Gillian Murphy - Publications, H-index & Citations

Gillian Murphy

cruk cambridge institute

120H指数

384论文数

4.5W被引数

收录论文 134

发表时间

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells (vol 112, pg 1895, 2015)使用抑制性单克隆抗体靶向ADAM-17在 triple-negative breast cancer 细胞中具有抗肿瘤作用（vol 112, pg 1895, 2015）

BRITISH JOURNAL OF CANCER

IF6.8

2025-03-14

PREAI

Caiazza, F.; Mcgowan, P. M.; Mullooly, M.; Murray, A.; Synnott, N.; O'Donovan, N.; Flanagan, L.; Tape, C. J.; Murphy, G.; Crown, J.; Duffy, M. J.

TIMP-3 facilitates binding of target metalloproteinases to the endocytic receptor LRP-1 and promotes scavenging of MMP-1

SCIENTIFIC REPORTS

IF3.9

2020-07-21

OAAI

Carreca, Anna P.; Pravata, Veronica M.; Markham, Matthew; Bonelli, Simone; Murphy, Gillian; Nagase, Hideaki; Troeberg, Linda; Scilabra, Simone D.

ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells L-选择素的ADAM17-dependent蛋白水解促进细胞毒性T细胞的早期克隆扩增

SCIENTIFIC REPORTS

IF3.9

2019-04-02

OAAI

Mohammed, Rebar N.; Wehenkel, Sophie C.; Galkina, Elena, V; Yates, Emma-Kate; Preece, Graham; Newman, Andrew; Watson, H. Angharad; Ohme, Julia; Bridgeman, John S.; Durairaj, Ruban R. P.; Moon, Owen R.; Ladell, Kristin; Miners, Kelly L.; Dolton, Garry; Troeberg, Linda; Kashiwagi, Masahide; Murphy, Gillian; Nagase, Hideaki; Price, David A.; Matthews, R. James; Knauper, Vera; Ager, Ann

INHIBITION OF LRP1 SHEDDING REVERSES CARTILAGE DEGRADATION IN OSTEOARTHRITIS

OSTEOARTHRITIS AND CARTILAGE

IF9

2018-04-01

OAAI

Yamamoto, K.; Scavenius, C.; Santamaria, S.; Botkjaer, K. A.; Dudhia, J.; Troeberg, L.; Itoh, Y.; Murphy, G.; Enghild, J. J.; Nagase, H.

Anti-tumor effects of a 'human & mouse cross-reactive' anti-ADAM17 antibody in a pancreatic cancer model in vivo “人和小鼠交叉反应” anti-ADAM17抗体在体内胰腺癌模型中的抗肿瘤作用

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

IF4.7

2017-12-01

PREAI

Ye, Jie; Yuen, Shun Ming; Murphy, Gillian; Xie, Ruiyu; Kwok, Hang Fai

Riding the metalloproteinase roller coaster

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2017-05-01

OAAI

Murphy, Gillian

Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis

ARTHRITIS & RHEUMATOLOGY

IF10.9

2017-04-28

OAAI

Yamamoto, Kazuhiro; Santamaria, Salvatore; Botkjaer, Kenneth A.; Dudhia, Jayesh; Troeberg, Linda; Itoh, Yoshifumi; Murphy, Gillian; Nagase, Hideaki

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

MABS

IF7.3

2017-03-17

OAAI

Santamaria, Salvatore; Fedorov, Oleg; McCafferty, John; Murphy, Gillian; Dudhia, Jayesh; Nagase, Hideaki; Yamamoto, Kazuhiro

ADAM17 is a psoriasis-relevant check-point controlling Th17-programming by inflammatory dermal dendritic cells

JOURNAL OF INVESTIGATIVE DERMATOLOGY

IF5.7

2016-09-01

OAAI

Kunze, A.; Oehrl, S.; Beckhove, P.; Murphy, G.; Enk, A.; Schaekel, K.

