Daniel B. Graham - Publications, H-index & Citations

Daniel B. Graham

broad institute of mit and harvard

47H指数

152论文数

1.2W被引数

收录论文 70

发表时间

A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions 基于结构信息的深度学习框架用于TCR-肽-HLA相互作用建模

Nature Communications

IF15.7

2026-09-25

OAAI

Kai Cao; Rui Li; Martin Stražar; Eric M. Brown; Phuong N. U. Nguyen; Marie-Madlen Pust; Jihye Park; Daniel B. Graham; Orr Ashenberg; Caroline Uhler; Ramnik J. Xavier

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology 炎症性肠病的机制：来自人类遗传学和化学生物学的见解

Immunity

IF26.3

2026-04-27

PREAI

Daniel B. Graham; Ramnik J. Xavier

Identifying microbial protease allergens through protein language model-guided homology 通过蛋白质语言模型引导的同源性鉴定微生物蛋白酶过敏原

Cell Systems

IF7.7

2026-02-20

OAAI

Kumar Thurimella; Elena Wu; Chenhao Li; Daniel B. Graham; Róisín M. Owens; Damian R. Plichta; Caroline L. Sokol; Ramnik J. Xavier; Sergio Bacallado

Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk 全基因组关联分析揭示自身免疫性甲状腺功能减退症的自身免疫和甲状腺特异性贡献以及与癌症风险的负相关关系

Nature Genetics

IF29

2026-02-01

OAAI

Reeve, Mary Pat; Kanai, Masahiro; Graham, Daniel B.; Karjalainen, Juha; Luo, Shuang; Kolosov, Nikita; Adams, Cameron; Ritari, Jarmo; Karczewski, Konrad J.; Kiiskinen, Tuomo; Jiang, Yu; Fuller, Zachary; Mehtonen, Juha; Kurki, Mitja I.; Khan, Zia; Daly, Mark J.; Partanen, Jukka; McCarthy, Mark I.; Artomov, Mykyta; Palotie, Aarno; Tuomi, Tiinamaija; Pirinen, Matti; Kero, Jukka; Xavier, Ramnik J.; Ripatti, Samuli

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit 双向CRISPR筛选解码GLIS3依赖性纤维化细胞回路

Nature

IF48.5

2026-01-07

OAAI

Vladislav Pokatayev; Alok Jaiswal; Angela R. Shih; Åsa Segerstolpe; Bihua Li; Elizabeth A. Creasey; Yanhua Zhao; Crystal Lin; Shane Murphy; Chih-Hung Chou; Daniel B. Graham; Ramnik J. Xavier

Real-World Treatment Patterns and Burden of Chronic Thromboembolic Pulmonary Hypertension Patients across Consultation Settings in the USA 美国不同会诊设置下慢性血栓栓塞性肺动脉高压患者的真实世界治疗模式与疾病负担

Pulmonary Therapy

IF3

2025-12-01

OAAI

Rivera-Lebron, Belinda; Witkin, Alison; Paoli, Carly J.; Small, Mark; Harvey, Mia; Graham, Daniel; Panjabi, Sumeet; Rendon, Gabriela Gomez; Rodriguez-Lopez, Josanna

Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-11-03

PREAI

Damm-Ganamet, Kelly L.; Moon, Clara; Wickenden, Alan D.; Tichenor, Mark; Ge, Yunhui; Mercado-Marin, Eduardo, V; Chiou, Brian; Manughian-Peter, Ayla; Mirzadegan, Taraneh; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.; Graham, Daniel B.; Perrigoue, Jacqueline

Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation 肠道神经系统对微生物群和2型炎症的区域性编码

Science

IF45.8

2025-10-30

PREAI

Peng Tan; Alok Jaiswal; Shane P. Murphy; Eric M. Brown; Hailey Wheeler; Chien-Wen Su; Emily P. Finan; Guadalupe J. Jasso; Hai Ning Shi; Daniel B. Graham; Toni M. Delorey; Jacques Deguine; Ramnik J. Xavier

Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation 自身免疫病风险基因ANKRD55通过代谢调控促进TH17效应功能

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2025-09-11

PREAI

Xu, Jinjin; Kong, Lingjia; Creasey, Elizabeth A.; Rath, Sneha; Deng, Lei; Avila-Pacheco, Julian; Li, Chenhao; Oliver, Blayne A.; Dao, Tyler T.; Shih, Angela R.; Daly, Mark J.; Shalek, Alex K.; Clish, Clary B.; Graham, Daniel B.; Deguine, Jacques; Xavier, Ramnik J.

Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network 限制克罗恩病的单细胞和空间转录组学突出了纤维化相关网络

Nature Genetics

IF0

2025-06-25

PREAI

Lingjia Kong; Sathish Subramanian; Åsa Segerstolpe; Vy Tran; Angela R. Shih; Grace T. Carter; Hiroko Kunitake; Shaina W. Twardus; Jasmine Li; Shivam Gandhi; Marco E. Kaper; Christy Cauley; Eric J. Chen; Caroline B. M. Porter; Toni M. Delorey; Liliana Bordeianou; Rocco Ricciardi; Ashwin N. Ananthakrishnan; Helena Lau; Daniel B. Graham; Richard Hodin; Jacques Deguine; Christopher S. Smillie; Ramnik J. Xavier

Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway 拟杆菌鞘脂通过甲羟戊酸途径促进抗炎反应

Cell Host & Microbe

IF18.7

2025-05-30

PREAI

Eric M. Brown; Emily R. Temple; Sarah Jeanfavre; Julian Avila-Pacheco; Noel Taylor; Kai Liu; Phuong N.U. Nguyen; Ahmed M.T. Mohamed; Panhasith Ung; Rebecca A. Walker; Daniel B. Graham; Clary B. Clish; Ramnik J. Xavier

The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin 溃疡性结肠炎相关基因NXPE1催化结肠黏蛋白上的糖基修饰

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-03-11

OAAI

Humeidi, Ranad; Oshiro-Rapley, Noriko; Gu, Xiebin; An, Joon Soo; Ananthakrishnan, Ashwin N.; Creasey, Elizabeth A.; Daly, Mark J.; Schreiber, Stuart L.; Graham, Daniel B.; Seyedsayamdost, Mohammad R.; Xavier, Ramnik J.

Extraaxial Poorly Differentiated Chordoma: Clinicopathologic and Molecular Genetic Characterization

MODERN PATHOLOGY

IF5.5

2025-03-01

PREAI

Sande, William J.; Folpe, Andrew L.; O'Connor, Paige; Graham, Daniel; Molligan, Jeremy F.; Lo, Ying-Chun; Cheung, Yvonne Y.; Ameline, Baptiste; Baumhoer, Daniel; Harder, Dorothee; Raskin, Kevin A.; Mount, Christopher W.; Hung, Yin P.; Nielsen, Gunnlaugur Petur; Kerr, Darcy A.; Buehler, Darya; Wenger, Doris E.; Thangaiah, Judith Jebastin

Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation

SCIENCE ADVANCES

IF12.5

2024-07-19

OAAI

Neale, Ilona; Reddy, Clark; Tan, Zher Yin; Li, Bihua; Nag, Partha P.; Park, Joshua; Park, Jihye; Carey, Kimberly L.; Graham, Daniel B.; Xavier, Ramnik J.

An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission 食道细胞图谱揭示了活动性嗜酸性食管炎和缓解期间的动态重新布线

NATURE COMMUNICATIONS

IF15.7

2024-04-18

OAAI

Ding, Jiarui; Garber, John J.; Uchida, Amiko; Lefkovith, Ariel; Carter, Grace T.; Vimalathas, Praveen; Canha, Lauren; Dougan, Michael; Staller, Kyle; Yarze, Joseph; Delorey, Toni M.; Rozenblatt-Rosen, Orit; Ashenberg, Orr; Graham, Daniel B.; Deguine, Jacques; Regev, Aviv; Xavier, Ramnik J.

Atypical Spindle Cell/Pleomorphic Lipomatous Tumor With Sarcomatous Transformation: Clinicopathologic and Molecular Analysis of 4 Cases

MODERN PATHOLOGY

IF5.5

2024-04-01

PREAI

Perret, Raul; Charville, Gregory W.; Alame, Melissa; Rebier, Flora; Soubeyran, Isabelle; Gross, John M.; Graham, Daniel; Green, Donald C.; Kerr, Darcy A.; Khan, Wahab A.; Cloutier, Jeffrey M.

Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses

CELL REPORTS

IF6.9

2024-03-01

OAAI

Brandt, Marta; Cao, Zhifang; Krishna, Chirag; Reedy, Jennifer L.; Gu, Xiebin; Dutko, Richard A.; Oliver, Blayne A.; Tusi, Betsabeh Khoramian; Park, Jihye; Richey, Lauren; Segerstolpe, Asa; Litwiler, Scott; Creasey, Elizabeth A.; Carey, Kimberly L.; Vyas, Jatin M.; Graham, Daniel B.; Xavier, Ramnik J.

Identification of highly selective SIK 1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2023-12-26

OAAI

Babbe, Holger; Sundberg, Thomas B.; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T.; Mak, Puiying A.; Mathur, Ashok; Mercado-Marin, Eduardo, V; Metkar, Shailesh; Raymond, Donald D.; Rives, Marie -Laure; Rizzolio, Michele; Shaffer, Paul L.; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P.; Wei, Jianmei; Desai, Prerak T.; Ong, Luvena L.; Koudriakova, Tatiana; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar K.; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B.; Plevy, Scott; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.

The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon (vol 56, pg 444, 2023)

IMMUNITY

IF26.3

2023-12-01

OAAI

Kong, Lingjia; Pokatayev, Vladislav; Lefkovith, Ariel; Carter, Grace T.; Creasey, Elizabeth A.; Krishna, Chirag; Subramanian, Sathish; Kochar, Bharati; Ashenberg, Orr; Lau, Helena; Ananthakrishnan, Ashwin N.; Graham, Daniel B.; Deguine, Jacques; Xavier, Ramnik J.

Genetic vulnerability to Crohn's disease reveals a spatially resolved epithelial restitution program 克罗恩病的遗传脆弱性揭示了空间分辨的上皮恢复计划

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2023-10-25

OAAI

Nakata, Toru; Li, Chenhao; Mayassi, Toufic; Lin, Helen; Ghosh, Koushik; Segerstolpe, Asa; Diamond, Emma L.; Herbst, Paula; Biancalani, Tommaso; Gaddam, Shreya; Parkar, Saurabh; Lu, Ziqing; Jaiswal, Alok; Li, Bihua; Creasey, Elizabeth A.; Lefkovith, Ariel; Daly, Mark J.; Graham, Daniel B.; Xavier, Ramnik J.

研究方向