未登录 分享 收藏
Design of a stable human acid-β-glucosidase: towards improved Gaucher disease therapy and mutation classification 稳定的人酸性-β-葡萄糖苷酶的设计: 改善戈谢病的治疗和突变分类 Pokorna, Sarka; Khersonsky, Olga; Lipsh-Sokolik, Rosalie; Goldenzweig, Adi; Nielsen, Rebekka; Ashani, Yacov; Peleg, Yoav; Unger, Tamar; Albeck, Shira; Dym, Orly; Tirosh, Asa; Tarayra, Rana; Hocquemiller, Michael; Laufer, Ralph; Ben-Dor, Shifra; Silman, Israel; Sussman, Joel L. L.; Fleishman, Sarel J. J.; Futerman, Anthony H. H. 分享 收藏
分享 收藏
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice Viayna, Elisabet; Coquelle, Nicolas; Cieslikiewicz-Bouet, Monika; Cisternas, Pedro; Oliva, Carolina A.; Sanchez-Lopez, Elena; Ettcheto, Miren; Bartolini, Manuela; De Simone, Angela; Ricchini, Mattia; Rendina, Marisa; Pons, Megane; Firuzi, Omidreza; Perez, Belen; Saso, Luciano; Andrisano, Vincenza; Nachon, Florian; Brazzolotto, Xavier; Luisa Garcia, Maria; Camins, Antoni; Silman, Israel; Jean, Ludovic; Inestrosa, Nibaldo C.; Colletier, Jacques-Philippe; Renard, Pierre-Yves; Munoz-Torrero, Diego 分享 收藏
分享 收藏
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor Catto, Marco; Pisani, Leonardo; de la Mora, Eugenio; Belviso, Benny Danilo; Mangiatordi, Giuseppe Felice; Pinto, Andrea; De Palma, Annalisa; Denora, Nunzio; Caliandro, Rocco; Colletier, Jacques-Philippe; Silman, Israel; Nicolotti, Orazio; Altomare, Cosimo Damiano 分享 收藏
Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3 Oukoloff, Killian; Coquelle, Nicolas; Bartolini, Manuela; Naldi, Marina; Le Guevel, Remy; Bach, Stephane; Josselin, Beatrice; Ruchaud, Sandrine; Catto, Marco; Pisani, Leonardo; Denora, Nunzio; Lacobazzi, Rosa Maria; Silman, Israel; Sussman, Joel L.; Buron, Frederic; Colletier, Jacques-Philippe; Jean, Ludovic; Routier, Sylvain; Renard, Pierre-Yves 分享 收藏
Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model Dighe, Satish N.; De la Mora, Eugenio; Chan, Stephen; Kantham, Srinivas; McColl, Gawain; Miles, Jared A.; Veliyath, Suresh Kumar; Sreenivas, B. Yogi; Nassar, Zeyad D.; Silman, Israel; Sussman, Joel L.; Weik, Martin; McGeary, Ross P.; Parat, Marie-Odile; Brazzolotto, Xavier; Ross, Benjamin P. 分享 收藏
分享 收藏
Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase Lalut, Julien; Santoni, Gianluca; Karila, Delphine; Lecoutey, Cedric; Davis, Audrey; Nachon, Florian; Silman, Israel; Sussman, Joel; Weik, Martin; Maurice, Tangui; Dallemagne, Patrick; Rochais, Christophe 分享 收藏
分享 收藏
分享 收藏
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability (vol 63, pg 337, 2016) Goldenzweig, Adi; Goldsmith, Moshe; Hill, Shannon E.; Gertman, Or; Laurino, Paola; Ashani, Yacov; Dym, Orly; Unger, Tamar; Albeck, Shira; Prilusky, Jaime; Lieberman, Raquel L.; Aharoni, Amir; Silman, Israel; Sussman, Joel L.; Tawfik, Dan S.; Fleishman, Sarel J. 分享 收藏
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis Galdeano, Caries; Coquelle, Nicolas; Cieslikiewicz-Bouet, Monika; Bartolini, Manuela; Perez, Belen; Clos, M. Victoria; Silman, Israel; Jean, Ludovic; Colletier, Jacques-Philippe; Renard, Pierre-Yves; Munoz-Toner, Diego 分享 收藏
分享 收藏
Collagen XIII secures pre-and postsynaptic integrity of the neuromuscular synapse 胶原蛋白XIII确保神经肌肉突触的突触前和突触后完整性 Haronen, Heli; Zainul, Zarin; Tu, Hongmin; Naumenko, Nikolay; Sormunen, Raija; Miinalainen, Ilkka; Shakirzyanova, Anastasia; Oikarainen, Tuomo; Abdullin, Azat; Martin, Paula; Santoleri, Sabrina; Koistinaho, Jari; Silman, Israel; Giniatullin, Rashid; Fox, Michael A.; Heikkinen, Anne; Pihlajaniemi, Taina 分享 收藏
Automated Structure- and Sequence-Based Design of Proteins for High Bacterial Expression and Stability 基于结构和序列的蛋白质的自动化设计，以实现高细菌表达和稳定性 Goldenzweig, Adi; Goldsmith, Moshe; Hill, Shannon E.; Gertman, Or; Laurino, Paola; Ashani, Yacov; Dym, Orly; Unger, Tamar; Albeck, Shira; Prilusky, Jaime; Lieberman, Raquel L.; Aharoni, Amir; Silman, Israel; Sussman, Joel L.; Tawfik, Dan S.; Fleishman, Sarel J. 分享 收藏
分享 收藏
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis Khare, Sagar D.; Kipnis, Yakov; Greisen, Per Jr; Takeuchi, Ryo; Ashani, Yacov; Goldsmith, Moshe; Song, Yifan; Gallaher, Jasmine L.; Silman, Israel; Leader, Haim; Sussman, Joel L.; Stoddard, Barry L.; Tawfik, Dan S.; Baker, David 分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