Shedding of Endogenous Interleukin-6 Receptor (IL-6R) Is Governed by A Disintegrin and Metalloproteinase (ADAM) Proteases while a Full-length IL-6R Isoform Localizes to Circulating Microvesicles 内源性Interleukin-6受体 (IL-6R) 的脱落由解整合素和金属蛋白酶 (ADAM) 蛋白酶控制，而全长IL-6R同工型定位于循环微泡

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2015-10-01

123

OAAI

Schumacher, Neele; Meyer, Doerte; Mauermann, Andre; von der Heyde, Jan; Wolf, Janina; Schwarz, Jeanette; Knittler, Katharina; Murphy, Gillian; Michalek, Matthias; Garbers, Christoph; Bartsch, Joerg W.; Guo, Songbo; Schacher, Beate; Eickholz, Peter; Chalaris, Athena; Rose-John, Stefan; Rabe, Bjoern

Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity

ONCOGENE

IF7.3

2015-06-08

PREAI

O'Leary, L.; van der Sloot, A. M.; Reis, C. R.; Deegan, S.; Ryan, A. E.; Dhami, S. P. S.; Murillo, L. S.; Cool, R. H.; de Sampaio, P. Correa; Thompson, K.; Murphy, G.; Quax, W. J.; Serrano, L.; Samali, A.; Szegezdi, E.

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells

BRITISH JOURNAL OF CANCER

IF6.8

2015-05-26

OAAI

Caiazza, F.; McGowan, P. M.; Mullooly, M.; Murray, A.; Synnott, N.; O'Donovan, N.; Flanagan, L.; Tape, C. J.; Murphy, G.; Crown, J.; Duffy, M. J.

Altered MicroRNA Expression after Infection with Human Cytomegalovirus Leads to TIMP3 Downregulation and Increased Shedding of Metalloprotease Substrates, Including MICA

JOURNAL OF IMMUNOLOGY

IF3.4

2014-08-01

OAAI

Esteso, Gloria; Luzon, Elisa; Sarmiento, Elisabeth; Gomez-Caro, Ruth; Steinle, Alexander; Murphy, Gillian; Carbone, Javier; Vales-Gomez, Mar; Reyburn, Hugh T.

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

FASEB JOURNAL

IF4.2

2014-07-30

OAAI

Effenberger, Timo; von der Heyde, Jan; Bartsch, Kareen; Garbers, Christoph; Schulze-Osthoff, Klaus; Chalaris, Athena; Murphy, Gillian; Rose-John, Stefan; Rabe, Bjoern

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase (vol 114, pg 1213, 2001)

JOURNAL OF CELL SCIENCE

IF3.6

2014-04-01

OAAI

Nath, Deepa; Williamson, Nicola J.; Jarvis, Robert; Murphy, Gillian

THE AMINOPEPTIDASE CD13 REGULATES HOMOTYPIC AGGREGATION OF NEUTROPHILS

THORAX

IF7.7

2012-11-19

OAAI

Fiddler, C. A.; Murphy, G.; Cowburn, A. S.; Parfrey, H.; Chilvers, E. R.

ADAM17 as a Therapeutic Target for the Treatment of Breast Cancer: Preclinical Studies with an Inhibitory Monoclonal Antibody

EUROPEAN JOURNAL OF CANCER

IF7.1

2012-11-01

PREAI

Caiazza, F.; Murphy, G.; McGowan, P. M.; Crown, J.; Duffy, M. J.

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1 基质金属蛋白酶1对三螺旋胶原蛋白裂解的结构见解

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2012-07-03

181

OAAI

Manka, Szymon W.; Carafoli, Federico; Visse, Robert; Bihan, Dominique; Raynal, Nicolas; Farndale, Richard W.; Murphy, Gillian; Enghild, Jan J.; Hohenester, Erhard; Nagase, Hideaki

Activity of the specific anti-ADAM17 inhibitory IgG antibody (Ab), D1(A12) in an ovarian cancer model in vivo

CANCER RESEARCH

IF16.6

2012-04-01

PREAI

Richards, Frances M.; Tape, Christopher; Jodrell, Duncan I.; Murphy, Gillian

Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Ubiquitination at Lys581 Increases Cellular Invasion through Type I Collagen

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2012-03-01

OAAI

Eisenach, Patricia A.; de Sampaio, Pedro Correa; Murphy, Gillian; Roghi, Christian

研究方向