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Exploiting metabolic vulnerabilities of pediatric rhabdomyosarcoma with novelnicotinamide phosphoribosyltransferase (NAMPT) inhibitor OT-82 McKay-Corkum, Grace; Collins, Victor J.; Yeung, Choh; Ito, Takeshi; Issaq, Sameer H.; Mendoza, Arnulfo; Yamamoto, Kazutoshi; Cherukuri, Murali; Neckers, Len; Heske, Christine M. 分享 收藏
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Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species Sudarshan, Sunil; Sourbier, Carole; Kong, Hye-Sik; Block, Karen; Romero, Vladimir A. Valera; Yang, Youfeng; Galindo, Cynthia; Mollapour, Mehdi; Scroggins, Bradley; Goode, Norman; Lee, Min-Jung; Gourlay, Campbell W.; Trepel, Jane; Linehan, W. Marston; Neckers, Len 分享 收藏
Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8-9, 2022 van Oosten-Hawle, Patricija; Backe, Sarah J.; Ben-Zvi, Anat; Bourboulia, Dimitra; Brancaccio, Mara; Brodsky, Jeff; Clark, Melody; Colombo, Giorgio; Cox, Marc B.; de los Rios, Paolo; Echtenkamp, Frank; Edkins, Adrienne; Freeman, Brian; Goloubinoff, Pierre; Houry, Walid; Johnson, Jill; LaPointe, Paul; Li, Wei; Mezger, Valerie; Neckers, Len; Nillegoda, Nadinath B.; Prahlad, Veena; Reitzel, Adam; Scherz-Shouval, Ruth; Sistonen, Lea; Tsai, Francis T. F.; Woodford, Mark R.; Mollapour, Mehdi; Truman, Andrew W. 分享 收藏
Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-Time Monitoring of Pyruvate Metabolic Fluxes in Vivo and Targeting Intratumor Metabolic Plasticity with Small Molecules Oshima, Nobu; Aisu, Yuki; Ishida, Ryo; Kishimoto, Shun; Hisamori, Shigeo; Tsunoda, Shigeru; Kaihara, Satoshi; Obama, Kazutaka; Krishna, Murali C.; Neckers, Len 分享 收藏
Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma Pahwa, Roma; Dubhashi, Janhavi; Singh, Anand; Jailwala, Parthav; Lobanov, Alexei; Thomas, Craig J.; Ceribelli, Michele; Wilson, Kelli; Ricketts, Christopher J.; Vocke, Cathy D.; Wells, Catherine; Bottaro, Donald P.; Linehan, W. Marston; Neckers, Len; Srinivasan, Ramaprasad 分享 收藏
Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer Shkedi, Arielle; Taylor, Isabelle R.; Echtenkamp, Frank; Ramkumar, Poornima; Alshalalfa, Mohamed; Rivera-Marquez, Genesis M.; Moses, Michael A.; Shao, Hao; Karnes, Robert Jeffrey; Neckers, Len; Feng, Felix; Kampmann, Martin; Gestwicki, Jason E. 分享 收藏
HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts Pipalia, Nina H.; Saad, Syed Z.; Subramanian, Kanagaraj; Cross, Abigail; Al-Motawa, Aisha; Garg, Kunal; Blagg, Brian S. J.; Neckers, Len; Helquist, Paul; Wiest, Olaf; Ory, Daniel S.; Maxfield, Frederick R. 分享 收藏
Proteasome inhibition disrupts the metabolism of fumarate hydratase-deficient tumors by downregulating p62 and c-Myc Sourbier, Carole; Ricketts, Christopher J.; Liao, Pei-Jyun; Matsumoto, Shingo; Wei, Darmood; Lang, Martin; Railkar, Reema; Yang, Youfeng; Wei, Ming-Hui; Agarwal, Piyush; Krishna, Murali; Mitchell, James B.; Trepel, Jane B.; Neckers, Len; Linehan, W. Marston 分享 收藏
Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 Xu, Wanping; Beebe, Kristin; Chavez, Juan D.; Boysen, Marta; Lu, YinYing; Zuehlke, Abbey D.; Keramisanou, Dimitra; Trepel, Jane B.; Prodromou, Christosomos; Mayer, Matthias P.; Bruce, James E.; Gelis, Ioannis; Neckers, Len 分享 收藏
The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis Baechler, S. A.; Factor, V. M.; Dalla Rosa, I; Ravji, A.; Becker, D.; Khiati, S.; Jenkins, L. M. Miller; Lang, M.; Sourbier, C.; Michaels, S. A.; Neckers, L. M.; Zhang, H. L.; Spinazzola, A.; Huang, S. N.; Marquardt, J. U.; Pommier, Y. 分享 收藏
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Evaluation of LDH inhibition as a treatment strategy in Ewing sarcoma Heske, Christine M.; Gibson, Anna E.; Baumgart, Josh T.; Yeung, Choh; Issaq, Sameer H.; Mendoza, A.; Johnson, Michelle S.; Squadrito, Guiseppe L.; Culp, Lillian; Darley-Usmar, Victor M.; Neckers, Len M. 分享 收藏
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HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation Tigue, Megan L.; Kijima, Toshiki; Prince, Thomas L.; Yim, Kendrick H.; Schwartz, Harvey; Beebe, Kristin; Lee, Sunmin; Budzynski, Marek A.; Williams, Heinric; Trepel, Jane B.; Sistonen, Lea; Calderwood, Stuart; Neckers, Len 分享 收藏
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