Toni T. Seppälä - Publications, H-index & Citations

Toni T. Seppälä

Tampere University Hospital

52H指数

397论文数

1.0W被引数

收录论文 87

发表时间

Incidence Rates of Melanoma and Lung Cancer Are Generally Low in the Lynch Syndromes and Vary Across path_MMR Variants: A Prospective Lynch Syndrome Database Report 林奇综合征中黑色素瘤和肺癌的发病率通常较低，且在不同path_MMR变异中存在差异：一项前瞻性林奇综合征数据库报告

Cancers

IF4.4

2026-07-28

OAAI

John D. Potter; Finlay A. Macrae; Julian R. Sampson; Saskia Haupt; Toni T. Seppälä; Sinead Cameron-Mackintosh; Aysel Ahadova; Matthias Kloor; Pål Møller; PLSD Collaborators

Treatment of localized rectal cancer in the Nordic countries—comparison of Nordic to Dutch, ESMO, and NCCN guidelines 北欧国家局部直肠癌的治疗——北欧指南与荷兰、ESMO及NCCN指南的比较

Scandinavian Journal of Surgery

IF1.8

2026-07-20

PREAI

Erkki-Ville Wirta; Usman Saeed; Gijs Stuart; Laurids Østergaard Poulsen; Camilla Qvortrup; Pia Österlund; Jørgen Smeby; Jens Ravn Eriksen; Bengt Glimelius; Esther Consten; Pamela Buchwald; Toni T. Seppälä; Johannes Kurt Schultz

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights 结直肠癌中肿瘤浸润边界指数（TIBI）：连接浸润性形态学与分子洞察

The Journal of Pathology

IF0

2026-06-18

OAAI

Akseli Kehusmaa; Jouni Härkönen; Huayi Li; Päivi Sirniö; Ville K Äijälä; Henna Karjalainen; Meeri Kastinen; Vilja V Tapiainen; Tuomo Mantere; Vesa-Matti Pohjanen; Hanna Elomaa; Onni Sirkiä; Nicolas Pasquier; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Taneli T Mattila; Outi Lindgren; Janette Savela; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Markus J Mäkinen; Anne Tuomisto; Johanna Ivaska; Juha P Väyrynen

ESGO Consensus Statement on endometrial cancer prevention, risk reduction strategies, and management of women with Lynch syndrome ESGO关于子宫内膜癌预防、风险降低策略以及林奇综合征患者管理的共识声明

European Journal of Cancer

IF7.1

2026-04-15

OAAI

Claudia Marchetti; Murat Gultekin; Carolina Maria Sassu; François Planchamp; Laura Burney Ellis; Sarah Bowden; Vasilis Theodoulidis; Vesna Kesic; Beyhan Ataseven; Giovanni Scambia; LecuruFabrice Lécuru; Maurizio Genuardi; Mev Dominguez-Valentin; Toni T. Seppälä; Frédéric Amant; Mihaela Grigore; Stephan Polterauer; Bilal Esat Temiz; Hasan Volkan Ege; Simona Duranti

Nanopore sequencing reveals hidden landscape of short L1 transductions in colorectal cancer 纳米孔测序揭示了结直肠癌中短L1转导的隐藏景观

Communications Biology

IF5.1

2026-02-12

OAAI

Päivi Nummi; Aurora Taira; Janne Ravantti; Tuukka Norri; Niko Välimäki; Anna Lepistö; Laura Renkonen-Sinisalo; Selja Koskensalo; Toni T. Seppälä; Ari Ristimäki; Kyösti Tahkola; Anne Mattila; Jan Böhm; Jukka-Pekka Mecklin; Emma Siili; Annukka Pasanen; Oskari Heikinheimo; Ralf Bützow; Auli Karhu; Lauri A. Aaltonen; Kimmo Palin; Tatiana Cajuso

MLH1 Lynch Syndrome Colorectal Cancers Are Driven by Heterogeneous Wnt Pathway Gene Mutations MLH1 Lynch综合征结直肠癌是由异质性Wnt通路基因突变驱动的

Gastroenterology

IF25.1

2026-01-20

OAAI

Kalle E. Hokkanen; Joni Panula; Jan Böhm; Jukka-Pekka Mecklin; Päivi Peltomäki; Toni T. Seppälä

