Ravindranathan, Ramya; Somuncu, Ozge; Jiao, Yuqing; da Costa, Alexandre Andre B. A.; Lamarre, Benjamin P.; Martignetti, David B.; Zambrano, Gabriella A.; Mukkavalli, Sirisha; Liu, Joyce; Kochupurakkal, Bose; Lazaro, Jean-Bernard; Parmar, Kalindi; Shapiro, Geoffrey I.; D'Andrea, Alan D. 分享 收藏
Co-clinical endometrial cancer (EC) patient-derived organoids (PDO) to assess functional effects of replication stress (RS)-targeting agents Ivanova, Elena; Saldanha, Aisha L.; Roychoudhury, Shrabasti; Kochupurakkal, Bose; Zlota, Ari P.; Padrick, Clare E.; Vo, Ha V.; Greenberg, Eli K.; Sawyer, Hannah; Feeney, Carina; Qi, Courtney H.; Narayan, Swati; Curtis, Jennifer D.; Tayob, Nabihah; Nucci, Marisa R.; Konstantinopoulos, Panagiotis; Chowdhury, Dipanjan; Shapiro, Geoffrey; Paweletz, Cloud P.; Matulonis, Ursula A.; Liu, Joyce F. 分享 收藏
Single strand DNA GAP accumulation as a functional biomarker for USP1 inhibitor sensitivity in ovarian cancer patient-derived organoid models Da Costa, Alexandre Andre B. A.; Somuncu, Ozge; Ravindranathan, Ramya; Mukkavalli, Sirisha; Martigneti, David; Huy Nguyen; Jiao, Yuqing; Lamarre, Benjamin; Sadatrezai, Golbahar; Moreau, Lisa; Liu, Joyce; Iyer, Divya; Lazaro, Jean-Bernard; Shapiro, Geoffrey; Parmar, Kalindi; D'Andrea, Alan D. 分享 收藏
Detection and dynamic monitoring of clonal hematopoiesis mutations in women receiving systemic therapies for high grade serous ovarian carcinoma Porter, Rebecca L.; Qi, Courtney H.; Feeney, Carina; Narayan, Swati; Tayob, Nabihah; Curtis, Jennifer; Campos, Susana; Horowitz, Neil; Krasner, Carolyn; Lee, Elizabeth; Stover, Elizabeth; Wright, Alexi; Weeks, Lachelle; Gibson, Christopher; Liu, Joyce; Konstantinopoulos, Panagiotis; Lindsley, Robert C.; Matulonis, Ursula 分享 收藏
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An implantable microdevice to interrogate responses to therapy in ovarian cancer Stover, Elizabeth H.; Tatarova, Zuzana; Bhagavatula, Sharath K.; Dominas, Christine; Polak, Madeline; Rabbitt, Alexis; Gardner, Jeanette; MacNeill, Kim; Azzolini, Natalie; Ahn, Sebastian; Worley, Michael J., Jr.; Elias, Kevin M.; Kolin, David L.; Liu, Joyce F.; Matulonis, Ursula A.; Silverman, Stuart G.; Horowitz, Neil S.; Jonas, Oliver 分享 收藏
USP1 inhibition induces single strand DNA gap accumulation and overcomes PARP inhibitor resistance in BRCA1 deficient cancer cells da Costa, Alexandre A. B. A.; Somuncu, Ozge; Ravindranathan, Ramya; Mukkavalli, Sirisha; Martignetti, David B.; Nguyen, Huy; Jiao, Yuqing; Lamarre, Benjamin; Moreau, Lisa; Liu, Joyce; Iyer, Divya; Lazaro, Jean-Bernard; Shapiro, Geoffrey I.; Parmar, Kalindi; D'Andrea, Alan D. 分享 收藏
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Individualizing treatment using patient derived organoids, BH3 profiling and microfluidics: A proof of concept in a patient with low-grade serous ovarian carcinoma Meisenheimer, Brittany; Vo, Ha V.; McQueeney, Kelley E.; Saldanha, Aisha L.; Feeney, Carina; Qi, Courtney H.; Narayan, Swati; Curtis, Jennifer D.; Nucci, Marisa R.; Letai, Anthony; Paweletz, Cloud P.; Liu, Joyce F.; Matulonis, Ursula A.; Ivanova, Elena 分享 收藏
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