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A rare human variant that disrupts GPR10 signalling causes weight gain in mice Talbot, Fleur; Feetham, Claire H.; Mokrosinski, Jacek; Lawler, Katherine; Keogh, Julia M.; Henning, Elana; de Oliveira, Edson Mendes; Ayinampudi, Vikram; Saeed, Sadia; Bonnefond, Amelie; Arslan, Mohammed; Yeo, Giles S. H.; Froguel, Philippe; Bechtold, David A.; Adamson, Antony; Humphreys, Neil; Barroso, Ines; Luckman, Simon M.; Farooqi, I. Sadaf 分享 收藏
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior He, Yang; Brouwers, Bas; Liu, Hesong; Liu, Hailan; Lawler, Katherine; Mendes de Oliveira, Edson; Lee, Dong-Kee; Yang, Yongjie; Cox, Aaron R.; Keogh, Julia M.; Henning, Elana; Bounds, Rebecca; Perdikari, Aliki; Ayinampudi, Vikram; Wang, Chunmei; Yu, Meng; Tu, Longlong; Zhang, Nan; Yin, Na; Han, Junying; Scarcelli, Nikolas A.; Yan, Zili; Conde, Kristine M.; Potts, Camille; Bean, Jonathan C.; Wang, Mengjie; Hartig, Sean M.; Liao, Lan; Xu, Jianming; Barroso, Ines; Mokrosinski, Jacek; Xu, Yong; Farooqi, I. Sadaf 分享 收藏
Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities 类固醇受体辅激活因子-1缺乏引起的肥胖与内分泌和代谢异常有关 Cacciottolo, Tessa M.; Henning, Elana; Keogh, Julia M.; Lassen, Pierre Bel; Lawler, Katherine; Bounds, Rebecca; Ahmed, Rachel; Perdikari, Aliki; de Oliveira, Edson Mendes; Smith, Miriam; Godfrey, Edmund M.; Johnson, Elspeth; Hodson, Leanne; Clement, Karine; van der Klaauw, Agatha A.; Farooqi, I. Sadaf 分享 收藏
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Obesity-Associated GNAS Mutations and the Melanocortin Pathway de Oliveira, Edson Mendes; Keogh, Julia M.; Talbot, Fleur; Henning, Elana; Ahmed, Rachel; Perdikari, Aliki; Bounds, Rebecca; Wasiluk, Natalia; Ayinampudi, Vikram; Barroso, Ines; Mokrosinski, Jacek; Jyothish, Deepthi; Lim, Sharon; Gupta, Sanjay; Kershaw, Melanie; Matei, Cristina; Partha, Praveen; Randell, Tabitha; McAulay, Antoinette; Wilson, Louise C.; Cheetham, Tim; Crowne, Elizabeth C.; Clayton, Peter; Farooqi, I. Sadaf 分享 收藏
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation Brouwers, Bas; de Oliveira, Edson Mendes; Marti-Solano, Maria; Monteiro, Fabiola B. F.; Laurin, Suli-Anne; Keogh, Julia M.; Henning, Elana; Bounds, Rebecca; Daly, Carole A.; Houston, Shane; Ayinampudi, Vikram; Wasiluk, Natalia; Clarke, David; Plouffe, Bianca; Bouvier, Michel; Babu, M. Madan; Farooqi, I. Sadaf; Mokrosinski, Jacek 分享 收藏
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities Sonoyama, Takuhiro; Stadler, Lukas K. J.; Zhu, Mingyan; Keogh, Julia M.; Henning, Elana; Hisama, Fuki; Kirwan, Peter; Jura, Magdalena; Blaszczyk, Beata K.; DeWitt, David C.; Brouwers, Bas; Hyvonen, Marko; Barroso, Ines; Merkle, Florian T.; Appleyard, Suzanne M.; Wayman, Gary A.; Farooqi, I. Sadaf 分享 收藏
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription Marenne, Gaelle; Hendricks, Audrey E.; Perdikari, Aliki; Bounds, Rebecca; Payne, Felicity; Keogh, Julia M.; Lelliott, Christopher J.; Henning, Elana; Pathan, Saad; Ashford, Sofie; Bochukova, Elena G.; Mistry, Vanisha; Daly, Allan; Hayward, Caroline; Wareham, Nicholas J.; O'Rahilly, Stephen; Langenberg, Claudia; Wheeler, Eleanor; Zeggini, Eleftheria; Farooqi, I. Sadaf; Barroso, Ines 分享 收藏
