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D

Daniel J. Siegwart

University of Texas Southwestern Medical Center

58H指数
137论文数
1.6W被引数
收录论文 87
发表时间
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Myogenic Fusogen-Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle肌源性融合蛋白工程化脂质纳米颗粒增强骨骼肌中的mRNA递送
errAdvanced Functional Materials
IF19
err2026-09-16
err0
errOAAI
errFangyu Zhang; Zhisheng Xu; Yaou Duan; Yehui Sun; Shiying Wu; Tao Long; Mateusz Durbacz; Li Zhang; Yufen Xiao; Yu-Chung Pien; Erick D. Guerrero; Zeru Tian; Xu Wang; Pratima Basak; Sumanta Chatterjee; Ning Liu; Xiaochun Li; Eric N. Olson; Daniel J. Siegwart
err分享
err收藏
mRNA-LNP therapeutics for obesity: weight loss with metabolic repairmRNA-LNP疗法用于肥胖：具有代谢修复的体重减轻
errNature Reviews Endocrinology
IF40
err2026-08-14
err0
PREAI
errJun Liao; Lukas Farbiak; Daniel J. Siegwart; Chuang Liu
err分享
err收藏
Nanotechnology-mediated precision delivery of mRNA纳米技术介导的mRNA精确递送
errNature Materials
IF38.5
err2026-06-18
err0
PREAI
errHongzhang Deng; Lin Li; Caiyan Zhao; Zhongliang Wang; Yufen Xiao; Pei Huang; Daniel Siegwart; Xiaoyuan Chen
err分享
err收藏
‘Tripod-like’ lung-targeting (LuT) lipids for highly efficient and selective LNPs for gene delivery and editing“三脚架状” 肺靶向 (LuT) 脂质，用于基因递送和编辑的高效和选择性lnp
errNature Biomedical Engineering
IF26.6
err2026-03-17
err0
errOAAI
errZeru Tian; Xu Wang; Sumanta Chatterjee; William Miller; Erick Guerrero; Yun-Chieh Sung; Alexis Pacheco Benitez; Sean Dilliard; Xiaoyan Bian; Amogh Vaidya; Xizhen Lian; Stephen Moore; Yehui Sun; Minjeong Kim; Yufen Xiao; Shiying Wu; Bret M. Evers; Jeon Lee; Lukas Farbiak; Daniel J. Siegwart
err分享
err收藏
SORT LNPs encapsulating Cas9 mRNA achieve efficient editing in skeletal muscle in a dystrophic mouse modelSORT LNPs封装的Cas9 mRNA在杜氏肌营养不良小鼠模型中实现了骨骼肌的高效编辑。
errMolecular Therapy
IF12
err2026-03-11
err0
errOAAI
errSukanya Iyer; Katelyn Daman; Yehui Sun; Amanda Tutto; Sarah E. Holbrook; Anya T. Joynt; Jing Yan; Prajakta Ambegaokar; Dongsheng Guo; Pengpeng Liu; Jennifer Stauffer; Stacy A. Maitland; Sang M. Lee; Yufen Xiao; Hsi-Chien Huang; Lihua J. Zhu; Thomas L. Gallagher; Gregory A. Cox; Allison M. Keeler; Daniel J. Siegwart
err分享
err收藏
The RNA delivery dilemma—lipid versus polymer nanoparticle platforms
errDrug Delivery and Translational Research
IF5.5
err2026-01-30
err0
PREAI
errCláudia Martins; Michael J. Mitchell; Dan Peer; Yvonne Perrie; Daniel J. Siegwart; María José Alonso; Juan Aparicio-Blanco
err分享
err收藏
Multiplexed lipid nanoparticle barcoding reveals tissue-dynamic kinetic insights and enriched cellular tropism in hepatic zones多重脂质纳米颗粒条形码技术揭示了组织动态动力学见解以及在肝区内的富集细胞趋向性
errNature Communications
IF15.7
err2026-01-07
err0
errOAAI
