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Preclinical evaluation of the novel [18F]CHDI-650 PET ligand for non-invasive quantification of mutant huntingtin aggregates in Huntington's disease Zajicek, Franziska; Verhaeghe, Jeroen; De Lombaerde, Stef; Van Eetveldt, Annemie; Miranda, Alan; Munoz-Sanjuan, Ignacio; Dominguez, Celia; Khetarpal, Vinod; Bard, Jonathan; Liu, Longbin; Staelens, Steven; Bertoglio, Daniele 分享 收藏
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease Liu, Longbin; Malagu, Karine; Haughan, Alan F.; Khetarpal, Vinod; Stott, Andrew J.; Esmieu, William; Vater, Huw D.; Webster, Stephen J.; van de Poel, Amanda J.; Clissold, Cole; Cosgrove, Brett; Sutton, Benjamin; Spencer, Jonathan A.; Breccia, Perla; Gancia, Emanuela; Bonomo, Silvia; Ladduwahetty, Tammy; Lazari, Ovadia; Patel, Hiral; Atton, Helen C.; Clifton, Steve; Mota, Daniel M.; Magnani, Dario; O'Neill, Amy; Stebbeds, Marta; Macabuag, Natsuko; Todd, Daniel; Herva, Maria E.; Mitchell, Philip; Visser, Mijke; Compte Sancerni, Sara; Grand Moursel, Laure; da Silva, Marta; Kritikou, Eva; Heikkinen, Taneli T.; Bolkvadze, Tamuna; Fodale, Valentina; Spadafora, Debora; Daldin, Manuel; Bresciani, Alberto; Mangette, John E.; Doherty, Elizabeth M.; Lee, Matthew R.; Herbst, Todd; Monteagudo, Edith; Macdonald, Douglas; Plotnikov, Nikolay V.; Chambers, Mark; Mcallister, George; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
In Vivo Cerebral Imaging of Mutant Huntingtin Aggregates Using 11C-CHDI-180R PET in a Nonhuman Primate Model of Huntington Disease Bertoglio, Daniele; Weiss, Alison R.; Liguore, William; Martin, Lauren Drew; Hobbs, Theodore; Templon, John; Srinivasan, Sathya; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Khetarpal, Vinod; Verhaeghe, Jeroen; Staelens, Steven; Link, Jeanne; Liu, Longbin; Bard, Jonathan A.; McBride, Jodi L. 分享 收藏
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Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Brown, Christopher J.; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P.; Esposito, Simone; Gadouleau, Elise; Giles, Paul R.; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E.; Marriner, Gwendolyn A.; Marston, Richard W.; Mills, Matthew R.; Monteagudo, Edith; Forsberg-Moren, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A.; Vecchi, Andrea; Veneziano, Maria; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia 分享 收藏
Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology 开发HDAC4-Selective蛋白降解剂以研究HDAC4在亨廷顿病病理学中的作用 Macabuag, Natsuko; Esmieu, William; Breccia, Perla; Jarvis, Rebecca; Blackaby, Wesley; Lazari, Ovadia; Urbonas, Liudvikas; Eznarriaga, Maria; Williams, Rachel; Strijbosch, Annelieke; Van de Bospoort, Rhea; Matthews, Kim; Clissold, Cole; Ladduwahetty, Tammy; Vater, Huw; Heaphy, Patrick; Stafford, Douglas G.; Wang, Hong -Jun; Mangette, John E.; McAllister, George; Beaumont, Vahri; Vogt, Thomas F.; Wilkinson, Hilary A.; Doherty, Elizabeth M.; Dominguez, Celia 分享 收藏
A HUNTINGTON'S DISEASE EMBRYONIC STEM CELL PHENOTYPIC HTS TO IDENTIFY SMALL MOLECULE MODULATORS OF MUTANT HUNTINGTIN Todd, Daniel; Stebbeds, Marta; Thatcher, Emma; Barnard, Amy; Anton, Jeremy; Sienerth, Arnold; Visser, Mijke; Mitchell, Philip; Breccia, Perla; Smith, David; McAllister, George; Haque, Tasir; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio 分享 收藏
Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [11C]CHDI-00485180-R and [11C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin Delva, Aline; Koole, Michel; Serdons, Kim; Bormans, Guy; Liu, Longbin; Bard, Jonathan; Khetarpal, Vinod; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Wood, Andrew; Skinbjerg, Mette; Wang, Yuchuan; Vandenberghe, Wim; Van Laere, Koen 分享 收藏
Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease Ladduwahetty, Tammy; Lee, Matthew R.; Maillard, Michel C.; Cachope, Roger; Todd, Daniel; Barnes, Michael; Beaumont, Vahri; Chauhan, Alka; Gallati, Caroline; Haughan, Alan F.; Kempf, Georg; Luckhurst, Christopher A.; Matthews, Kim; McAllister, George; Mitchell, Philip; Patel, Hiral; Rose, Mark; Saville-Stones, Elizabeth; Steinbacher, Stefan; Stott, Andrew J.; Thatcher, Emma; Tierney, Jason; Urbonas, Liudvikas; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Validation, kinetic modeling, and test-retest reproducibility of [18F]SynVesT-1 for PET imaging of synaptic vesicle glycoprotein 2A in mice Bertoglio, Daniele; Zajicek, Franziska; De Lombaerde, Stef; Miranda, Alan; Stroobants, Sigrid; Wang, Yuchuan; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Liu, Longbin; Verhaeghe, Jeroen; Staelens, Steven 分享 收藏
