Lei Chen - Publications, H-index & Citations

陈

陈磊 (Lei Chen)

tongji university

53H指数

209论文数

9.4K被引数

收录论文 110

发表时间

Ketogenic diet exacerbates DSS-induced colitis through a β-hydroxybutyrate-Thomasclavelia spiroformis-γδ17 T cell axis in mice 生酮饮食通过β-羟基丁酸-Thomasclavelia spiroformis-γδ17 T细胞轴加剧DSS诱导的小鼠结肠炎

Nature Communications

IF15.7

2026-04-23

OAAI

Yameng Liu; Xuan Wu; Li Chen; Shan Wang; Jingyi Xu; Weifeng Wang; Xueting Yao; Wei Xie; Xianchun Zhong; Shuai Li; Yueying Li; Lin Han; Cen Xie; Lei Chen; Frank J. Gonzalez; Weiwei Liu

In situ fabrication of high-toughness (Ti,W)C-based multiphase ceramics via ZrSi2-assisted reactive hot pressing: Microstructural evolution and toughening mechanisms ZrSi2辅助反应热压原位制备高韧性(Ti,W)C基多相陶瓷：微观结构演变与增韧机制

International Journal of Refractory Metals and Hard Materials

IF4.6

2026-04-22

PREAI

Boxin Wei; Yan Li; Yang Yang; Liang Zheng; Dong Wang; Lei Chen; Yujin Wang

Electrical conductivity investigation of B-site Ga3+ ion doped BaBiNb5O15 ceramics B位Ga3+离子掺杂BaBiNb5O15陶瓷的电导率研究

materials science and engineering: b

IF0

2026-04-17

PREAI

Han Wang; Jiamiao Tuo; Xinyu Hu; Shuyao Cao; Weiguo Wang; Qinfu Zhao; Lei Chen; Qiang Liu; Fang Kang; Ping Zhang; Xianyu Li; Gangling Hao

Single-cell Analysis Reveals a LAMB3-dependent Immunosuppressive Environment in Gallbladder Neck/Cystic Duct Carcinoma 单细胞分析揭示胆囊颈/胆囊管癌中LAMB3依赖性的免疫抑制性微环境

JHEP Reports

IF7.5

2026-04-17

OAAI

Xuebing Shi; Shuai Li; Mixue Bai; Zhihua Xie; Qingbao Cheng; Xinyao Qiu; Tao Zhou; Xinyu Jiang; Shuai Yang; Ji Hu; Dongdong Xue; Shuowu Liu; Yani Zhang; Yixian Wang; Jing Wu; Jinxia Bao; Hongyang Wang; Xiaoqing Jiang; Lei Chen

TRPV4 is involved in NLRP3 and NLRP1 inflammasomes activation after pilocarpine-induced status epilepticus in mice TRPV4 参与小鼠匹鲁卡品诱导的癫痫持续状态后的 NLRP3 和 NLRP1 炎症小体的激活。

Cellular and Molecular Life Sciences

IF6.2

2026-03-29

OAAI

Lihan Liu; Guowen Zhang; Yu Xu; Xiaolin Wang; Sha Sha; Chunfeng Wu; Wei Li; Lei Chen

Physicochemical Characterization, Prebiotic Potential, and Lipid-Lowering Effect of Mesembryanthemum crystallinum L. Polysaccharide 物理化学表征、益生元潜力和降脂作用：Mesembryanthemum crystallinum L. 多糖

Foods

IF5.1

2026-03-29

OAAI

Hui Cao; Bing Yang; Yangyang Wang; Jingjing Zhang; Huaxing Xiong; Haolin Zhang; Zhanhui Cao; Hui Teng; Lei Chen; Hui Wang

Long-term outcomes by clinical and molecular risk stratification in patients with medulloblastoma receiving risk-adapted therapy 髓母细胞瘤患者接受风险适应性治疗后，根据临床和分子风险分层评估的长期结局

