未登录 Identification of small molecule inhibitors of PPM1D using an integrated drug discovery platform 使用集成药物发现平台鉴定PPM1D小分子抑制剂 Shaw, Subrata; Jiang, Wei; Rush, Jason; Dumont, Nancy; Kim, John; Singh, Ritu; Skepner, Adam; Khodier, Carol; Raffier, Cerise; Murphy, Zachary; Yan, Ni; Schluter, Cameron; Yu, Xiao; Szuchnicki, Mateusz; Sathappa, Murugappan; Kahn, Josephine; Sperling, Adam S.; Wagner, Florence; Mckinney, David C.; Gould, Alexandra E.; Garvie, Colin W.; Miller, Peter G. 分享 收藏
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo Xie, Stanley C.; Tai, Chia-Wei; Morton, Craig J.; Ma, Liting; Huang, Shih-Chung; Wittlin, Sergio; Du, Yawei; Hu, Yongbo; Dogovski, Con; Salimimarand, Mina; Griffin, Robert; England, Dylan; de la Cruz, Elisa; Deni, Ioanna; Yeo, Tomas; Burkhard, Anna Y.; Striepen, Josefine; Schindler, Kyra A.; Crespo, Benigno; Gamo, Francisco J.; Khandokar, Yogesh; Hutton, Craig A.; Rabie, Tayla; Birkholtz, Lyn-Marie; Famodimu, Mufuliat T.; Delves, Michael J.; Bolsher, Judith; Koolen, Karin M. J.; van der Laak, Rianne; Aguiar, Anna C. C.; Pereira, Dhelio B.; Guido, Rafael V. C.; Creek, Darren J.; Fidock, David A.; Dick, Lawrence R.; Brand, Stephen L.; Gould, Alexandra E.; Langston, Steven; Griffin, Michael D. W.; Tilley, Leann 分享 收藏
Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome Deni, Ioanna; Stokes, Barbara H.; Ward, Kurt E.; Fairhurst, Kate J.; Pasaje, Charisse Flerida A.; Yeo, Tomas; Akbar, Shirin; Park, Heekuk; Muir, Ryan; Bick, Daniella S.; Zhan, Wenhu; Zhang, Hao; Liu, Yi Jing; Ng, Caroline L.; Kirkman, Laura A.; Almaliti, Jehad; Gould, Alexandra E.; Duffey, Maelle; O'Donoghue, Anthony J.; Uhlemann, Anne-Catrin; Niles, Jacquin C.; da Fonseca, Paula C. A.; Gerwick, William H.; Lin, Gang; Bogyo, Matthew; Fidock, David A. 分享 收藏
分享 收藏
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors 乌干达恶性疟原虫分离株对蛋白酶体抑制剂的敏感性 Garg, Shreeya; Kreutzfeld, Oriana; Chelebieva, Sevil; Tumwebaze, Patrick K.; Byaruhanga, Oswald; Okitwi, Martin; Orena, Stephen; Katairo, Thomas; Nsobya, Samuel L.; Conrad, Melissa D.; Aydemir, Ozkan; Legac, Jennifer; Gould, Alexandra E.; Bayles, Brett R.; Bailey, Jeffrey A.; Duffey, Maelle; Lin, Gang; Kirkman, Laura A.; Cooper, Roland A.; Rosenthal, Philip J. 分享 收藏
Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome 设计具有体内抗恶性疟原虫的口服功效和对人蛋白酶体的选择性的蛋白酶体抑制剂 Xie, Stanley C.; Metcalfe, Riley D.; Mizutani, Hirotake; Puhalovich, Tanya; Hanssen, Eric; Morton, Craig J.; Du, Yawei; Dogovski, Con; Huang, Shih-Chung; Ciavarri, Jeffrey; Hales, Paul; Griffin, Robert J.; Cohen, Lawrence H.; Chuang, Bei-Ching; Wittlin, Sergio; Deni, Ioanna; Yeo, Tomas; Ward, Kurt E.; Barry, Daniel C.; Liu, Boyin; Gillett, David L.; Crespo-Fernandez, Benigno F.; Ottilie, Sabine; Mittal, Nimisha; Churchyard, Alisje; Ferguson, Daniel; Aguiar, Anna Caroline C.; Guido, Rafael V. C.; Baum, Jake; Hanson, Kirsten K.; Winzeler, Elizabeth A.; Gamo, Francisco-Javier; Fidock, David A.; Baud, Delphine; Parker, Michael W.; Brand, Stephen; Dick, Lawrence R.; Griffin, Michael D. W.; Gould, Alexandra E.; Tilley, Leann 分享 收藏
Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route Vyskocil, Stepan; Cardin, David; Ciavarri, Jeffrey; Conlon, Joe; Cullis, Courtney; England, Dylan; Gershman, Rachel; Gigstad, Kenneth; Gipson, Krista; Gould, Alexandra; Greenspan, Paul; Griffin, Robert; Gulavita, Nanda; Harrison, Sean; Hu, Zhigen; Hu, Yongbo; Hata, Akito; Huang, Jian; Huang, Shih-Chung; Janowick, Dave; Jones, Matthew; Kolev, Vihren; Langston, Steven P.; Lee, Hong Myung; Li, Gang; Lok, David; Ma, Liting; Mai, Doanh; Malley, Jenna; Matsuda, Atsushi; Mizutani, Hirotake; Mizutani, Miho; Molchanova, Nina; Nunes, Elise; Pusalkar, Sandeep; Renou, Christelle; Rowland, Scott; Sato, Yosuke; Shaw, Michael; Shen, Luhua; Shi, Zhan; Skene, Robert; Soucy, Francois; Stroud, Steve; Xu, He; Xu, Tianlin; Abu-Yousif, Adnan O.; Zhang, Ji 分享 收藏
Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non-Small Cell Lung Cancer Gonzalvez, Francois; Vincent, Sylvie; Baker, Theresa E.; Gould, Alexandra E.; Li, Shuai; Wardwell, Scott D.; Nadworny, Sara; Ning, Yaoyu; Zhang, Sen; Huang, Wei-Sheng; Hu, Yongbo; Li, Feng; Greenfield, Matthew T.; Zech, Stephan G.; Das, Biplab; Narasimhan, Narayana, I; Clackson, Tim; Dalgarno, David; Shakespeare, William C.; Fitzgerald, Michael; Chouitar, Johara; Griffin, Robert J.; Liu, Shengwu; Wong, Kwok-Kin; Zhu, Xiaotian; Rivera, Victor M. 分享 收藏
Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors 吡唑并嘧啶氨基磺酸盐作为ATG7抑制剂的发现和优化 Huang, Shih-Chung; Adhikari, Sharmila; Brownell, James E.; Calderwood, Emily F.; Chouitar, Jouhara; D'Amore, Natalie Roy; England, Dylan B.; Foley, Klaudia; Harrison, Sean J.; LeRoy, Patrick J.; Lok, David; Lublinsky, Anna; Ma, Li-Ting; Menon, Saurabh; Yang, Yu; Zhang, Ji; Gould, Alexandra E. 分享 收藏
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome Xie, Stanley C.; Gillett, David L.; Spillman, Natalie J.; Tsu, Christopher; Luth, Madeline R.; Ottilie, Sabine; Duffy, Sandra; Gould, Alexandra E.; Hales, Paul; Seager, Benjamin A.; Charron, Carlie L.; Bruzzese, Frank; Yang, Xiaofeng; Zhao, Xiansi; Huang, Shih-Chung; Hutton, Craig A.; Burrows, Jeremy N.; Winzeler, Elizabeth A.; Avery, Vicky M.; Dick, Lawrence R.; Tilley, Leann 分享 收藏
Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway Gavin, James M.; Hoar, Kara; Xu, Qing; Ma, Jingya; Lin, Yafang; Chen, Jiejin; Chen, Wei; Bruzzese, Frank J.; Harrison, Sean; Mallender, William D.; Bump, Nancy J.; Sintchak, Michael D.; Bence, Neil F.; Li, Ping; Dick, Lawrence R.; Gould, Alexandra E.; Chen, Jesse J. 分享 收藏
Potent Histone Deacetylase Inhibitors Derived from 4-(Aminomethyl)-N-hydroxybenzamide with High Selectivity for the HDAC6 Isoform Blackburn, Christopher; Barrett, Cynthia; Chin, Janice; Garcia, Kris; Gigstad, Kenneth; Gould, Alexandra; Gutierrez, Juan; Harrison, Sean; Hoar, Kara; Lynch, Chrissie; Rowland, R. Scott; Tsu, Chris; Ringeling, John; Xu, He 分享 收藏
Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6 Gavin, James M.; Chen, Jesse J.; Liao, Hua; Rollins, Neil; Yang, Xiaofeng; Xu, Qing; Ma, Jingya; Loke, Huay-Keng; Lingaraj, Trupti; Brownell, James E.; Mallender, William D.; Gould, Alexandra E.; Amidon, Benjamin S.; Dick, Lawrence R. 分享 收藏
Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors Gould, Alexandra E.; Adams, Ruth; Adhikari, Sharmila; Aertgeerts, Kathleen; Afroze, Roushan; Blackburn, Christopher; Calderwood, Emily F.; Chau, Ryan; Chouitar, Jouhara; Duffey, Matthew O.; England, Dylan B.; Farrer, Cheryl; Forsyth, Nancy; Garcia, Khristofer; Gaulin, Jeffery; Greenspan, Paul D.; Guo, Ribo; Harrison, Sean J.; Huan, Shih-Chung; Iartchouk, Natalia; Janowick, Dave; Kim, Mi-Sook; Kulkarni, Bheemashankar; Langston, Steven P.; Liu, Jane X.; Ma, Li-Ting; Menon, Saurabh; Mizutani, Hirotake; Paske, Erin; Renou, Christelle C.; Rezaei, Mansoureh; Rowland, R. Scott; Sintchak, Michael D.; Smith, Michael D.; Stroud, Stephen G.; Tregay, Ming; Tian, Yuan; Veiby, Ole P.; Vos, Tricia J.; Vyskocil, Stepan; Williams, Juliet; Xu, Tianlin; Yang, Johnny J.; Yano, Jason; Zeng, Hongbo; Zhang, Dong Mei; Zhang, Qin; Galvin, Katherine M. 分享 收藏
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors Dales, NA; Gould, AE; Brown, JA; Calderwood, EF; Guan, B; Minor, CA; Gavin, JM; Hales, P; Kaushik, VK; Stewart, M; Tummino, PJ; Vickers, CS; Ocain, TD; Patane, MA 分享 收藏
分享 收藏
分享 收藏
分享 收藏
(+)-trienomycins A, B, C, and F and (+)-mycotrienins I and II: Relative and absolute stereochemistry Smith, AB; Wood, JL; Wong, W; Gould, AE; Rizzo, CJ; Barbosa, J; Komiyama, K; Omura, S 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
