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Toshiyuki Ishiwata

Tokyo Metropolitan Institute for Geriatrics and Gerontology
H指数:53
被引数:7,891
浏览量:0

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Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study

BLU554对胰腺导管腺癌的细胞毒性及诱导衰老作用：一项体外研究

BMC Cancer
IF3.4
2025-12-240
OAAI
Masakazu Fujiwara; Seiichi Shinji; Yuuki Shichi; Keisuke Nonaka; Yasuko Hasegawa; Kimimasa Takahashi; Hirofumi Rokutan; Tomio Arai; Toshiyuki Ishiwata
Morphological and functional analysis of colorectal cancer cell lines in 2D and 3D culture models
SCIENTIFIC REPORTS
IF3.9
2025-01-240
OAAI
Shinji, Seiichi; Ogawa, Yutaro; Yamada, Takeshi; Matsuda, Akihisa; Uehara, Kay; Yokoyama, Yasuyuki; Takahashi, Goro; Iwai, Takuma; Miyasaka, Toshimitsu; Kanaka, Shintaro; Hayashi, Koki; Shichi, Yuuki; Fujiwara, Masakazu; Takahashi, Kimimasa; Arai, Tomio; Ishiwata, Toshiyuki; Yoshida, Hiroshi
Accelerated telomere shortening in adrenal zona reticularis in patients with prolonged critical illness
FRONTIERS IN ENDOCRINOLOGY
IF4.6
2023-09-040
OAAI
Nonaka, Keisuke; Takubo, Kaiyo; Aida, Junko; Watai, Yoriko; Komatsu, Akiko; Gomi, Fujiya; Shichi, Yuuki; Yamazaki, Yuto; Ishiwata, Toshiyuki; Sasano, Hironobu; Arai, Tomio
Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice
SCIENTIFIC REPORTS
IF3.9
2023-08-303
OAAI
Doshida, Yuta; Hashimoto, Shinichi; Iwabuchi, Sadahiro; Takino, Yuka; Ishiwata, Toshiyuki; Aigaki, Toshiro; Ishigami, Akihito
Spatiotemporal changes of tissue glycans depending on localization in cardiac aging
REGENERATIVE THERAPY
IF3.5
2023-03-014
OAAI
Itakura, Yoko; Hasegawa, Yasuko; Kikkawa, Yurika; Murakami, Yuina; Sugiura, Kosuke; Nagai-Okatani, Chiaki; Sasaki, Norihiko; Umemura, Mariko; Takahashi, Yuji; Kimura, Tohru; Kuno, Atsushi; Ishiwata, Toshiyuki; Toyoda, Masashi
mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma
FRONTIERS IN ONCOLOGY
IF3.3
2023-01-277
OAAI
Michishita, Masaki; Ochiai, Kazuhiko; Nakahira, Rei; Azakami, Daigo; Machida, Yukino; Nagashima, Tomokazu; Nakagawa, Takayuki; Ishiwata, Toshiyuki
Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
CELL CHEMICAL BIOLOGY
IF7.2
2022-11-011
OAAI
Ueda, Yoshibumi; Miura, Yuri; Tomishige, Nario; Sugimoto, Naotoshi; Murase, Megumi; Kawamura, Genki; Sasaki, Norihiko; Ishiwata, Toshiyuki; Ozawa, Takeaki
Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures
JOURNAL OF PERSONALIZED MEDICINE
IF3
2022-05-0419
OA
Shichi, Yuuki; Gomi, Fujiya; Sasaki, Norihiko; Nonaka, Keisuke; Arai, Tomio; Ishiwata, Toshiyuki
Morphofunctional analysis of human pancreatic cancer cell lines in 2-and 3-dimensional cultures
SCIENTIFIC REPORTS
IF3.9
2021-03-2423
OAAI
Minami, Fuuka; Sasaki, Norihiko; Shichi, Yuuki; Gomi, Fujiya; Michishita, Masaki; Ohkusu-Tsukada, Kozo; Toyoda, Masashi; Takahashi, Kimimasa; Ishiwata, Toshiyuki
Polyvinyl alcohol increased growth, migration, invasion, and sphere size in the PK-8 pancreatic ductal adenocarcinoma cell line
HELIYON
IF3.6
2021-02-012
OAAI
Gomi, Fujiya; Sasaki, Norihiko; Shichi, Yuuki; Minami, Fuuka; Shinji, Seiichi; Toyoda, Masashi; Ishiwata, Toshiyuki
Increased expression of ganglioside GM2 correlates with aggressiveness of human pancreatic ductal adenocarcinoma
CANCER RESEARCH
IF16.6
2020-08-151
PRE