Urothelium marker UPK2 identifies aggressive colorectal cancers with distinct molecular and histological features 尿路上皮标志物UPK2识别具有独特分子和形态学特征的侵袭性结直肠癌

British Journal of Cancer

IF6.8

2025-12-11

OAAI

Ville K. Äijälä; Jouni Härkönen; Päivi Sirniö; Tuomo Mantere; Hanna Elomaa; Onni Sirkiä; Akseli Kehusmaa; Henna Karjalainen; Meeri Kastinen; Vilja V. Tapiainen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Anne Tuomisto; Markus J. Mäkinen; Juha P. Väyrynen

Skin cancer risk in hereditary mixed cancer syndromes 遗传性混合癌综合征中的皮肤癌风险

HEREDITARY CANCER IN CLINICAL PRACTICE

IF2.4

2025-12-02

PREAI

Nikkola, Veera; Alakoski, Anna; Mecklin, Jukka-Pekka; Seppala, Toni T.; Nikkola, Jussi; Schrader, Kashmintan

PTEN status, tumor immune microenvironment, and survival in colorectal cancer PTEN状态、肿瘤免疫微环境及结直肠癌中的生存情况

Virchows Archiv

IF3.1

2025-11-18

OAAI

Joni Karjalainen; Onni Sirkiä; Päivi Sirniö; Hanna Elomaa; Henna Karjalainen; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Vesa-Matti Pohjanen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Taneli T. Mattila; Outi Lindgren; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Anne Tuomisto; Markus J. Mäkinen; Juha P. Väyrynen

Constrained hypermutation and absence of TERT promoter mutations in Lynch syndrome-associated urothelial cancer Lynch综合征相关尿路上皮癌中的受限高突变和TERT启动子突变的缺失

Cell Reports

IF6.9

2025-10-03

OAAI

Jussi Nikkola; Lauri Ryyppö; Juuso Vuorinen; Lauri Moilanen; Maarit Ahtiainen; Kirsi Pylvänäinen; Hanna Selin; Tuomo Virtanen; Matti Nykter; Thea Veitonmäki; Jukka-Pekka Mecklin; Toni T. Seppälä; Matti Annala

Integrative omics approaches to uncover liquid-based cancer-predicting biomarkers in Lynch syndrome 整合组学方法以揭示林奇综合征中基于液体的癌症预测生物标志物

International Journal of Cancer

IF4.7

2025-08-26

OAAI

Minta Kärkkäinen; Tero Sievänen; Tia-Marje Korhonen; Joonas Tuomikoski; Kirsi Pylvänäinen; Sami Äyrämö; Toni T. Seppälä; Jukka-Pekka Mecklin; Eija K. Laakkonen; Tiina Jokela

Characteristics and significance of γδ T cells in colorectal cancer γδ T细胞在结直肠癌中的特征与意义

OncoImmunology

IF6.3

2025-07-28

OAAI

Henna Karjalainen; Jouni Härkönen; Päivi Sirniö; Hanna Elomaa; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Sara A. Väyrynen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Anne Tuomisto; Markus J. Mäkinen; Juha P. Väyrynen

Integrating Tumor Intraepithelial CD8+ and Stromal FOXP3+ T-Cell Densities as an Enhanced Immune Prognostic Index in Colorectal Cancer 整合肿瘤上皮内CD8+和间质FOXP3+ T细胞密度作为结直肠癌的增强型免疫预后指数

Laboratory Investigation

IF4.2

2025-07-17

OAAI

Anne Tuomisto; Päivi Sirniö; Hanna Elomaa; Henna Karjalainen; Ville K. Äijälä; Meeri Kastinen; Vilja V. Tapiainen; Maarit Ahtiainen; Olli Helminen; Erkki-Ville Wirta; Jukka Rintala; Sanna Meriläinen; Juha Saarnio; Tero Rautio; Toni T. Seppälä; Jan Böhm; Jukka-Pekka Mecklin; Markus J. Mäkinen; Juha P. Väyrynen