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Neural correlates of body composition in frontotemporal dementia Ahmed, R.; Landin-Romero, R.; Liang, C.; Keogh, J.; Henning, E.; Emma, D.; Hodges, J.; Kiernan, M.; Sadaf, F.; Piguet, O. 分享 收藏
Neural networks associated with body composition in frontotemporal dementia Ahmed, Rebekah M.; Landin-Romero, Ramon; Liang, Cheng T.; Keogh, Julia M.; Henning, Elana; Strikwerda-Brown, Cherie; Devenney, Emma M.; Hodges, John R.; Kiernan, Matthew C.; Farooqi, I. Sadaf; Piguet, Olivier 分享 收藏
Crucial Role of the SH2B1 PH Domain for the Control of Energy Balance Flores, Anabel; Argetsinger, Lawrence S.; Stadler, Lukas K. J.; Malaga, Alvaro E.; Vander, Paul B.; DeSantis, Lauren C.; Joe, Ray M.; Cline, Joel M.; Keogh, Julia M.; Henning, Elana; Barroso, Ines; de Oliveira, Edson Mendes; Chandrashekar, Gowri; Clutter, Erik S.; Hu, Yixin; Stuckey, Jeanne; Farooqi, I. Sadaf; Myers, Martin G., Jr.; Carter-Su, Christin 分享 收藏
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis Yang, Yongjie; van der Klaauw, Agatha A.; Zhu, Liangru; Cacciottolo, Tessa M.; He, Yanlin; Stadler, Lukas K. J.; Wang, Chunmei; Xu, Pingwen; Saito, Kenji; Hinton, Antentor; Yan, Xiaofeng; Keogh, Julia M.; Henning, Elana; Banton, Matthew C.; Hendricks, Audrey E.; Bochukova, Elena G.; Mistry, Vanisha; Lawler, Katherine L.; Liao, Lan; Xu, Jianming; O'Rahilly, Stephen; Tong, Qingchun; Barroso, Ines; O'Malley, Bert W.; Farooqi, I. Sadaf; Xu, Yong; Balasubramanian, Senduran; Clapham, Peter; Coates, Guy; Cox, Tony; Daly, Allan; Danecek, Petr; Du, Yuanping; Durbin, Richard; Edkins, Sarah; Ellis, Peter; Flicek, Paul; Guo, Xiaosen; Guo, Xueqin; Huang, Liren; Jackson, David K.; Joyce, Chris; Keane, Thomas; Kolb-Kokocinski, Anja; Langford, Cordelia; Li, Yingrui; Liang, Jieqin; Lin, Hong; Liu, Ryan; Maslen, John; McCarthy, Shane; Muddyman, Dawn; Quail, Michael A.; Stalker, Jim; Sun, Jianping; Tian, Jing; Wang, Guangbiao; Wang, Jun; Wang, Yu; Wong, Kim; Zhang, Pingbo; Birney, Ewan; Boustred, Chris; Brion, Marie-Jo; Chen, Lu; Clement, Gail; Danecek, Petr; Smith, George Davey; Day, Ian N. M.; Day-Williams, Aaron; Down, Thomas; Dunham, Ian; Durbin, Richard; Evans, David M.; Fatemifar, Ghazaleh; Gaunt, Tom R.; Geihs, Matthias; Greenwood, Celia M. T.; Hart, Deborah; Howie, Bryan; Huang, Jie; Hubbard, Tim; Hysi, Pirro; Iotchkova, Valentina; Jamshidi, Yalda; Kemp, John P.; Lachance, Genevieve; Lawson, Daniel; Lek, Monkol; Lopes, Margarida; MacArthur, Daniel G.; Marchini, Jonathan; Massimo, Mangino; Mathieson, Iain; McCarthy, Shane; Memari, Yasin; Metrustry, Sarah; Min, Josine L.; Moayyeri, Alireza; Muddyman, Dawn; Northstone, Kate; Panoutsopoulou, Kalliope; Paternoster, Lavinia; Perry, John R. B.; Quaye, Lydia; Richards, J. Brent; Ring, Susan; Ritchie, Graham R. S.; Schiffels, Stephan; Shihab, Hashem