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J

James Spicer

king's college london

67H指数
566论文数
1.6W被引数
收录论文 167
发表时间
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Oncology drug development in the UK: analysis of the past 25 years and focus on the 2026 reboot of the clinical trial regulatory framework英国肿瘤药物研发：过去25年的分析及对2026年临床试验监管框架重启的关注
errBritish Journal of Cancer
IF6.8
err2026-07-23
err0
errOAAI
errPaulina Czajka-Francuz; Chris Twelves; James Spicer; Archana Munje; Laura Vidal; Ruth Plummer; Dinesh Mistry; Maksym Novikov; Jim Bush; Gopalakrishnan Srinivasan; Soma Das; Sharan Sandhu; Vikram Bohra; Chinmayee Joshi; Ken Morrison; Suvarna Chavan; Fiona Thistlethwaite; Andrew Walding; Glen Clack; Michael George; Debashis Sarker; Raghib Ali; Sarah P. Blagden; Thomas R. Jeffry Evans; Kamal S. Saini
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err收藏
Preclinical characterization and phase 1 clinical testing of targeting mitochondrial peroxiredoxin 3 in cancer靶向线粒体过氧还原蛋白3在癌症中的临床前表征和I期临床测试
errNature Communications
IF15.7
err2026-07-14
err0
errOAAI
errVictoria Gibson; Joanna Dzialo; Terri Messier; Aleksandra Bzura; Charlotte Poile; Jan Rogel; Jens C. Hahne; Aida Habibovic; Stephanie Stead; Alexis Saaman; Kevin G. Blyth; Peter W. Szlosarek; Simon Lord; Fiona Thistlethwaite; Min Zhang; Apostolos Nakas; Peter Wells-Jordan; Kudzayi Kutywayo; Kelly J. Butnor; Nicholas. H. Heintz; George N. Naumov; Maurice Dungey; Julio Herrero Colomina; Burak Aktas; Sean Dulloo; James Spicer; Dean A. Fennell; Brian Cunniff
err分享
err收藏
Predictors and Outcomes of Non-Small Cell Lung Carcinoma Patients Following Severe Immune Checkpoint Inhibitor Toxicity: A Real-World UK Multi-Centre Study非小细胞肺癌患者发生严重免疫检查点抑制剂毒性的预测因素与结局：一项英国多中心真实世界研究
errCancers
IF4.4
err2026-03-03
err0
errOAAI
errUmair Mahmood; Eleni Josephides; Meenali Chitnis; Michael Skwarski; Spyridon Gennatas; Sharmistha Ghosh; James Spicer; Eleni Karapanagiotou; Tanya Ahmad; Martin Forster; Mariam Jamal-Hanjani; Sarah Benafif; Charles Swanton; Siow-Ming Lee; Dionysis Papadatos-Pastos; Alexandros Georgiou; Nicholas Coupe
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Independent Testing of Published CT Models for PD-L1 Status in Non-Small Cell Lung Cancer针对非小细胞肺癌PD-L1状态的已发表CT模型独立测试
errRadiology
IF15.2
err2026-03-01
err0
PREAI
errO'Shea, Robert; Horst, Carolyn; Manickavasagar, Thubeena; Josephides, Eleni; Hunter, Sarah; Taniere, Phillipe; Nonaka, Daisuke; Van Hemelrijck, Mieke; Spicer, James; Hughes, Daniel J.; Cook, Gary J. R.; Bille, Andrea; Karapanagiotou, Eleni; Goh, Vicky
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Nonallergic urticarial skin reactions associated with MOv18 IgE, a first-in-class IgE antibody recognizing folate receptor alpha (FRα): linking allergooncology with dermatology与MOv18 IgE相关的非过敏性荨麻疹皮肤反应，MOv18 IgE是一种靶向叶酸受体α（FRα）的第一类IgE抗体：连接过敏肿瘤学与皮肤病学
errBritish Journal of Dermatology
IF9.6
err2026-01-01
err0
PREAI
errChauhan, Jitesh; Stavraka, Chara; Tull, Thomas J.; Willsmore, Zena; Semkova, Kristina, V; McGrath, John; Lacy, Katie E.; Joseph, Debra H.; Spicer, James; Bax, Heather J.; Karagiannis, Sophia N.
