Connie Ha

University of California System

H指数:16

被引数:3,984

个人简介

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Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease

PILRA的缺失促进小胶质细胞免疫代谢，以减少阿尔茨海默病细胞和动物模型中的淀粉样蛋白病理。

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2025-12-030

PRE

Weerakkody, Tanya N.; Sabelstrom, Hanna; Andrews, Shan V.; Chadarevian, Jean Paul; Chin, Marcus Y.; Tatarakis, David; Propson, Nicholas E.; Kim, Do Jin; Theolis, Richard; Parico, Gian Carlo G.; Misker, Hiwot; Kung, Jennifer E.; Bandyopadhyay, Abira; Robles Colmenares, Yaneth; Jackson, Taggra-Nicole; Qerqez, Ahlam N.; Balasundar, Srijana; Davis, Sonnet S.; Ha, Connie; Ghosh, Rajarshi; Ravi, Ritesh; Rana, Anil; Germain, Kyla; Tao, Arnold; Xiong, Ken; Braun, Dylan; Raju, Karthik; Huang, Kang-Chieh; Zhan, Lihong; Guo, Jing L.; Safari Yazd, Hoda; Sarrafha, Lily; Capocchi, Joia Kai; Hasselmann, Jonathan; Chadarevian, Alina L.; Tu, Christina; Mansour, Kimiya; Eskandari-Sedighi, Ghazaleh; Tesi, Niccolo; Van Der Lee, Sven; Hulsman, Marc; Oshegov, Georgii; Pijnenburg, Yolande; Calvert, Meredith; Holstege, Henne; Suh, Jung H.; Di Paolo, Gilbert; Davtyan, Hayk; Lewcock, Joseph W.; Blurton-Jones, Mathew; Monroe, Kathryn M.

Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial

实验性eIF2B激活剂DNL343在TDP-43病理学的临床前模型和随机临床试验中的ALS患者中调节整合应激反应

Nature Communications

IF15.7

2025-08-180

OAAI

Brittany N. Flores; Seungyoon B. Yu; Isaac V. Cohen; Melania H. Fanok; Wei Luan; Romeo D. Maciuca; Linus D. Sun; Richard M. Tsai; Maurits Vissers; Lars Smits; Tommy M. Bunte; Anna Bakardjiev; Srijana Balasundar; Meredith E. K. Calvert; Marcus Y. Chin; Sarah K. Dobbins; William E. Dowdle; Meng Fang; Jules A. A. C. Heuberger; Connie L. Ha; Fen Huang; Takashi Miyamoto; Maksim Osipov; Lidia Madrid San Martin; Katie Saund; David Tatarakis; Anthony Q. Vu; Chenling Xiong; Gene W. Yeo; Geert Jan Groeneveld; Leonard H. van den Berg; Shyeilla Dhuria; Anthony A. Estrada; Danna Jennings; Thomas Sandmann; Carole Ho; Kimberly Scearce-Levie; Ernie Yulyaningsih; Adam K. Walker; Gilbert Di Paolo; Lesley A. Kane; Matthew D. Troyer; Joseph W. Lewcock

DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response

ELIFE

IF0

2024-09-171

Yulyaningsih, Ernie; Suh, Jung H.; Fanok, Melania; Chau, Roni; Solanoy, Hilda; Takahashi, Ryan; Bakardjiev, Anna, I; Becerra, Isabel; Benitez, N. Butch; Chiu, Chi-Lu; Davis, Sonnet S.; Dowdle, William E.; Earr, Timothy; Estrada, Anthony A.; Gill, Audrey; Ha, Connie; Haddick, Patrick C. G.; Henne, Kirk R.; Larhammar, Martin; Leung, Amy W-S; Maciuca, Romeo; Memarzadeh, Bahram; Nguyen, Hoang N.; Nugent, Alicia A.; Osipov, Maksim; Ran, Yingqing; Rebadulla, Kevin; Roche, Elysia; Sandman, Thomas; Wang, Jing; Lewcock, Joseph W.; Scearce-Levie, Kimberly; Kane, Lesley A.; Sanchez, Pascal E.

Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2024-08-145

PRE

Barker, Scarlett J.; Thayer, Mai B.; Kim, Chaeyoung; Tatarakis, David; Simon, Matthew J.; Dial, Rebekah; Nilewski, Lizanne; Wells, Robert C.; Zhou, Yinhan; Afetian, Megan; Akkapeddi, Padma; Chappell, Alfred; Chew, Kylie S.; Chow, Johann; Clemens, Allisa; Discenza, Claire B.; Dugas, Jason C.; Dwyer, Chrissa; Earr, Timothy; Ha, Connie; Ho, Yvonne S.; Huynh, David; Lozano, Edwin I.; Jayaraman, Srini; Kwan, Wanda; Mahon, Cathal; Pizzo, Michelle; Robles-Colmenares, Yaneth; Roche, Elysia; Sanders, Laura; Stergioulis, Alexander; Tong, Raymond; Tran, Hai; Zuchero, Joy Yu; Estrada, Anthony A.; Gadkar, Kapil; Koth, Christopher M. M.; Sanchez, Pascal E.; Thorne, Robert G.; Watts, Ryan J.; Sandmann, Thomas; Kane, Lesley A.; Rigo, Frank; Dennis, Mark S.; Lewcock, Joseph W.; Devos, Sarah L.

Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

MOLECULAR NEURODEGENERATION

IF17.5

2022-06-1146

OAAI

Xia, Dan; Lianoglou, Steve; Sandmann, Thomas; Calvert, Meredith; Suh, Jung H.; Thomsen, Elliot; Dugas, Jason; Pizzo, Michelle E.; DeVos, Sarah L.; Earr, Timothy K.; Lin, Chia-Ching; Davis, Sonnet; Ha, Connie; Leung, Amy Wing-Sze; Hoang Nguyen; Chau, Roni; Yulyaningsih, Ernie; Lopez, Isabel; Solanoy, Hilda; Masoud, Shababa T.; Liang, Chun-chi; Lin, Karin; Astarita, Giuseppe; Khoury, Nathalie; Zuchero, Joy Yu; Thorne, Robert G.; Shen, Kevin; Miller, Stephanie; Palop, Jorge J.; Garceau, Dylan; Sasner, Michael; Whitesell, Jennifer D.; Harris, Julie A.; Hummel, Selina; Gnorich, Johannes; Wind, Karin; Kunze, Lea; Zatcepin, Artem; Brendel, Matthias; Willem, Michael; Haass, Christian; Barnett, Daniel; Zimmer, Till S.; Orr, Anna G.; Scearce-Levie, Kimberly; Lewcock, Joseph W.; Di Paolo, Gilbert; Sanchez, Pascal E.

Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2020-05-27132

PREAI

Ullman, Julie C.; Arguello, Annie; Getz, Jennifer A.; Bhalla, Akhil; Mahon, Cathal S.; Wang, Junhua; Giese, Tina; Bedard, Catherine; Kim, Do Jin; Blumenfeld, Jessica R.; Liang, Nicholas; Ravi, Ritesh; Nugent, Alicia A.; Davis, Sonnet S.; Ha, Connie; Duque, Joseph; Tran, Hai L.; Wells, Robert C.; Lianoglou, Steve; Daryani, Vinay M.; Kwan, Wanda; Solanoy, Hilda; Hoang Nguyen; Earr, Timothy; Dugas, Jason C.; Tuck, Michael D.; Harvey, Jennifer L.; Reyzer, Michelle L.; Caprioli, Richard M.; Hall, Sejal; Poda, Suresh; Sanchez, Pascal E.; Dennis, Mark S.; Gunasekaran, Kannan; Srivastava, Ankita; Sandmann, Thomas; Henne, Kirk R.; Thorne, Robert G.; Di Paolo, Gilbert; Astarita, Giuseppe; Diaz, Dolores; Silverman, Adam P.; Watts, Ryan J.; Sweeney, Zachary K.; Kariolis, Mihalis S.; Henry, Anastasia G.

