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Inhibitory effects of molnupiravir on Crimean-Congo hemorrhagic fever virus polymerase 莫纳皮拉韦对克里米亚-刚果出血热病毒聚合酶的抑制作用 Sloan, Angela; Gordon, Calvin J.; Prevost, Jeremie; Audet, Jonathan; Fulton, Kathleen; Woolner, Emma; Chang, Ming-Hao; Walker, Simon M.; Tchesnokov, Egor P.; Das, Kalyan; Safronetz, David; Gotte, Matthias 分享 收藏
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A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent 组装后的构象变化使SARS-CoV-2聚合酶获得延伸活性。 Klein, Misha; Das, Arnab; Bera, Subhas C.; Anderson, Thomas K.; Kocincova, Dana; Lee, Hery W.; Wang, Bing; Papini, Flavia S.; Marecki, John C.; Arnold, Jamie J.; Cameron, Craig E.; Raney, Kevin D.; Artsimovitch, Irina; Gotte, Mathias; Kirchdoerfer, Robert N.; Depken, Martin; Dulin, David 分享 收藏
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SARS-CoV-2 resistance analyses from the Phase 3 PINETREE study of remdesivir treatment in nonhospitalized participants Rodriguez, Lauren; Lee, Hery W.; Li, Jiani; Martin, Ross; Han, Dong; Xu, Simin; Moshiri, Jasmine; Peinovich, Nadine; Camus, Gregory; Perry, Jason K.; Hyland, Robert H.; Porter, Danielle P.; Abdelghany, Mazin; Gotte, Matthias; Hedskog, Charlotte 分享 收藏
Mechanism and spectrum of inhibition of a 4'-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses Gordon, Calvin J.; Walker, Simon M.; Tchesnokov, Egor P.; Kocincova, Dana; Pitts, Jared; Siegel, Dustin S.; Perry, Jason K.; Feng, Joy Y.; Bilello, John P.; Gotte, Matthias 分享 收藏
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Evolution of naturally arising SARS-CoV-2 defective interfering particles Girgis, Samer; Xu, Zaikun; Oikonomopoulos, Spyros; Fedorova, Alla D.; Tchesnokov, Egor P.; Gordon, Calvin J.; Schmeing, T. Martin; Goette, Matthias; Sonenberg, Nahum; Baranov, Pavel, V; Ragoussis, Jiannis; Hobman, Tom C.; Pelletier, Jerry 分享 收藏
Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms Stevens, Laura J.; Pruijssers, Andrea J.; Lee, Hery W.; Gordon, Calvin J.; Tchesnokov, Egor P.; Gribble, Jennifer; George, Amelia S.; Hughes, Tia M.; Lu, Xiaotao; Li, Jiani; Perry, Jason K.; Porter, Danielle P.; Cihlar, Tomas; Sheahan, Timothy P.; Baric, Ralph S.; Gotte, Matthias; Denison, Mark R. 分享 收藏
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition Baldwin, Eric T.; Gotte, Matthias; Tchesnokov, Egor P.; Arnold, Eddy; Hagel, Margit; Nichols, Charles; Dossang, Pam; Lamers, Marieke; Wan, Paul; Steinbacher, Stefan; Romero, Donna L. 分享 收藏
The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2 Feng, Joy Y.; Du Pont, Venice; Babusis, Darius; Gordon, Calvin J.; Tchesnokov, Egor P.; Perry, Jason K.; Duong, Vincent; Vijjapurapu, Arya; Zhao, Xiaofeng; Chan, Julie; Cohen, Cal; Juneja, Kavita; Cihlar, Tomas; Gotte, Matthias; Bilello, John P. 分享 收藏
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Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium** Bader, Chantal D.; Panter, Fabian; Garcia, Ronald; Tchesnokov, Egor P.; Haid, Sibylle; Walt, Christine; Sproeer, Cathrin; Kiefer, Alexander F.; Goette, Matthias; Overmann, Jorg; Pietschmann, Thomas; Mueller, Rolf 分享 收藏
Knowledge Gaps in the Understanding of Antimicrobial Resistance in Canada McCubbin, Kayley D.; Anholt, R. Michele; de Jong, Ellen; Ida, Jennifer A.; Nobrega, Diego B.; Kastelic, John P.; Conly, John M.; Gotte, Matthias; McAllister, Tim A.; Orsel, Karin; Lewis, Ian; Jackson, Leland; Plastow, Graham; Wieden, Hans-Joachim; McCoy, Kathy; Leslie, Myles; Robinson, Joan L.; Hardcastle, Lorian; Hollis, Aidan; Ashbolt, Nicholas J.; Checkley, Sylvia; Tyrrell, Gregory J.; Buret, Andre G.; Rennert-May, Elissa; Goddard, Ellen; Otto, Simon J. G.; Barkema, Herman W. 分享 收藏
Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action (vol 295, pg 16156, 2020) Tchesnokov, Egor P.; Gordon, Calvin J.; Woolner, Emma; Kocincova, Dana; Perry, Jason K.; Feng, Joy Y.; Porter, Danielle P.; Gotte, Matthias 分享 收藏
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