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Sheila K. Singh

centre for discovery in cancer research

43H指数
498论文数
2.0W被引数
收录论文 156
发表时间
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Expanded NK and fratricide-resistant CD70 CAR-NK cells are potent against patient-derived glioblastoma cells in vitro and in vivo扩增的NK细胞和抗 fratricide 的CD70 CAR-NK细胞在体外和体内对来自患者的胶质母细胞瘤细胞具有显著作用
errCancer Immunology Immunotherapy
IF5.1
err2026-08-31
err0
errOAAI
errMisaal Mehboob; Matthew Rätsep; Adnan Moinuddin; Ana Portillo; Fatemeh Vahedi; Mohammadamin Sookhaklari; Ella C. Troy; Yasemin Sezgin; Vaseem Shaikh; William Maich; Chitra Venugopal; Meisam Naeimi Kararoudi; Dean A. Lee; Sheila K. Singh; Ali A. Ashkar
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uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell targetuPAR在复发性胶质母细胞瘤中高表达，并代表CAR T细胞候选靶点
errScience Translational Medicine
IF14.6
err2026-05-13
err0
PREAI
errWilliam T. Maich; Muhammad Vaseem Shaikh; Anish Puri; Martin A. Rossotti; Shan Grewal; Aapti Khanna; Alisha Anand; Nicholas Mikolajewicz; Mathieu P. Seyfrid; Dillon A. McKenna; Minomi Subapanditha; Daniel Mobilio; Greg Hussack; Joey G. Sheff; Jennifer J. Hill; Mo Taleb; Jacek M. Kwiecien; Sabra Salim; Neil Savage; Bill Wang; Sunjay Sharma; Abdelsimar Omar; Chirayu Chokshi; Kui Zhai; Shawn C. Chafe; Jason Moffat; Thomas Kislinger; Chitra Venugopal; Kevin A. Henry; Sheila K. Singh
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err收藏
Targeting SRC enhances differentiation and promotes multifaceted cell death mechanisms in recurrent group 3 medulloblastoma靶向SRC增强分化并促进复发性组3型髓母细胞瘤的多方面细胞死亡机制
errCell Death & Disease
IF9.6
err2026-04-24
err0
errOAAI
errHelgi Kuzmychova; Ujala Chawla; Emma Martell; Akaljot Grewal; Charul Jain; Kayshana Ramnauth; Esha Kaul; Harshal Senthil; Chitra Venugopal; Christopher M. Anderson; Sheila K. Singh; Tanveer Sharif
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Generation of Allogeneic CAR-T Circumvents Functional Deficits in Patient-Derived Autologous Product for Glioblastoma同种异体CAR-T的产生克服了患者来源的自体产品在胶质母细胞瘤中的功能缺陷
errInternational Journal of Cancer
IF4.7
err2026-04-24
err0
errOAAI
errSabra K. Salim; Muhammad Vaseem Shaikh; Jeffrey Wei; William T. Maich; Alisha Anand; Oliver Y. Tang; Minomi K. Subapanditha; Zahra Alizada; Yujin Suk; Manoj Singh; Kui Zhai; Aapti Khanna; Benjamin Brakel; Vassil Dimitrov; Zoya Tabunshchyk; Katie Chan; Kevin R. Brown; Parvez Vora; Donald M. O'Rourke; Zev A. Binder; Chitra Venugopal; Jason Moffat; Sheila K. Singh
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err收藏
Emerging paradigms in the study of brain metastases脑转移瘤研究中的新兴范式
errScience Signaling
IF6.6
err2026-04-07
err0
PREAI
errShawn C. Chafe; Daniel Mobilio; Kui Zhai; Agata M. Kieliszek; Chitra Venugopal; Sheila K. Singh
err分享
err收藏
Glioblastoma cells that evade chemoradiotherapy-induced cell death exhibit a bifurcated glycolytic program胶质母细胞瘤细胞通过逃避化疗和放疗诱导的细胞死亡，表现出一种分叉的糖酵解程序。
errCell Death & Disease
IF9.6
err2026-03-25
err0
errOAAI
errEmma Martell; Helgi Kuzmychova; Ujala Chawla; Akaljot Grewal; Charul Jain; Chitra Venugopal; Christopher M. Anderson; Sheila K. Singh; Tanveer Sharif
err分享
err收藏
National multicentered retrospective review of salvage therapy for pediatric medulloblastoma: a Canadian experience (vol 41, 391,2025)多中心回顾性研究加拿大儿童髓母细胞瘤挽救性治疗经验（第41卷，第391页，2025年）
errCHILDS NERVOUS SYSTEM
IF1.2
err2026-01-14
err0
PREAI
errKameda-Smith, Michelle M.; Lannon, Melissa; Almojuela, Alysa; MacLean, Mark A.; Persad, Amit; Sader, Nicholas; Kulamurugan, Arani; Manoranjan, Branavan; Erker, Craig; Aminnejad, Minoo; Crooks, Bruce; Vitali, Aleksander M.; Hader, Walter; Walling, Simon; McNeely, P. Daniel; Yarascavitch, Blake; Ajani, Olufemi; Farrokhyar, Forough; Fleming, Adam; Singh, Sheila K.
