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W

William L. Dewey

Virginia Commonwealth University

52H指数
378论文数
9.5K被引数
收录论文 78
发表时间
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Structural Determinants of μ-Opioid Receptor Antagonism and Respiratory Liability in Phenylfentanyl Analogues苯基哌替啶类似物中μ-阿片受体拮抗作用和呼吸副作用的结构决定因素
errACS Chemical Neuroscience
IF3.9
err2026-04-30
err0
errOAAI
errEnnian Li; Balaji S. Kale; Abeje A. Silte; Rui Lyu; Neha Upadhyay; Logan T. Neel; Ahmed Reda; Huiqun Wang; William L. Dewey; Piyusha P. Pagare; Yan Zhang
err分享
err收藏
Investigating the Landscape of C6-Azaindole Side Chain on the Epoxymorphinan Skeleton via the Nitrogen Walk Concept: A Strategy to Enhance Drug-Like Properties
errJournal of Medicinal Chemistry
IF6.8
err2026-01-22
err0
errOAAI
errLogan Neel; Hongguang Ma; Ahmed Reda; Mengchu Li; Rachael Flammia; Samuel Woodard; James C. Gillespie; Dana E. Selley; William L. Dewey; Piyusha P. Pagare; Yan Zhang
err分享
err收藏
Design, Syntheses, and Pharmacological Evaluations of Core Ring Expanded Fentanyl Analogues as Potential Counteracting Agents Against Fentanyl Induced Respiratory Depression
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2025-11-01
err0
PREAI
errSilte, Abeje A.; Li, Ennian; Kale, Balaji S.; Neel, Logan; Upadhyay, Neha; Flammia, Rachael; Lyu, Rui; St Onge, Celsey M.; Reda, Ahmed; Woodard, Samuel; Gillespie, James C.; Kim, Daniel; Selley, Dana E.; Dewey, William L.; Pagare, Piyusha P.; Zhang, Yan
err分享
err收藏
Exploring substitution effects on the potential dominant conformations of NBF derivatives leading to functional conversion at the mu opioid receptor探索NBF衍生物在μ阿片受体上引起功能转化的潜在主导构象的替代效应
errRSC CHEMICAL BIOLOGY
IF3.1
err2025-01-01
err0
errOAAI
errLi, Ennian; Reda, Ahmed; Ma, Hongguang; Woodard, Samuel; Gillespie, James C.; Selley, Dana E.; Dewey, William L.; Pagare, Piyusha P.; Zhang, Yan
err分享
err收藏
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-05-30
err1
errOAAI
errSt. Onge, Celsey M.; Pagare, Piyusha P.; Zheng, Yi; Arriaga, Michelle; Stevens, David L.; Mendez, Rolando E.; Poklis, Justin L.; Halquist, Matthew S.; Selley, Dana E.; Dewey, William L.; Banks, Matthew L.; Zhang, Yan
err分享
err收藏
The role of morphine- and fentanyl-induced impairment of intestinal epithelial antibacterial activity in dysbiosis and its impact on the microbiota-gut-brain axis
errFASEB JOURNAL
IF4.2
err2024-04-22
err4
errOAAI
errMuchhala, Karan H.; Kallurkar, Prajkta S.; Kang, Minho; Koseli, Eda; Poklis, Justin L.; Xu, Qingguo; Dewey, William L.; Fettweis, Jennifer M.; Jimenez, Nicole R.; Akbarali, Hamid I.
err分享
err收藏
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-12-29
err0
PREAI
errLi, Mengchu; Pagare, Piyusha P.; Ma, Hongguang; St Onge, Celsey M.; Mendez, Rolando E.; Gillespie, James C.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan
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err收藏
Structural Alterations of the Address Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-12-20
err8
errOAAI
errMa, Hongguang; Pagare, Piyusha P.; Li, Mengchu; Neel, Logan T.; Mendez, Rolando E.; Gillespie, James C.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan
err分享
err收藏
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2022-11-30
err7
errOAAI
errLi, Mengchu; Stevens, David L.; Arriaga, Michelle; Townsend, E. Andrew; Mendez, Rolando E.; Blajkevch, Nadejda A.; Selley, Dana E.; Banks, Matthew L.; Negus, S. Stevens; Dewey, William L.; Zhang, Yan
err分享
err收藏
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-03-08
err10
errOAAI
errPagare, Piyusha P.; Li, Mengchu; Zheng, Yi; Kulkarni, Abhishek S.; Obeng, Samuel; Huang, Boshi; Ruiz, Christian; Gillespie, James C.; Mendez, Rolando E.; Stevens, David L.; Poklis, Justin L.; Halquist, Matthew S.; Dewey, William L.; Selley, Dana E.; Zhang, Yan
