Timothy J. Kieffer - Publications, H-index & Citations

Timothy J. Kieffer

aardvark therapeutics

72H指数

290论文数

2.0W被引数

收录论文 140

发表时间

ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition ARD-101，一种肠道特异性的TAS2R激动剂，可减少成人饥饿感，并在DPP-4抑制条件下促进DIO小鼠的体重减轻。

Molecular Metabolism

IF6.6

2026-03-14

OAAI

Zhenhuan Zheng; Jeremy H. Pettus; Alexa Warner; Bryan Jones; Megan Pugsley; Justin Stege; Brad Hirakawa; Manasi Jaiman; Jerlyn Tolentino; Tien-Li Lee; Timothy J. Kieffer

Advances in Islet Transplantation and the Future of Stem Cell-Derived Islets to Treat Diabetes 胰岛移植的进展及干细胞衍生胰岛治疗糖尿病的未来

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE

IF10.1

2024-07-29

PREAI

Kieffer, Timothy J.; Hoesli, Corinne A.; Shapiro, A. M. James

PDX1+cell budding morphogenesis in a stem cell-derived islet spheroid system

NATURE COMMUNICATIONS

IF15.7

2024-07-13

OAAI

Zhao, Jia; Liang, Shenghui; Cen, Haoning Howard; Li, Yanjun; Baker, Robert K.; Ruprai, Balwinder; Gao, Guang; Zhang, Chloe; Ren, Huixia; Tang, Chao; Chen, Liangyi; Liu, Yanmei; Lynn, Francis C.; Johnson, James D.; Kieffer, Timothy J.

Single-dose GLP-1-based Pancreatic Gene Therapy Maintains Weight Loss After Semaglutide Withdrawal in a Murine Model of Obesity 单剂量GLP-1-based胰腺基因治疗在小鼠肥胖模型中维持Semaglutide停药后的体重减轻

METABOLISM-CLINICAL AND EXPERIMENTAL

IF11.9

2024-06-01

PREAI

Fitzpatrick, Alice Liou; Wang, Suya; Cozzi, Emily; Seeley, Randy; Caplan, Jay; Kieffer, Timothy; Rajagopalan, Harith

Metabolic switching, growth kinetics and cell yields in the scalable manufacture of stem cell-derived insulin-producing cells

STEM CELL RESEARCH & THERAPY

IF7.3

2024-01-02

OAAI

Iworima, Diepiriye G.; Baker, Robert K.; Ellis, Cara; Sherwood, Chris; Zhan, Lisa; Rezania, Alireza; Piret, James M.; Kieffer, Timothy J.

Encapsulated stem cell-derived β cells exert glucose control in patients with type 1 diabetes

NATURE BIOTECHNOLOGY

IF41.7

2023-11-27

OAAI

Keymeulen, Bart; De Groot, Kaat; Jacobs-Tulleneers-Thevissen, Daniel; Thompson, David M.; Bellin, Melena D.; Kroon, Evert J.; Daniels, Mark; Wang, Richard; Jaiman, Manasi; Kieffer, Timothy J.; Foyt, Howard L.; Pipeleers, Daniel

Thyroid Hormone Levels Correlate With the Maturation of Implanted Pancreatic Endoderm Cells in Patients With Type 1 Diabetes

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

IF5.1

2023-09-06

PREAI

Ramzy, Adam; Saber, Nelly; Bruin, Jennifer E.; Thompson, David M.; Kim, Peter T. W.; Warnock, Garth L.; Kieffer, Timothy J.

Human A2-CAR T Cells Reject HLA-A2+ Human Islets Transplanted Into Mice Without Inducing Graft-versus-host Disease 人类A2-CAR T细胞排斥移植到小鼠体内的HLA-A2人类胰岛，而不会诱导移植物抗宿主病

TRANSPLANTATION

IF5

2023-08-02

OAAI

Ellis, Cara E.; Mojibian, Majid; Ida, Shogo; Fung, Vivian C. W.; Skovso, Sos; McIver, Emma; O'Dwyer, Shannon; Webber, Travis D.; Braam, Mitchell J. S.; Saber, Nelly; Sasaki, Shugo; Lynn, Francis C.; Kieffer, Timothy J.; Levings, Megan K.

Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension culture

SCIENTIFIC REPORTS

IF3.9

2023-06-01

OAAI

Braam, Mitchell J. S.; Zhao, Jia; Liang, Shenghui; Ida, Shogo; Kloostra, Nick K. K.; Iworima, Diepiriye G. G.; Tang, Mei; Baker, Robert K. K.; Quiskamp, Nina; Piret, James M. M.; Kieffer, Timothy J. J.

Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture system

CELL REPORTS METHODS

IF4.5

2023-05-01

OAAI

Liang, Shenghui; Zhao, Jia; Baker, Robert K.; Tran, Elisa; Zhan, Lisa; Kieffer, Timothy J.

The Impact of Different Implantation Sites and Sex on the Differentiation of Human Pancreatic Endoderm Cells Into Insulin-Secreting Cells In Vivo

DIABETES

IF7.5

2023-02-06

OAAI

Saber, Nelly; Ellis, Cara E. E.; Iworima, Diepiriye G. G.; Baker, Robert K. K.; Rezania, Alireza; Kieffer, Timothy J. J.

Dynamic Ins2 Gene Activity Defines β-Cell Maturity States

DIABETES

IF7.5

2022-09-28

OAAI

Chu, Chieh Min Jamie; Modi, Honey; Ellis, Cara; Krentz, Nicole A. J.; Skovso, Sos; Zhao, Yiwei Bernie; Cen, Haoning; Noursadeghi, Nilou; Panzhinskiy, Evgeniy; Hu, Xiaoke; Dionne, Derek A.; Xia, Yi Han; Xuan, Shouhong; Huising, Mark O.; Kieffer, Timothy J.; Lynn, Francis C.; Johnson, James D.

Insulin Null β-cells Have a Prohormone Processing Defect That Is Not Reversed by AAV Rescue of Proinsulin Expression 胰岛素无效的 β 细胞具有激素原加工缺陷，不能被AAV拯救胰岛素原表达所逆转

ENDOCRINOLOGY

IF3.3

2022-04-18

OAAI

Ramzy, Adam; Edeer, Nazde; Baker, Robert K.; O'Dwyer, Shannon; Mojibian, Majid; Verchere, C. Bruce; Kieffer, Timothy J.

ALTERED ISLET PROHORMONE PROCESSING: A CAUSE OR CONSEQUENCE OF DIABETES?胰岛激素原加工改变: 糖尿病的原因或后果？

PHYSIOLOGICAL REVIEWS

IF28.7

2022-01-01

PREAI

Ramzy, Adam; Kieffer, Timothy J.

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes

CELL STEM CELL

IF20.4

2021-12-01

176

PREAI

Ramzy, Adam; Thompson, David M.; Ward-Hartstonge, Kirsten A.; Ivison, Sabine; Cook, Laura; Garcia, Rosa, V; Loyal, Jackson; Kim, Peter T. W.; Warnock, Garth L.; Levings, Megan K.; Kieffer, Timothy J.

Article Deletion of pancreas-specific miR-216a reduces beta-cell mass and inhibits pancreatic cancer in mice

CELL REPORTS MEDICINE

IF10.6

2021-11-01

OAAI

Erener, Suheda; Ellis, Cara E.; Ramzy, Adam; Glavas, Maria M.; O'Dwyer, Shannon; Pereira, Sandra; Wang, Tom; Pang, Janice; Bruin, Jennifer E.; Riedel, Michael J.; Baker, Robert K.; Webber, Travis D.; Lesina, Marina; Blu, Matthias; Algu, Hana; Kopp, Janel L.; Herzig, Stephan; Kieffer, Timothy J.

Pancreatic islets in bed with microvasculature-companions for life

CELL REPORTS MEDICINE

IF10.6

2021-11-01

OAAI

Hoesli, Corinne A.; Kieffer, Timothy J.

Developmental Timing of High-Fat Diet Exposure Impacts Glucose Homeostasis in Mice in a Sex-Specific Manner

DIABETES

IF7.5

2021-09-20

OAAI

Glavas, Maria M.; Lee, Ann Y.; Miao, Ian; Yang, Fan; Mojibian, Majid; O'Dwyer, Shannon M.; Kieffer, Timothy J.

Role of myeloid cell leptin signaling in the regulation of glucose metabolism

SCIENTIFIC REPORTS

IF3.9

2021-09-15

OAAI

Pereira, Sandra; Cline, Daemon L.; Chan, Melissa; Chai, Kalin; Yoon, Ji Soo; O'Dwyer, Shannon M.; Ellis, Cara E.; Glavas, Maria M.; Webber, Travis D.; Baker, Robert K.; Erener, Suheda; Covey, Scott D.; Kieffer, Timothy J.

Process parameter development for the scaled generation of stem cell-derived pancreatic endocrine cells

STEM CELLS TRANSLATIONAL MEDICINE

IF4.9

2021-08-13

OAAI

Iworima, Diepiriye G.; Rieck, Sebastian; Kieffer, Timothy J.

研究方向