A.; Shin, So-Youn; Small, Kerrin S.; Artigas, Maria Soler; Soranzo, Nicole; Southam, Lorraine; Spector, Timothy D.; St Pourcain, Beate; Surdulescu, Gabriela; Tachmazidou, Ioanna; Timpson, Nicholas J.; Tobin, Martin D.; Valdes, Ana M.; Visscher, Peter M.; Wain, Louise V.; Walter, Klaudia; Ward, Kirsten; Wilson, Scott G.; Wong, Kim; Yang, Jian; Zeggini, Eleftheria; Zhang, Feng; Zheng, Hou-Feng; Anney, Richard; Ayub, Muhammad; Barrett, Jeffrey C.; Blackwood, Douglas; Bolton, Patrick F.; Breen, Gerome; Collier, David A.; Craddock, Nick; Crooks, Lucy; Curran, Sarah; Curtis, David; Durbin, Richard; Gallagher, Louise; Geschwind, Daniel; Gurling, Hugh; Holmans, Peter; Lee, Irene; Lonnqvist, Jouko; McCarthy, Shane; McGuffin, Peter; McIntosh, Andrew M.; McKechanie, Andrew G.; McQuillin, Andrew; Morris, James; Muddyman, Dawn; O'Donovan, Michael C.; Owen, Michael J.; Palotie, Aarno; Parr, Jeremy R.; Paunio, Tiina; Pietilainen, Olli; Rehnstrom, Karola; Sharp, Sally I.; Skuse, David; St Clair, David; Suvisaari, Jaana; Walters, James T. R.; Williams, Hywel J.; Bochukova, Elena; Bounds, Rebecca; Dominiczak, Anna; Durbin, Richard; Keogh, Julia; Marenne, Gaelle; McCarthy, Shane; Morris, Andrew; Muddyman, Dawn; Porteous, David J.; Smith, Blair H.; Tachmazidou, Ioanna; Wheeler, Eleanor; Zeggini, Eleftheria; Al Turki, Saeed; Anderson, Carl A.; Antony, Dinu; Beales, Phil; Bentham, Jamie; Bhattacharya, Shoumo; Calissano, Mattia; Carss, Keren; Chatterjee, Krishna; Cirak, Sebahattin; Cosgrove, Catherine; Durbin, Richard; Fitzpatrick, David R.; Floyd, James; Foley, A. Reghan; Franklin, Christopher S.; Futema, Marta; Grozeva, Detelina; Humphries, Steve E.; Hurles, Matthew E.; McCarthy, Shane; Mitchison, Hannah M.; Muddyman, Dawn; Muntoni, Francesco; Onoufriadis, Alexandros; Parker, Victoria; Payne, Felicity; Plagnol, Vincent; Raymond, F. Lucy; Roberts, Nicola; Savage, David B.; Scambler, Peter; Schmidts, Miriam; Schoenmakers, Nadia; Semple, Robert K.; Serra, Eva; Spasic-Boskovic, Olivera; Stevens, Elizabeth; van Kogelenberg, Margriet; Vijayarangakannan, Parthiban; Walter, Klaudia; Williamson, Kathleen A.; Wilson, Crispian; Whyte, Tamieka; Ciampi, Antonio; Greenwood, Celia M. T.; Li, Rui; Metrustry, Sarah; Oualkacha, Karim; Tachmazidou, Ioanna; Xu, ChangJiang; Zeggini, Eleftheria; Bobrow, Martin; Bolton, Patrick F.; Durbin, Richard; Fitzpatrick, David R.; Griffin, Heather; Hurles, Matthew E.; Kaye, Jane; Kennedy, Karen; Kent, Alastair; Muddyman, Dawn; Muntoni, Francesco; Raymond, F. Lucy; Semple, Robert K.; Smee, Carol; Spector, Timothy D.; Timpson, Nicholas J.; Charlton, Ruth; Ekong, Rosemary; Futema, Marta; Humphries, Steve E.; Khawaja, Farrah; Lopes, Luis R.; Migone, Nicola; Payne, Stewart J.; Plagnol, Vincent; Pollitt, Rebecca C.; Povey, Sue; Ridout, Cheryl K.; Robinson, Rachel L.; Scott, Richard H.; Shaw, Adam; Syrris, Petros; Taylor, Rohan; Vandersteen, Anthony M.; Barrett, Jeffrey C.; Smith, George Davey; Durbin, Richard; Fitzpatrick, David R.; Hurles, Matthew E.; Kaye, Jane; Kennedy, Karen; Langford, Cordelia; McCarthy, Shane; Muddyman, Dawn; Owen, Michael