Therapeutic Targeting of Oncogene-Induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma 靶向癌基因诱导的转录-复制冲突在胰导管腺癌中的治疗应用

Gastroenterology

IF25.1

2025-04-08

OAAI

Shanna J. Smith; Fan Meng; Robert G. Lingeman; Caroline M. Li; Min Li; Galyah Boneh; Toni T. Seppälä; Thuy Phan; Haiqing Li; Richard A. Burkhart; Vishwas Parekh; Syed Rahmanuddin; Laleh G. Melstrom; Robert J. Hickey; Vincent Chung; Yilun Liu; Linda H. Malkas; Mustafa Raoof

Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma

BRITISH JOURNAL OF CANCER

IF6.8

2025-02-18

OAAI

Elomaa, Hanna; Tarkiainen, Vilma; Aijala, Ville K.; Sirnio, Paivi; Ahtiainen, Maarit; Sirkia, Onni; Karjalainen, Henna; Kastinen, Meeri; Tapiainen, Vilja V.; Rintala, Jukka; Merilainen, Sanna; Saarnio, Juha; Rautio, Tero; Tuomisto, Anne; Helminen, Olli; Wirta, Erkki-Ville; Seppala, Toni T.; Bohm, Jan; Makinen, Markus J.; Mecklin, Jukka-Pekka; Vayrynen, Juha P.

Commentary on Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank

JOURNAL OF MEDICAL GENETICS

IF3.7

2024-10-07

PREAI

Moller, Pal; Sappala, Toni T.; Domiguez-Valentin, Mev; Sampson, Julian

Lynch syndrome-associated and sporadic microsatellite unstable colorectal cancers: different patterns of clonal evolution yield highly similar tumours

HUMAN MOLECULAR GENETICS

IF3.2

2024-08-24

OAAI

Martin, Samantha; Katainen, Riku; Taira, Aurora; Valimaki, Niko; Ristimaki, Ari; Seppala, Toni; Renkonen-Sinisalo, Laura; Lepisto, Anna; Tahkola, Kyosti; Mattila, Anne; Koskensalo, Selja; Mecklin, Jukka-Pekka; Rajamaki, Kristiina; Palin, Kimmo; Aaltonen, Lauri A.

In vivo CRISPR screening identifies geranylgeranyl diphosphate as a pancreatic cancer tumor growth dependency

MOLECULAR METABOLISM

IF6.6

2024-07-01

OAAI

Kubota, Casie S.; Myers, Stephanie L.; Seppaelae, Toni T.; Burkhart, Richard A.; Espenshade, Peter J.

Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision

BRITISH JOURNAL OF SURGERY

IF8.7

2024-05-09

OAAI

Zaffaroni, Gloria; Mannucci, Alessandro; Koskenvuo, Laura; de Lacy, Borja; Maffioli, Anna; Bisseling, Tanya; Half, Elizabeth; Cavestro, Giulia Martina; Valle, Laura; Ryan, Neil; Aretz, Stefan; Brown, Karen; Buttitta, Francesco; Carneiro, Fatima; Claber, Oonagh; Blanco-Colino, Ruth; Collard, Maxime; Crosbie, Emma; Cunha, Miguel; Doulias, Triantafyllos; Fleming, Christina; Heinrich, Henriette; Hueneburg, Robert; Metras, Julie; Nagtegaal, Iris; Negoi, Ionut; Nielsen, Maartje; Pellino, Gianluca; Ricciardiello, Luigi; Sagir, Abdurrahman; Sanchez-Guillen, Luis; Seppaelae, Toni T.; Siersema, Peter; Striebeck, Benedikt; Sampson, Julian R.; Latchford, Andrew; Parc, Yann; Burn, John; Moeslein, Gabriela

High immune cell infiltration predicts improved survival in cholangiocarcinoma

FRONTIERS IN ONCOLOGY

IF3.3

2024-05-01

OAAI

Wirta, Erkki-Ville; Szeto, Sade; Koppatz, Hanna; Nordin, Arno; Makisalo, Heikki; Arola, Johanna; Siren, Jukka; Ahtiainen, Maarit; Bohm, Jan; Mecklin, Jukka-Pekka; Sallinen, Ville; Seppala, Toni T.

研究方向