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National multicentered retrospective review of salvage therapy for pediatric medulloblastoma: a Canadian experience全国多中心回顾性研究：儿童髓母细胞瘤挽救性治疗——加拿大的经验
errCHILDS NERVOUS SYSTEM
IF1.2
err2025-12-01
err1
PREAI
errKameda-Smith, Michelle M.; Lannon, Melissa; Almojuela, Alysa; Maclean, Mark A.; Persad, Amit; Sader, Nicholas; Kulamuraugan, Arani; Manoranjan, Branavan; Erker, Craig; Aminnejad, Minoo; Crookes, Bruce; Vitali, Aleksander M.; Hader, Walter; Walling, Simon; McNeely, Daniel; Yarascavitch, Blake; Ajani, Olufemi; Farrokhyar, Forough; Fleming, Adam; Singh, Sheila K.
err分享
err收藏
Correction: 89Zr-labeled ImmunoPET targeting the cancer stem cell antigen CD133 using fully-human antibody constructs更正：使用全人源抗体构建体，对靶向癌症干细胞抗原CD133的89Zr标记免疫PET进行修正。
errEJNMMI Research
IF3
err2025-11-04
err0
errOAAI
errKevin Wyszatko; Melissa Chassé; Nancy Janzen; Luis Rafael Silva; Luke Kwon; Teesha Komal; Manuela Ventura; Chitra Venugopal; Sheila K. Singh; John F. Valliant; Saman Sadeghi
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err收藏
Quantitative surfaceome profiling of high-risk medulloblastoma prioritizes the oncofetal antigen GPC2 for potent CAR-T cell therapy高风险髓母细胞瘤的定量表面组分析优先考虑癌胚抗原GPC2用于有效的CAR-T细胞疗法
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errUsta, Diren; Gwynne, William; Suk, Yujin; Chen, Yiyun; Radosevic, Molly T.; Chernova, Daria; Delaidelli, Alberto; Feng, Yushen; Nasajpour, Emon; Trissal, Maria C.; Poetschke, Rebecca D.; Dunham, Christopher; Labanie, Louai; Van Der Lugt, Jasper; Nierkens, Stefan; Filbin, Mariella G.; Petritsch, Claudia K.; Sorensen, Poul; Ryan, Katherine J.; Venugopal, Chitra; Sotillo, Elena; Mackall, Crystal L.; Singh, Sheila K.; Heitzeneder, Sabine
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High-resolution proteomic analysis of medulloblastoma clinical samples identifies MYC immunohistochemistry as a powerful outcome predictor outperforming genetic amplification detection高分辨率蛋白质组学分析对髓母细胞瘤临床样本的研究确定了MYC免疫组化是一种强大的预后预测因子，其预测性能优于基因扩增检测。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
PREAI
errDelaidelli, Alberto; Burwag, Fares; Suk, Yujin; Shyp, Taras; Kosteniuk, Suzanne; Dunham, Christopher; Cheng, Sylvia; Okonechnikov, Konstantin; Schrimpf, Daniel; Von Deimling, Andreas; Ellezam, Benjamin; Perreault, Sebastien; Singh, Sheila; Hawkins, Cynthia; Kool, Marcel; Pfister, Stefan; Steidl, Christian; Hughes, Christopher; Korshunov, Andrey; Sorensen, Poul
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D-serine facilitates aggressive migration and stemness of recurrent glioblastoma cells by interacting with host endothelial cellsD-丝氨酸通过与宿主内皮细胞相互作用，促进复发胶质母细胞瘤细胞的侵袭性迁移和干性。
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errMota, Ryan; Lu, Ping; Martell, Emma; Cuesta, Alejandra Llanes; Liang, Lisa; Singh, Sheila K.; Sharif, Tanveer; Anderson, Christopher M.
err分享
err收藏
Investigating the cytotoxicity of expanded NK and CD70-targeting CAR-NK cells against brain tumor cells
errJOURNAL OF IMMUNOLOGY
IF3.4
err2025-11-01
err0
PREAI
errMehboob, Misaal; Ratsep, Matthew; Portillo, Ana; Sezgin, Yasemin; Shaikh, Vaseem; Kararoudi, Meisam Naeimi; Singh, Sheila; Ashkar, Ali A.
err分享
err收藏
Dynamic and multi-omic profiling of glioblastoma to guide personalized medicine胶质母细胞瘤的动态和多组学分析以指导个性化医学
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errKhanna, Aapti; Qazi, Maleeha A.; Richards, Laura; Pugh, Trevor; Bates, Gary D.; Khoo, Amanda; Kuhlmann, Laura; Kislinger, Thomas; Reimand, Juri; Venugopal, Chitra; Singh, Sheila K.
