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丁

丁侃 (Kan Ding)

chinese academy of sciences

53H指数
254论文数
7.7K被引数
收录论文 145
发表时间
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Intratumoral Enterobacter hormaechei drives gemcitabine resistance in pancreatic cancer via cddL-mediated drug inactivation肿瘤内霍氏肠杆菌通过cddL介导的药物失活驱动胰腺癌的吉西他滨耐药性
erriMeta
IF33.2
err2026-04-29
err0
errOAAI
errJun-Feng Peng; Meixia Li; Ting Niu; Judong Li; Wei Niu; Minghui Zheng; Quanjiang Ji; Chuan Li; Chenghao Shao; Kan Ding
err分享
err收藏
Fucoidan SPW-05-S2 from Sargassum fusiforme inhibits African swine fever virus replication by blocking PAK2/Talin-1 mediated viral endocytosis and factory formationSargassum fusiforme来源的Fucoidan SPW-05-S2通过阻断PAK2/Talin-1介导的病毒内吞和工厂形成来抑制非洲猪瘟病毒复制
errInternational Journal of Biological Macromolecules
IF8.5
err2026-04-02
err0
errOAAI
errSiqi Wan; Baoyi Song; Saijuan Li; Caiqin Cao; Man Lu; Guiqing Peng; Kan Ding; Kun Han; Mei Yu
err分享
err收藏
Active fragment assembly strategy enabling fast discovery of KRAS inhibitors against pancreatic cancer cells活性片段组装策略，用于快速发现针对胰腺癌细胞的KRAS抑制剂
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-03-28
err0
PREAI
errPengli Zhang; Lili Kong; Xianghui Meng; Yating Chen; Yukun Jiao; Zixuan Su; Xiaorong Song; Kan Ding; Guoqin Xia
err分享
err收藏
1,3-and 1,4-linked polysaccharides uptake in intestinal cells relies on clathrin/dynamin 1/Rab5-dependent endocytosis肠细胞中1，3-和1，4-连接的多糖的摄取依赖于网格蛋白/动力蛋白1/Rab5-dependent的内吞作用
errNature Communications
IF15.7
err2026-01-26
err0
errOAAI
errWenfeng Liao; Dianxiu Cao; Ying Wang; Zhenyun Du; Jian Yao; Pengfei Dou; Yuandong Zheng; Zhiming Wang; Xia Chen; Peipei Wang; Chungwah Ma; Hao Chen; Xingxing Diao; Kaiping Wang; Kan Ding
err分享
err收藏
Polysaccharides from Syzygium aromaticum binding to 3CLpro contain glycoproteins interacting with RdRp against SARS-CoV-2丁香属芳香木姜子多糖与3CLpro结合，含有与抗SARS-CoV-2的RdRp相互作用的糖蛋白
errCarbohydrate Polymers
IF12.5
err2025-12-11
err0
PREAI
errCan Jin; Bo Feng; Pengfei Dou; Yuan Zhou; Tingting Guo; Yuxuan Liu; Yaqi Ding; Meixia Li; Xia Chen; Zhenyun Du; Chunfan Huang; Xuan Li; Xiaojuan Xu; H. Eric Xu; Xinwen Chen; Kaiping Wang; Yi Zang; Jia Li; Kan Ding
err分享
err收藏
A structurally defined galactoglucan from Arisaema erubescens with a multi-target tumor-associated protein binding domain一种结构明确的掌叶半夏来源的半乳葡聚糖，其具有多靶点肿瘤相关蛋白结合域
errCarbohydrate Research
IF2.5
err2025-12-01
err0
PREAI
errZhu, Yue; Jin, Can; Ding, Kan
err分享
err收藏
GH28 polygalacturonase of human gut Bacteroides spp. confers the degradation of a novel branched galacturonan isolated from Jasminum nudiflorum人肠道拟杆菌属（Bacteroides spp.）的GH28多聚半乳糖醛酸酶能够降解从Jasminum nudiflorum中分离得到的一种新型支链半乳糖醛酸。
errCarbohydrate Polymers
IF12.5
err2025-11-25
err0
PREAI
errYun Li; Tingmei Hu; Meixia Li; Huixian Chen; Lana Duo; Can Jin; Kan Ding
err分享
err收藏
Decoding the pharmacokinetics of intravenous lentinan: A multiscale journey from the blood to hepatic Kupffer cells' lysosomes解码静脉用香菇多糖的药代动力学：一项从血液到肝库普弗细胞溶酶体的多尺度研究
errCarbohydrate Polymers
IF12.5
err2025-11-19
err0
PREAI
errXu Mu; Jinglin Wang; Shuai Wan; Jingyi Wang; Lei Huang; Nire Wu; Yuxue Zhan; Yuxuan Liu; Yu Zhang; Ziming Zheng; Kan Ding; Kaiping Wang
err分享
err收藏
Photo-assisted four-component one-pot assembly of a branched heptasaccharide derived from Carthamus tinctorius基于向日葵的分支七糖的光辅助四组分一锅法组装
errJournal of Carbohydrate Chemistry
IF2.2
err2025-10-01
err0
PREAI
errHu, Chaoyu; Wu, Ruixue; Ni, Xiang; Ma, Wenjing; Hao, Tianhui; Xu, Zhuojia; Ding, Kan; Li, Tiehai
err分享
err收藏
A dual-target pectin-like polysaccharide LRP01B from Lamiophlomis rotata induces pancreatic cancer cell apoptosis in vitro and in vivo by causing mitochondrial dysfunction一种来自Lamiophlomis rotata的双靶标果胶样多糖LRP01B通过诱导线粒体功能障碍，在体外和体内诱导胰腺癌细胞凋亡。