Med

IF11.8

2026-03-27

PREAI

Hailong Liu; Yu Su; Jiao Zhang; Xuan Chen; Kaiwen Deng; Li Chen; Jin Feng; Xiaochong Wu; Craig Daniels; Yanong Li; Jing Zhang; Yahui Zhao; Yanfeng Shi; Fei Liu; Zhaoyang Feng; Dongyang Wang; Dongming Han; Wei Wang; Ming Wang; Junping Zhang

Correction: Dual-energy CT extracellular volume fraction predicts tumor collagen ratio and possibly survival for inoperable pancreatic cancer patients 更正：双能量CT细胞外容积分数可预测不可手术胰腺癌患者的肿瘤胶原比例，并可能预测其生存情况。

European Radiology

IF4.7

2026-03-26

PREAI

Wei Liu; Yi Chen; Tiansong Xie; Zehua Zhang; Yu Wang; Xuebin Xie; Lei Chen; Zhengrong Zhou

CSRNP1 Promotes Apoptosis and Mitochondrial Dysfunction via ROS-Mediated JNK/p38 MAPK Pathway Activation in Hepatocellular Carcinoma CSRNP1 通过 ROS 介导的 JNK/p38 MAPK 通路激活促进肝细胞癌的凋亡和线粒体功能障碍

Oncology Research

IF4.1

2026-01-01

PREAI

Shi, Huihui; Chen, Lei; Huang, Juan; Lin, Xuejing; Huang, Lei; Tang, Min; Lu, Kai; Wang, Wenchao; Zhu, Maoling

Stereotactic body radiotherapy with sintilimab and bevacizumab biosimilar in anti-PD-1 refractory hepatocellular carcinoma: the ReUNION-1 phase 2 trial 立体定向体部放射治疗联合信迪利单抗和贝伐珠单抗生物类似物治疗抗PD-1耐药的肝细胞癌：ReUNION-1期2临床试验

Nature Communications

IF15.7

2025-12-18

OAAI

Jing Tang; Yongqiang Yang; Dongen Liu; Bicheng Wang; Zhenyu Lin; Zilong Wu; Jinfeng Zhang; Dejun Zhang; Yaqin Liu; Minghui Ge; Lei Chen; Gang Wu; Tao Zhang; Jun Xue

Isorhynchophylline-loaded silk sericin/gelatin methacrylate crosslinked hydrogel: A synergistic platform for accelerated wound healing 异叶钩藤碱负载的丝素蛋白/明胶甲基丙烯酸酯交联水凝胶：一种加速伤口愈合的协同平台

International Journal of Biological Macromolecules

IF8.5

2025-11-10

PREAI

Lei Chen; Li-li Liu; Zun-jiang Zhao; Da-lun Lv; Cheng Cheng; Xu-lin Chen; Hui-juan Shu

Impact of Blood Pressure Across the Life Course on Arterial Stiffness in Midlife: The Mediating Role of Metabolic Factors 生命历程中血压对中年动脉僵硬的影响：代谢因素的介导作用

MedComm

IF10.7

2025-10-22

OAAI

Yang Wang; Shi-Qi Liu; Ze-Jiaxin Niu; Ming-Ke Chang; Ming-Fei Du; Hao Jia; Yue Sun; Dan Wang; Gui-Lin Hu; Zi-Yue Man; Chao Chu; Teng Zhang; Xi Zhang; Yu Yan; Tong-Shuai Guo; Rui-Yu Wang; Sheng-Hao Zuo; Hao Li; Lei Chen; Ying Xiong; Zhong-Min Tian; Gregory Y. H. Lip; Zu-Yi Yuan; Yu-Ming Kang; Yao Lu; Jian-Jun Mu

Causal Associations of Cardiovascular Proteins and Diabetic Nephropathy Revealed by Mediation and Phenome-Wide Mendelian Randomization 中介分析和全表型孟德尔随机化揭示的心血管蛋白质与糖尿病肾病之间的因果关联

