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收藏An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex
Shannon, Ashleigh; Chazot, Aurelie; Feracci, Mikael; Falcou, Camille; Fattorini, Veronique; Selisko, Barbara; Good, Steven; Moussa, Adel; Sommadossi, Jean-Pierre; Ferron, Francois; Alvarez, Karine; Canard, Bruno
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收藏A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Shannon, Ashleigh; Fattorini, Veronique; Sama, Bhawna; Selisko, Barbara; Feracci, Mikael; Falcou, Camille; Gauffre, Pierre; El Kazzi, Priscila; Delpal, Adrien; Decroly, Etienne; Alvarez, Karine; Eydoux, Cecilia; Guillemot, Jean-Claude; Moussa, Adel; Good, Steven S.; La Colla, Paolo; Lin, Kai; Sommadossi, Jean-Pierre; Zhu, Yingxiao; Yan, Xiaodong; Shi, Hui; Ferron, Francois; Canard, Bruno
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收藏Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses
Good, Steven S.; Shannon, Ashleigh; Lin, Kai; Moussa, Adel; Julander, Justin G.; La Colla, Paolo; Collu, Gabriella; Canard, Bruno; Sommadossi, Jean-Pierre
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收藏AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19
Good, Steven S.; Westover, Jonna; Jung, Kie Hoon; Zhou, Xiao-Jian; Moussa, Adel; La Colla, Paolo; Collu, Gabriella; Canard, Bruno; Sommadossi, Jean-Pierre
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收藏Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis
Berliba, Elina; Bogus, Maxim; Vanhoutte, Frederic; Berghmans, Pieter-Jan; Good, Steven S.; Moussa, Adel; Pietropaolo, Keith; Murphy, Robert L.; Zhou, Xiao-Jian; Sommadossi, Jean-Pierre
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收藏Development of an Efficient Manufacturing Process to GSK2248761A API
Bret, Celine; Smith, Elaine; Vit, Erica; Hayes, Jerome F.; Hayler, John D.; Ironmonger, Alan; Pascoe, David; Hodnett, Neil; Stanway, Jonathan; Etridge, Stephen; Stewart, Alistair; Wang, Jingyang; Mayes, Benjamin A.; Moussa, Adel
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收藏Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor
Dousson, Cyril; Alexandre, Francois-Rene; Amador, Agnes; Bonaric, Severine; Bot, Stephanie; Caillet, Catherine; Convard, Thierry; da Costa, Daniel; Lioure, Marie-Pierre; Roland, Arlene; Rosinovsky, Elodie; Maldonado, Sebastien; Parsy, Christophe; Trochet, Christophe; Storer, Richard; Stewart, Alistair; Wang, Jingyang; Mayes, Benjamin A.; Musiu, Chiara; Poddesul, Barbara; Vargiu, Luana; Liuzzi, Michel; Moussa, Adel; Jakubik, Jocelyn; Hubbard, Luke; Seifer, Maria; Standring, David
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收藏Scalable Synthesis of a Nucleoside Phosphoramidate Prodrug Inhibitor of HCV NS5B RdRp: Challenges in the Production of a Diastereomeric Mixture
Mayes, Benjamin A.; Wang, Jingyang; Arumugasamy, Jeevanandam; Arunachalam, Kannan; Baloglu, Erkan; Bauer, David; Becker, Alan; Chaudhuri, Narayan; Glynn, Roberta; Latham, G. Mark; Li, Jie; Lim, Jinsoo; Liu, Jia; Mathieu, Steve; McGarry, F. Patrick; Rosinovsky, Elodie; Soret, Adrien F.; Stewart, Alistair; Moussa, Adel
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