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An oral heme oxygenase inhibitor targets immunosuppressive perivascular macrophages in preclinical models of cancer一种口服的血红素加氧酶抑制剂靶向癌症的预临床模型中的免疫抑制性血管周巨噬细胞
errScience Translational Medicine
IF14.6
err2025-08-06
err0
PREAI
errMeriem Bahri; Taha Al-Adhami; Emre Demirel; Jit Sarkar; Karen T. Feehan; Joanne E. Anstee; Tik Shing Cheung; Dominika Sosnowska; Chloé A. Woodman; William Macmorland; Dorothy D. Yang; James Rosekilly; Renee Gitsaki-Taylor; Cheryl E. Gillett; Cheryl L. Scudamore; James Spicer; Khondaker Miraz Rahman; James N. Arnold
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Assessment of biophysical properties of the first-in-class anti-cancer IgE antibody drug MOv18 IgE demonstrates monomeric purity and stability评估首批抗癌IgE抗体药物MOv18 IgE的生物物理性质，显示出单体纯度和稳定性。
errMABS
IF7.3
err2025-05-28
err0
errOAAI
errPaul Considine; Panida Punnabhum; Callum G. Davidson; Georgina B. Armstrong; Michaela Kreiner; Heather J. Bax; Jitesh Chauhan; James Spicer; Debra H. Josephs; Sophia N. Karagiannis; Gavin Halbert; Zahra Rattray
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A Phase Ib, Open-Label Trial Of MOv18 IgE In Patients With Advanced Ovarian Cancer (vol 35, 101893, 2025)I期b临床试验：MOv18 IgE在晚期卵巢癌患者中的应用（卷35，101893，2025）
errINTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
IF4.7
err2025-05-01
err0
PREAI
errKristeleit, Rebecca; Basu, Bristi; Miller, Rowan; Iglesias, Jose; Calam, Andrew; Nirsimloo, Rachel; Green, Clare; Walther, Axel; Twelves, Christopher; Spicer, James
err分享
err收藏
Non-Allergic Urticarial Skin Reactions Associated With MOv18 IgE, a First-In-Class IgE Antibody Recognising Folate Receptor Alpha与MOv18 IgE相关的非过敏性荨麻疹性皮肤反应，MOv18 IgE是一种识别叶酸受体α的第一类IgE抗体
errALLERGY
IF12
err2025-03-06
err0
errOAAI
errStavraka, C; Chauhan, J; Crescioli, S; Mcsweeney, SM; Pope, A; Gillett, C; Di Meo, A; Prassas, I; Laddach, R; Stoker, K; Mccraw, AJ; Adams, R; Tull, TJ; Naban, N; Willsmore, Z; Semkova, KV; Grattan, CEH; Mcgrath, J; Till, SJ; Corrigan, CJ; Kristeleit, R; Tsoka, S; Diamandis, EP; Lacy, KE; Pinder, S; Josephs, DH; Spicer, J; Bax, HJ; Karagiannis, SN
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Physiochemical and functional evaluation of the first-in-class anti-cancer IgE antibody drug, MOv18, through process development and good manufacturing practice production通过工艺开发和良好生产规范生产，对首个同类抗肿瘤IgE抗体药物MOv18进行理化性质和功能评价
errMABS
IF7.3
err2025-01-20
err1
errOAAI
errHeather J Bax; Jitesh Chauhan; Alexandra J McCraw; Melanie Grandits; Chara Stavraka; Heike Lentfer; Tim Hillyer; Simon Carroll; Kim Vigor; Chris Selkirk; Mariangela Figini; Jack Cheeseman; Paulina A Urbanowicz; Richard A Gardner; Daniel I R Spencer; Nigel Westwood; Sarah Mellor; James Spicer; Debra H Josephs; Sophia N Karagiannis
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Long term efficacy of first-line afatinib and the clinical utility of ctDNA monitoring in patients with suspected or confirmed EGFR mutant non-small cell lung cancer who were unsuitable for chemotherapy一线阿法替尼的长期疗效和ctDNA监测在不适合化疗的疑似或确诊EGFR突变非小细胞肺癌患者中的临床应用
errBRITISH JOURNAL OF CANCER
IF6.8
err2024-12-05
err0
errOAAI
errPopat, Sanjay; Januszewski, Adam; O'Brien, Mary; Ahmad, Tanya; Lewanski, Conrad; Dernedde, Ulrike; Jankowska, Petra; Mulatero, Clive; Shah, Riyaz; Hicks, Jonathan; Geldart, Tom; Cominos, Mathilda; Gray, Gill; Spicer, James; Bell, Karen; Roitt, Simon; Morris, Clive; Ngai, Yenting; Hughes, Laura; Hackshaw, Allan; Wilson, William
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err收藏
Equity of access and clinical impact of genomic testing in patients with cancer in a UK early phase clinical trials unit癌症患者中基因组检测的可及性公平性与临床影响：一项在英国早期临床试验单位的研究
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errPoon, J.; Aktas, B. Y.; Kristeleit, R.; Josephs, D.; Spicer, J.; Sarker, D.
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A phase II trial of the IO102-IO103 vaccine plus pembrolizumab: Completed cohort for first-line (1L) treatment of advanced squamous cell carcinoma of the head and neck (SCCHN)IO102-IO103疫苗联合帕博利珠单抗的二项期临床试验：完成了一线（1L）治疗晚期头颈鳞状细胞癌（SCCHN）的队列。
errANNALS OF ONCOLOGY
IF65.4
err2024-09-01
err0
PREAI
errRiess, J. W.; Spicer, J.; Seiwert, T.; Villaflor, V.; Rubio Perez, J.; Shaw, P. H.; Soria Rivas, A.; Chaney, M.; Abildgaard, C.; Patel, P.; Iglesias, M.; Ahmad, Q.; McDowell, D.; Garrido Lopez, P.