Sasaki, Norihiko; Hirabayashi, Kenichi; Michishita, Masaki; Takahashi, Kimimasa; Hasegawa, Fumio; Gomi, Fujiya; Itakura, Yoko; Nakamura, Naoya; Toyoda, Masashi; Ishiwata, Toshiyuki
A newly established neuroendocrine carcinoma cell line from a human ascending colon tumor shows high proliferation and CD133 expression in spherical cancer stem cell-like formation
CANCER RESEARCH
IF16.6
2020-08-150
PRE
Shinji, Seiichi; Sasaki, Norihiko; Yamada, Takeshi; Koizumi, Michihiro; Ohta, Ryo; Matsuda, Akihisa; Takahashi, Goro; Hotta, Masahiro; Iwai, Takuma; Hara, Keisuke; Takeda, Kohki; Ueda, Koji; Kuriyama, Sho; Ishiwata, Toshiyuki; Yoshida, Hiroshi
Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage
SCIENTIFIC REPORTS
IF3.9
2019-12-1825
OAAI
Sasaki, Norihiko; Hirabayashi, Kenichi; Michishita, Masaki; Takahashi, Kimimasa; Hasegawa, Fumio; Gomi, Fujiya; Itakura, Yoko; Nakamura, Naoya; Toyoda, Masashi; Ishiwata, Toshiyuki
Correlation Between Telomere Attrition of Zona Fasciculata and Adrenal Weight Reduction in Older Men
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
2019-10-099
OAAI
Nonaka, K.; Aida, Junko; Takubo, Kaiyo; Yamazaki, Yuto; Gao, Xin; Komatsu, Akiko; Takakuma, Shoichiro; Kakizaki, Mototsune; Inoshita, Naoko; Gomi, Fujiya; Ishiwata, Toshiyuki; Chong, Ja-Mun; Arai, Tomio; Sasano, Hironobu
Enhanced morphological and functional differences of pancreatic cancer with epithelial or mesenchymal characteristics in 3D culture
SCIENTIFIC REPORTS
IF3.9
2019-07-2634
OAAI
Shichi, Yuuki; Sasaki, Norihiko; Michishita, Masaki; Hasegawa, Fumio; Matsuda, Yoko; Arai, Tornio; Gomi, Fujiya; Aida, Junko; Takubo, Kaiyo; Toyoda, Masashi; Yoshimura, Hisashi; Takahashi, Kimimasa; Ishiwata, Toshiyuki
Metastasis-promoting role of H19 long non-coding RNA in pancreatic cancer cells
CANCER RESEARCH
IF16.6
2019-07-010
PRE
Sasaki, Norihiko; Toyoda, Masashi; Yoshimura, Hisashi; Matsuda, Yoko; Arai, Tomio; Itakura, Yoko; Gomi, Fujiya; Aida, Junko; Ishiwata, Toshiyuki
Correlation Between Differentiation of Adrenocortical Zones and Telomere Lengths Measured by Q-FISH
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
IF5.1
2019-06-2010
OAAI
Nonaka, Keisuke; Aida, Junko; Takubo, Kaiyo; Yamazaki, Yuto; Takakuma, Shoichiro; Kakizaki, Mototsune; Matsuda, Yoko; Ishikawa, Naoshi; Ishiwata, Toshiyuki; Chong, Ja-Mun; Arai, Tomio; Sasano, Hironobu
Solid-type poorly differentiated adenocarcinoma of the stomach: clinicopathological and molecular characteristics and histogenesis
GASTRIC CANCER
IF5.1
2018-08-0721
OAAI
Arai, Tomio; Matsuda, Yoko; Aida, Junko; Takubo, Kaiyo; Ishiwata, Toshiyuki
ABCG2-positive cells derived from ABCG2-negative pancreatic cancer cells in 3D-culture conditions show high stemness and anti-cancer drug resistance
CANCER RESEARCH
IF16.6
2018-07-010
PRE
Sasaki, Norihiko; Hasegawa, Fumio; Michishita, Masaki; Matsuda, Yoko; Arai, Tomio; Ishikawa, Naoshi; Itakura, Yoko; Aida, Junko; Takubo, Kaiyo; Toyoda, Masashi; Ishiwata, Toshiyuki
Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis
LABORATORY INVESTIGATION
IF4.2
2018-06-0154
OAAI
Yoshimura, Hisashi; Matsuda, Yoko; Yamamoto, Masami; Michishita, Masaki; Takahashi, Kimimasa; Sasaki, Norihiko; Ishikawa, Naoshi; Aida, Junko; Takubo, Kaiyo; Arai, Tomio; Ishiwata, Toshiyuki

研究方向

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N
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