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H

Hilal A. Lashuel

ecole polytechnique federale de lausanne

92H指数
333论文数
2.8W被引数
收录论文 159
发表时间
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Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity利用人诱导多能干细胞来源的多巴胺能神经元模拟帕金森病病理，揭示了路易小体形成的关键机制和异质性
errScience Advances
IF12.5
err2026-07-10
err0
errOAAI
errAnne-Laure Mahul-Mellier; Lukas van den Heuvel; Maxime Teixeira; Manel L. N. Boussouf; Gaspard Oudinot; Amélie Thonet; Davide Speri; Yllza Jasiqi; Christina Ulrich; Razan Sheta; Walid Idi; Mary Croisier; Stéphanie Clerc-Rosset; Jérôme Blanc; Graham Knott; Abid Oueslati; Hilal A. Lashuel
err分享
err收藏
Cracking the code of native amyloid fibrils: advances and next steps to enable pathology-informed therapeutic and diagnostic破解天然淀粉样蛋白纤维的密码：进展与下阶段进展以实现病理信息指导的诊疗方法
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2026-04-20
err0
PREAI
errHilal A. Lashuel
err分享
err收藏
A genomics health strategy for the Arabian Gulf阿拉伯湾的基因组健康战略
errNature Medicine
IF50
err2026-03-04
err0
PREAI
errHamad Ali; Barrak Alahmad; Abdullah Alibrahim; Dana Marafi; Hind Alsharhan; Salman Al Sabah; Almundher Al-Maawali; Khalid A. Fakhro; Hilal A. Lashuel; Fowzan S. Alkuraya; Omer S. Alkhnbashi; Alawi Alsheikh-Ali; Fahd Al-Mulla; Ahmad Abou Tayoun
err分享
err收藏
Integrating the genome and exposome for precision health in Kuwait整合基因组与暴露组以实现科威特精准健康
errNature Reviews Genetics
IF52
err2025-07-31
err0
PREAI
errHamad Ali; Barrak Alahmad; Faisal H. Al-Refaei; Ahmad Abou Tayoun; Hilal A. Lashuel; Salman Al Sabah; Fahd Al-Mulla
err分享
err收藏
Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases纳米等离激元红外微阵列传感器，用于基于结构蛋白生物标志物的神经退行性疾病药物筛选
errAdvanced Science
IF14.1
err2025-07-28
err0
errOAAI
errDeepthy Kavungal; Enzo Morro; Senthil T Kumar; Berkay Dagli; Hilal A Lashuel; Hatice Altug
err分享
err收藏
Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging自动驾驶显微技术检测蛋白质聚集的起始并实现智能布里渊成像
errNature Communications
IF15.7
err2025-07-24
err0
errOAAI
errKhalid A. Ibrahim; Camille Cathala; Carlo Bevilacqua; Lely Feletti; Robert Prevedel; Hilal A. Lashuel; Aleksandra Radenovic
err分享
err收藏
Bridging borders for resilience in cancer control in the Middle East: a strategic alliance of Saudi Arabia, Qatar, and Jordan为中东癌症控制建立韧性：沙特阿拉伯、卡塔尔和约旦的战略联盟
errlancet oncology
IF0
err2025-06-11
err0
PREAI
errHanan Jafar; Saleh A Alessy; Murugan Subramanian; Hikmat Abdel-Razeq; Mohammed Bin Hamed Al-Thani; Feras Al-Fararjeh; Khalid Al-Rumaihi; Laith Al-Showbaki; Salha Bujassoum Al Bader; Kamal Al-rabi; Abdullah Ali Alsharm; Ali Abdullah Alqarni; Ali Al-Zahrani; Yaser Rayyan; Hilal Lashuel; Asem Mansour; Laila Tutunji; Lotfi Chouchane; Saleh A Alqahtani; Abdalla Awidi
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err收藏
Qatar national cancer care and research: pioneering strategies for global health excellence卡塔尔国家癌症护理与研究中心：全球健康卓越的开拓性策略
errlancet oncology
IF0
err2025-06-11
err0
PREAI
errMohammed Bin Hamed Al-Thani; Murugan Subramanian; Najeeb Halabi; Salha Bujassoum Al Bader; Jingxuan Shan; Khalid Rashid Al-Rumaihi; M Walid Qoronfleh; Hilal A Lashuel; Lotfi Chouchane
err分享
err收藏
Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex亨廷顿包涵体在亨廷顿病人类大脑皮层中具有独特的免疫表型和泛素化谱。
errSCIENTIFIC REPORTS
IF3.9
err2025-05-03
err0
errOAAI
errSwanson, Molly E. V.; Tan, Adelie Y. S.; Tippett, Lynette J.; Turner, Clinton P.; Curtis, Maurice A.; Scotter, Emma L.; Lashuel, Hilal A.; Dragunow, Mike; Faull, Richard L. M.; Murray, Helen C.; Singh-Bains, Malvindar K.
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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical useAlpha-synuclein种子扩增试验：数据共享和标准化对临床应用至关重要
errSCIENCE ADVANCES
IF12.5