errStephen T. Moore; Xizhen Lian; Amogh Vaidya; Sumanta Chatterjee; Julien Santelli; Yehui Sun; Lukas Farbiak; Hao Zhu; Daniel J. Siegwart
err分享
err收藏
The origin of hepatocellular carcinoma depends on metabolic zonation肝细胞癌的起源取决于代谢分区
errScience
IF45.8
err2025-11-06
err0
PREAI
errJason Guo; Roger Liang; Andrew Chung; Zhijie Li; Boyuan Li; Eric Chen; Lin Li; Jingjing Wang; Meng-Hsiung Hsieh; Ivy Xiangyi Fang; Benjamin Kroger; Yunguan Wang; Min Zhu; Xiongzhao Ren; Greg Mannino; Yuemeng Jia; Yonglong Wei; Stephen Moore; Daniel J. Siegwart; Stephen S. Chung; Zixi Wang; Tripti Sharma; Suman Komjeti; Yi Han; Purva Gopal; Guanghua Xiao; Tao Wang; Hao Zhu
err分享
err收藏
Co-transcriptional modifications of 2’-hydroxyls on synthetic mRNA enhance ribonuclease resistance and lipid nanoparticle thermostability合成mRNA上2’-羟基的共转录修饰增强了核糖核酸酶抵抗力和脂质纳米颗粒的热稳定性
errMolecular Therapy Nucleic Acids
IF6.1
err2025-10-21
err0
errOAAI
errKohki Yamada; Yun-Chieh Sung; Tsung-Ying Lee; Daniel J. Siegwart
err分享
err收藏
Investigating the Functional Contributions of Phospholipids in Selective Organ Targeting Lipid Nanoparticles探究磷脂在选择性器官靶向脂质纳米颗粒中的功能贡献
errBiomaterials
IF12.9
err2025-08-30
err0
PREAI
errErick D. Guerrero; Amogh Vaidya; Julien Santelli; Zeru Tian; Gabriela A. Pazzi; Daniel J. Siegwart
err分享
err收藏
Structure–Activity Relationship of Ionizable Lipids for siRNA and mRNA Lipid Nanoparticle Design可电离脂质的结构-活性关系及其在siRNA和mRNA脂质纳米颗粒设计中的应用
errACS Biomaterials Science & Engineering
IF5.5
err2025-07-11
err0
PREAI
errSang M. Lee; Yehui Sun; Sumanta Chatterjee; Hu Xiong; Qiang Cheng; Xu Wang; Daniel J. Siegwart
err分享
err收藏
Reducing Complexity in Lipid Nanoparticles: Three-Component Zwitterionic Amino Lipids for Targeted Extrahepatic mRNA Delivery降低脂质纳米颗粒的复杂性：三组分两性离子氨基酸脂质用于靶向肝外mRNA递送
errACS Biomaterials Science & Engineering
IF5.5
err2025-07-09
err0
PREAI
errJoshua J. Robinson; Di Zhang; Pratima Basak; Amogh Vaidya; Sumanta Chatterjee; Xiaoyan Bian; Minjeong Kim; Xizhen Lian; Yehui Sun; Erick Guerrero; Xu Wang; Sang M. Lee; Shuai Liu; Junyu Gong; Mayank Tiwari; Godwin K. Babanyinah; Mihaela C. Stefan; Lukas Farbiak; Daniel J. Siegwart
err分享
err收藏
Publisher Correction: High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics出版商更正: 高密度刷状聚合物脂质减少抗PEG抗体结合，用于重复施用mRNA治疗剂
errNature Materials
IF38.5
err2025-06-04
err0
PREAI
errYufen Xiao; Xizhen Lian; Yehui Sun; Yun-Chieh Sung; Amogh Vaidya; Zexiang Chen; Ankit Gupta; Sumanta Chatterjee; Lining Zheng; Erick Guerrero; Xu Wang; Lukas Farbiak; Yangyang Yang; Marc I. Diamond; Cecilia Leal; Jeffrey G. McDonald; Daniel J. Siegwart
err分享
err收藏
Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-12-10
err0
PREAI
