Mark E. Haskins - Publications, H-index & Citations

Mark E. Haskins

university of pennsylvania

52H指数

488论文数

9.4K被引数

收录论文 105

发表时间

Progression of vertebral bone disease in mucopolysaccharidosis VII dogs from birth to skeletal maturity

MOLECULAR GENETICS AND METABOLISM

IF3.5

2021-08-01

OAAI

Peck, Sun H.; Lau, Yian Khai; Kang, Jennifer L.; Lin, Megan; Arginteanu, Toren; Matalon, Dena R.; Bendigo, Justin R.; O'Donnell, Patricia; Haskins, Mark E.; Casal, Margret L.; Smith, Lachlan J.

Molecular profiling of failed endochondral ossification in mucopolysaccharidosis VII

BONE

IF3.6

2019-11-01

OAAI

Peck, Sun H.; Tobias, John W.; Shore, Eileen M.; Malhotra, Neil R.; Haskins, Mark E.; Casal, Margret L.; Smith, Lachlan J.

Preclinical development of a platform for enzyme therapy in the CNS of MPS I and MPS II patients based on intrathecal AAV delivery

MOLECULAR GENETICS AND METABOLISM

IF3.5

2018-02-01

PREAI

Hinderer, Christian; Hordeaux, Juliette; Katz, Nathan; Bell, Peter; Goode, Tamara; Haskins, Mark E.; Wilson, James M.

Treatment of brain disease in the mucopolysaccharidoses

MOLECULAR GENETICS AND METABOLISM

IF3.5

2017-12-01

OAAI

Scarpa, Maurizio; Orchard, Paul J.; Schulz, Angela; Dickson, Patricia I.; Haskins, Mark E.; Escolar, Maria L.; Giugliani, Roberto

Neonatal tolerance induction enables accurate evaluation of gene therapy for MPS I in a canine model

MOLECULAR GENETICS AND METABOLISM

IF3.5

2016-09-01

OAAI

Hinderer, Christian; Bell, Peter; Louboutin, Jean-Pierre; Katz, Nathan; Zhu, Yanqing; Lin, Gloria; Choa, Ruth; Bagel, Jessica; O'Donnell, Patricia; Fitzgerald, Caitlin A.; Langan, Therese; Wang, Ping; Casal, Margret L.; Haskins, Mark E.; Wilson, James M.

Urinary glycosaminoglycan concentration as a biomarker for effectiveness of enzyme replacement and gene therapy in large animal models of mucopolysaccharidoses

MOLECULAR GENETICS AND METABOLISM

IF3.5

2016-02-01

PREAI

Casal, Margret L.; Wang, Ping; ODonnell, Patricia A.; Sikora, Tracey; Langan, Therese; O'Malley, Thomas; Ferla, Rita; Auricchio, Alberto; Wilson, James M.; Gao, Guangping; Ponder, Katherine; Haskins, Mark E.

Cathepsin-mediated alterations in TGF-beta related signaling underlie the cartilage and bone defects associated with impaired lysosomal targeting

MOLECULAR GENETICS AND METABOLISM

IF3.5

2016-02-01

PREAI

Steet, Richard; Flanagan-Steet, Heather; Aarnio, Megan; Kwan, Brian; Guihard, Pierre; Petrey, Aaron; Haskins, Mark; Blanchard, Frederic

Pharmacodynamics, pharmacokinetics and biodistribution of recombinant human N-acetylgalactosamine 4-sulfatase after 6 months of therapy in cats using different IV infusion durations

MOLECULAR GENETICS AND METABOLISM

IF3.5

2016-02-01

OAAI

Ruane, Therese; Haskins, Mark; Cheng, Alphonsus; Wang, Ping; Aguirre, Gustavo; Knox, Van W. (Rafe); Qi, Yulan; Tompkins, Troy; O'Neill, Charles A.

Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII

MOLECULAR THERAPY

IF12

2016-02-01

OAAI

Gurda, Brittney L.; De Lataillade, Adrien De Guilhem; Bell, Peter; Zhu, Yanqing; Yu, Hongwei; Wang, Ping; Bagel, Jessica; Vite, Charles H.; Sikora, Tracey; Hinderer, Christian; Calcedo, Roberto; Yox, Alexander D.; Steet, Richard A.; Ruane, Therese; O'Donnell, Patricia; Gao, Guangping; Wilson, James M.; Casal, Margret; Ponder, Katherine P.; Haskins, Mark E.

