未登录 MELLODDY: Cross-pharma Federated Learning at Unprecedented Scale Unlocks Benefits in QSAR without Compromising Proprietary Information MELLODDY: 跨制药联合学习以前所未有的规模在不损害专有信息的情况下解锁QSAR的好处 Heyndrickx, Wouter; Mervin, Lewis; Morawietz, Tobias; Sturm, Noe; Friedrich, Lukas; Zalewski, Adam; Pentina, Anastasia; Humbeck, Lina; Oldenhof, Martijn; Niwayama, Ritsuya; Schmidtke, Peter; Fechner, Nikolas; Simm, Jaak; Arany, Adam; Drizard, Nicolas; Jabal, Rama; Afanasyeva, Arina; Loeb, Regis; Verma, Shlok; Harnqvist, Simon; Holmes, Matthew; Pejo, Balazs; Telenczuk, Maria; Holway, Nicholas; Dieckmann, Arne; Rieke, Nicola; Zumsande, Friederike; Clevert, Djork-Arne; Krug, Michael; Luscombe, Christopher; Green, Darren; Ertl, Peter; Antal, Peter; Marcus, David; Do Huu, Nicolas; Fuji, Hideyoshi; Pickett, Stephen; Acs, Gergely; Boniface, Eric; Beck, Bernd; Sun, Yax; Gohier, Arnaud; Rippmann, Friedrich; Engkvist, Ola; Goeller, Andreas H.; Moreau, Yves; Galtier, Mathieu N.; Schuffenhauer, Ansgar; Ceulemans, Hugo 分享 收藏
Discovery of New Binders for DCAF1, an Emerging Ligase Target in the Targeted Protein Degradation Field 发现DCAF1的新结合物，DCAF1是靶向蛋白质降解领域中的新兴连接酶靶标 Vulpetti, Anna; Holzer, Philipp; Schmiedeberg, Niko; Imbach-Weese, Patricia; Pissot-Soldermann, Carole; Hollingworth, Gregory J.; Radimerski, Thomas; Thoma, Claudio R.; Stachyra, Therese-Marie; Wojtynek, Matthias; Maschlej, Magdalena; Chau, Suzanne; Schuffenhauer, Ansgar; Fernandez, Cesar; Schroder, Martin; Renatus, Martin 分享 收藏
分享 收藏
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing Soldermann, Carole Pissot; Simic, Oliver; Renatus, Martin; Erbel, Paulus; Melkko, Samu; Wartmann, Markus; Bigaud, Marc; Weiss, Andreas; McSheehy, Paul; Endres, Ralf; Santos, Paulo; Blank, Jutta; Schuffenhauer, Ansgar; Bold, Guido; Buschmann, Nicole; Zoller, Thomas; Altmann, Eva; Manley, Paul W.; Dix, Ina; Buchdunger, Elisabeth; Scesa, Julien; Quancard, Jean; Schlapbach, Achim; Bornancin, Frederic; Radimerski, Thomas; Regnier, Catherine H. 分享 收藏
Evolution of Novartis' Small Molecule Screening Deck Design 诺华小分子筛板设计的演变 Schuffenhauer, Ansgar; Schneider, Nadine; Hintermann, Samuel; Auld, Douglas; Blank, Jutta; Cotesta, Simona; Engeloch, Caroline; Fechner, Nikolas; Gaul, Christoph; Giovannoni, Jerome; Jansen, Johanna; Joslin, John; Krastel, Philipp; Lounkine, Eugen; Manchester, John; Monovich, Lauren G.; Pelliccioli, Anna Paola; Schwarze, Manuel; Shultz, Michael D.; Stiefl, Nikolaus; Baeschlin, Daniel K. 分享 收藏
Systematic Chemogenetic Library Assembly Canham, Stephen M.; Wang, Yuan; Cornett, Allen; Auld, Douglas S.; Baeschlin, Daniel K.; Patoor, Maude; Skaanderup, Philip R.; Honda, Ayako; Llamas, Luis; Wendel, Greg; Mapa, Felipa A.; Aspesi, Peter, Jr.; Labbe-Giguere, Nancy; Gamber, Gabriel G.; Palacios, Daniel S.; Schuffenhauer, Ansgar; Deng, Zhan; Nigsch, Florian; Frederiksen, Mathias; Bushell, Simon M.; Rothman, Deborah; Jain, Rishi K.; Hemmerle, Horst; Briner, Karin; Porter, Jeffery A.; Tallarico, John A.; Jenkins, Jeremy L. 分享 收藏
Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes Renner, Steffen; Bergsdorf, Christian; Bouhelal, Rochdi; Koziczak-Holbro, Magdalena; Amati, Andrea Marco; Techer-Etienne, Valerie; Flotte, Ludivine; Reymann, Nicole; Kapur, Karen; Hoersch, Sebastian; Oakeley, Edward James; Schuffenhauer, Ansgar; Gubler, Hanspeter; Lounkine, Eugen; Farmer, Pierre 分享 收藏
Dark chemical matter as a promising starting point for drug lead discovery Wassermann, Anne Mai; Lounkine, Eugen; Hoepfner, Dominic; Le Goff, Gaelle; King, Frederick J.; Studer, Christian; Peltier, John M.; Grippo, Melissa L.; Prindle, Vivian; Tao, Jianshi; Schuffenhauer, Ansgar; Wallace, Iain M.; Chen, Shanni; Krastel, Philipp; Cobos-Correa, Amanda; Parker, Christian N.; Davies, John W.; Glick, Meir 分享 收藏
分享 收藏
分享 收藏
分享 收藏
Recent trends and observations in the design of high-quality screening collections Renner, Steffen; Popov, Maxim; Schuffenhauer, Ansgar; Roth, Hans-Joerg; Breitenstein, Werner; Marzinzik, Andreas; Lewis, Ian; Krastel, Philipp; Nigsch, Florian; Jenkins, Jeremy; Jacoby, Edgar 分享 收藏
分享 收藏
分享 收藏
Bioactivity-guided mapping and navigation of chemical space Renner, Steffen; van Otterlo, Willem A. L.; Seoane, Marta Dominguez; Moecklinghoff, Sabine; Hofmann, Bettina; Wetzel, Stefan; Schuffenhauer, Ansgar; Ertl, Peter; Oprea, Tudor I.; Steinhilber, Dieter; Brunsveld, Luc; Rauh, Daniel; Waldmann, Herbert 分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}