errInternational Journal of Biological Macromolecules
IF8.5
err2025-08-30
err0
PREAI
errJianhao Xie; Juan Su; Wanqi Zhou; Simin Cai; Wenfeng Liao; Jianing Zong; Junfeng Peng; Huanhuan Qu; Fei He; Kan Ding
err分享
err收藏
D-glucuronyl C5-Epimerase Binds to EGFR to Suppress Kidney FibrosisD-葡糖醛酰 C5-表异构酶与 EGFR 结合以抑制肾脏纤维化
errAdvanced Science
IF14.1
err2025-08-11
err0
errOAAI
errXiaoqi Jing; Jun Wu; Jingru Ning; Xiaoyu Ding; Zhenyun Du; Xiaojiang Wang; Lulin Huang; Ran Wang; Changlin Mei; Kan Ding
err分享
err收藏
Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin枸杞多糖通过靶向Noggin改善悬吊诱导的骨丢失
errfaseb journal
IF0
err2025-07-10
err0
PREAI
errChuanxin Sun; Yuke He; Xia Chen; Kan Ding; Chang Chen
err分享
err收藏
A novel method to quantify Dendrobium officinale polysaccharides in biological samples via 99mTc-labelling and radioHPGPC analysis一种通过99mTc标记和放射HPGPC分析来定量测定石斛多糖生物样品的新方法
errCarbohydrate Polymers
IF12.5
err2025-06-21
err0
PREAI
errPengfei Dou; Jinglin Wang; Yamin Shu; Fang Cheng; Gang Nie; Li Luo; Zhijing Wu; Ziming Zheng; Yongkang Gai; Junxi Liu; Yan Liu; Yinxing Zhou; Yu Zhang; Xiaoli Lan; Kan Ding; Kaiping Wang
err分享
err收藏
A polysaccharide from Gynostemma pentaphyllum: structure characterization and anti-insulin resistance potential through Galectin-3 modulation绞股蓝多糖：结构表征及通过Galectin-3调控发挥的抗胰岛素抵抗潜力
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2025-05-01
err0
PREAI
errRen, Mingwang; Sun, Guoqing; Ding, Xiaoyu; Yu, Xiaolin; He, Li; Xiao, Shiji; Dong, Minjian; Yang, Jianwen; Ding, Kan
err分享
err收藏
Impacts of sulfate polysaccharide JCS1S2 on retinal neovascularization in oxygen-induced retinopathy rats硫酸多糖JCS1S2对氧诱导视网膜病变大鼠视网膜新生血管的影响
errFRONTIERS IN PHARMACOLOGY
IF4.8
err2025-04-09
err0
errOAAI
errBai, Yang; Wang, Rui; Jin, Can; Wang, Lili; Tang, Yun; Wang, Han; Ding, Kan; Cai, Shanjun
err分享
err收藏
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota从Lycium barbarum果实中分离的肽聚糖通过调节TGF-β/Smad7信号通路和肠道微生物群来缓解小鼠的肝纤维化。
errACTA PHARMACOLOGICA SINICA
IF8.4
err2025-01-20
err0
PREAI
errNie, YM; Zhou, WQ; Niu, T; Mao, MF; Zhan, YX; Li, Y; Wang, KP; Li, MX; Ding, K
err分享
err收藏
A novel pectin-like polysaccharide from Crocus sativus targets Galectin-3 to inhibit hepatic stellate cells activation and liver fibrosis一种新的番红花果胶样多糖靶向Galectin-3抑制肝星状细胞活化和肝纤维化
errCARBOHYDRATE POLYMERS
IF12.5
err2025-01-01
err1
PREAI
errTang, Bixi; Jin, Can; Li, Maoting; Liu, Siqi; Zhang, Xuemei; Li, Jia; Ding, Kan; Zang, Yi
err分享
err收藏
Structural elucidation of an active arabinoglucan from Gomphrena globosa and its protection effect and mechanism against metabolic dysfunction-associated steatohepatitis
errCARBOHYDRATE POLYMERS
IF12.5
err2025-01-01
err0
PREAI
errChen, Meilin; Zong, Jianing; He, Fei; Zhou, Wanqi; Liu, Renjie; Xia, Haoran; Mao, Mengfei; Jin, Can; Wang, Kaiping; Ding, Kan
err分享
err收藏
The structure elucidation and alleviating effect on liver fibrosis in vivo of pectin-like polysaccharide isolated from Buddleja officinalis
errINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
IF8.5
err2025-01-01
err0
PREAI
errZong, Jianing; Li, Yun; Zhou, Wanqi; Mao, Mengfei; Xu, Xin; Cai, Simin; Li, Meixia; Ding, Kan
err分享
err收藏
Design and Synthesis of Dual Galectin-3 and EGFR Inhibitors Against Liver Fibrosis
errCHEMISTRY-AN ASIAN JOURNAL
IF3.3
err2024-11-21
err0
PREAI
errLiu, Shuanglin; He, Fei; Jin, Can; Li, Qing; Zhao, Guilong; Ding, Kan
err分享
err收藏

研究方向

细胞膜蛋白聚糖在疾病中结构和功能相关机制研究糖类药物的新靶标分子发现多糖结构解析聚糖-蛋白相互作用中药多糖生物活性筛选构效关系研究多糖吸收机制研究细胞膜硫酸乙酰肝素蛋白聚糖糖链合成酶和降解酶在肿瘤和神经系统疾病发展中的功能机制聚糖介导的microRNA在肿瘤血管生成中的功能机制抗肿瘤中药多糖结构靶向性及其功能机制研究
合作学者
合作期刊
张莉娜 封面图
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