H. Shelton Earp - Publications, H-index & Citations

H. Shelton Earp

University of North Carolina at Chapel Hill

81H指数

513论文数

2.8W被引数

收录论文 132

发表时间

Structure-guided design and engineering of a biparatopic antibody targeting CCR2 in triple negative breast cancer 基于结构的C型化学趋化因子受体2（CCR2）靶向双旁特异抗体在 triple negative breast cancer 中的设计与工程化

Journal of Controlled Release

IF11.5

2025-10-15

OAAI

Timothy S. Little; Yuyan Wang; Ameya P. Chaudhari; Omar M. Budayr; Jessica G. Tetterton-Kellner; Alex Bastian; Adam D. Brown; Natalie E. Jasiewicz; Amelia McCue; Henry S. Earp; Brian C. Miller; Juliane Nguyen

Host responses to S. pneumoniae in wild type and Mertk mutant mice 野生型和Mertk突变型小鼠对S. pneumoniae的宿主应答

PLOS ONE

IF2.6

2025-04-16

OAAI

McPeek, Matthew K.; Martin, Jessica R.; Gomez, John C.; Li, Yitong; Dang, Hong; Earp, H. Shelton

Discovery of Novel TYRO3/MERTK Dual Inhibitors 新型TYRO3/MERTK双抑制剂的发现

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-04-11

PREAI

Kong, Deyu; Zhao, Jichen; Huang, Daowei; Stashko, Michael A.; Yan, Dan; Ding, Ransheng; Guduru, Shiva K. R.; Zhou, Yubai; Kania, Catherine E.; Earp III, H. Shelton; Frye, Stephen V.; Huelse, Justus M.; Kireev, Dmitri; Deryckere, Deborah; Graham, Douglas K.; Wang, Xiaodong

MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity

LEUKEMIA

IF13.4

2024-09-25

PREAI

Huelse, Justus M.; Bhasin, Swati S.; Jacobsen, Kristen M.; Yim, Juhye; Thomas, Beena E.; Branella, Gianna M.; Bakhtiari, Mojtaba; Chimenti, Madison L.; Baxter, Travon A.; Raikar, Sunil S.; Wang, Xiaodong; Frye, Stephen V.; Henry, Curtis J.; Earp, H. Shelton; Bhasin, Manoj; DeRyckere, Deborah; Graham, Douglas K.

The University of North Carolina Cancer Survivorship Cohort: A Resource for Collaborative Survivorship Research

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

IF3.4

2024-09-06

PREAI

Anderson, Chelsea; Bensen, Jeannette T.; Allott, Emma H.; Basta, Patricia V.; Irwin, Debra E.; Gerstel, Adrian; Farnan, Laura; Tan, Hung-Jui; Kent, Erin E.; Kuo, Tzy-Mey; Baggett, Christopher D.; Olshan, Andrew F.; Earp, H. Shelton; Nichols, Hazel B.

Co-targeting JAK1/STAT6/GAS6/TAM signaling improves chemotherapy efficacy in Ewing sarcoma

NATURE COMMUNICATIONS

IF15.7

2024-06-21

OAAI

Yu, Le; Deng, Yu; Wang, Xiaodong; Santos, Charlene; Davis, Ian J.; Earp, H. Shelton; Liu, Pengda

Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-04-01

PREAI

Kong, Deyu; Tian, Qiang; Chen, Zhilong; Zheng, Hongchao; Stashko, Michael A.; Yan, Dan; Earp, H. Shelton; Frye, Stephen V.; Deryckere, Deborah; Kireev, Dmitri; Graham, Douglas K.; Wang, Xiaodong

PIM kinase inhibition synergizes with a MERTK inhibitor to treat osimertinib resistant EGFR-mutant non-small cell lung cancer

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Yan, Dan; Wang, Xiaodong; Frye, Stephen V.; Earp, H. Shelton; DeRyckere, Deborah; Graham, Douglas K.

TAM family kinases as therapeutic targets at the interface of cancer and immunity TAM家族激酶作为癌症和免疫界面的治疗靶点

NATURE REVIEWS CLINICAL ONCOLOGY

IF82.2

2023-09-04

PREAI

Deryckere, Deborah; Huelse, Justus M.; Earp, H. Shelton; Graham, Douglas K.