Delayed hypertrophic differentiation of epiphyseal chondrocytes contributes to failed secondary ossification in mucopolysaccharidosis VII dogs

MOLECULAR GENETICS AND METABOLISM

IF3.5

2015-11-01

OAAI

Peck, Sun H.; O'Donnell, Philip J. M.; Kang, Jennifer L.; Malhotra, Neil R.; Dodge, George R.; Pacifici, Maurizio; Shore, Eileen M.; Haskins, Mark E.; Smith, Lachlan J.

Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting

JOURNAL OF BONE AND MINERAL RESEARCH

IF5.9

2015-09-25

OAAI

Flanagan-Steet, Heather; Aarnio, Megan; Kwan, Brian; Guihard, Pierre; Petrey, Aaron; Haskins, Mark; Blanchard, Frederic; Steet, Richard

Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates

MOLECULAR THERAPY

IF12

2015-08-01

OAAI

Hinderer, Christian; Bell, Peter; Louboutin, Jean-Pierre; Zhu, Yanqing; Yu, Hongwei; Lin, Gloria; Choa, Ruth; Gurda, Brittney L.; Bagel, Jessica; O'Donnell, Patricia; Sikora, Tracey; Ruane, Therese; Wang, Ping; Tarantal, Alice F.; Casal, Margret L.; Haskins, Mark E.; Wilson, James M.

What managers should never want to hear: silence

MANAGEMENT DECISION

IF5.1

2015-07-13

PREAI

Haskins, Mark E.; Freeman, R. Edward

Evaluating the impact of systemic AAV9.cIDUA administration on brain pathology in MPS I dogs

MOLECULAR GENETICS AND METABOLISM

IF3.5

2015-02-01

PREAI

Bell, Peter; Gurda, Brittney L.; Zhu, Yanqing; Sikora, Tracey; Ruane, Therese; O'Donnell, Patricia; Haskins, Mark E.; Wilson, James M.

Pentosan polysulfate: New mechanistic insights and treatment of the mucopolysaccharidoses

MOLECULAR GENETICS AND METABOLISM

IF3.5

2015-02-01

PREAI

Simonaro, Calogera M.; Tomatsu, Shunji; Ge, Yi; Meng, Fanli; Frohbergh, Michael; Haskins, Mark E.; Ruane, Therese; Wang, Raymond Y.; Vera, Moin; Solyom, Alexander; Schuchman, Edward H.

Intrathecal injection of lentiviral vector results in high expression in the brain of mucopolysaccharidosis VII dogs but the pattern of expression is different than for AAV9 or AAV-rh10

MOLECULAR GENETICS AND METABOLISM

IF3.5

2015-02-01

PREAI

Ponder, Katherine; Kobayashi, Hiroshi; Ohashi, Toya; Izuka, Sayoko; Bell, Peter; Gurda, Brittney; Wilson, James; Casal, Margaret; Haskins, Mark

Failed vertebral bone formation in mucopolysaccharidosis VII dogs is associated with impaired chondrocyte hypertrophic differentiation

MOLECULAR GENETICS AND METABOLISM

IF3.5

2015-02-01

PREAI

Peck, Sun H.; O'Donnell, Philip J. M.; Shore, Eileen M.; Pacifici, Maurizio; Haskins, Mark E.; Malhotra, Neil R.; Smith, Lachlan J.

Adeno-associated virus vector-mediated gene therapy can effectively treat CNS and cardiac lesions and induce immune tolerance to the therapeutic enzyme in large animal models of mucopolysaccharidosis type I

MOLECULAR GENETICS AND METABOLISM

IF3.5

2015-02-01

PREAI

Wilson, James M.; Hinderer, Christian; Bell, Peter; Gurda, Brittney L.; Wang, Qiang; Louboutin, Jean-Pierre; Zhu, Yanqing; Choa, Ruth; Lin, Gloria; Bagel, Jessica; O'Donnell, Patricia; Sikora, Tracey; Ruane, Therese; Wang, Ping; Haskins, Mark E.

Intrathecal Gene Therapy Corrects CNS Pathology in a Feline Model of Mucopolysaccharidosis I

MOLECULAR THERAPY

IF12

2014-12-01

109

OAAI

Hinderer, Christian; Bell, Peter; Gurda, Brittney L.; Wang, Qiang; Louboutin, Jean-Pierre; Zhu, Yanqing; Bagel, Jessica; O'Donnell, Patricia; Sikora, Tracey; Ruane, Therese; Wang, Ping; Haskins, Mark E.; Wilson, James M.

Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2014-09-29

OAAI

研究方向