J.; Palotie, Aarno; Richards, J. Brent; Soranzo, Nicole; Spector, Timothy D.; Stalker, Jim; Timpson, Nicholas J.; Zeggini, Eleftheria; Amuzu, Antoinette; Casas, Juan Pablo; Chambers, John C.; Cocca, Massimiliano; Dedoussis, George; Gambaro, Giovanni; Gasparini, Paolo; Gaunt, Tom R.; Huang, Jie; Iotchkova, Valentina; Isaacs, Aaron; Johnson, Jon; Kleber, Marcus E.; Kooner, Jaspal S.; Langenberg, Claudia; Luan, Jian'an; Malerba, Giovanni; Marz, Winfried; Matchan, Angela; Min, Josine L.; Morris, Richard; Nordestgaard, Borge G.; Benn, Marianne; Ring, Susan; Scott, Robert A.; Soranzo, Nicole; Southam, Lorraine; Timpson, Nicholas J.; Toniolo, Daniela; Traglia, Michela; Tybjaerg-Hansen, Anne; van Duijn, Cornelia M.; van Leeuwen, Elisabeth M.; Varbo, Anette; Whincup, Peter; Zaza, Gianluigi; Zeggini, Eleftheria; Zhang, Weihua 分享 收藏
Genetic architecture of human thinness compared to severe obesity 与严重肥胖相比，人类瘦弱的遗传结构 Riveros-McKay, Fernando; Mistry, Vanisha; Bounds, Rebecca; Hendricks, Audrey; Keogh, Julia M.; Thomas, Hannah; Henning, Elana; Corbin, Laura J.; Benzeval, Michaela; Burton, Jonathan; Buck, Nicholas; Jackle, Annette; Kumari, Meena; Laurie, Heather; Lynn, Peter; Pudney, Stephen; Rabe, Birgitta; Wolke, Dieter; O'Rahilly, Stephen; Zeggini, Eleftheria; Wheeler, Eleanor; Barroso, Ines; Farooqi, I. Sadaf 分享 收藏
Low-frequency variation in TP53 has large effects on head circumference and intracranial volume TP53的低频变异对头围和颅内容积有很大影响 Haworth, Simon; Shapland, Chin Yang; Hayward, Caroline; Prins, Bram P.; Felix, Janine F.; Medina-Gomez, Carolina; Rivadeneira, Fernando; Wang, Carol; Ahluwalia, Tarunveer S.; Vrijheid, Martine; Guxens, Monica; Sunyer, Jordi; Tachmazidou, Ioanna; Walter, Klaudia; Iotchkova, Valentina; Jackson, Andrew; Cleal, Louise; Huffmann, Jennifer; Min, Josine L.; Sass, Laerke; Timmers, Paul R. H. J.; Al Turki, Saeed; Anderson, Carl A.; Anney, Richard; Antony, Dinu; Artigas, Maria Soler; Ayub, Muhammad; Bala, Senduran; Barrett, Jeffrey C.; Barroso, Ines; Beales, Phil; Bentham, Jamie; Bhattacharya, Shoumo; Birney, Ewan; Blackwood, Douglas; Bobrow, Martin; Bochukova, Elena; Bolton, Patrick F.; Bounds, Rebecca; Boustred, Chris; Breen, Gerome; Calissano, Mattia; Carss, Keren; Charlton, Ruth; Chatterjee, Krishna; Chen, Lu; Ciampi, Antonio; Cirak, Sebahattin; Clapham, Peter; Clement, Gail; Coates, Guy; Cocca, Massimiliano; Collier, David A.; Cosgrove, Catherine; Cox, Tony; Craddock, Nick; Crooks, Lucy; Curran, Sarah; Curtis, David; Daly, Allan; Danecek, Petr; Day, Ian N. M.; Day-Williams, Aaron; Dominiczak, Anna; Down, Thomas; Du, Yuanping; Dunham, Ian; Durbin, Richard; Edkins, Sarah; Ekong, Rosemary; Ellis, Peter; Evans, David M.; Farooqi, I. Sadaf; Fitzpatrick, David R.; Flicek, Paul; Floyd, James; Foley, A. Reghan; Franklin, Christopher S.; Futema, Marta; Gallagher, Louise; Gaunt, Tom R.; Geihs, Matthias; Geschwind, Daniel; Greenwood, Celia M. T.; Griffin, Heather; Grozeva, Detelina; Guo, Xiaosen; Guo, Xueqin; Gurling, Hugh; Hart, Deborah; Hendricks, Audrey