errWu, Shiying; Yang, Yangyang; Lian, Xizhen; Zhang, Fangyu; Hu, Chao; Tsien, Jet; Chen, Zexiang; Sun, Yehui; Vaidya, Amogh; Kim, Minjeong; Sung, Yun-Chieh; Xiao, Yufen; Bian, Xiaoyan; Wang, Xu; Tian, Zeru; Guerrero, Erick; Robinson, Joshua; Basak, Pratima; Qin, Tian; Siegwart, Daniel J.
err分享
err收藏
Nucleic Acid Therapy for the Skin皮肤核酸治疗
errJOURNAL OF INVESTIGATIVE DERMATOLOGY
IF5.7
err2024-09-01
err0
PREAI
errChai, Andreas C.; Siegwart, Daniel J.; Wang, Richard C.
err分享
err收藏
Expanding RNAi to Kidneys, Lungs, and Spleen via Selective ORgan Targeting (SORT) siRNA Lipid Nanoparticles通过选择性器官靶向 (SORT) siRNA脂质纳米颗粒将RNAi扩展到肾脏，肺和脾脏
errADVANCED MATERIALS
IF26.8
err2024-07-08
err2
PREAI
errVaidya, Amogh; Moore, Stephen; Chatterjee, Sumanta; Guerrero, Erick; Kim, Minjeong; Farbiak, Lukas; Dilliard, Sean A.; Siegwart, Daniel J.
err分享
err收藏
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells骨髓归巢脂质纳米颗粒用于患病和恶性造血干细胞的基因组编辑
errNATURE NANOTECHNOLOGY
IF34.9
err2024-05-23
err13
PREAI
errLian, Xizhen; Chatterjee, Sumanta; Sun, Yehui; Dilliard, Sean A.; Moore, Stephen; Xiao, Yufen; Bian, Xiaoyan; Yamada, Kohki; Sung, Yun-Chieh; Levine, Rachel M.; Mayberry, Kalin; John, Samuel; Liu, Xiaoye; Smith, Caroline; Johnson, Lindsay T.; Wang, Xu; Zhang, Cheng Cheng; Liu, David R.; Newby, Gregory A.; Weiss, Mitchell J.; Yen, Jonathan S.; Siegwart, Daniel J.
err分享
err收藏
In situ production and secretion of proteins endow therapeutic benefit against psoriasiform dermatitis and melanoma
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-12-18
err1
errOAAI
errCheng, Qiang; Farbiak, Lukas; Vaidya, Amogh; Guerrero, Erick; Lee, Eunice E.; Rose, Elysha K.; Wang, Xu; Robinson, Joshua; Lee, Sang M.; Wei, Tuo; Miller, William E.; Benedicto, Ester Alvarez; Lian, Xizhen; Wang, Richard C.; Siegwart, Daniel J.
err分享
err收藏
Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models肺分类lnp可在囊性纤维化模型中实现精确的同源定向修复介导的CRISPR/Cas基因组校正
errNATURE COMMUNICATIONS
IF15.7
err2023-11-11
err38
errOAAI
errWei, Tuo; Sun, Yehui; Cheng, Qiang; Chatterjee, Sumanta; Traylor, Zachary; Johnson, Lindsay T.; Coquelin, Melissa L.; Wang, Jialu; Torres, Michael J.; Lian, Xizhen; Wang, Xu; Xiao, Yufen; Hodges, Craig A.; Siegwart, Daniel J.
err分享
err收藏
Modular Design of Biodegradable Ionizable Lipids for Improved mRNA Delivery and Precise Cancer Metastasis Delineation In Vivo
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-10-19
err39
PREAI
errChen, Zhaoming; Tian, Yang; Yang, Jieyu; Wu, Fapu; Liu, Senyao; Cao, Wenwen; Xu, Weijia; Hu, Tao; Siegwart, Daniel J.; Xiong, Hu
err分享
err收藏

研究方向

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合作学者
合作期刊
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Róbert Langer
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Kazunori Kataoka
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