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First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase I dose exploration5 MTAP缺失的实体瘤患者中MTA合作PRMT5抑制剂AMG 193的首次人体研究: I期剂量探索的结果5 Rodon, J.; Prenen, H.; Sacher, A.; Villalona-Calero, M.; Penel, N.; El Helali, A.; Rottey, S.; Yamamoto, N.; Ghiringhelli, F.; Goebeler, M. E.; Doi, T.; Postel-Vinay, S.; Lin, C. -c.; Liu, C.; Chuang, C. -h.; Keyvanjah, K.; Eggert, T.; Neil, B. h. o ' 分享 收藏
Type II RAF inhibitor tovorafenib in recurrent/refractory (R/R) melanoma or other solid tumors with RAF fusions and/or RAF1 amplification Type II RAF抑制剂tovorafenib在复发/难治性（R/R）黑色素瘤或其他具有RAF融合和/或RAF1扩增的实体瘤中的应用 Vieito, M.; Garralda, E.; Mehmi, I.; Marqueste, C. Gaudy; O'Neil, B. H.; Medina, T. M.; Body, A.; Arance, A. M.; Kummar, S.; Najjar, Y. G.; Bedard, P. L.; Chu, C.; McKenna, C.; Hume, S.; Kopp, L. M.; Lee, J. 分享 收藏
Impact of AI clinical trial program on screening, matching, and enrollment of patients over 6 months 人工智能临床试验项目对6个月内患者筛查、匹配和入组的影响 Shepard, D.; Mallahan, S.; Osterman, C.; Skelly, D.; Patnaude, E.; Weiss, M.; O'Neil, B. H.; Rao, A.; Abdulla, N. E.; Zarzour, A.; Sankhala, K. Kumar; Goldstein, M. G.; Parsons, B.; La Porte, P.; Franzen, A. G.; Cohen, E.; Cooney, M. 分享 收藏
Phase II results of the porcupine (PORCN) inhibitor zamaporvint (RXC004) in genetically selected microsatellite stable colorectal cancer patients Cook, N.; Bridgewater, J. A.; Saunders, M. P.; Kopetz, S.; Garcia-Carbonero, R.; Beom, S-H.; O'Neil, B. H.; Wilson, R. H.; Graham, J.; Maurel, J.; Kim, T. W.; Chau, I.; Saleha, S.; Goodwin, L.; Wilson, D.; Robertson, J.; Timmis, H.; Asken, E.; Woodcock, S. A.; Morris, V. 分享 收藏
Common variation in a long non-coding RNA gene modulates variation of circulating TGF-β2 levels in metastatic colorectal cancer patients (Alliance) 长链非编码RNA基因的常见变异调节转移性结直肠癌患者循环TGF-β2水平的变化 (联盟) Quintanilha, Julia C. F.; Sibley, Alexander B.; Liu, Yingmiao; Niedzwiecki, Donna; Halabi, Susan; Rogers, Layne; O'Neil, Bert; Kindler, Hedy; Kelly, William; Venook, Alan; McLeod, Howard L.; Ratain, Mark J.; Nixon, Andrew B.; Innocenti, Federico; Owzar, Kouros 分享 收藏
A first-inhuman study of the highly selective PI3Ka inhibitor RLY-5836 in patients with advanced breast cancer and other solid tumors Varkaris, Andreas; Isakoff, Steven; Perez, Cesar A.; O'Neil, Bert; Hamilton, Erika; Conlin, Erin; Tan, Gege; Li, Xiaoyan; Timm, Alison; Samadani, Ramin; Puente-Poushnejad, Erika; Kwak, Eunice; Mar, Brenton G.; Schram, Alison M. 分享 收藏
A meta-analysis of efficacy and safety data from head-to-head first-line trials of epidermal growth factor receptor inhibitors versus bevacizumab in adult patients with RAS wild-type metastatic colorectal cancer by sidedness 来自表皮生长因子受体抑制剂与贝伐单抗在RAS野生型转移性结直肠癌成年患者中的头对头一线试验的疗效和安全性数据的荟萃分析 Yoshino, Takayuki; Hooda, Naushin; Younan, Diana; Muro, Kei; Shitara, Kohei; Heinemann, Volker; O'neil, Bert Howard; Herrero, Fernando Rivera; Peeters, Marc; Soeda, Junpei; Suh, Mina; Reichert, Heidi; Mezzi, Khalid; Fryzek, Jon; Chia, Victoria; Rehn, Marko; Stintzing, Sebastian 分享 收藏
Initial results from first-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in biomarker-selected solid tumors Rodon, Jordi; Yamamoto, Noboru; Doi, Toshihiko; Ghiringhelli, Francois; Goebeler, Maria-Elisabeth; Fujuwara, Yutaka; Villalona-Calero, Miguel; Penel, Nicolas; Patnaik, Amita; Machiels, Jean-Pascal; Addeo, Alfredo; Abbruzzese, James; Postel-Vinay, Sophie; Rottey, Sylvie; Liu, Chunxu; Chuang, Chen-Hua; Kormany, William; Hughes, Paul; Keyvanjah, Kiana; O'Neil, Bert 分享 收藏
A meta-analysis of efficacy and safety from head-to-head first-line (1L) trials of epidermal growth factor receptor inhibitors (EGFRIs) versus bevacizumab in combination with chemotherapy (CT) doublets in patients with RAS wild-type (WT) metastatic colorectal cancer (mCRC) by sidedness Yoshino, T.; Hooda, N.; Younan, D.; Muro, K.; Shitara, K.; Heinemann, V.; O'Neil, B.; Herrero, F. Rivera; Peeters, M.; Soeda, J.; Suh, M.; Reichart, H.; Mezzi, K.; Fryzek, J.; Chia, V.; Rehn, M.; Stintzing, S. 分享 收藏