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err收藏
Reactive Oligodendrocytes Promote Glioblastoma Progression via CCL5/CCR5-Mediated Glioma Stem Cell Maintenance反应性少突胶质细胞通过CCL5/CCR5介导的胶质瘤干细胞维持促进胶质母细胞瘤进展
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errMikolajewicz, Nicholas; Zhai, Kui; Venugopal, Chitra; Singh, Sheila; Moffat, Jason
err分享
err收藏
A GENOME-WIDE IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES BACE1 AS A THERAPEUTIC VULNERABILITY OF LUNG CANCER BRAIN METASTASIS全基因组体内CRISPR激活筛选确定了BACE1为肺癌脑转移的疗法易感性靶点
errNEURO-ONCOLOGY
IF13.4
err2025-11-01
err0
errOAAI
errChafe, Shawn; Zhai, Kui; Aghaei, Nikoo; Miletic, Petar; Huang, Zhi; Brown, Kevin; Mobilio, Daniel; Young, Daniel; Suk, Yujin; Grewal, Shan; Mckenna, Dillon; Alizada, Zahra; Kieliszek, Agata; Lam, Fred; Escudero, Laura; Huang, Qian; Huebner, Ariana; Lu, Jack; Ang, Patrick; Anand, Alisha; Custers, Stefan; Apel, Erika; Slassi, Sarah; Brakel, Benjamin; Kim, Jongmyung; Liu, James; Bassey-Archibong, Blessing; Abdo, Rober; Shargall, Yaron; Lu, Jian-Qiang; Cutz, Jean-Claude; Zhang, Qi; Li, Shawn; Venugopal, Chitra; Hynds, Robert; Dufour, Antoine; Moffat, Jason; Swanton, Charles; Bao, Shideng; Singh, Sheila
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From hope to loss and back again: loved ones' experience with glioblastoma in the spatial heterogeneity challenge从希望到失落再回到希望：在空间异质性挑战中与胶质母细胞瘤抗争的亲人经历
errBRITISH JOURNAL OF NEUROSURGERY
IF0.8
err2025-10-01
err0
PREAI
errLannon, Melissa; Hart, Shannon; Martyniuk, Amanda; Sharma, Sunjay V.; Acai, Anita; Singh, Sheila
err分享
err收藏
TARGETING NON-GENETIC KINASE-DEPENDENT SIGNALING TO PREVENT GROUP 3 MEDULLOBLASTOMA RECURRENCE靶向非遗传性激酶依赖性信号通路以预防组3型髓母细胞瘤复发
errNEURO-ONCOLOGY
IF13.4
err2025-10-01
err0
errOAAI
errKuzmychova, H.; Chawla, U.; Martell, E.; Senthil, H.; Grewal, A.; Jain, C.; Venugopal, C.; Singh, S. K.; Sharif, T.
err分享
err收藏
29 SNAT2 AS A NOVEL TARGETABLE VULNERABILITY IN RECURRENT GLIOBLASTOMA29 SNAT2 作为复发胶质母细胞瘤的新型可靶向的易损性
errNeuro-Oncology Advances
IF4.1
err2025-08-31
err0
errOAAI
errAnish Puri; Jose C Bozelli Jr; William Maich; Dillon McKenna; Manoj Singh; Benjamin Brakel; Lucas Asselstine; Shawn C Chafe; Chitra Venugopal; Philip Britz-McKibbin; Sheila K Singh
err分享
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27 GENETIC SCREENING REVEALS FEN1 AS A DRIVER OF STEMNESS AND TEMOZOLOMIDE RESISTANCE IN GLIOBLASTOMA27 基因筛查揭示FEN1是胶质母细胞瘤中维持干细胞特性及替莫唑胺耐药性的驱动因子
errNeuro-Oncology Advances
IF4.1
err2025-08-31
err0
errOAAI
errBenjamin A Brakel; Dillon McKenna; Ali Saleh; Anish Puri; Vaseem Muhammad Shaikh; Manoj Singh; Nicholas Mikolajewicz; Marcello Beltrami; Alisha Anand; Petar Miletic; Kevin R Brown; David Tieu; Abdo-jose Tomajian; William Maich; Sabra Salim; Yujin Suk; Minomi Subapanditha; Deena Gendoo; Chitra Venugopal; Jason Moffat; Sachin Katyal; Sheila K Singh; Chirayu R Chokshi
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研究方向

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合作学者
合作期刊
M
Michael Weller
H 指数: 175 · 论文数: 2.8K
A
Andreas von Deimling
H 指数: 175 · 论文数: 1.8K
C
Charles Swanton
H 指数: 137 · 论文数: 1.2K
M
Michael D. Taylor
H 指数: 132 · 论文数: 1.7K
P
Paul Kubes
H 指数: 128 · 论文数: 658
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