err2025-04-04
err0
PREAI
errLashuel, Hilal A.; Surmeier, D. James; Simuni, Tanya; Merchant, Kalpana; Caughey, Byron; Soto, Claudio; Fares, Mohamed-Bilal; Heym, Roland G.; Melki, Ronald
err分享
err收藏
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein多靶向大环肽作为自引发和交叉引发α-Synuclein淀粉样蛋白自组装的纳摩尔级抑制剂
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-01-31
err0
errOAAI
errHornung, Simon; Vogl, Dominik P.; Naltsas, Denise; Volta, Beatrice Dalla; Ballmann, Markus; Marcon, Beatrice; Syed, Muhammed Muazzam Kamil; Wu, Yiyang; Spanopoulou, Anna; Feederle, Regina; Heidrich, Luzia; Bernhagen, Juergen; Koeglsperger, Thomas; Hoeglinger, Guenter U.; Rammes, Gerhard; Lashuel, Hilal A.; Kapurniotu, Aphrodite
err分享
err收藏
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
errSCIENCE ADVANCES
IF12.5
err2024-11-01
err0
errOAAI
errSokratian, Arpine; Zhou, Ye; Tatli, Meltem; Burbidge, Kevin J.; Xu, Enquan; Viverette, Elizabeth; Donzelli, Sonia; Duda, Addison M.; Yuan, Yuan; Li, Huizhong; Strader, Samuel; Patel, Nirali; Shiell, Lauren; Malankhanova, Tuyana; Chen, Olivia; Mazzulli, Joseph R.; Perera, Lalith; Stahlberg, Henning; Borgnia, Mario; Bartesaghi, Alberto; Lashuel, Hilal A.; West, Andrew B.
err分享
err收藏
A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-09-03
err0
errOAAI
errLin, Xiaoxi; Mandal, Shaswati; Nithun, Raj V.; Kolla, Rajasekhar; Bouri, Bouchra; Lashuel, Hilal A.; Jbara, Muhammad
err分享
err收藏
Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis
errMOVEMENT DISORDERS
IF7.6
err2024-06-30
err4
errOAAI
errBurre, Jacqueline; Edwards, Robert H.; Halliday, Glenda; Lang, Anthony E.; Lashuel, Hilal A.; Melki, Ronald; Murayama, Shigeo; Outeiro, Tiago F.; Papa, Stella M.; Stefanis, Leonidas; Woerman, Amanda L.; Surmeier, Dalton James; Kalia, Lorraine V.; Takahashi, Ryosuke
err分享
err收藏
Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates (vol 14, 3939, 2023)
errNATURE COMMUNICATIONS
IF15.7
err2024-05-30
err0
errOAAI
errLimorenko, Galina; Tatli, Meltem; Kolla, Rajasekhar; Nazarov, Sergey; Weil, Marie-Theres; Schoendorf, David C.; Geist, Daniela; Reinhardt, Peter; Ehrnhoefer, Dagmar E.; Stahlberg, Henning; Gasparini, Laura; Lashuel, Hilal A.
err分享
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Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-05-16
err1
errOAAI
errZhang, Zhidian; Gehin, Charlotte; Abriata, Luciano A.; Dal Peraro, Matteo; Lashuel, Hilal
err分享
err收藏
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology(Feb, 10.1038/s41589-024-01551-2, 2024)
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-02-27
err0
errOAAI
errBalana, Aaron T.; Mahul-Mellier, Anne-Laure; Nguyen, Binh A.; Horvath, Mian; Javed, Afraah; Hard, Eldon R.; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M. -Y.; Luk, Kelvin C.; Saelices, Lorena; Lashuel, Hilal A.; Pratt, Matthew R.
err分享
err收藏
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-02-12
err19
errOAAI
errBalana, Aaron T.; Mahul-Mellier, Anne-Laure; Nguyen, Binh A.; Horvath, Mian; Javed, Afraah; Hard, Eldon R.; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M. -Y.; Luk, Kelvin C.; Saelices, Lorena; Lashuel, Hilal A.; Pratt, Matthew R.
err分享
err收藏
Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2023-12-20
err2
errOAAI
errYang, Lixin; Jasiqi, Yllza; Lashuel, Hilal
err分享
err收藏
Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore基于生物纳米孔的蛋白质翻译后修饰的深度学习辅助单分子检测
errACS NANO
IF16
err2023-12-19
err11
errOAAI
errCao, Chan; Magalhaes, Pedro; Krapp, Lucien F.; Juarez, Juan F. Bada; Mayer, Simon Finn; Rukes, Verena; Chiki, Anass; Lashuel, Hilal A.; Dal Peraro, Matteo
err分享
err收藏

研究方向

暂无研究方向
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