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease Bertoglio, Daniele; Bard, Jonathan; Hessmann, Manuela; Liu, Longbin; Gaertner, Annette; De Lombaerde, Stef; Huscher, Britta; Zajicek, Franziska; Miranda, Alan; Peters, Finn; Herrmann, Frank; Schaertl, Sabine; Vasilkovska, Tamara; Brown, Christopher J.; Johnson, Peter D.; Prime, Michael E.; Mills, Matthew R.; Van der Linden, Annemie; Mrzljak, Ladislav; Khetarpal, Vinod; Wang, Yuchuan; Marchionini, Deanna M.; Skinbjerg, Mette; Verhaeghe, Jeroen; Dominguez, Celia; Staelens, Steven; Munoz-Sanjuan, Ignacio 分享 收藏
Longitudinal preclinical evaluation of the novel radioligand [11C]CHDI-626 for PET imaging of mutant huntingtin aggregates in Huntington's disease Bertoglio, Daniele; Verhaeghe, Jeroen; Miranda, Alan; Wyffels, Leonie; Stroobants, Sigrid; Mrzljak, Ladislav; Khetarpal, Vinod; Skinbjerg, Mette; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Staelens, Steven 分享 收藏
Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem Bertoglio, Daniele; Verhaeghe, Jeroen; Wyffels, Leonie; Miranda, Alan; Stroobants, Sigrid; Mrzljak, Ladislav; Dominguez, Celia; Skinbjerg, Mette; Bard, Jonathan; Liu, Longbin; Munoz-Sanjuan, Ignacio; Staelens, Steven 分享 收藏
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates Herrmann, Frank; Hessmann, Manuela; Schaertl, Sabine; Berg-Rosseburg, Karola; Brown, Christopher J.; Bursow, Galina; Chiki, Anass; Ebneth, Andreas; Gehrmann, Miriam; Hoeschen, Nicole; Hotze, Madlen; Jahn, Stefanie; Johnson, Peter D.; Khetarpal, Vinod; Kiselyov, Alex; Kottig, Karsten; Ladewig, Stefanie; Lashuel, Hilal; Letschert, Sven; Mills, Matthew R.; Petersen, Kathrin; Prime, Michael E.; Scheich, Christoph; Schmiedel, Gerhard; Wityak, John; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan A. 分享 收藏
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Lee, Matthew R.; Brown, Christopher J.; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Conlon, Mike; Davis, Randall; Ensor, Samantha; Esposito, Simone; Moren, Anton Forsberg; Gai, Xinjie; Green, Samantha; Greenaway, Catherine; Haber, James; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; He-mann, Manuela; Hsai, Ming Min; Kotey, Adrian; Mangette, John E.; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Varnas, Katarina; Varrone, Andrea; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia 分享 收藏
Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease Van de Poel, Amanda; Toledo-Sherman, Leticia; Breccia, Perla; Cachope, Roger; Bate, Jennifer R.; Angulo-Herrera, Ivan; Wishart, Grant; Matthews, Kim L.; Martin, Sarah L.; Peacock, Marcus; Barnard, Amy; Cox, Helen C.; Jones, Graham; McAllister, George; Vater, Huw; Esmieu, William; Clissold, Cole; Lamers, Marieke; Leonard, Philip; Jarvis, Rebecca E.; Blackaby, Wesley; Eznarriaga, Maria; Lazari, Ovadia; Yates, Dawn; Rose, Mark; Jang, Sung-Wook; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class Ila HDAC Inhibitors for Huntington's Disease Stott, Andrew J.; Maillard, Michel C.; Beaumont, Vahri; Allcock, David; Aziz, Omar; Borchers, Alexander H.; Blackaby, Wesley; Breccia, Perla; Creighton-Gutteridge, Gillian; Haughan, Alan F.; Jarvis, Rebecca E.; Luckhurst, Christopher A.; Matthews, Kim L.; McAllister, George; Pollack, Scott; Saville-Stones, Elizabeth; Van de Poel, Amanda J.; Vater, Huw D.; Vann, Julie; Williams, Rachel; Yates, Dawn; Munoz-Sanjuan, Ignacio; Dominguez, Celia 分享 收藏
Kinetic Modelling and Test-Retest Reproducibility for the Dopamine D1R Radioligand [11C]SCH23390 in Healthy and Diseased Mice 多巴胺D1R放射性配体 [11C]SCH23390在健康和患病小鼠中的动力学模型和重测重现性 Bertoglio, Daniele; Verhaeghe, Jeroen; Miranda, Alan; Wyffels, Leonie; Stroobants, Sigrid; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Skinbjerg, Mette; Liu, Longbin; Staelens, Steven 分享 收藏
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