TAM receptor tyrosine kinase MERTK as a therapeutic target in the tumor immune microenvironment in a murine Kras mutant lung cancer model

JOURNAL OF IMMUNOLOGY

IF3.4

2023-05-01

OAAI

Yan, Dan; Wang, Xiaodong; Frye, Stephen; Earp, H. Shelton; DeRyckere, Deborah; Graham, Douglas K.

The p65/RelA subunit of NF-κB suppresses the sustained, antiapoptotic activity of Jun kinase induced by tumor necrosis factor

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

OAAI

Reuther-Madrid, JY; Kashatus, D; Chen, SQ; Li, X; Westwick, J; Davis, RJ; Earp, HS; Wang, CY; Baldwin, AS

HER4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-28

176

OAAI

Sartor, CI; Zhou, H; Kozlowska, E; Guttridge, K; Kawata, E; Caskey, L; Harrelson, J; Hynes, N; Ethier, S; Calvo, B; Earp, HS

Heregulin-dependent delay in mitotic progression requires HER4 and BRCA1

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Muraoka-Cook, Rebecca S.; Caskey, Laura S.; Sandahl, Melissa A.; Hunter, Debra M.; Husted, Carty; Strunk, Karen E.; Sartor, Carolyn I.; Rearick, William A., Jr.; McCall, Wesley; Sgagias, Magdalene K.; Cowan, Kenneth H.; Earp, H. Shelton, III

The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Feng, Shu-Mang; Muraoka-Cook, Rebecca S.; Hunter, Debra; Sandahl, Melissa A.; Caskey, Laura S.; Miyazawa, Keiji; Atfi, Azeddine; Earp, H. Shelton, III

ErbB4 Splice Variants Cyt1 and Cyt2 Differ by 16 Amino Acids and Exert Opposing Effects on the Mammary Epithelium In Vivo

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-21

OAAI

Muraoka-Cook, Rebecca S.; Sandahl, Melissa A.; Strunk, Karen E.; Miraglia, Leah C.; Husted, Carty; Hunter, Debra M.; Elenius, Klaus; Chodosh, Lewis A.; Earp, H. Shelton, III

Inhibiting efferocytosis reverses macrophage-mediated immunosuppression in the leukemia microenvironment 抑制白血病微环境中巨噬细胞介导的免疫抑制

FRONTIERS IN IMMUNOLOGY

IF5.9

2023-03-07

OAAI

Cruz, Joselyn Cruz; Allison, Kristen C.; Page, Lauren S.; Jenkins, Alexis J.; Wang, Xiaodong; Earp, H. Shelton; Frye, Stephen V.; Graham, Douglas K.; Verneris, Michael R.; Lee-Sherick, Alisa B.

Discovery and characterization of a functional scFv for CCR2 inhibition via an extracellular loop

INTERNATIONAL JOURNAL OF PHARMACEUTICS

IF5.2

2023-02-01

OAAI

Jasiewicz, Natalie E.; Brown, Adam D.; Deci, Michael; Matysiak, Silvina; Earp, H. Shelton; Nguyen, Juliane

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation

NUCLEIC ACIDS RESEARCH

IF13.1

2022-10-27

OAAI

Wang, Jun; Park, Kwang-Su; Yu, Xufen; Gong, Weida; Earp, H. Shelton; Wang, Gang Greg; Jin, Jian; Cai, Ling

MERTK activation drives osimertinib resistance in EGFR-mutant non small cell lung cancer

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2022-08-01

OAAI

Yan, Dan; Huelse, Justus M.; Kireev, Dmitri; Tan, Zikang; Chen, Luxiao; Goyal, Subir; Wang, Xiaodong; Frye, Stephen, V; Behera, Madhusmita; Schneider, Frank; Ramalingam, Suresh S.; Owonikoko, Taofeek; Earp, H. Shelton; DeRyckere, Deborah; Graham, Douglas K.

TNK2/ACK1-mediated phosphorylation of ATP5F1A (ATP synthase F1 subunit alpha) selectively augments survival of prostate cancer while engendering mitochondrial vulnerability

AUTOPHAGY

IF14.3

2022-07-27

OAAI

Chouhan, Surbhi; Sawant, Mithila; Weimholt, Cody; Luo, Jingqin; Sprung, Robert W.; Terrado, Mailyn; Mueller, David M.; Earp, H. Shelton; Mahajan, Nupam P.

研究方向