First-in-human study of SGN-B7H4V, a B7-H4-directed vedotin ADC, in patients with advanced solid tumors: Preliminary results of a phase I study (SGNB7H4V-001) Perez, C. A.; Henry, J. T.; Lakhani, N.; Call, J. A.; Hamilton, E. P.; Colon-Otero, G.; Diamond, J. R.; O'Neil, B.; Kalyan, A.; Sonpavde, G. P.; Candilejo, I. Moreno; Awan, A. A.; Fontana, E.; Xu, P.; Zhang, F.; Nazarenko, N.; Patnaik, A. 分享 收藏
Phase II randomised, double-blind study of mFOLFIRINOX plus ramucirumab versus mFOLFIRINOX plus placebo in advanced pancreatic cancer patients (HCRN GI14-198) Shaib, Walid L.; Manali, Rupji; Liu, Yuan; El-Rayes, Bassel; Loehrer, Patrick; O'Neil, Bert; Cohen, Steven; Khair, Tina; Robin, Erwin; Huyck, Timothy; Bekaii-Saab, Tanios 分享 收藏
Pembrolizumab for previously treated, microsatellite instability-high/mismatch repair-deficient advanced colorectal cancer: final analysis of KEYNOTE-164 Pembrolizumab用于先前治疗的微卫星不稳定性高/错配修复缺陷的晚期结直肠癌: KEYNOTE-164的最终分析 Le, Dung T.; Diaz Jr, Luis A.; Kim, Tae Won; Van Cutsem, Eric; Geva, Ravit; Jaeger, Dirk; Hara, Hiroki; Burge, Matthew; O'Neil, Bert H.; Kavan, Petr; Yoshino, Takayuki; Guimbaud, Rosine; Taniguchi, Hiroya; Elez, Elena; Al-Batran, Salah-Eddin; Boland, Patrick M.; Cui, Yi; Leconte, Pierre; Marinello, Patricia; Andre, Thierry 分享 收藏
Age and comorbidity association with survival outcomes in metastatic colorectal cancer: CALGB 80405 analysis McCleary, Nadine J.; Zhang, Sui; Ma, Chao; Ou, Fang-Shu; Bainter, Tiffany M.; Venook, Alan P.; Niedzwiecki, Donna; Lenz, Heinz-Josef; Innocenti, Federico; O'Neil, Bert H.; Polite, Blase N.; Hochster, Howard S.; Atkins, James N.; Goldberg, Richard M.; Ng, Kimmie; Mayer, Robert J.; Blanke, Charles D.; O'Reilly, Eileen M.; Fuchs, Charles S.; Meyerhardt, Jeffrey A. 分享 收藏
A phase I evaluation of the effect of curcumin on dose-limiting toxicity and pharmacokinetics of irinotecan in participants with solid tumors Gbolahan, Olumide B.; O'Neil, Bert H.; McRee, Autumn J.; Sanoff, Hanna K.; Fallon, John K.; Smith, Philip C.; Ivanova, Anastasia; Moore, Dominic T.; Dumond, Julie; Asher, Gary N. 分享 收藏
BRE12-158: A post-neoadjuvant, randomized phase 2 trial of personalized therapy vs. treatment of physician's choice for patients with residual triple negative breast cancer Schneider, Bryan P.; Jiang, Guanglong; Ballinger, Tarah J.; Shen, Fei; Chitambar, Christopher; Nanda, Rita; Falkson, Carla; Lynce, Filipa C.; Gallagher, Christopher; Isaacs, Claudine; Blaya, Marcelo; Paplomata, Elisavet; Walling, Radhika; Daily, Karen; Mahtani, Reshma; Thompson, Michael A.; Graham, Robert; Cooper, Maureen E.; Pavlick, Dean C.; Albacker, Lee A.; Gregg, Jeffery; Solzak, Jeffery P.; Chen, Yu-Hsiang; Bales, Casey L.; Cantor, Erica; Hancock, Bradley A.; Kassem, Nawal; Helft, Paul; O'Neil, Bert; Storniolo, Anna Maria; Badve, Sunil; Miller, Kathy D.; Radovich, Milan 分享 收藏
Pembrolizumab (pembro) for previously treated, microsatellite instabilityehigh (MSI-H)/mismatch repair-deficient (dMMR) metastatic colorectal cancer (mCRC): Final analysis of KEYNOTE-164 Le, D. T.; Diaz, L.; Kim, T. W.; Van Cutsem, E.; Geva, R.; Jager, D.; Hara, H.; Burge, M.; O'Neil, B.; Kavan, P.; Yoshino, T.; Guimbaud, R.; Taniguchi, H.; Elez, E.; Al-Batran, S-E.; Boland, P.; Cui, Y.; Leconte, P.; Marinello, P.; Andre, T. 分享 收藏
A Phase I Study of an IDO-1 Inhibitor (LY3381916) as Monotherapy and in Combination With an Anti-PD-L1 Antibody (LY3300054) in Patients With Advanced Cancer IDO-1抑制剂 (LY3381916) 作为单一疗法并与Anti-PD-L1抗体 (LY3300054) 联合用于晚期癌症患者的I期研究 Kotecki, Nuria; Vuagnat, Perrine; O'Neil, Bert H.; Jalal, Shadia; Rottey, Sylvie; Prenen, Hans; Benhadji, Karim A.; Xia, Meng; Szpurka, Anna M.; Saha, Abhijoy; Wallin, Johan; Suriyapperuma, Subha; Galvao, Violeta R.; Geeganage, Sandaruwan; Doman, Thompson N.; Gandhi, Leena; Xu, Xiaojian; Bendell, Johanna 分享 收藏
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