E.; Holmans, Peter; Howie, Bryan; Huang, Jie; Huang, Liren; Hubbard, Tim; Humphries, Steve E.; Hurles, Matthew E.; Hysi, Pirro; Jackson, David K.; Jamshidi, Yalda; Joyce, Chris; Karczewski, Konrad J.; Kaye, Jane; Keane, Thomas; Kemp, John P.; Kennedy, Karen; Kent, Alastair; Keogh, Julia; Khawaja, Farrah; van Kogelenberg, Margriet; Kolb-Kokocinski, Anja; Lachance, Genevieve; Langford, Cordelia; Lawson, Daniel; Lee, Irene; Lek, Monkol; Li, Rui; Li, Yingrui; Liang, Jieqin; Lin, Hong; Liu, Ryan; Lonnqvist, Jouko; Lopes, Luis R.; Lopes, Margarida; MacArthur, Daniel G.; Mangino, Massimo; Marchini, Jonathan; Marenne, Gaelle; Maslen, John; Mathieson, Iain; McCarthy, Shane; McGuffin, Peter; McIntosh, Andrew M.; McKechanie, Andrew G.; McQuillin, Andrew; Memari, Yasin; Metrustry, Sarah; Migone, Nicola; Mitchison, Hannah M.; Moayyeri, Alireza; Morris, Andrew; Morris, James; Muddyman, Dawn; Muntoni, Francesco; Northstone, Kate; O'Donovan, Michael C.; O'Rahilly, Stephen; Onoufriadis, Alexandros; Oualkacha, Karim; Owen, Michael J.; Palotie, Aarno; Panoutsopoulou, Kalliope; Parker, Victoria; Parr, Jeremy R.; Paternoster, Lavinia; Paunio, Tiina; Payne, Felicity; Payne, Stewart J.; Perry, John R. B.; Pietilainen, Olli; Plagnol, Vincent; Pollitt, Rebecca C.; Porteous, David J.; Povey, Sue; Quail, Michael A.; Quaye, Lydia; Raymond, F. Lucy; Rehnstrom, Karola; Richards, J. Brent; Ridout, Cheryl K.; Ring, Susan; Ritchie, Graham R. S.; Roberts, Nicola; Robinson, Rachel L.; Savage, David B.; Scambler, Peter; Schiffels, Stephan; Schmidts, Miriam; Schoenmakers, Nadia; Scott, Richard H.; Semple, Robert K.; Serra, Eva; Sharp, Sally I.; Shaw, Adam; Shihab, Hashem A.; Shin, So-Youn; Skuse, David; Small, Kerrin S.; Smee, Carol; Smith, Blair H.; Soranzo, Nicole; Southam, Lorraine; Spasic-Boskovic, Olivera; Spector, Timothy D.; St Clair, David; Stalker, Jim; Stevens, Elizabeth; Sun, Jianping; Surdulescu, Gabriela; Suvisaari, Jaana; Syrris, Petros; Taylor, Rohan; Tian, Jing; Tobin, Martin D.; Valdes, Ana M.; Vandersteen, Anthony M.; Vijayarangakannan, Parthiban; Visscher, Peter M.; Wain, Louise V.; Walters, James T. R.; Wang, Guangbiao; Wang, Jun; Wang, Yu; Ward, Kirsten; Wheeler, Eleanor; Whyte, Tamieka; Williams, Hywel J.; Williamson, Kathleen A.; Wilson, Crispian; Wilson, Scott G.; Wong, Kim; Xu, ChangJiang; Yang, Jian; Zhang, Feng; Zhang, Pingbo; Zheng, Hou-Feng; Smith, George Davey; Fisher, Simon E.; Wilson, James F.; Cole, Tim J.; Fernandez-Orth, Dietmar; Bonnelykke, Klaus; Bisgaard, Hans; Pennell, Craig E.; Jaddoe, Vincent W. V.; Dedoussis, George; Timpson, Nicholas; Zeggini, Eleftheria; Vitart, Veronique; St Pourcain, Beate 分享 收藏
A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome Bochukova, Elena G.; Lawler, Katherine; Croizier, Sophie; Keogh, Julia M.; Patel, Nisha; Strohbehn, Garth; Lo, Kitty K.; Humphrey, Jack; Hokken-Koelega, Anita; Damen, Layla; Donze, Stephany; Bouret, Sebastien G.; Plagnol, Vincent; Farooqi, I. Sadaf 分享 收藏
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