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err收藏
Plasmid DNA ionisable lipid nanoparticles as non-inert carriers and potent immune activators for cancer immunotherapy
errJOURNAL OF CONTROLLED RELEASE
IF11.5
err2024-05-01
err1
errOAAI
errQin, Yue; Rouatbi, Nadia; Wang, Julie Tzu-Wen; Baker, Rafal; Spicer, James; Walters, Adam A.; Al-Jamal, Khuloud T.
err分享
err收藏
Durable responses to ATR inhibition with ceralasertib in tumors with genomic defects and high inflammation
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2024-01-16
err8
errOAAI
errDillon, Magnus T.; Guevara, Jeane; Mohammed, Kabir; Patin, Emmanuel C.; Smith, Simon A.; Dean, Emma; Jones, Gemma N.; Willis, Sophie E.; Petrone, Marcella; Silva, Carlos; Thway, Khin; Bunce, Catey; Roxanis, Ioannis; Nenclares, Pablo; Wilkins, Anna; Mclaughlin, Martin; Jayme-Laiche, Adoracion; Benafif, Sarah; Nintos, Georgios; Kwatra, Vineet; Grove, Lorna; Mansfield, David; Proszek, Paula; Martin, Philip; Moore, Luiza; Swales, Karen E.; Banerji, Udai; Saunders, Mark P.; Spicer, James; Forster, Martin D.; Harrington, Kevin J.
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Phase Ib/II open label, multi-arm, parallel cohort dose finding and expansion study of NUC-3373 in combination with pembrolizumab in patients with advanced solid tumors or docetaxel in patients with lung cancer (NuTide:303)
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errWilson, Richard H.; Thistlethwaite, Fiona; McKissock, Fiona G.; Oelmann, Elisabeth; Bloss, Jeffrey D.; Spicer, James F.; Middleton, Gary
err分享
err收藏
RSO-021, a first-in-class covalent inhibitor of mitochondrial PRX3: From bench to bedside
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2023-12-01
err0
PREAI
errFennell, Dean A.; Dulloo, Sean; Szlosarek, Peter; Thistlethwaite, Fiona; Lord, Simon; Rahman, Najib M.; Cunniff, Brian; Dzialo, Joanna; Poile, Charlotte; Panchal, Rakesh; Duncan, Jarrett; Graham, Pip; Bexon, Alice; Naumov, George N.; Spicer, James
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PD-1-expressing macrophages and CD8 T cells are independent predictors of clinical benefit from PD-1 inhibition in advanced mesotheliomaPD-1-expressing巨噬细胞和CD8 T细胞是晚期间皮瘤PD-1抑制临床获益的独立预测因子
errJOURNAL FOR IMMUNOTHERAPY OF CANCER
IF10.6
err2023-10-25
err3
errOAAI
errHomicsko, Krisztian; Zygoura, Panagiota; Norkin, Maxim; Tissot, Stephanie; Shakarishvili, Nicholas; Popat, Sanjay; Curioni-Fontecedro, Alessandra; O'Brien, Mary; Pope, Anthony; Shah, Riyaz; Fisher, Patricia; Spicer, James; Roy, Amy; Gilligan, David; Rusakiewicz, Sylvie; Fortis, Ekaterina; Marti, Nesa; Kammler, Roswitha; Finn, Stephen P.; Coukos, Georges; Dafni, Urania; Peters, Solange; Stahel, Rolf A.
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A phase II trial of the IO102-IO103 vaccine plus pembrolizumab: preliminary analysis for first-line (1L) treatment of non-small cell lung cancer (NSCLC) and squamous cell carcinoma of the head and neck (SCCHN)
errANNALS OF ONCOLOGY
IF65.4
err2023-10-01
err0
errOAAI
errRiess, J. W.; Cohen, E.; Spicer, J.; Shaw, P. H.; Rubio Perez, J.; Medina Rodriguez, L.; Chaney, M. F.; O'Neill, S.; Pedersen, A. W.; McDowell, D.; Ehrnrooth, E.; Lopez, P. Garrido
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Lung cancer in never smokers (LCINS): Clinicopathological characteristics and treatment outcomes from a university cancer centre in London
errANNALS OF ONCOLOGY
IF65.4
err2023-10-01
err0
errOAAI
errGousis, C.; Josephides, E.; McGrath, H.; Ryanna, K.; Santis, G.; Bille, A.; Smith, D.; Ahmad, S.; Ghosh, S.; Gennatas, S.; Karapanagiotou, E. M.; Spicer, J.; Georgiou, A.
err分享
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研究方向

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