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M

Monika Raab

Goethe University

H指数:25

被引数:2,226

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Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

通过mRNA脂质体靶向再激活新型肿瘤抑制因子DAPK1（p53的上游调节因子），在高级别浆液性卵巢癌中可降低预临床试验模型的细胞活力并增强药物敏感性。

Cancer Communications

IF24.9

2025-05-200

OAAI

Targeting polo-like kinase 1: advancements and future directions in anti-cancer drug discovery

靶向polo样激酶1: 抗癌药物发现的进展和未来方向

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2024-07-291

OA

Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-2092

OAAI

The Role of DAPK1 in the Cell Cycle Regulation of Cervical Cancer Cells and in Response to Topotecan

JOURNAL OF CANCER

IF3.2

2022-01-018

OAAI

PLK1-dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV-infected mice

PLK1-dependent磷酸化抑制EBV感染小鼠的EBNA2活性和淋巴瘤发生

IF6.2

2021-10-045

OA

Non-mitotic functions of polo-like kinases in cancer cells

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

IF8.3

2021-01-0159

PREAI

The Prognostic Relevance of the Proliferation Markers Ki-67 and Plk1 in Early-Stage Ovarian Cancer Patients With Serous, Low-Grade Carcinoma Based on mRNA and Protein Expression

FRONTIERS IN ONCOLOGY

IF3.3

2020-10-0719

OAAI

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

NATURE COMMUNICATIONS

IF15.7

2019-10-2216

OAAI

Immune adaptor SKAP1 acts a scaffold for Polo-like kinase 1 (PLK1) for the optimal cell cycling of T-cells

SCIENTIFIC REPORTS

IF3.9

2019-07-1819

OAAI

Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability

IF7.7

2019-04-0129

OAAI

Modulation of the Allosteric Communication between the Polo-Box Domain and the Catalytic Domain in Plk1 by Small Compounds

ACS CHEMICAL BIOLOGY

IF3.8

2018-06-2117

OAAI

PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells

NATURE COMMUNICATIONS

IF15.7

2018-03-1644

OAAI

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

NATURE COMMUNICATIONS

IF15.7

2017-07-1231

OAAI

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

IF25.9

2016-06-2135

OAAI

Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells

ACS CHEMICAL BIOLOGY

IF3.8

2015-08-2759

PREAI

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1

MOLECULAR ONCOLOGY

IF4.5

2014-08-1147

OAAI

Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells

IF25.9

2014-07-0120

OAAI

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis

MOLECULAR ONCOLOGY

IF4.5

2014-01-1759

OAAI

SKAP1 Protein PH Domain Determines RapL Membrane Localization and Rap1 Protein Complex Formation for T Cell Receptor (TCR) Activation of LFA-1

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2011-08-0138

OAAI

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

NATURE COMMUNICATIONS

IF15.7

2011-07-1978

OAAI