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Inosine monophosphate dehydrogenase 2 (IMPDH2) modulates response to therapy and chemo-resistance in triple negative breast cancer 肌苷单磷酸脱氢酶2 (IMPDH2) 调节三阴性乳腺癌对治疗和化疗耐药的反应 Fernandes, Tatiane da Silva; Gillard, Bryan M.; Dai, Tao; Martin, Jeffrey C.; Chaudhry, Kanita A.; Dugas, Scott M.; Fisher, Alyssa A.; Sharma, Pia; Wu, Rongrong; Attwood, Kristopher M.; Dasgupta, Subhamoy; Takabe, Kazuaki; Rosario, Spencer R.; Bianchi-Smiraglia, Anna 分享 收藏
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Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer Singh, Samara P.; Dosch, Austin R.; Mehra, Siddharth; Silva, Iago de Castro; Garrido, Vanessa Tonin; Bianchi, Anna; Amirian, Haleh; Box, Edmond W.; Datta, Jashodeep; Nagathihalli, Nagaraj S.; Merchant, Nipun B. 分享 收藏
Neutrophil-intrinsic tumor necrosis factor (TNF) is a novel driver of T-cell and cancer-associated fibroblast (CAF) dysfunction in pancreatic cancer Bianchi, Anna; Amirian, Haleh; Silva, Iago De Castro; Ogobuiro, Ifeanyichukwu; Rajkumar, Karthik; Adams, Andrew Mark; Garrido, Vanessa; Singh, Samara; Mehra, Siddharth; Rafie, Christine; Nagathihalli, Nagarj; Stelekati, Erietta; Merchant, Nipun; Datta, Jashodeep 分享 收藏
Granulocytic MDSC-derived NLRP3 inflammasome activation is a novel regulator of inflammatory CAF skewness in pancreatic cancer Rajkumar, Karthik; Deshpande, Nilesh U.; Silva, Iago de Castro; Bianchi, Anna; Ogobuiro, Ifeanyichukwu; Amirian, Haleh; Adams, Andrews; Garrido, Vanessa; Mehra, Siddharth; Singh, Samara; Nagathihalli, Nagaraj; Merchant, Nipun B.; Datta, Jashodeep 分享 收藏
Alcoholic chronic inflammation driven CREB mediates acinar-to-ductal reprogramming and promote neoplastic progression Mehra, Siddharth; Srinivasan, Supriya; Bianchi, Anna; Dosch, Austin; Singh, Samara; Garrido, Vanessa; Silva, Iago De Castro; Krishnamoorthy, Varunkumar; Jinka, Sudhakar; Datta, Jashodeep; Merchant, Nipun B.; Nagathihalli, Nagaraj 分享 收藏
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Tumor cell-macrophage crosstalk drives immune suppression in pancreatic cancer Mehra, Siddharth; Garrido, Vanessa; Singh, Samara; Silva, Iago De Castro; Zhou, Zhiqun; Srinivasan, Supriya; Nivelo, Luis Alberto; Bianchi, Anna; Adams, Andrew; Amirian, Haleh; Morey, Lluis; Ban Yuguang; Villarino, Alejandro; Datta, Jashodeep; Merchant, Nipun; Nagathihalli, Nagaraj 分享 收藏
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Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer MEK和STAT3联合抑制通过富集具有间充质干细胞样特征的癌症相关成纤维细胞来克服胰腺癌的免疫治疗耐药性，从而揭示基质可塑性 Datta, Jashodeep; Dai, Xizi; Bianchi, Anna; Silva, Iago De Castro; Mehra, Siddharth; Garrido, Vanessa T.; Lamichhane, Purushottam; Singh, Samara P.; Zhou, Zhiqun; Dosch, Austin R.; Messaggio, Fanuel; Ban, Yuguang; Umland, Oliver; Hosein, Peter J.; Nagathihalli, Nagaraj S.; Merchant, Nipun B. 分享 收藏
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Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer Datta, Jashodeep; Bianchi, Anna; Silva, Iago De Castro; Deshpande, Nilesh U.; Cao, Long Long; Mehra, Siddharth; Singh, Samara; Rafie, Christine; Sun, Xiaodian; Chen, Xi; Dai, Xizi; Colaprico, Antonio; Sharma, Prateek; Dosch, Austin R.; Pillai, Asha; Hosein, Peter J.; Nagathihalli, Nagaraj S.; Komanduri, Krishna, V; Wilson, Julie M.; Ban, Yuguang; Merchant, Nipun B. 分享 收藏
Phosphorylation of guanosine monophosphate reductase triggers a GTP-dependent switch from pro- to anti-oncogenic function of EPHA4 Wolff, David W.; Deng, Zhiyong; Bianchi-Smiraglia, Anna; Foley, Colleen E.; Han, Zhannan; Wang, Xingyou; Shen, Shichen; Rosenberg, Masha M.; Moparthy, Sudha; Yun, Dong Hyun; Chen, Jialin; Baker, Brian K.; Roll, Matthew, V; Magiera, Andrew J.; Li, Jun; Hurley, Edward; Feltri, Maria Laura; Cox, Anderson O.; Lee, Jingyun; Furdui, Cristina M.; Liu, Liang; Bshara, Wiam; LaConte, Leslie E. W.; Kandel, Eugene S.; Pasquale, Elena B.; Qu, Jun; Hedstrom, Lizbeth; Nikiforov, Mikhail A. 分享 收藏
Regulation of local GTP availability controls RAC1 activity and cell invasion (vol 12, 6091, 2021) 调节局部GTP可用性控制RAC1活性和细胞侵袭 (vol 12，6091，2021) Bianchi-Smiraglia, Anna; Wolff, David W.; Marston, Daniel J.; Deng, Zhiyong; Han, Zhannan; Moparthy, Sudha; Wombacher, Rebecca M.; Mussell, Ashley L.; Shen, Shichen; Chen, Jialin; Yun, Dong-Hyun; O'Brien Cox, Anderson; Furdui, Cristina M.; Hurley, Edward; Feltri, Maria Laura; Qu, Jun; Hollis, Thomas; Kengne, Jules Berlin Nde; Fongang, Bernard; Sousa, Rui J.; Kandel, Mikhail E.; Kandel, Eugene S.; Hahn, Klaus M.; Nikiforov, Mikhail A. 分享 收藏
Regulation of local GTP availability controls RAC1 activity and cell invasion 调节局部GTP可用性控制RAC1活性和细胞侵袭 Bianchi-Smiraglia, Anna; Wolff, David W.; Marston, Daniel J.; Deng, Zhiyong; Han, Zhannan; Moparthy, Sudha; Wombacher, Rebecca M.; Mussell, Ashley L.; Shen, Shichen; Chen, Jialin; Yun, Dong-Hyun; O'Brien Cox, Anderson; Furdui, Cristina M.; Hurley, Edward; Feltri, Maria Laura; Qu, Jun; Hollis, Thomas; Kengne, Jules Berlin Nde; Fongang, Bernard; Sousa, Rui J.; Kandel, Mikhail E.; Kandel, Eugene S.; Hahn, Klaus M.; Nikiforov, Mikhail A. 分享 收藏
Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer Dosch, Austin R.; Singh, Samara; Dai, Xizi; Mehra, Siddharth; Silva, Iago De Castro; Bianchi, Anna; Srinivasan, Supriya; Gao, Zhen; Ban, Yuguang; Chen, Xi; Banerjee, Sulagna; Nagathihalli, Nagaraj S.; Datta, Jashodeep; Merchant, Nipun B. 分享 收藏
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