err分享
err收藏
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment外周选择性 μ 阿片受体配体作为潜在阿片类药物诱导便秘治疗的合理设计、化学合成和生物学评价
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-03-08
err4
errOAAI
errHuang, Boshi; Li, Mengchu; Klongkumnuankarn, Pornprom; Mendez, Rolando E.; Gillespie, James C.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan
err分享
err收藏
Opioid-like adverse effects of tianeptine in male rats and mice
errPSYCHOPHARMACOLOGY
IF3.3
err2022-02-24
err11
errOAAI
errBaird, T. R.; Akbarali, H., I; Dewey, W. L.; Elder, H.; Kang, M.; Marsh, S. A.; Peace, M. R.; Poklis, J. L.; Santos, E. J.; Negus, S. S.
err分享
err收藏
Chronic Morphine Induces IL-18 in Ileum Myenteric Plexus Neurons Through Mu-opioid Receptor Activation in Cholinergic and VIPergic Neurons
errJOURNAL OF NEUROIMMUNE PHARMACOLOGY
IF3.5
err2022-02-02
err4
errOAAI
errMuchhala, Karan H.; Koseli, Eda; Gade, Aravind R.; Woods, Kareem; Minai, Suha; Kang, Minho; McQuiston, A. Rory; Dewey, William L.; Akbarali, Hamid, I
err分享
err收藏
Role of β-arrestin-2 in short- and long-term opioid tolerance in the dorsal root ganglia
errEUROPEAN JOURNAL OF PHARMACOLOGY
IF4.7
err2021-05-01
err12
errOAAI
errMuchhala, Karan H.; Jacob, Joanna C.; Dewey, William L.; Akbarali, Hamid, I
err分享
err收藏
Fentanyl depression of respiration: Comparison with heroin and morphine
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2019-12-23
err124
errOAAI
errHill, Rob; Santhakumar, Rakulan; Dewey, William; Kelly, Eamonn; Henderson, Graeme
err分享
err收藏
Prolonged ethanol administration prevents the development of tolerance to morphine-induced respiratory depression
errDRUG AND ALCOHOL DEPENDENCE
IF3.6
err2019-12-01
err1
errOAAI
errHill, Rob; Roberts, Joanne; Maclachlan, John; Dewey, William; Kelly, Eamonn; Henderson, Graeme
err分享
err收藏
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-11-29
err15
PREAI
errMa, Hongguang; Obeng, Samuel; Wang, Huiqun; Zheng, Yi; Li, Mengchu; Jali, Abdulmajeed M.; Stevens, David L.; Dewey, William L.; Selley, Dana E.; Zhang, Yan
err分享
err收藏
Experimental Colitis Enhances the Rate of Antinociceptive Tolerance to Morphine via Peripheral Opioid Receptors
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2019-09-01
err18
errOAAI
errKomla, Essie; Stevens, David L.; Zheng, Yi; Zhang, Yan; Dewey, William L.; Akbarali, Hamid, I
err分享
err收藏
Characterization of 17-CyclopropyInnethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(indole-7-carboxamido)morphinan (NAN) as a Novel Opioid Receptor Modulator for Opioid Use Disorder Treatment
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2019-02-13
err20
errOAAI
errObeng, Samuel; Jali, Abdulmajeed; Zheng, Yi; Wang, Huiqun; Schwienteck, Kathryn L.; Chen, Chongguang; Stevens, David L.; Akbarali, Hamid I.; Dewey, William L.; Banks, Mathew L.; Liu-Chen, Lee-Yuan; Selley, Dana E.; Zhang, Yan
err分享
err收藏
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido]morphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2019-01-04
err20
errOAAI
errZheng, Yi; Obeng, Samuel; Wang, Huiqun; Jali, Abdulmajeed M.; Peddibhotla, Bharath; Williams, Dwight A.; Zou, Chuanchun; Stevens, David L.; Dewey, William L.; Akbarali, Hamid I.; Selley, Dana E.; Zhang, Yan
err分享
err收藏

研究方向

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合作学者
合作期刊
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Benjamin F. Cravatt
H 指数: 148 · 论文数: 867
B
Billy R. Martin
H 指数: 96 · 论文数: 560
A
Aron H. Lichtman
H 指数: 79 · 论文数: 301
I
I. P. Beletskaya
H 指数: 71 · 论文数: 1.9K
E
Eamonn Kelly
H 指数: 67 · 论文数: 258
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