Novel FACS based method demonstrates CNS cell-type distribution and efficacy of a BBB penetrant ERT in a mouse model of MPS II

MOLECULAR GENETICS AND METABOLISM

IF3.5

2020-02-010

PREAI

The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation

SCIENCE SIGNALING

IF6.6

2017-04-1850

PREAI

Senger, Kate; Pham, Victoria C.; Varfolomeev, Eugene; Hackney, Jason A.; Corzo, Cesar A.; Collier, Jenna; Lau, Vivian W. C.; Huang, Zhiyu; Hamidzhadeh, Kajal; Caplazi, Patrick; Peng, Ivan; Setiadi, A. Francesca; Francis, Ross; Paler-Martinez, Andres; Kwon, Youngsu C.; Ramirez-Carrozzi, Vladimir; Sun, Yonglian; Grigg, Patricia W.; Roose-Girma, Merone; Jeet, Surinder; Barck, Kai H.; Pham, Anna; Ota, Naruhisa; Ha, Connie; Stinson, Jeremy; Guillory, Joseph; Tam, Lucinda; Modrusan, Zora; Emson, Claire; McKenzie, Brent S.; Townsend, Michael J.; Carano, Richard A. D.; Warming, Soren; Vucic, Domagoj; DeVoss, Jason; Lee, Wyne P.; Lill, Jennie R.; Zarrin, Ali A.

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types

SCIENTIFIC REPORTS

IF3.9

2017-03-3162

OAAI

Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations

NATURE GENETICS

IF31.8

2016-02-29669

PREAI

Bueno, Raphael; Stawiski, Eric W.; Goldstein, Leonard D.; Durinck, Steffen; De Rienzo, Assunta; Modrusan, Zora; Gnad, Florian; Nguyen, Thong T.; Jaiswal, Bijay S.; Chirieac, Lucian R.; Sciaranghella, Daniele; Dao, Nhien; Gustafson, Corinne E.; Munir, Kiara J.; Hackney, Jason A.; Chaudhuri, Amitabha; Gupta, Ravi; Guillory, Joseph; Toy, Karen; Ha, Connie; Chen, Ying-Jiun; Stinson, Jeremy; Chaudhuri, Subhra; Zhang, Na; Wu, Thomas D.; Sugarbaker, David J.; de Sauvage, Frederic J.; Richards, William G.; Seshagiri, Somasekar

Heterogeneous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis

THORAX

IF7.7

2014-09-12215

OAAI

Endogenously Expressed IL-13Rα2 Attenuates IL-13-Mediated Responses but Does Not Activate Signaling in Human Lung Fibroblasts

JOURNAL OF IMMUNOLOGY

IF3.4

2014-07-0162

OAAI

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer

NATURE COMMUNICATIONS

IF15.7

2014-05-0886

OAAI

Liu, Jinfeng; McCleland, Mark; Stawiski, Eric W.; Gnad, Florian; Mayba, Oleg; Haverty, Peter M.; Durinck, Steffen; Chen, Ying-Jiun; Klijn, Christiaan; Jhunjhunwala, Suchit; Lawrence, Michael; Liu, Hanbin; Wan, Yinan; Chopra, Vivek; Yaylaoglu, Murat B.; Yuan, Wenlin; Ha, Connie; Gilbert, Houston N.; Reeder, Jens; Pau, Gregoire; Stinson, Jeremy; Stern, Howard M.; Manning, Gerard; Wu, Thomas D.; Neve, Richard M.; de Sauvage, Frederic J.; Modrusan, Zora; Seshagiri, Somasekar; Firestein, Ron; Zhang, Zemin

Connie Ha

个人简介

教育背景

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