ENDOCRINOLOGY AND METABOLISM

IF4.2

2025-10-01

OAAI

Chen, Lei; Zuo, Yongdi; He, Manrong; Du, Jingxue; Tang, Wanxin

ALKBH5 deficiency suppresses hepatocarcinogenesis in mice via m6A-dependent STAT1 restoration ALKBH5 缺乏通过 m6A 依赖的 STAT1 恢复抑制小鼠肝细胞癌发生。

Acta Pharmacologica Sinica

IF8.4

2025-08-21

PREAI

Kai-ting Wang; Shuai Yang; Zi-han Zhao; Chun-hua Rui; Si-yun Shen; Dan Cao; Lin-na Guo; Shan-hua Tang; Lei Chen; Hong-yang Wang; Xin-yao Qiu

Construction and validation of consensus clustering-derived metabolism- and immune-associated genes model for prognosis prediction in cancer patients with liver metastases 基于共识聚类导出的代谢和免疫相关基因模型的构建与验证，用于预测伴有肝转移的癌症患者的预后

Cancer Letters

IF10.1

2025-07-12

PREAI

Jing Wu; Xinyao Qiu; Tao Zhou; Yani Zhang; Shuai Li; Ji Hu; Siyun Shen; Lei Chen; Yingcheng Yang; Shuai Yang; Hongyang Wang

Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression 胆囊癌的多组学分析确定了与疾病进展相关的不同肿瘤微环境

Nature Genetics

IF0

2025-06-26

PREAI

Tao Zhou; Yanhong Wu; Shuai Li; Xinyao Qiu; Erdong Liu; Zhihua Xie; Xuebing Shi; Yani Zhang; Guosheng Ma; Wenbo Guo; Xiang Wang; Kaiting Wang; Xiaomeng Yao; Ji Hu; Siyun Shen; Shuai Yang; Xiaoqing Jiang; Jing Fu; Hongyang Wang; Jin Gu; Lei Chen

TMEM115 as an Oncogenic and Immunological Biomarker in Hepatocellular Carcinoma

LIVER INTERNATIONAL

IF5.2

2025-04-01

PREAI

Sun, Pingping; Xu, Haiyan; Guo, Chengfeng; Yang, Lei; Zhang, Xiaojing; Lu, Bing; Chen, Lei; Huang, Jianfei

Imaging features of epidermoid cysts in intrapancreatic spleen: a single center study of 24 patients 胰腺内脾脏表皮样囊肿的影像学特征：一项单中心24例患者研究

BMC GASTROENTEROLOGY

IF2.6

2025-02-22

OAAI

Zhang, Zehua; Hu, Feixiang; Xie, Tiansong; Zhang, Yuqin; Zheng, Qiang; Liu, Wei; Chen, Lei; Zhou, Zhengrong

Loss of MNX1 Sensitizes Tumors to Cytotoxic T Cells by Degradation of PD-L1 mRNA MNX1的缺失通过PD-L1 mRNA的降解使肿瘤对细胞毒性T细胞敏感

ADVANCED SCIENCE

IF14.1

2025-02-06

OAAI

Li, ZZ; Chen, L; Zhang, G; Wang, S; Xu, EH; Teng, JL; Xu, JC; Peng, F; Min, QJ; Wang, ZY; Shao, SJ; Zhao, LM; Shan, BE; Wang, Y; Zhan, QM; Liu, XF

Spatial single-cell protein landscape reveals vimentinhigh macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma

NATURE CANCER

IF28.5

2024-09-26

PREAI

Qiu, Xinyao; Zhou, Tao; Li, Shuai; Wu, Jianmin; Tang, Jing; Ma, Guosheng; Yang, Shuai; Hu, Ji; Wang, Kaiting; Shen, Siyun; Wang, Hongyang; Chen, Lei

研究方向